DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr62 and AT3G09080

DIOPT Version :9

Sequence 1:	NP_001259886.1	Gene:	Wdr62 / 33367	FlyBaseID:	FBgn0031374	Length:	2397	Species:	Drosophila melanogaster
Sequence 2:	NP_001327466.1	Gene:	AT3G09080 / 820061	AraportID:	AT3G09080	Length:	1103	Species:	Arabidopsis thaliana

Alignment Length:	1138	Identity:	287/1138 - (25%)
Similarity:	500/1138 - (43%)	Gaps:	202/1138 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 SEKIKLKKVLGLTVCSNAALDVSPVSGLLAYPAGCTVVLFNAKRQTQAYLVNTSR--KAFTSVAF 117
            |.|:.|::::|||..:...|.....|....|.|||.||:::....||::||.:.|  |..:.||.
plant    13 STKLILQEIIGLTTKNANGLASVTCSSKCVYLAGCVVVVYDVDSCTQSHLVVSHRMPKPLSCVAI 77

  Fly   118 SRCGRYVATGECGINPAIKVWELETPNGSLEHCSGGSVVAEFVDHKYAVTCVAFSPTGKYLVSVG 182
            |:.||:||.||.....|:.:|:          |....:|:|...|.|...|::|||.|:||||||
plant    78 SQNGRFVAAGESPNLSAVLIWD----------CDTLGLVSELKGHLYGSQCLSFSPNGEYLVSVG 132

  Fly   183 SQHDMIVNVFDWRANLKMASNKIS---SKVAAVCFSEDGSYFVTVGNRHVKYWYLEGGRKYKDPI 244
            .    .:.::|||.::.:|..|.|   |::.:|.||.:|.:.||.||:|:|:|.:  |...:...
plant   133 G----YIYLWDWRKSILVAKVKASSNCSEITSVTFSSNGKFIVTSGNKHLKFWTV--GSFQRTRS 191

  Fly   245 PLMGRSAILGDLRD------NDFCAVACGKGICAE----------STYAITRQGHLVEFSSRRLL 293
            ..:|..|..|:..|      |.|.:|.....:.:.          |.||:|..|.|:..|...|:
plant   192 SKVGSLAFHGNQTDDGFQKGNSFVSVISANRVNSSGSDEQIDEVISIYALTEAGVLMLMSYGMLI 256

  Fly   294 DKWVQCRTTNANCICVNERFILVGCAESIIRIFNSATLEYVTTL-------PRTHYLGVDVAQGI 351
            .|.|..:......:..:.|.|...|::.::::|...||:|..|:       ..|.    :::|..
plant   257 KKSVDLKVQKCFALSASSRLIACACSKGMVQLFTPETLDYAGTIQFSDAKSSNTE----NLSQSP 317

  Fly   352 QINHIMSVPQQAKFPDCIAMVFDEQRSKVSCVYNDHSLYIWDLRDISRVGKSHSFLYHSTCIWGV 416
            :..:|.|.|  ..|||.:|..| ....|:..:|.:.|||:||:.|:::..:....:.||..||.:
plant   318 EPKNIESSP--GIFPDAVACQF-STTDKLVVIYGNRSLYVWDVDDVNKPTRCSMMISHSAGIWDI 379

  Fly   417 ETVPY-NVEREPSQTLPEEC-----FVTCSSDDTIRVWGLDGCTNNDIYRRNIYSKELLKIVYSD 475
            :.:.. |:....:..:...|     |.|||.|.|||:|.|....|.  ...|..|..      |:
plant   380 KNLSCGNMHSPTAACVARGCSEGVSFTTCSEDGTIRLWDLAFQVNP--LEANASSNP------SE 436

  Fly   476 DELQFIKDQGSS-LFDKAGNSSYDGRNGVRCIKISPELQHLASGDRCGNIRVYSLVNLRLLTTIE 539
            ...|.|....|: :|::....:...:.|.|.:.:|.:.::||:||..||:.:|.|........::
plant   437 SSTQGIMHLASAGIFERDLVETCGSKFGFRALAVSEDGKYLAAGDCGGNLHIYDLQESEYTCFMD 501

  Fly   540 AHESEVLCLEYS-------NEKIERKLLASASRDRLIHVFDVAQNYLLLQTLDDHSSSITSIKFV 597
            |||:|:..|.:|       :.:....||||..:.|.||::||.:|:..:.::.. |:::||:||.
plant   502 AHEAEIQSLSFSFPVLTNVDSENASSLLASGGKGRAIHIYDVKRNFDPVGSVCG-SAAVTSVKFA 565

  Fly   598 GAGLNFQMISCGADKSIMF----RSFQGNIFMRGTNTSGKTTLYDMEVDSNAKHILTACQDRNVR 658
            ..|.  :|::.|||:..||    ::....:....|.|....|:||:.||..:..::|..||:.:.
plant   566 CNGR--KMLTSGADRLQMFDVNRKASSVRLSPSHTQTLSHGTIYDVAVDPTSGLVVTVGQDKKIN 628

  Fly   659 VYGTQNAKQTKTFKGSHSDEGSLIKLSLDPSGIYVATSCTDKTLAVYDYYSNECMARMYGHSELV 723
            ::..::.|..::|| ...|.|..:|:.||||..|:..|.:::|:...|:.:.|.:|:..||.|.|
plant   629 IFDIESGKLVRSFK-QDRDHGDPVKVILDPSCNYLVCSYSNRTICFVDFVTGELVAQATGHGEAV 692

