DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr62 and wdr62

DIOPT Version :9

Sequence 1:	NP_001259886.1	Gene:	Wdr62 / 33367	FlyBaseID:	FBgn0031374	Length:	2397	Species:	Drosophila melanogaster
Sequence 2:	XP_699579.3	Gene:	wdr62 / 570949	ZFINID:	ZDB-GENE-060503-291	Length:	1519	Species:	Danio rerio

Alignment Length:	1449	Identity:	489/1449 - (33%)
Similarity:	722/1449 - (49%)	Gaps:	295/1449 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SQSQSPLASPLTPSPSSVFGSPKFPANYERS----------EKIKLKKVLGLTVCSNAALDVSPV 79
            |.:||.|.|....:.::   |...|||..|.          .::.|:||||:|..|::||...|.
Zfish    11 SMNQSCLTSRAKKANNN---STSVPANTRRKTRQSHRRDIHNRVVLEKVLGITASSSSALTCDPN 72

  Fly    80 SGLLAYPAGCTVVLFNAKRQTQAYLVNTSRKAFTSVAFSRCGRYVATGECGINPAIKVWELETPN 144
            :||:||||||.:|:.:.|:..|.::.|||||.|:::|||:.|:|:.|||.|..|.::||::
Zfish    73 TGLVAYPAGCVIVILSPKKNKQTHIFNTSRKTFSALAFSQNGKYLVTGESGHMPCVRVWDV---- 133

  Fly   145 GSLEHCSGGSVVAEFVDHKYAVTCVAFSPTGKYLVSVGSQHDMIVNVFDWRANLKMASNKISSKV 209
                  :..:.|||...|||.|:||||||.|.|:||||.|||..|:|::|:....:||||:||:|
Zfish   134 ------AERTQVAEVQCHKYGVSCVAFSPNGSYIVSVGYQHDRTVSVWEWKKGTVIASNKVSSRV 192

  Fly   210 AAVCFSEDGSYFVTVGNRHVKYWYLEGG--RKYKDPIPLMGRSAILGDLRDNDFCAVACGKGICA 272
            ..|.||||.|||||.||||||:|||:..  |:....:||:|||.:||:.:::.||.:|||:|..|
Zfish   193 LGVSFSEDNSYFVTAGNRHVKFWYLDASKERRVNSTVPLIGRSGLLGEHQNSQFCGLACGRGSMA 257

  Fly   273 ESTYAITRQGHLVEFSSRRLLDKWVQCRTTNANCICVNERFILVGCAESIIRIFNSATLEYVTTL 337
            .|||.||..|.|.:|:|.|.||.||..:||:|.|:.|:..|:..|||:..:|:|:...|.|:|||
Zfish   258 SSTYCITHTGLLCQFNSNRQLDSWVDLKTTSAQCLSVSGTFVFCGCADGTVRVFSPQDLRYITTL 322

  Fly   338 PRTHYLGVDVAQGIQINHIMSVPQQAKFPDCIAMVFDEQRSKVSCVYNDHSLYIWDLRDISRVGK 402
            .|.|.|||||:||.|..|:.|...:|::||.:|:.||.....::|||||||:|:||:|||..|||
Zfish   323 HRPHCLGVDVSQGTQPGHLFSANPEAQYPDTLALTFDPVTKHLTCVYNDHSVYVWDVRDIRNVGK 387

  Fly   403 SHSFLYHSTCIWGVETVPYNVEREPSQTLPEECFVTCSSDDTIRVWGLDGCTNNDI---YRRNIY 464
            .:|.||||.|:|.|||.| .:|...:..|....|:|||||:|||:|..:...::..   .|.|:|
Zfish   388 VYSALYHSGCVWSVETYP-ELEDPSAACLSPGSFLTCSSDNTIRLWRSESPQSHSAALGLRHNLY 451

  Fly   465 SKELLKIVYSDDELQFIKDQGSSLFDKA-GNSSYDGRNGVRCIKISPELQHLASGDRCGNIRVYS 528
            |:::::|||.||:.|::|.:.    :|| |.:..||::|:|.:.|||:.||||:|||.||:|::.
Zfish   452 SQDIVRIVYVDDDTQYLKAEA----EKAEGGAGQDGKSGIRVLGISPDGQHLAAGDRSGNLRIFG 512

