DRSC/TRiP Functional Genomics Resources

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Protein Alignment Wdr62 and Dcaf4

DIOPT Version :9

Sequence 1:NP_001259886.1 Gene:Wdr62 / 33367 FlyBaseID:FBgn0031374 Length:2397 Species:Drosophila melanogaster
Sequence 2:NP_001158728.1 Gene:Dcaf4 / 73828 MGIID:1921078 Length:532 Species:Mus musculus


Alignment Length:549 Identity:100/549 - (18%)
Similarity:175/549 - (31%) Gaps:228/549 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   449 GLDGCTNNDIYRRNIYSKEL----LKIVYSDD----ELQFIKDQGSSLFDK-----AGNSSYDGR 500
            |.:.|  |.:.:..|..||:    |:::..:|    ::..:....||:..|     ...|||   
Mouse    96 GHNNC--NPLTKEGIQQKEMESRRLQLLQQEDMQKKKITRVGFNASSILRKNQLGFLNFSSY--- 155

  Fly   501 NGVRCIKISPELQ-----------------HLAS-----------GDR---CGNIRV----YSLV 530
                | ::|.||:                 .|||           .||   ..::::    |.::
Mouse   156 ----C-RLSHELRVSCMERKKVEIQSSDPSALASDRFNFIMADTTSDRLFTVNDVKIGGSKYGII 215

  Fly   531 NLRLLTT----IEAHESEVLCLEYSNEKIERKLLASASRDRLIHVFDVAQNYLLL---------- 581
            ||:.|..    ::.||:    |.::|.|:.....||     |.|:    .:::||          
Mouse   216 NLQGLKAPTFEVQMHEN----LYFTNRKVNSVCWAS-----LNHL----DSHILLCLMGLAETPG 267

  Fly   582 --------------QTLDDHSSSITSIKFVGA-----GLNFQMISC---GADKSIMFRSFQGNIF 624
                          |...|....:.|.:..||     .||.|..:|   |..:.::.        
Mouse   268 CATLLPASLFVSNHQAGTDQPGMLCSFRIPGAWSCAWSLNVQANNCFSTGLSRRVLL-------- 324

  Fly   625 MRGTN-TSGKTTLYDMEVDSNAKH-------ILTACQDRNVRVYGTQNAKQTKTFKGS---HSDE 678
               || .:|....|.:..|..|:.       :...|:...:.....::..|.|.:|.:   |...
Mouse   325 ---TNVVTGHRQSYRINSDVLAQQFAVKTPLLFNGCRSGEIFAIDLRSPSQAKGWKATQIFHDSA 386

  Fly   679 GSLIKLSLDPSGIYVATSCTDKTLAVYDYYSNECMARMYGHSELVTGLKFTNDCRHL-------- 735
            .:.:::..:...: :|:..:.| :.::|..:.:|:.:..||         .|:..:|        
Mouse   387 VTSVQVFKEEQHL-MASDMSGK-IKLWDLRATKCVRQYEGH---------VNEYAYLPLHMHEEE 440

  Fly   736 --ISASGDGCIF-IWQVPHDMIVTMQARMSQQRLRSGHAPLPRPLAPISPPDGIVLESPTSEIEQ 797
              :.|.|..|.. ||.: ||      ||:    ||:    :|.|             .|||:...
Mouse   441 GILVAVGQDCYTRIWSL-HD------ARL----LRT----IPSP-------------CPTSKANI 477

  Fly   798 PQL--QPKFGVAERFSDVGQLPQWAMRKAAADSDSGALSIPTPSGGSATVPGMHAASS-----MG 855
            |.:  .|:.                                   |||...||:..|..     ..
Mouse   478 PSVAFSPRL-----------------------------------GGSRGAPGLLMAVQQDLYCFA 507

  Fly   856 NLSSSPSQQMTGLAPRARGRWAQRSTQLE 884
            ..||.|..|       ..|||...|...|
Mouse   508 YSSSCPDSQ-------EEGRWELPSVSNE 529

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Wdr62NP_001259886.1 WD40 73..448 CDD:295369
WD40 repeat 73..107 CDD:293791
WD40 repeat 113..161 CDD:293791
WD40 158..574 CDD:225201 36/176 (20%)
WD40 repeat 167..207 CDD:293791
WD40 repeat 209..285 CDD:293791
WD40 repeat 254..294 CDD:293791
WD40 repeat 303..338 CDD:293791
WD40 repeat 353..407 CDD:293791
WD40 385..747 CDD:225201 70/403 (17%)
WD40 436..748 CDD:295369 71/404 (18%)
WD40 repeat 505..540 CDD:293791 13/73 (18%)
WD40 repeat 546..586 CDD:293791 10/63 (16%)
WD40 repeat 591..631 CDD:293791 10/48 (21%)
WD40 repeat 637..672 CDD:293791 6/41 (15%)
WD40 repeat 679..717 CDD:293791 4/37 (11%)
WD40 repeat 723..749 CDD:293791 7/36 (19%)
Dcaf4NP_001158728.1 WD40 repeat 299..335 CDD:293791 9/46 (20%)
WD40 <315..484 CDD:225201 37/218 (17%)
WD40 <327..484 CDD:295369 34/195 (17%)
WD40 repeat 342..381 CDD:293791 5/38 (13%)
WD40 repeat 387..423 CDD:293791 4/37 (11%)
WD40 repeat 431..467 CDD:293791 12/50 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167833467
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.930

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