DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15356 and Emsy

DIOPT Version :9

Sequence 1:	NP_608633.1	Gene:	CG15356 / 33370	FlyBaseID:	FBgn0031377	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	XP_006507678.1	Gene:	Emsy / 233545	MGIID:	1924203	Length:	1329	Species:	Mus musculus

Alignment Length:	1144	Identity:	288/1144 - (25%)
Similarity:	429/1144 - (37%)	Gaps:	370/1144 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWPQTLEMSRDECRGMLRRLELESYSHVVSVFRAQGALSETKAKLLEELRQQFHINQERHRAEVR 65
            :||..|::|||||:.:||:||||:|:.|:|..||||.|::.|..||.||.:...|:.||||||||
Mouse     4 VWPTLLDLSRDECKRILRKLELEAYAGVISALRAQGDLTKEKKDLLGELSKVLSISTERHRAEVR 68

  Fly    66 RAANDEQLCTIAE--------------NVCGPNTWQEWSREGRRLYPLLPRISPQTALSIVANDL 116
            ||.|||:|.|||.              ::.|||:..|||.|||||.||:||:.||||.::.||.:
Mouse    69 RAVNDERLTTIAHKMNLSLYLGERPSYSMSGPNSSSEWSIEGRRLVPLMPRLVPQTAFTVTANAV 133

  Fly   117 AAKACEENAKLAAPAETA-----VHFG---------EALVEQASLMSLKYPRGARIQDTAMVIMA 167
            |..|.:.||.|..|||||     |.:.         ...|...|:.::|.||.|....:.:|
Mouse   134 ANAAVQHNASLPVPAETASKDVVVCYSYTSTTSTPTSTPVPSGSIATVKSPRPASPASSVVV--- 195

  Fly   168 EPFKVPDLPNEVKKMTQKRKENDSGIDGKPNKKRHMQQPHPQQPHLQASQQQQQSQQLNPNSSNP 232
                   ||:......:....:|.  |.||.|:|                      :.|.:||:|
Mouse   196 -------LPSGSTVYVKSVSCSDE--DEKPRKRR----------------------RTNSSSSSP 229

  Fly   233 GMEEADP---VPPEKRMTARTLQQRYFYQQQMKHKQRLAS-KRNLANRL-----------GSPSA 282
            .:.:..|   ||..|.:|.           .:....:::: .:::||.|           ..||.
Mouse   230 VVLKEVPKAVVPVSKTITV-----------PVSGSPKMSNIMQSIANSLPPHMSPVKITFTKPST 283

  Fly   283 QSGNPLGGRNMPSSGGDTSTAKRSAAPAKSGRRAQKQLQQQQKLQQHQQQKVLM----QSQETVP 343
            |:.|             |:|                             |||::    .|...||
Mouse   284 QTTN-------------TTT-----------------------------QKVIIVTTSPSSTFVP 306

  Fly   344 NHMVVQPHVEYVLDEALKTLAASNPPTPTSTVA-----PPYTILNEPRPLVTLKPLKTIKPMIYG 403
            |          :|.:: ...||.....|||.:|     ||..|......|||
Mouse   307 N----------ILSKS-HNYAAVTKLVPTSVIASTTQKPPVVITASQASLVT------------- 347

  Fly   404 PQSGMPSAEIGSPTTPGSRGFANSPIVFKEKLQASP-VQVATQGQGSPTKKFVAEERHADAMPSA 467
            ..|...|:...||        .:|.:.....:.::| |.::|..||..|...........:..|.
Mouse   348 SSSNGNSSSTSSP--------ISSTVAVTTVVSSTPSVVMSTVAQGVSTSAIKVASTRLPSPKSL 404

  Fly   468 ATTPTPISTANLPLAPQIISVQKIPAPSMGGKLRAAVASPTS-----STNSTLLPPGAKTT---- 523
            .:.||.| .|..|...|....|::  ..:..:.:..||.|:|     ....:.||||.|.|
Mouse   405 VSGPTQI-LAQFPKQHQQSPKQQL--QQVQQQTQQPVAQPSSVSQQQQPQQSALPPGIKPTIQIK 466

