DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr62 and AT5G23430

DIOPT Version :9

Sequence 1:	NP_001259886.1	Gene:	Wdr62 / 33367	FlyBaseID:	FBgn0031374	Length:	2397	Species:	Drosophila melanogaster
Sequence 2:	NP_851064.1	Gene:	AT5G23430 / 832409	AraportID:	AT5G23430	Length:	837	Species:	Arabidopsis thaliana

Alignment Length:	878	Identity:	172/878 - (19%)
Similarity:	300/878 - (34%)	Gaps:	282/878 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   540 AHESEVLCLEYSNEKIERK---LLASASRDRLIHVFDVAQNYLLLQTLDDHSSSITSIKFVGAGL 601
            ||.:.|.||     ||.||   :|.:...|..::::.:.:...:| :|..|||.|.|:.|..:.:
plant    14 AHSAAVNCL-----KIGRKSSRVLVTGGEDHKVNLWAIGKPNAIL-SLYGHSSGIDSVTFDASEV 72

  Fly   602 NFQMISCGADKSIMFRSFQGNIFMRGTNTSGKTTLYDMEVDSNAKHILTACQDRNVRVYGTQNAK 666
               :::.||                   .||...|:|:|                       .||
plant    73 ---LVAAGA-------------------ASGTIKLWDLE-----------------------EAK 92

  Fly   667 QTKTFKGSHSDEGSLIKLSLDPSGIYVATSCTDKTLAVYDYYSNECMARMYGHSELVTGLKFTND 731
            ..:|..|..|   :.|.:...|.|.:.|:...|..|.::|.....|:....||:..|..|:||.|
plant    93 IVRTLTGHRS---NCISVDFHPFGEFFASGSLDTNLKIWDIRKKGCIHTYKGHTRGVNVLRFTPD 154

  Fly   732 CRHLISASGDGCIFIWQVPHDMIVT-MQARMSQQRLRSGHAPLPRPLAPISPPDGIVLESPTSEI 795
            .|.::|...|..:.:|.:....::| .::...|.:....|            |...:|.:.:::
plant   155 GRWVVSGGEDNIVKVWDLTAGKLLTEFKSHEGQIQSLDFH------------PHEFLLATGSAD- 206

  Fly   796 EQPQLQPKFGVAERFSDVGQLPQWAMRKAAADSDSGALSIPTPSGGSATVPGMHAASSMGNLSSS 860
                ...||...|.|..:|                        |||..|. |:..      ||.:
plant   207 ----RTVKFWDLETFELIG------------------------SGGPETA-GVRC------LSFN 236

  Fly   861 PSQQ--MTGLAPRARGRWAQRSTQLETADDLRSNSESPLGTVSSVGGHSGVNV---QTSDYNSAS 920
            |..:  :.||         |.|.::.:.:.:|.              |.||:|   :.||.|...
plant   237 PDGKTVLCGL---------QESLKIFSWEPIRC--------------HDGVDVGWSRLSDMNVHE 278

  Fly   921 SK--DITYNQT--------------YLSEDSSIDSGMETRRG----ELKFIGSSNNGTVVTVSSV 965
            .|  ..:|||:              .::.|::..:|...:|.    :...:..:|:.||:...||
plant   279 GKLLGCSYNQSCVGVWVVDLSRTEPCMAGDTAQSNGHPEKRSCSGRDPVVLNDNNSKTVLGKLSV 343

  Fly   966 SS--------------IAVS-----ASNGAMSTGSGAAQQRLQLPDKRLKPGLRFDTHTHDHDGD 1011
            |.              ::||     ::....|.|..:..|..:...|..||..|.....:
plant   344 SQNVDPLLKETKSLGRLSVSQNSDPSTKETKSIGRSSTSQNSESSMKESKPLGRLSVSQN----- 403

  Fly  1012 VEDISDGERTSSDHGMFYNNLAPSTPTDFKVTAMNEDELRKSV---------RRQKFEKSGLQLT 1067
             .|:|...||.|..|..     |.||  .:|::.|..:....|         .|:.|.|:    .
plant   404 -SDVSKESRTFSSTGSL-----PGTP--HRVSSTNVSKATSGVSTAVSNAATSRRNFTKA----N 456

  Fly  1068 PSALSGNGSSHTASTGTGTSDTEDEGSTPSAENAE---RSLASTL-GGSSENLPQSSTNSFLHAA 1128
            |.|...|.::..|......:|...|.:|.|....:   |::..:| ...|...|.|..|..|..|
plant   457 PKANPVNKAADFAPVIVPRADPRIEQATESRAELDIIARTMPYSLQAADSRRSPSSRNNPDLPDA 521

  Fly  1129 ---------------LPEG---PGLTTPMERGGSSRRSIS----AKHNTENGKS-VAAPPTITKS 1170
                           :|:|   ||....|.  |::.|||:    .::...|.:| :.:||
plant   522 SVLEMSESQPVEPNNIPDGGTLPGGKVGMR--GATERSINDFRYKRYGRSNSRSRMGSPP----- 579

  Fly  1171 YTSTKKEELLQVINKVKQQLENGTRKNGNTRLNAIAEVGHRPLRGSHSISDLSLAANLDGSRNAG 1235
               ...:|...:::....:..:.|......|..::  |.:|..||..|        |.:|
plant   580 ---RNHDENYDLVSHRSNRDPSPTESQKGGRFQSL--VINRERRGRFS--------NFEG----- 626

  Fly  1236 GGPGRYQKPVDSHDTSQYTSPQNTTATAAPTN--TQQQIQPPVQQQYQIPKEPH--QQAQQQHQQ 1296
                    ||.:..:....:|     ...|:|  .|:....||:|....|.|.:  :....:|.|
plant   627 --------PVSNFSSGNMPAP-----NIRPSNMFKQRGNHMPVEQGIDSPSEENIVEDIMGKHNQ 678

  Fly  1297 YAPPASQQFFNCAAPKSKLQQNFQTMRQVQQHY 1329
            :.              |.:|.....::.|::::
plant   679 FV--------------SSMQSRLAKLQVVRRYW 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr62	NP_001259886.1	WD40	73..448	CDD:295369
		WD40 repeat	73..107	CDD:293791
		WD40 repeat	113..161	CDD:293791
		WD40	158..574	CDD:225201	11/36 (31%)
		WD40 repeat	167..207	CDD:293791
		WD40 repeat	209..285	CDD:293791
		WD40 repeat	254..294	CDD:293791
		WD40 repeat	303..338	CDD:293791
		WD40 repeat	353..407	CDD:293791
		WD40	385..747	CDD:225201	49/209 (23%)
		WD40	436..748	CDD:295369	49/210 (23%)
		WD40 repeat	505..540	CDD:293791	172/878 (20%)
		WD40 repeat	546..586	CDD:293791	10/42 (24%)
		WD40 repeat	591..631	CDD:293791	5/39 (13%)
		WD40 repeat	637..672	CDD:293791	5/34 (15%)
		WD40 repeat	679..717	CDD:293791	8/37 (22%)
		WD40 repeat	723..749	CDD:293791	9/25 (36%)
AT5G23430	NP_851064.1	WD40	9..261	CDD:238121	73/371 (20%)
		WD40 repeat	63..99	CDD:293791	12/80 (15%)
		WD40 repeat	104..140	CDD:293791	8/35 (23%)
		WD40 repeat	147..182	CDD:293791	9/34 (26%)
		WD40 repeat	188..222	CDD:293791	8/74 (11%)
		Katanin_con80	678..829	CDD:372820	4/34 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000