DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr62 and Wdr43

DIOPT Version :9

Sequence 1:	NP_001259886.1	Gene:	Wdr62 / 33367	FlyBaseID:	FBgn0031374	Length:	2397	Species:	Drosophila melanogaster
Sequence 2:	NP_001032880.2	Gene:	Wdr43 / 362703	RGDID:	1565005	Length:	674	Species:	Rattus norvegicus

Alignment Length:	814	Identity:	138/814 - (16%)
Similarity:	257/814 - (31%)	Gaps:	299/814 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   436 FVTCSSDDTIRVWGLDGCTNNDIYRRNIYSKEL----LKIVYSDDELQFIKDQGSSLFDKAGNSS 496
            |...|||..:|||   ...||.:::..:.|..|    ..:.::...||            |..|.
  Rat    29 FALASSDGHLRVW---ETANNRLHQEYVPSAHLSGTCTCLAWAPARLQ------------AKESH 78

  Fly   497 YDGRNGVRCIKISPELQHLASGDRCGNIRVYSLVNLRLLTTI--EAHESEVLCLEY--------- 550
            ...:.....|..:.:...||.|...|:|.:||.|...|.:.:  ..||..|.|:::
  Rat    79 QRKKRKSEAIGTNDQADLLALGTAVGSILLYSTVKGELHSKLISGGHEKRVNCIQWHQDNDCLYS 143

  Fly   551 -SNEKI-----------------------------ERKLLASASRDRLIHVFDVAQNYLLLQTLD 585
             |::|.                             :.|:|.||.|...:.|.:..:.|   :...
  Rat   144 CSDDKYIVEWSTQMCRVKCKWKGDNSSVSSLCISPDGKMLLSAGRTIKLWVLETKEVY---RHFT 205

  Fly   586 DHSSSITSIKFVGAGLNFQMISCGADKSIMFRSFQGNIFMRGTNTSGKTTLYDMEVDSNAKHILT 650
            .|::.::|::|.         :...::|..|....|..|:.|
  Rat   206 GHATPVSSLRFT---------TIRPNESQPFDGVTGLYFLSG----------------------- 238

  Fly   651 ACQDR--NVRVYGTQNAKQTKTFKGSHSDEGSLIKLSLDPS---GIYVATSCTDKTLAVYDYYSN 710
            |..||  ||....::|.:::.....:.:||...|.|:|..:   .:.:|..|.|..:.::::..|
  Rat   239 AVHDRLLNVWQVRSENKEKSAVMSFTVTDEPVYIDLTLSENKEEPVKLAVVCRDGQVHLFEHVLN 303

  Fly   711 ECMARMYGHSELVTGLKFTNDCRHLISASGDGCIFIWQVPHDMIVTMQARMSQQRLRSGHAPLPR 775
                   ||.:    ...|::|...::..|                           .|....|:
  Rat   304 -------GHCK----KPLTSNCTIQVATPG---------------------------KGKKATPK 330

  Fly   776 PLAPISPPDGIVLE------------SPTSEIEQPQLQPK--FGVAERFSDVGQLPQWAMRKAAA 826
            |:..::.  |..|:            .||  ||:..|..|  ....||  |:...  |     |.
  Rat   331 PIPILAA--GFCLDKMSLLLVYGSWFQPT--IERLALNSKDTHICLER--DISNC--W-----AP 382

  Fly   827 DSDSGALSIPTPSGGSAT------VPGMHA--------------ASSMGNLSSSPSQQMTGLAPR 871
            ..::....:.||...|..      |||.||              ...:|...::..:::..:...
  Rat   383 TVETAITKVKTPVMNSEAKVLVPGVPGHHAPIKLLPAQPKEAENKRKLGGKEATIEERLGAMDLD 447

  Fly   872 ARGRWAQRSTQLET-------ADDLRSNS---------------------ESPLGTV-------- 900
            .||:   :...|:|       |..|.||.                     ..||..|
  Rat   448 RRGK---KDDLLQTNSFPVLLAQGLESNDFEMLNKVLQTRNVNLIKKTVLRMPLHAVIPLLQELT 509

  Fly   901 SSVGGHSGVNVQTSDYNSASSKDITYNQTYLS-------EDSSIDSGMETRRGELKFIGSSNNGT 958
            ..:.||....|....:....   :|.:.:|||       :..::...||:|....:.:...:...
  Rat   510 KRLQGHPNSAVLMVQWLKCV---LTIHASYLSTLPDLVHQLGTLYQLMESRVKTFQKLSHLHGKL 571

  Fly   959 VVTVSSVSSIAVSASNGAMSTGSGAAQQRLQLPDKRLKPGLRFDTHTHDHDGDVEDISDGERTSS 1023
            ::.|:.|:                |:::..::|...||..|.::..:.:.:.| ::|.  |:.|.
  Rat   572 ILLVTQVT----------------ASEKTKKMPSPGLKAKLVYEEESSEEESD-DEIP--EKDSD 617

  Fly  1024 DHGMFYNNLAPSTPTDFKVTAMNEDELRKSVRRQKFEKSGLQLTPSALSGNGSSHTASTGTGTSD 1088
            |:                   .:|||.:.|...:..::                          |
  Rat   618 DN-------------------WDEDEEKDSENDEAVDE--------------------------D 637

  Fly  1089 TE-DEGSTPSAENAERSLASTLGGSSENLPQSST 1121
            :| ||......|:.|.:....|.|.|:..|::.:
  Rat   638 SENDEAVDEEDEDREAASEKELNGDSDLDPENES 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr62	NP_001259886.1	WD40	73..448	CDD:295369	5/11 (45%)
		WD40 repeat	73..107	CDD:293791
		WD40 repeat	113..161	CDD:293791
		WD40	158..574	CDD:225201	37/182 (20%)
		WD40 repeat	167..207	CDD:293791
		WD40 repeat	209..285	CDD:293791
		WD40 repeat	254..294	CDD:293791
		WD40 repeat	303..338	CDD:293791
		WD40 repeat	353..407	CDD:293791
		WD40	385..747	CDD:225201	66/360 (18%)
		WD40	436..748	CDD:295369	66/361 (18%)
		WD40 repeat	505..540	CDD:293791	10/36 (28%)
		WD40 repeat	546..586	CDD:293791	10/78 (13%)
		WD40 repeat	591..631	CDD:293791	7/39 (18%)
		WD40 repeat	637..672	CDD:293791	6/36 (17%)
		WD40 repeat	679..717	CDD:293791	7/40 (18%)
		WD40 repeat	723..749	CDD:293791	3/25 (12%)
Wdr43	NP_001032880.2	WD40	19..271	CDD:295369	54/291 (19%)
		WD40	<19..217	CDD:225201	40/205 (20%)
		WD40 repeat	19..57	CDD:293791	10/30 (33%)
		WD40 repeat	63..124	CDD:293791	14/72 (19%)
		WD40 repeat	129..165	CDD:293791	4/35 (11%)
		WD40 repeat	172..205	CDD:293791	7/35 (20%)
		WD40 repeat	211..261	CDD:293791	13/81 (16%)
		WD40 repeat	270..317	CDD:293791	11/57 (19%)
		Utp12	473..569	CDD:281932	13/98 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337023
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930