  Fly   529 LVNLRLLTTIEAHESEVLCLEYSNEKIERKLLASASRDRLIHVFDVAQNYLLLQTLDDHSSSITS 593
            |..:..|..||||:||||||.:|..:....||||||||||||:||:.....|:||:.|||:|||:
Zfish   513 LQFMDELQKIEAHDSEVLCLAFSPAETGLHLLASASRDRLIHIFDMDSKCNLVQTVYDHSASITA 577

  Fly   594 IKFVGAGLNFQMISCGADKSIMFRSFQ----GNIFMRGTNTSGKTTLYDMEVDSNAKHILTACQD 654
            :||.|......|:|||||||:.|||.:    |.:|.|..:...|||||||::|:...|...||||
Zfish   578 VKFTGLNSELCMVSCGADKSVYFRSAEKTSDGLVFSRSHHIVEKTTLYDMDLDATRTHTAIACQD 642

  Fly   655 RNVRVYGTQNAKQTKTFKGSHSDEGSLIKLSLDPSGIYVATSCTDKTLAVYDYYSNECMARMYGH 719
            ||:|||..::.|..|.||||.:|:|:|:|:.|||||:::||||:||.:.|:||.|.||:|.::||
Zfish   643 RNIRVYNVKSGKMKKCFKGSMNDDGTLLKVQLDPSGMFLATSCSDKNICVFDYESGECVATLFGH 707

  Fly   720 SELVTGLKFTNDCRHLISASGDGCIFIWQVPHDMIVTMQARMSQQRLRSG----HAPLPRP---- 776
            ||:|||:||:.||||||:.|||.|:|:|::...|..:|:.|:::::.::|    .||..:.
Zfish   708 SEIVTGMKFSQDCRHLITVSGDSCVFVWRLDSQMTNSMRKRLAERKQQAGLRLQRAPTKQEVIRR 772

  Fly   777 -------------------LAPISPPDGIV-------LESPTSEIEQPQLQPKFGVAERFSDVGQ 815
                               :|.::|.||:.       |:|..:.::...||..          |:
Zfish   773 ETYITVPCNALTHMEEDGLMAEVNPEDGLEDCRTPDRLDSTDASLDSVVLQTN----------GK 827

  Fly   816 LPQWAMRKAAADSDSGALSIPTPSGGSATVPGMHAASSMGNLSSSPSQQMTGLAPRA----RGRW 876
            :|.|..|                .||.....|                  ||.|.|.    :|||
Zfish   828 MPMWVRR----------------LGGEGEKDG------------------TGAANRVQYQPQGRW 858

  Fly   877 AQRSTQL--ETADDLRSNSESPLG-TVSSVGGHSGVNVQTSDYNSASSKDITYNQTYLSEDSSID 938
            |.:|..|  .|..:::|| :.||. |.|.|.|...:           .:|..::...|  ||.:|
Zfish   859 AVQSDPLAIRTVLEMKSN-QLPLSHTPSRVMGEEEL-----------EEDPRFHPQSL--DSLLD 909

  Fly   939 SGME--TRRGELKFIGSSNNG----------------------TVVTVSSVSSIAVSASNGAMST 979
            ..:|  ....|.|..|.|::|                      .:.:......|...|::.|:||
Zfish   910 EDLEDGEEEEEEKICGVSSDGFSSSLHGPEFLQFPHGEENFNPELSSSEKTGYILYPANSTALST 974

  Fly   980 GSGAAQQRLQL------PD-KRLKPGLRF-----DTHT-HDHDGDVEDISD-------------- 1017
            |.|....:...      || :.|.|....     ::|: ..||.|.:.:|.
Zfish   975 GEGEFDVKALCEGTAGDPDEEELSPDSACSAESPESHSDQPHDQDTDSLSQVSSTGSSGVEEDEE 1039

  Fly  1018 -------------GERTSSDHGMFYNNLAPSTPTD-------------------FKVTAMNEDEL 1050
                         |..|:.......::|.|:|.::                   |:..|......
Zfish  1040 ESGTLLRQHFDTLGVATNEKFNTDLSSLQPTTESNFLNPRLSISTRFLSRFQSRFRSAACRPAAC 1104

  Fly  1051 RKSVRRQKFEKSGLQLT---PSALSGNGS---SHTASTGTGTSDTEDEGSTPSAENAERSLASTL 1109
            ..|:..:..:...|..|   |..||.:||   .........:|.:....|.||....:.:|
Zfish  1105 LSSIPDESTDSQTLDQTMEKPKHLSNSGSVEEKEKTVIKRRSSMSSRRSSNPSLLRWKNAL---- 1165