  Fly   524 -PKKFNILEGDAKPKTLPSSAVRLLPYTEPIGGPLSPLKDSRVTPLSSASTVNIIKNIPASSLNN 587
             .....|:....:|.       ::||  :|:...|         |.||.|.:.::     ||...
Mouse   467 QESGVKIITQQVQPS-------KILP--KPVTATL---------PTSSNSPIMVV-----SSNGA 508

  Fly   588 TLITPLPSAGTTMPANLFRAKVTPSIKGASGAAGGATVIGAAGATGIGGAGAGPQILGNIKLTSS 652
            .:.|.|.:..|...|...|..|:||:...:...|.||.                     :|.||.
Mouse   509 IMTTKLVTTPTGTQATYTRPTVSPSLGRVATTPGAATY---------------------VKTTSG 552

  Fly   653 SGGAATIKQVPSSALRNIKICSPNGKLFLQPGKLPAGSIIHKFNNASSTAVSAAGGVVTTTTTTV 717
            |    .|..||.|      :.:..||:.                  ||..||.    .||..||:
Mouse   553 S----IITVVPKS------LATLGGKII------------------SSNIVSG----TTTKITTI 585

  Fly   718 SPTKQPAREQRISIQKILQPATGSASSGSSSPTTTTTTISGLTSSAKQPGLGNKPTTLTFATAGG 782
            ..|.:|   ..|.:||    .||..           |||.||      || .|..|||..|   |
Mouse   586 PMTSKP---NVIVVQK----TTGKG-----------TTIQGL------PG-KNVVTTLLNA---G 622

  Fly   783 GKNNLVFLPASAASGMRALTLATKPKSNVLV-----IGASTSPASAASSP-----NPSGGT---- 833
            |:..|..:||.|..   |:..||:|.:.::|     ||::..|| |...|     ...|.|
Mouse   623 GEKTLQTVPAGAKP---AIITATRPITKMIVTQPKGIGSAVQPA-AKIIPTKIVYGQQGKTQVLI 683

  Fly   834 KPK------------ANQLITEDTPIDIINMPIIVAD-------------------NGTAAELNQ 867
            |||            ..||:||     .:.....|||                   :.::.|.:|
Mouse   684 KPKPVTFQATVVSEQTRQLVTE-----TLQQASRVADASNSSAQEGKEEPQGYTDSSSSSTESSQ 743

  Fly   868 ASVKNSPLVVFNAT---DW---EMELDQAAT---KSASTTSKQALDDV--IIEEDEDAEEEARES 921
            :|..:.|:|...|:   ||   |:.::.:.|   :..|:.|:.|...:  ::|..:...:|..||
Mouse   744 SSQDSQPVVHVIASRRQDWSEHEIAMETSPTIIYQDVSSESQSATSTIKALLELQQTTVKEKLES 808

  Fly   922 SEQPSTMDLNNSIIEL-------HPEDDSAIEYVDMDLEQPVEIESTSNISPETATTTLKAAIVS 979
            ..:..|:||:...:.:       |..:..:|..|:.:|   |....|:..:.|.........:..
Mouse   809 KPRQPTIDLSQMAVPIQMTQEKRHSPESPSIAVVESEL---VAEYITTERTDEGTEVAFPLLVSH 870

  Fly   980 TSPQQQQQQPQKKHPPLEHPLSAGAAAGTGSSTGAAVQS 1018
            .|..||..|||:  ..|:|.    |.:.|.:.|...|:|
Mouse   871 RSQPQQPSQPQR--TLLQHV----AQSQTATQTSVVVKS 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15356	NP_608633.1	ENT	16..82	CDD:281696	37/79 (47%)
Emsy	XP_006507678.1	ENT	19..81	CDD:367629	36/61 (59%)
Emsy	XP_006507678.1	PABP-1234	<965..1108	CDD:130689
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838875
Domainoid	1	1.000	72	1.000	Domainoid score	I9339
eggNOG	1	0.900	-	-		E1_KOG4675
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	150	1.000	Inparanoid score	I4364
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008212
OrthoInspector	1	1.000	-	-		oto92364
orthoMCL	1	0.900	-	-		OOG6_109408
Panther	1	1.100	-	-	LDO	PTHR16500
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5579
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.870