DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdr62 and poc1b

DIOPT Version :9

Sequence 1:	NP_001259886.1	Gene:	Wdr62 / 33367	FlyBaseID:	FBgn0031374	Length:	2397	Species:	Drosophila melanogaster
Sequence 2:	NP_956412.1	Gene:	poc1b / 386932	ZFINID:	ZDB-GENE-031118-54	Length:	490	Species:	Danio rerio

Alignment Length:	553	Identity:	112/553 - (20%)
Similarity:	192/553 - (34%)	Gaps:	174/553 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   374 DEQRSKVSCVYNDHSLYIWDLRDISRVGKSHSFLYHSTCIWGVETVPYNVEREPSQTLPEECFVT 438
            ::|.:..||   |.||.||:|...:|   :..|:.|:..|.||...       ||.:|    ..:
Zfish    30 NKQLATGSC---DKSLMIWNLAPKAR---AFRFVGHTDVITGVNFA-------PSGSL----VAS 77

  Fly   439 CSSDDTIRVWGLDGCTNNDIYRRNIYSKELLKIVYSDDELQFIKDQGSSLFDKAGNSSYDGRNGV 503
            .|.|.|:|:|                             ...||  |.|...||..:|      |
Zfish    78 SSRDQTVRLW-----------------------------TPSIK--GESTVFKAHTAS------V 105

  Fly   504 RCIKISPELQHLASGDRCGNIRVYSLVNLRLLTTIEAHESEVLCLEYSNEKIERKLLASASRDRL 568
            |.:..|.:.|.|.:.....:::|:.:...:.|.::..|.:.|.|..:|.   :.:|:||...||.
Zfish   106 RSVNFSRDGQRLVTASDDKSVKVWGVERKKFLYSLNRHTNWVRCARFSP---DGRLIASCGDDRT 167

  Fly   569 IHVFDVAQNYLLLQTLDDHSSSITSIKFVGAGLNFQMISCGADKSIMFRSFQGNIFMRGTNTSGK 633
            :.::|.: ::.......|:..|.|.:.|..:|.  .:.|.|||.:|
Zfish   168 VRLWDTS-SHQCTNIFTDYGGSATFVDFNSSGT--CIASSGADNTI------------------- 210

  Fly   634 TTLYDMEVDSNAKHILTACQDRNVRVYGTQNAKQTKTFKGSHSDEGSLIKLSLDPSGIYVATSCT 698
             .::|:..:...:|            |...||              .:...|..|||.|:.:..:
Zfish   211 -KIWDIRTNKLIQH------------YKVHNA--------------GVNCFSFHPSGNYLISGSS 248

  Fly   699 DKTLAVYDYYSNECMARMYGHSELVTGLKFTNDCRHLISASGDGCIFIWQVPHDMIVTMQARMSQ 763
            |.|:.:.|......:..::||...|..:.|:.|.....|...|..:.:|:...|       .::.
Zfish   249 DSTIKILDLLEGRLIYTLHGHKGPVLTVTFSRDGDLFASGGADSQVLMWKTNFD-------SLNY 306

  Fly   764 QRLRSGHA----PLPRP----LAPIS-----PPDGIVLESPTSEIE--QPQLQPKFGVAERFSDV 813
            :.|.|.|:    |.|.|    :.|.|     |.:|.|..:|.::.:  .||:          .:|
Zfish   307 RELLSRHSKRVTPDPPPHLMDIYPRSHHRHHPQNGTVEINPVADTQSTDPQV----------VEV 361

  Fly   814 GQLPQWAMRKAAADSDSGALSIPTPSGGSATVPGMHAASSMGNLSSSPSQQMTG--LAPRARGRW 876
            |       |...:.:|                     |.:....|||.:|..:|  |.|
Zfish   362 G-------RVVFSTTD---------------------ARNYDGASSSRAQFTSGMDLGP------ 392

  Fly   877 AQRSTQLETADDLRSNSESPLGTVSSVGGHSGV 909
            .:..||....:|.........|..:|....||:
Zfish   393 LRTHTQAREEEDENQEERFAGGMTASPAERSGI 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr62	NP_001259886.1	WD40	73..448	CDD:295369	22/73 (30%)
		WD40 repeat	73..107	CDD:293791
		WD40 repeat	113..161	CDD:293791
		WD40	158..574	CDD:225201	46/199 (23%)
		WD40 repeat	167..207	CDD:293791
		WD40 repeat	209..285	CDD:293791
		WD40 repeat	254..294	CDD:293791
		WD40 repeat	303..338	CDD:293791
		WD40 repeat	353..407	CDD:293791	10/32 (31%)
		WD40	385..747	CDD:225201	74/361 (20%)
		WD40	436..748	CDD:295369	59/311 (19%)
		WD40 repeat	505..540	CDD:293791	5/34 (15%)
		WD40 repeat	546..586	CDD:293791	8/39 (21%)
		WD40 repeat	591..631	CDD:293791	8/39 (21%)
		WD40 repeat	637..672	CDD:293791	5/34 (15%)
		WD40 repeat	679..717	CDD:293791	8/37 (22%)
		WD40 repeat	723..749	CDD:293791	6/25 (24%)
poc1b	NP_956412.1	WD40	10..298	CDD:238121	77/373 (21%)
		WD40	14..>300	CDD:225201	78/375 (21%)
		WD 1. /evidence=ECO:0000255	16..55		10/30 (33%)
		WD40 repeat	22..58	CDD:293791	11/33 (33%)
		WD 2. /evidence=ECO:0000255	58..97		16/80 (20%)
		WD40 repeat	63..99	CDD:293791	15/77 (19%)
		WD 3. /evidence=ECO:0000255	100..139		9/44 (20%)
		WD40 repeat	106..141	CDD:293791	6/34 (18%)
		WD 4. /evidence=ECO:0000255	142..181		10/42 (24%)
		WD40 repeat	147..181	CDD:293791	9/37 (24%)
		WD 5. /evidence=ECO:0000255	184..223		11/60 (18%)
		WD40 repeat	189..225	CDD:293791	10/69 (14%)
		WD 6. /evidence=ECO:0000255	226..265		10/52 (19%)
		WD40 repeat	231..254	CDD:293791	7/22 (32%)
		WD 7. /evidence=ECO:0000255	268..307		9/45 (20%)
		WD40 repeat	273..314	CDD:293791	9/47 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	375..427		14/57 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576154
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930