  Fly   724 TGLKFTNDCRHLISASGDGCIFIWQVPHDM------IVTMQARMSQQRLRSGHAPLPRPLAPISP 782
            ||:.|..||:|:||.:.|||||:|::|..|      .|....|::..:|.. ...:...|...:|
plant   693 TGVIFLPDCKHIISVASDGCIFVWKLPLRMATRIIRAVNENGRLTVAQLEK-FKQIAVDLEEDNP 756

  Fly   783 PDGIVLES--PTSE-IEQPQLQPKFGVAERFSDVGQLPQWAMRKA-------------------- 824
            .|.....:  |..| .:|.|.:..:..:.:|| |.:||:||..|.
plant   757 NDASCSANYKPVEENADQMQQRSPWTSSFKFS-VSRLPKWAQAKVETSDIATNCQDSISNQKHED 820

  Fly   825 ---------AADSDSGALSIPTPSGGSATVPGMHAASSMGNLS-SSPSQQMTGLA------PRAR 873
                     |.:..|..|...||..||.|     ..:.:|:|| ||...:.:||.      .:.:
plant   821 KSMANTIDNAEECSSVNLEYQTPKQGSRT-----ENACLGSLSKSSNDTETSGLQGDDPSNRKEK 880

  Fly   874 GRWAQRSTQLETADDLRSNSESPLGTVSSVGGHSGVNVQTSDYNSASSKDITY---NQTYLSEDS 935
            .||   :|......||.:   :|....|.:......|..|.  :||...|:..   |...:.::.
plant   881 TRW---NTIYNVCLDLLN---TPNIQASFIKQQKPENFCTK--HSAGQGDMFKQFDNSLSIIDNV 937

  Fly   936 SIDSGMETRRGELKFIGSSNNGTVVTVSSVSSIAVSASNGAMSTGSGAAQQRLQLPDKR------ 994
            ..:...:.||...:|:                        ......|..:|..:.|.::
plant   938 EAEKSSQQRRYSSQFV------------------------LRRDYIGGTKQFTRTPSQKSGYKTL 978

  Fly   995 --LKPGLRFDTHTHDHDGDVEDISDGERTSSDHGMFYNNLAP-----------------STPTDF 1040
              ::..:..||.........|:..:.::|||:  :|::.||.                 :|....
plant   979 RSIQEHIPLDTVNDQSSHSSEEHPEQDKTSSE--VFHDTLADESLQERITSCRQALHGLNTAAAV 1041

  Fly  1041 KVTAMNE-------DELRKSVRRQKFEKSGLQL 1066
            .|.:::|       |::...:|.|.|:::.|.:
plant  1042 FVQSISELSTASPRDQISGELRAQLFDEAALMI 1074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr62	NP_001259886.1	WD40	73..448	CDD:295369	117/408 (29%)
		WD40 repeat	73..107	CDD:293791	12/33 (36%)
		WD40 repeat	113..161	CDD:293791	14/47 (30%)
		WD40	158..574	CDD:225201	124/455 (27%)
		WD40 repeat	167..207	CDD:293791	17/42 (40%)
		WD40 repeat	209..285	CDD:293791	24/91 (26%)
		WD40 repeat	254..294	CDD:293791	13/55 (24%)
		WD40 repeat	303..338	CDD:293791	8/41 (20%)
		WD40 repeat	353..407	CDD:293791	16/53 (30%)
		WD40	385..747	CDD:225201	112/379 (30%)
		WD40	436..748	CDD:295369	100/323 (31%)
		WD40 repeat	505..540	CDD:293791	9/34 (26%)
		WD40 repeat	546..586	CDD:293791	12/46 (26%)
		WD40 repeat	591..631	CDD:293791	12/43 (28%)
		WD40 repeat	637..672	CDD:293791	8/34 (24%)
		WD40 repeat	679..717	CDD:293791	12/37 (32%)
		WD40 repeat	723..749	CDD:293791	15/25 (60%)
AT3G09080	NP_001327466.1	WD40	69..418	CDD:421866	104/371 (28%)
		WD40 repeat	73..111	CDD:293791	14/47 (30%)
		WD40 repeat	116..151	CDD:293791	15/38 (39%)
		WD40 repeat	159..187	CDD:293791	12/29 (41%)
		WD40 repeat	215..249	CDD:293791	7/33 (21%)
		WD40 repeat	255..323	CDD:293791	13/71 (18%)
		WD40	466..718	CDD:421866	82/255 (32%)
		WD40 repeat	467..512	CDD:293791	14/44 (32%)
		WD40 repeat	518..555	CDD:293791	10/36 (28%)
		WD40 repeat	559..594	CDD:293791	11/36 (31%)
		WD40 repeat	607..644	CDD:293791	10/37 (27%)
		WD40 repeat	651..686	CDD:293791	11/34 (32%)
		WD40 repeat	692..718	CDD:293791	15/25 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	54	1.000	Domainoid score	I4171
eggNOG	1	0.900	-	-		E1_KOG1408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1017450at2759
OrthoFinder	1	1.000	-	-		FOG0003218
OrthoInspector	1	1.000	-	-		oto2877
orthoMCL	1	0.900	-	-		OOG6_103235
Panther	1	1.100	-	-	LDO	PTHR45589
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2177
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.780