DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15356 and emsy

DIOPT Version :9

Sequence 1:	NP_608633.1	Gene:	CG15356 / 33370	FlyBaseID:	FBgn0031377	Length:	1023	Species:	Drosophila melanogaster
Sequence 2:	XP_004912274.1	Gene:	emsy / 100136947	XenbaseID:	XB-GENE-6257795	Length:	1341	Species:	Xenopus tropicalis

Alignment Length:	1130	Identity:	287/1130 - (25%)
Similarity:	429/1130 - (37%)	Gaps:	345/1130 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWPQTLEMSRDECRGMLRRLELESYSHVVSVFRAQGALSETKAKLLEELRQQFHINQERHRAEVR 65
            :||..|:.|||||:.:||:||||:|:.|:|..||||.|.:.|..||.||.:...|:.||||||||
Frog    21 VWPTLLDFSRDECKRILRKLELEAYAGVISALRAQGDLCKEKKDLLGELSKVLSISTERHRAEVR 85

  Fly    66 RAANDEQLCTIAENVCGPNTWQEWSREGRRLYPLLPRISPQTALSIVANDLAAKACEENAKLAAP 130
            ||.|||:|.|||.|:.|||:..|||.|||||.||:||:.||||.:..||.:|..|.:.||.|..|
Frog    86 RAVNDERLTTIAHNMSGPNSSSEWSIEGRRLVPLMPRLVPQTAFTATANAVANAAGQHNASLPDP 150

  Fly   131 AET-----AVHFG---------EALVEQASLMSLKYPRGARIQDTAMVIMAEPFKVPDLPN---- 177
            |||     .|.:.         ...|...|:.::|.||.|......:|          ||:
Frog   151 AETGNKEVVVCYSYTSTTSTPTSTPVPSGSVATVKSPRPASPASNVVV----------LPSGSTV 205

  Fly   178 EVKKMTQKRKENDSGIDGKPNKKRHMQQPHPQQPHLQASQQQQQSQQLNPNSSNPGMEEADPVPP 242
            .||.:      |.|..|.||.|:|                      :.|.|||:|.:.:..|.|.
Frog   206 YVKSV------NCSDDDEKPRKRR----------------------RTNSNSSSPVVLKEVPKPT 242

  Fly   243 EKRMTARTLQQRYFYQQQMKHKQRLASKRNLANRL-----------GSPSAQSGNPLGGRNMPSS 296
            ..  .::|:........:|.:     ..:::||.|           ..|:.|:.|
Frog   243 TP--VSKTITVPVTGSPKMSN-----IMQSIANSLPPHMSPVKITFTKPATQTTN---------- 290

  Fly   297 GGDTSTAKRSAAPAKSGRRAQKQLQQQQKLQQHQQQKVLM----QSQETVPNHMVVQPHVEYVLD 357
               |||                             |||::    .|...|||          :|.
Frog   291 ---TST-----------------------------QKVIIVTTSPSSTFVPN----------ILS 313

  Fly   358 EALKTLAASNPPTPTSTVAPPYTILNEPRPLVTLKPLKTIKPMIYGPQSGMPSAEIGSPTTPGSR 422
            :: ...||.....|||.:    |...:.:|||           :...||   |....|.|:..|.
Frog   314 KS-HNYAAVTKLVPTSVI----TSATQKQPLV-----------VTASQS---SVVTSSSTSSSSP 359

  Fly   423 GFANSPIVFKEKLQASP-VQVATQGQGSPTKKFVAEERHADAMPSAATTPTPISTANLPLAPQII 486
            ...:..|.....:.::| :.::|...|:.|....|......:..|..|:|:.| .|.||...|..
Frog   360 PLTSGSIAVTTVVSSTPSLVMSTVAPGASTSAVKAATNRLPSPKSLVTSPSQI-LAQLPKQYQQS 423

  Fly   487 ---SVQKIPAPSMGGKLRAAVASPTSSTNSTLLPPGAKTTPKKFNILEGDAKP--KTLPSSAVRL 546
               .:..||..:.......|:.:|.:.|:    ||.|:..|     :....||  :....|.|::
Frog   424 PKHQIHTIPQQTQQLAQATAITNPGTITH----PPTAQQPP-----MPAAMKPTIQIKQESGVKI 479

