DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdr62 and katnb1

DIOPT Version :9

Sequence 1:	NP_001259886.1	Gene:	Wdr62 / 33367	FlyBaseID:	FBgn0031374	Length:	2397	Species:	Drosophila melanogaster
Sequence 2:	NP_998183.1	Gene:	katnb1 / 406291	ZFINID:	ZDB-GENE-040426-1954	Length:	694	Species:	Danio rerio

Alignment Length:	802	Identity:	156/802 - (19%)
Similarity:	260/802 - (32%)	Gaps:	259/802 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   535 LTTIEAHESEVLCLEYSNEKIERKLLASASRDRLIHVFDVAQNYLLLQTLDDHSSSITSIKFVGA 599
            |..|.||.|.|..|...  |...:|||:...|..::::.|::...:: :|..|:|::..|:|
Zfish    13 LQEIVAHSSNVSSLVLG--KSSGRLLATGGEDCRVNIWAVSKPNCIM-SLTGHTSAVGCIQF--- 71

  Fly   600 GLNFQMISCGADKSIMFRSFQGNIFMRGTNTSGKTTLYDMEVDSNAKHILTACQDRNVRVYGTQN 664
                        .|...|...|::       ||...|:|:|.
Zfish    72 ------------NSSEERVVAGSL-------SGSLRLWDLEA----------------------- 94

  Fly   665 AKQTKTFKGSHSDEGSLIKLSLDPSGIYVATSCTDKTLAVYDYYSNECMARMYGHSELVTGLKFT 729
            ||..:|..|   .:.|:..|...|.|.|:|:...|..:.::|.....|:.|..||::.|..|.|:
Zfish    95 AKILRTLMG---HKASISSLDFHPMGEYLASGSVDSNIKLWDVRRKGCVFRYKGHTQAVRCLAFS 156

  Fly   730 NDCRHLISASGDGCIFIWQVPHDMIVTMQARMSQQRLRSGHAPLPRPLAPISPPDGIVLESPTSE 794
            .|.:.|.|||.|..:.:|.:....::|                              ...|.||.
Zfish   157 PDGKWLASASDDSTVKLWDLIAGKMIT------------------------------EFTSHTSA 191

  Fly   795 IEQPQLQPKFGVAERFSDVGQLPQWAMRKAAADSDSGALSIPTPSGGSATVPGMHAASSMGNLSS 859
            :...|..|.              ::.:...:||
Zfish   192 VNVVQFHPN--------------EYLLASGSAD-------------------------------- 210

  Fly   860 SPSQQMTGLAPRARGRWAQRSTQLETADDLRSNSESPLGTVSSVGGHSGVNVQTSDYNSASSKDI 924
                       |....|     .||..:.:.| ||...|.|.||    ..|...|...|.|...:
Zfish   211 -----------RTVKLW-----DLEKFNMIGS-SEGETGVVRSV----LFNPDGSCLYSGSENTL 254

  Fly   925 TYNQTYLSEDSSIDSGMETRRGELKFIGSSNNGTVVTVSSVSSIA--VSASNGAMSTGS---GAA 984
               :.|..|.......:....|::..:..|||..:....|.::::  |...|....:||   |..
Zfish   255 ---RVYGWEPDRCFDVVHVGWGKVSDLAISNNQMIAVSYSHTNVSWYVVDLNRVKKSGSVIQGLI 316

  Fly   985 QQR-LQLPDKRLKPGLRFDTHTHDHDGDVEDISDGERTSSDHGMFYNNLAPSTPTDFKVTAMNED 1048
            |.: :..|...|...||               .:.||                ||    |:....
Zfish   317 QDKPIPAPSSALGTTLR---------------RNYER----------------PT----TSCTGQ 346

  Fly  1049 ELRKSVRRQKFEKSGLQLTPSALSGNGSSHTASTGTGTSDTEDEGSTPSAENAE--------RSL 1105
            |:::|....:....|.:.:||:               ..:.||:.|:....|.|        ||:
Zfish   347 EMKQSSEADRRSPEGERRSPSS---------------EDEKEDKESSAEITNPEDYKEIFQPRSV 396

  Fly  1106 AS-TLGGSSENLPQSSTNSFLHAALPEGPG----LTTP-MERGGSSRRSISAKHNTENGKS--VA 1162
            .| |...::|..|....:||..:.| |.||    :.|| ::|.|..:..|::....:..:.  :|
Zfish   397 ISRTPPKTTEPFPAPLEHSFSESVL-EKPGPVVKIVTPVIDRAGQLKGPITSSTPVQRVEPTVIA 460

  Fly  1163 APPTITKSYTSTKKEELLQVINKVKQQLENG---TRKNGNTRLNAIAEVGH-------------- 1210
            |.|......|::.......|:|..|.:...|   :.:|....|||...:.|
Zfish   461 AAPRPVAVVTTSASSPSRPVVNTTKPKPSTGIILSTRNEPIGLNAGDFLSHARNAKASAMGDEEA 525

  Fly  1211 -RPLRGSHSISDLSLAA---NLDGSRNAGGGPGRYQKPVDS----HDTSQYTSPQNTTATAAP-- 1265
             ..:|..|....:.|::   |||..|:.... |..:..:||    :|.|......| .....|
Zfish   526 LAQIRKGHDTMCVMLSSRSKNLDSVRSVWAS-GDVKTSLDSAVSMNDLSIVVDVLN-IINLKPSL 588

  Fly  1266 ------TNTQQQIQPPVQQQYQ 1281
                  |:...||:..:|.:|:
Zfish   589 WKLDLCTSILPQIEELLQSRYE 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr62	NP_001259886.1	WD40	73..448	CDD:295369
		WD40 repeat	73..107	CDD:293791
		WD40 repeat	113..161	CDD:293791
		WD40	158..574	CDD:225201	12/38 (32%)
		WD40 repeat	167..207	CDD:293791
		WD40 repeat	209..285	CDD:293791
		WD40 repeat	254..294	CDD:293791
		WD40 repeat	303..338	CDD:293791
		WD40 repeat	353..407	CDD:293791
		WD40	385..747	CDD:225201	51/211 (24%)
		WD40	436..748	CDD:295369	51/212 (24%)
		WD40 repeat	505..540	CDD:293791	2/4 (50%)
		WD40 repeat	546..586	CDD:293791	8/39 (21%)
		WD40 repeat	591..631	CDD:293791	5/39 (13%)
		WD40 repeat	637..672	CDD:293791	5/34 (15%)
		WD40 repeat	679..717	CDD:293791	10/37 (27%)
		WD40 repeat	723..749	CDD:293791	10/25 (40%)
katnb1	NP_998183.1	WD40	<3..295	CDD:225201	82/432 (19%)
		WD40	13..292	CDD:238121	81/429 (19%)
		WD 1	18..58		11/42 (26%)
		WD 2	61..100		14/83 (17%)
		WD40 repeat	67..103	CDD:293791	13/80 (16%)
		WD 3	103..142		10/41 (24%)
		WD40 repeat	108..144	CDD:293791	9/35 (26%)
		WD 4	145..186		13/70 (19%)
		WD40 repeat	151..186	CDD:293791	10/64 (16%)
		WD 5	188..226		10/99 (10%)
		WD40 repeat	192..228	CDD:293791	9/98 (9%)
		WD 6	229..269		10/46 (22%)
		WD40 repeat	234..268	CDD:293791	9/40 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	319..410		24/140 (17%)
		Rib_recp_KP_reg	346..476	CDD:282899	31/145 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	470..492		4/21 (19%)
		Katanin_con80	535..686	CDD:290636	17/78 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000