  Fly  1110 GGSSENLPQSSTNSFLHAALPEGPGLTTPMERGGSSRRSISAKHNTENGKSVAAPPTITKSYTST 1174
             |...|..||:|.|...|     ||:.:......|...|::....:..|.:.::...|.:   |.
Zfish  1166 -GEITNKNQSTTQSTTSA-----PGVLSNKSTSNSCDASVTRSRQSYMGPTASSRAKINQ---SN 1221

  Fly  1175 KKEELLQVINKVKQQLENGTRKNGNTRLNAIAEVGH--------------------RPLRGSHSI 1219
            ..|.|...|::             .|.|||:..|.|                    .|:.|:||
Zfish  1222 SVESLNLCISE-------------ETPLNALPNVEHSKENMIPPSSPVVSSAPLHQSPVLGNHS- 1272

  Fly  1220 SDLSLAANLDGSRNAGGGP----GRYQKPVDSHDTSQYTSPQNTTATAAPTNTQQQIQPPVQQQY 1280
            :..||..:|.|...|...|    .|..| |:.||     ||:. .|...||           :..
Zfish  1273 ARASLRLDLIGHNRASLSPVSLKSRRGK-VEHHD-----SPRR-QALVTPT-----------EMR 1319

  Fly  1281 QIPKEPHQQAQQQHQQYAP 1299
            .:.||..:|.....|..||
Zfish  1320 SLGKESRKQISNIEQSLAP 1338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr62	NP_001259886.1	WD40	73..448	CDD:295369	184/376 (49%)
		WD40 repeat	73..107	CDD:293791	14/33 (42%)
		WD40 repeat	113..161	CDD:293791	15/47 (32%)
		WD40	158..574	CDD:225201	208/421 (49%)
		WD40 repeat	167..207	CDD:293791	22/39 (56%)
		WD40 repeat	209..285	CDD:293791	41/77 (53%)
		WD40 repeat	254..294	CDD:293791	18/39 (46%)
		WD40 repeat	303..338	CDD:293791	13/34 (38%)
		WD40 repeat	353..407	CDD:293791	25/53 (47%)
		WD40	385..747	CDD:225201	186/369 (50%)
		WD40	436..748	CDD:295369	160/319 (50%)
		WD40 repeat	505..540	CDD:293791	16/34 (47%)
		WD40 repeat	546..586	CDD:293791	21/39 (54%)
		WD40 repeat	591..631	CDD:293791	19/43 (44%)
		WD40 repeat	637..672	CDD:293791	16/34 (47%)
		WD40 repeat	679..717	CDD:293791	21/37 (57%)
		WD40 repeat	723..749	CDD:293791	17/25 (68%)
wdr62	XP_699579.3	WD40 repeat	64..100	CDD:293791	14/35 (40%)
		WD40	<84..312	CDD:295369	111/237 (47%)
		WD40	<90..459	CDD:225201	177/379 (47%)
		WD40 repeat	106..144	CDD:293791	15/47 (32%)
		WD40 repeat	149..185	CDD:293791	19/35 (54%)
		WD40 repeat	193..239	CDD:293791	25/45 (56%)
		WD40 repeat	282..323	CDD:293791	16/40 (40%)
		WD40	354..740	CDD:225201	193/390 (49%)
		WD40	355..736	CDD:295369	192/385 (50%)
		WD40 repeat	355..403	CDD:293791	27/47 (57%)
		WD40 repeat	490..524	CDD:293791	16/33 (48%)
		WD40 repeat	530..570	CDD:293791	21/39 (54%)
		WD40 repeat	575..613	CDD:293791	17/37 (46%)
		WD40 repeat	625..660	CDD:293791	16/34 (47%)
		WD40 repeat	669..705	CDD:293791	20/35 (57%)
		WD40 repeat	711..750	CDD:293791	20/38 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	339	1.000	Domainoid score	I1065
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1017450at2759
OrthoFinder	1	1.000	-	-		FOG0003218
OrthoInspector	1	1.000	-	-		otm24412
orthoMCL	1	0.900	-	-		OOG6_103235
Panther	1	1.100	-	-	LDO	PTHR45589
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2177
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.920