DRSC/TRiP Functional Genomics Resources

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Protein Alignment Wdr62 and TUP1

DIOPT Version :9

Sequence 1:NP_001259886.1 Gene:Wdr62 / 33367 FlyBaseID:FBgn0031374 Length:2397 Species:Drosophila melanogaster
Sequence 2:NP_010007.1 Gene:TUP1 / 850445 SGDID:S000000680 Length:713 Species:Saccharomyces cerevisiae


Alignment Length:515 Identity:94/515 - (18%)
Similarity:178/515 - (34%) Gaps:155/515 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   328 SATLEYVTTLPRT-----------------HYLGVDVAQGIQINHIMSVP------QQAKFPDCI 369
            |||....||...|                 |||   |....:.||...:|      .....||.:
Yeast   253 SATTATTTTATETEIKPKEEDATPASLHQDHYL---VPYNQRANHSKPIPPFLLDLDSQSVPDAL 314

  Fly   370 AMVFDEQRSKVSCVYNDHSLYIWDLRDISRVGKSHSFLYHSTCIWGVETVPYNVEREPSQTLPEE 434
                .:|.:....:||                               ..:|..::.|..::|...
Yeast   315 ----KKQTNDYYILYN-------------------------------PALPREIDVELHKSLDHT 344

  Fly   435 CFVTC---SSDDTIRVWGLDGCTNNDIYRRNIYSKELLKIVYSDDELQFIKDQGSSLFDKAGNSS 496
            ..|.|   |:|......|.:..|  .:||   .|...|....|||..  ..:..:|:.:....:|
Yeast   345 SVVCCVKFSNDGEYLATGCNKTT--QVYR---VSDGSLVARLSDDSA--ANNHRNSITENNTTTS 402

  Fly   497 YDGRN-------------------------------------GVRCIKISPELQHLASGDRCGNI 524
            .|...                                     .:|.:..||:.:.||:|.....|
Yeast   403 TDNNTMTTTTTTTITTTAMTSAAELAKDVENLNTSSSPSSDLYIRSVCFSPDGKFLATGAEDRLI 467

  Fly   525 RVYSLVNLRLLTTIEAHESEVLCLEY--SNEKIERKLLASASRDRLIHVFDVAQNYL-LLQTLDD 586
            |::.:.|.:::..::.||.::..|:|  |.:|     |.|.|.||.:.::|:..... |..:::|
Yeast   468 RIWDIENRKIVMILQGHEQDIYSLDYFPSGDK-----LVSGSGDRTVRIWDLRTGQCSLTLSIED 527

  Fly   587 HSSSITSI-------KFVGAGLNFQMISCGADKSI-MFRSFQGNIFMR--GTNTSG---KTTLYD 638
               .:|::       |::.||        ..|::: ::.|..|.:..|  ..|.||   |.::|.
Yeast   528 ---GVTTVAVSPGDGKYIAAG--------SLDRAVRVWDSETGFLVERLDSENESGTGHKDSVYS 581

  Fly   639 MEVDSNAKHILTACQDRNVRVYGTQNAKQTKTFKGSHS---------DEGSLIKLSLDPSGIYVA 694
            :....:.:.:::...||:|:::..|||......|..:|         .:..::.::...:..|:.
Yeast   582 VVFTRDGQSVVSGSLDRSVKLWNLQNANNKSDSKTPNSGTCEVTYIGHKDFVLSVATTQNDEYIL 646

  Fly   695 TSCTDKTLAVYDYYSNECMARMYGHSELVTGLKFTN------DCRHLISASGDGCIFIWQ 748
            :...|:.:..:|..|...:..:.||...|..:...|      :.....:.|||....||:
Yeast   647 SGSKDRGVLFWDKKSGNPLLMLQGHRNSVISVAVANGSPLGPEYNVFATGSGDCKARIWK 706

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Wdr62NP_001259886.1 WD40 73..448 CDD:295369 25/145 (17%)
WD40 repeat 73..107 CDD:293791
WD40 repeat 113..161 CDD:293791
WD40 158..574 CDD:225201 57/310 (18%)
WD40 repeat 167..207 CDD:293791
WD40 repeat 209..285 CDD:293791
WD40 repeat 254..294 CDD:293791
WD40 repeat 303..338 CDD:293791 5/9 (56%)
WD40 repeat 353..407 CDD:293791 8/59 (14%)
WD40 385..747 CDD:225201 75/432 (17%)
WD40 436..748 CDD:295369 72/382 (19%)
WD40 repeat 505..540 CDD:293791 8/34 (24%)
WD40 repeat 546..586 CDD:293791 11/42 (26%)
WD40 repeat 591..631 CDD:293791 9/49 (18%)
WD40 repeat 637..672 CDD:293791 7/34 (21%)
WD40 repeat 679..717 CDD:293791 4/37 (11%)
WD40 repeat 723..749 CDD:293791 7/32 (22%)
TUP1NP_010007.1 Tup_N 11..88 CDD:400755
WD40 343..706 CDD:238121 72/385 (19%)
WD40 repeat 347..383 CDD:293791 10/40 (25%)
WD40 repeat 394..438 CDD:293791 2/43 (5%)
WD40 repeat 447..483 CDD:293791 9/35 (26%)
WD40 repeat 488..523 CDD:293791 11/39 (28%)
WD40 repeat 530..566 CDD:293791 8/43 (19%)
WD40 repeat 579..627 CDD:293791 9/47 (19%)
WD40 repeat 633..669 CDD:293791 4/35 (11%)
WD40 repeat 675..705 CDD:293791 5/29 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C157342012
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.930

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