DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr62 and Mapkbp1

DIOPT Version :9

Sequence 1:	NP_001259886.1	Gene:	Wdr62 / 33367	FlyBaseID:	FBgn0031374	Length:	2397	Species:	Drosophila melanogaster
Sequence 2:	NP_001102059.1	Gene:	Mapkbp1 / 362197	RGDID:	1307578	Length:	1507	Species:	Rattus norvegicus

Alignment Length:	1735	Identity:	564/1735 - (32%)
Similarity:	812/1735 - (46%)	Gaps:	394/1735 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LQSQSQSPLASPLTPSPSSVFGSPKFPANYERSEKIKLKKVLGLTVCSNAALDVSPVSGLLAYPA 87
            :.|:.::.|.||......|..|:.:    .:.|.|:.|:||||:||.....|...|.|||:||||
  Rat     9 ITSRIKNLLRSPSIKLRRSKAGNRR----EDLSSKVTLEKVLGVTVSGGRGLACDPRSGLVAYPA 69

  Fly    88 GCTVVLFNAKRQTQAYLVNTSRKAFTSVAFSRCGRYVATGECGINPAIKVWELETPNGSLEHCSG 152
            ||.|||||.::..|.:::|:|||..|::|||..|:|:.|||.|..||::||::...|
  Rat    70 GCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWDVAERN-------- 126

  Fly   153 GSVVAEFVDHKYAVTCVAFSPTGKYLVSVGSQHDMIVNVFDWRANLKMASNKISSKVAAVCFSED 217
              .|||..:|||.|.||||||:.||:||||.||||||||:.|:.|:.:||||:||:|.||.||||
  Rat   127 --QVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRVTAVSFSED 189

  Fly   218 GSYFVTVGNRHVKYWYLEGGR--KYKDPIPLMGRSAILGDLRDNDFCAVACGKGICAESTYAITR 280
            .|||||.||||:|:|||:..:  |....:||:|||.:||:||:|.|..||||:|..|:||:.||.
  Rat   190 CSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACGRGKKADSTFCITS 254

  Fly   281 QGHLVEFSSRRLLDKWVQCR------TTNANCICVNERFILVGCAESIIRIFNSATLEYVTTLPR 339
            .|.|.|||.||||||||:.|      ||.|:||.|::.:|..|||:..:|:||.:.|.:::||||
  Rat   255 SGLLCEFSDRRLLDKWVELRNTDSFTTTVAHCISVSQEYIFCGCADGTVRLFNPSNLHFLSTLPR 319

  Fly   340 THYLGVDVAQGIQINHIMSVPQQAKFPDCIAMVFDEQRSKVSCVYNDHSLYIWDLRDISRVGKSH 404
            .|.||.|:|...:.:.:.|....|::||.||:.||.....:||||||||:|:||:||..:|||.:
  Rat   320 PHALGTDIATITEASRLFSGGANARYPDTIALTFDPANQWLSCVYNDHSIYVWDVRDPKKVGKVY 384

  Fly   405 SFLYHSTCIWGVETVPYNVEREPSQTLPEECFVTCSSDDTIRVWGLDGC-TNNDIYRRNIYSKEL 468
            |.||||:|:|.||..| .::......||...|:|||||:|||:|..:.. .:.....|||.|.:|
  Rat   385 SALYHSSCVWSVEVYP-EIKDSNQACLPPSSFITCSSDNTIRLWNTESSGVHGSALHRNILSNDL 448

  Fly   469 LKIVYSDDELQFIKDQGSSLFDKAGNSSYDGRNGVRCIKISPELQHLASGDRCGNIRVYSLVNLR 533
            :||:|.|...|.:.|......|||..|..|.|.|:|.:.|||..||||||||.|.:||:.|.:|.
  Rat   449 IKIIYVDGNTQALLDTELPGGDKADGSLMDPRVGIRSVCISPNGQHLASGDRMGTLRVHELQSLS 513

  Fly   534 LLTTIEAHESEVLCLEYSNEKIERKLLASASRDRLIHVFDVAQNYLLLQTLDDHSSSITSIKFVG 598
            .|..:|||:||:||||||......||||||||||||||.|..:.|.|.||||:||||||::||..
  Rat   514 ELLKVEAHDSEILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAA 578