  Fly   547 LPYTEPIGGPLSPLKDSRVTPLSSASTVNIIKNIP--ASSLNNTLITPLPSAGTTMPANLFRAKV 609
            :  |:.:       :.|::.|...::::....|.|  ..|.|..::|   :...|.|:.......
Frog   480 I--TQQV-------QPSKILPKPVSTSLPNSSNAPIMVVSSNGAIMT---TKLVTTPSGTQATYT 532

  Fly   610 TPSIKGASGAAGGATVIGAAGATGIGGAGAGPQILGNIKLTSSSGGAATIKQVPSSALRNIKICS 674
            .|:|..|.||...||    .|||             .:|.||.|    .|..||.|      :.:
Frog   533 RPTISSALGARMAAT----PGAT-------------YVKTTSGS----IITVVPKS------LAT 570

  Fly   675 PNGKLFLQPGKLPAGSIIHKFNNASSTAVSAAGGVVTTTTTTVSPTKQPAREQRISIQKILQPAT 739
            ..||:.                  ||..||.    .||..||:..|.:|   ..|.:||    .|
Frog   571 LGGKII------------------SSNIVSG----TTTKITTIPMTSKP---NVIVVQK----TT 606

  Fly   740 GSASSGSSSPTTTTTTISGLTSSAKQPGLGNKPTTLTFATAGGGKNNLVFLPASAASGMRALTLA 804
            |..           |||.||      ||   |....|...|||.|.    |.|..|....|:..|
Frog   607 GKG-----------TTIQGL------PG---KNVVTTLLNAGGDKT----LQAMPAGTKPAIITA 647

  Fly   805 TKPKSNVLVIGASTSPASAASSPNPS-------------GGT----KPK------------ANQL 840
            |:|.:.::|    |.|....|:..|:             |.|    |||            ..||
Frog   648 TRPITKMIV----TQPKGMGSTVQPATKIIPTKIVYGQQGKTQVLIKPKPVTFQATVMSEQTRQL 708

  Fly   841 ITED----------TPIDIINMPIIVADNGTAAELNQASVKNSPLV---VFNATDW---EMELDQ 889
            :||.          |...|..:......:.::.|.:|:|..:.|:|   ...:.||   |:.:|.
Frog   709 VTETLQQASRVVEATSATIQEVKEDTESSSSSTESSQSSQDSQPVVHVIASRSQDWAEHEIAMDT 773

  Fly   890 AAT----------KSASTTSKQALDDVIIEEDEDAEEEARESSEQPSTMDLNNSIIELHPEDD-- 942
            ..|          :||::|.|     .::|..:.|.:|..|:..:..|:||:...:.:....|
Frog   774 TPTIIYQDIGGESQSATSTIK-----ALMELQQTAVKEKVENKLRQPTIDLSQMAVPIQMAADKR 833

  Fly   943 ----SAIEYVDMDLEQPV------EIESTSNISPETATTTLKAAIVSTSPQQQQQQPQKKHPPLE 997
                |:|..|:.:|....      ::.||:.:|  :....|.:.:..:.|.||.||.|.....|:
Frog   834 HAEGSSIAMVESELVAEYLSTGKRQMASTNTVS--SGDMPLPSLLQVSHPSQQLQQVQPTRTLLQ 896

  Fly   998 HPLSAGAAAGTG--------SSTGA 1014
            |...:..|:...        ||:||
Frog   897 HVSQSQTASQASVVVKSIPTSSSGA 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15356	NP_608633.1	ENT	16..82	CDD:281696	38/65 (58%)
emsy	XP_004912274.1	ENT	36..100	CDD:367629	37/63 (59%)
		Herpes_BLLF1	<246..632	CDD:282904	118/559 (21%)
		PRK10927	<994..>1120	CDD:236797
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	78	1.000	Domainoid score	I8670
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	163	1.000	Inparanoid score	I4087
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008212
OrthoInspector	1	1.000	-	-		oto102673
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.050