DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Der-1 and DERL1

DIOPT Version :9

Sequence 1:	NP_001259892.1	Gene:	Der-1 / 33369	FlyBaseID:	FBgn0267972	Length:	245	Species:	Drosophila melanogaster
Sequence 2:	NP_077271.1	Gene:	DERL1 / 79139	HGNCID:	28454	Length:	251	Species:	Homo sapiens

Alignment Length:	250	Identity:	106/250 - (42%)
Similarity:	154/250 - (61%)	Gaps:	11/250 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DAGVWYRSLPRFTRYWLTATVVLSMLCRFDVIPLHWLHLDRSAVFSKLQLWRCMTSLFVFPISSN 66
            |.|.|:||:|..||||..|||.:.::.:..:|...:|.|...|...:.|:||.:|:.|.||:...
Human     3 DIGDWFRSIPAITRYWFAATVAVPLVGKLGLISPAYLFLWPEAFLYRFQIWRPITATFYFPVGPG 67

  Fly    67 TAFHFLINCFFIVQYSSKLEKDQYSRSPADYLYLLIVSAVLANIGGMIFNVYFLMDTLVLAITYI 131
            |.|.:|:|.:|:.|||::||...:...|||||::|:.:.:...|.|:..::..||..|::::.|:
Human    68 TGFLYLVNLYFLYQYSTRLETGAFDGRPADYLFMLLFNWICIVITGLAMDMQLLMIPLIMSVLYV 132

  Fly   132 WCQLNKDVTVSFWFGTRFKAMYLPWVLAAFEFIFHFSLAS-LVGIFVGHVYYFFKFQYSQDLGGT 195
            |.|||:|:.|||||||||||.|||||:..|.:|...|:.: |:|..|||:|:|..|:|..||||.
Human   133 WAQLNRDMIVSFWFGTRFKACYLPWVILGFNYIIGGSVINELIGNLVGHLYFFLMFRYPMDLGGR 197

  Fly   196 PLLETPQFLKRLVPDVSGGFGGFGLPPESRAPPRQATES-------PWGRGMTLG 243
            ..|.|||||.|.:|...||..|||:||.|.   |:|.:.       .||:|..||
Human   198 NFLSTPQFLYRWLPSRRGGVSGFGVPPASM---RRAADQNGGGGRHNWGQGFRLG 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Der-1	NP_001259892.1	DER1	10..202	CDD:282380	80/192 (42%)
DERL1	NP_077271.1	DER1	11..204	CDD:398288	80/192 (42%)
DERL1	NP_077271.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	229..251		5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154214
Domainoid	1	1.000	181	1.000	Domainoid score	I3505
eggNOG	1	0.900	-	-		E1_COG5291
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11483
Inparanoid	1	1.050	220	1.000	Inparanoid score	I3574
Isobase	1	0.950	-	0	Normalized mean entropy	S2094
OMA	1	1.010	-	-		QHG54051
OrthoDB	1	1.010	-	-		D1609512at2759
OrthoFinder	1	1.000	-	-		FOG0000789
OrthoInspector	1	1.000	-	-		oto88753
orthoMCL	1	0.900	-	-		OOG6_104075
Panther	1	1.100	-	-	LDO	PTHR11009
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2482
SonicParanoid	1	1.000	-	-		X5359
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750