DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdr62 and CG7568

DIOPT Version :9

Sequence 1:	NP_001259886.1	Gene:	Wdr62 / 33367	FlyBaseID:	FBgn0031374	Length:	2397	Species:	Drosophila melanogaster
Sequence 2:	NP_001263071.1	Gene:	CG7568 / 43482	FlyBaseID:	FBgn0039673	Length:	482	Species:	Drosophila melanogaster

Alignment Length:	338	Identity:	77/338 - (22%)
Similarity:	137/338 - (40%)	Gaps:	83/338 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   494 NSSYDGRNGVRCIKIS------------PELQHLASG---------------------------- 518
            |.|:| |:|.||:..|            .:::|:.||
  Fly   123 NVSFD-RSGERCLTGSYDRTCHVINTQTAQVEHILSGHDNVVFSVGFNFPHWLVYLQSGGSGNNL 186

  Fly   519 --------DRC------GNIRVYSLVNLRLLTTIEAHESEVLCLEYSNEKIERKLLASASRDRLI 569
                    |:.      |..:|:|..:.:.|.|...|.:|::..|:  ..::.|.:|:||.|...
  Fly   187 TTFSIIFSDKIVTGSFDGTAKVWSATSGQSLCTFYGHTAELVAAEF--HPVDGKSIATASLDGSA 249

  Fly   570 HVFDVAQNYLLLQTLDDHSSSITSIKFVGAGLNFQMISCGA-DKSIMF---RSFQGNIFMRGTNT 630
            .::||..:: .||.|..|.:.:.:.:|...|   ||:..|: |.|...   ||......:||.:.
  Fly   250 RIYDVETSH-ELQQLTHHGAEVIAARFNRDG---QMLLTGSFDHSAAIWDVRSKSLGHQLRGHSA 310

  Fly   631 SGKTTLYDMEVDSNAKHILTACQDRNVRVYGTQNAKQTKTFKGSHSDEGSLIKLSLDPSGIYVAT 695
            .....:::.    :...|.|...|...|::.|:...|.......||||  ::.:|.|.:|..:||
  Fly   311 ELSNCVWNF----SGSLIATGSLDNTARIWDTRKLDQELYLAARHSDE--VLDVSFDAAGQLLAT 369

  Fly   696 SCTDKTLAVYDYYSN---ECMARMYGHSELVTGLKFTNDCRHLISASGDGCIFIWQVPHDMIVTM 757
            ..:|.|..|:....:   |.::.|.|||:.|:.:.|:.....|::||.|....:|       :|.
  Fly   370 CSSDCTARVWRLEGSSELEMLSLMAGHSDEVSKVCFSPSGCMLLTASADNTARLW-------LTE 427

  Fly   758 QARMSQQRLRSGH 770
            ..:.||  :.:||
  Fly   428 SGQCSQ--VLAGH 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr62	NP_001259886.1	WD40	73..448	CDD:295369
		WD40 repeat	73..107	CDD:293791
		WD40 repeat	113..161	CDD:293791
		WD40	158..574	CDD:225201	25/133 (19%)
		WD40 repeat	167..207	CDD:293791
		WD40 repeat	209..285	CDD:293791
		WD40 repeat	254..294	CDD:293791
		WD40 repeat	303..338	CDD:293791
		WD40 repeat	353..407	CDD:293791
		WD40	385..747	CDD:225201	71/313 (23%)
		WD40	436..748	CDD:295369	71/314 (23%)
		WD40 repeat	505..540	CDD:293791	11/88 (13%)
		WD40 repeat	546..586	CDD:293791	11/39 (28%)
		WD40 repeat	591..631	CDD:293791	11/43 (26%)
		WD40 repeat	637..672	CDD:293791	6/34 (18%)
		WD40 repeat	679..717	CDD:293791	9/40 (23%)
		WD40 repeat	723..749	CDD:293791	7/25 (28%)
CG7568	NP_001263071.1	WD40	93..466	CDD:225201	77/338 (23%)
		WD40 repeat	122..158	CDD:293791	9/35 (26%)
		WD40	154..467	CDD:238121	69/306 (23%)
		WD40 repeat	189..222	CDD:293791	6/32 (19%)
		WD40 repeat	228..265	CDD:293791	11/39 (28%)
		WD40 repeat	270..306	CDD:293791	9/38 (24%)
		WD40 repeat	314..348	CDD:293791	6/37 (16%)
		WD40 repeat	355..393	CDD:293791	9/37 (24%)
		WD40 repeat	400..436	CDD:293791	10/44 (23%)
		WD40 repeat	442..466	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442333
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930