  Fly   599 AGLNFQMISCGADKSIMFRSFQ----GNIFMRGTNTSGKTTLYDMEVDSNAKHILTACQDRNVRV 659
            :....:||||||||||.||:.|    |..|.|..:...|||||||:|:.:.|:....|||||:|:
  Rat   579 SDGQVRMISCGADKSIYFRTAQKSGEGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRI 643

  Fly   660 YGTQNAKQTKTFKGSHSDEGSLIKLSLDPSGIYVATSCTDKTLAVYDYYSNECMARMYGHSELVT 724
            :...:.||.|.||||..::|:|||:..||||||:||||:||.|:::|::|.||:|.|:||||:||
  Rat   644 FNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFFSGECVATMFGHSEIVT 708

  Fly   725 GLKFTNDCRHLISASGDGCIFIWQVPHDMIVTMQARMSQQRLR---------------SG---HA 771
            |:||:|||:||||.|||.|||:|::..:|.::|:.|:::.|.|               ||   |.
  Rat   709 GMKFSNDCKHLISVSGDSCIFVWRLSSEMTISMRQRLAELRQRQRGIKQQGPTSPQKASGAKQHH 773

  Fly   772 PLPRPLAPISPPDGIVLESP---------TSEIEQPQLQPKFGVAERFSDVGQLPQWAMRKAAAD 827
            |      |:.||.|..|.|.         |.|.|.|.| |..|.             :.:|..|.
  Rat   774 P------PVVPPSGPALSSDSDKEGEDEGTEEEELPAL-PILGK-------------STKKELAS 818

  Fly   828 SDSGALSIPTPSGGSATVPGMHAASSMGNLSSSPSQQMTGLAPRARGRWAQRSTQLETAD--DLR 890
            ..|.|| :.:.|....:    .|..:|..|..:|:.. ||  |:.||||||...:|....  |||
  Rat   819 GSSPAL-LRSLSHWEMS----RAQENMEFLGPAPTAN-TG--PKRRGRWAQPGVELSVRSMLDLR 875

  Fly   891 ---SNSESPLG--------TVSSVGGHSGVNVQTSDYNSASSKD-------------------IT 925
               :.:.||.|        :.:..|.||   .|.:|.:.||..:                   ::
  Rat   876 QLETLAPSPRGPSQDSLAVSPTGPGKHS---PQAADLSCASQNERAPRLQASQPCSCPHIIQLLS 937

  Fly   926 YNQTYLSED---SSIDSGMETRRGELKFIGSSNNGTVVTVSSVSSIAVSASNGAMSTGSGAAQQR 987
            ..:...::|   :.|:.|       :.:...|::.|:.|    |:..|.|..|. |.|
  Rat   938 QEEGVFAQDLESAPIEDG-------IVYPEPSDSPTMDT----SAFQVQAPTGG-SLG------- 983

  Fly   988 LQLPDKRLKPGLR-FDTHTHDHDGDVEDISDGERTSSDHGMFYNNLAPSTPTDFKVTAMNEDELR 1051
                  |:.||.| .:.|:.|....| |.|....:|.:|                   .|||
  Rat   984 ------RVYPGSRGSEKHSPDSACSV-DYSSSRLSSPEH-------------------PNED--- 1019

  Fly  1052 KSVRRQKFEKSGLQLTPSALSGNG-SSHTASTGTGTSDTEDEGSTPSAENAERSLASTLGGSSEN 1115
                         ..:...||.:| ||.......|..:.|:||.|            .|.|..|.
  Rat  1020 -------------SESTEPLSVDGVSSDLEEQAEGEEEEEEEGGT------------GLCGLQEG 1059

  Fly  1116 LPQS-STNSFL--------HAALPEGPGLTTPMERGGSSRRSISAKHNTENGKSVAAPPTITKSY 1171
            .|.: ....||        :.|.|.||  ...:||  :..||||::...:...|....|:::.|.
  Rat  1060 SPHTPDQEQFLKQHFETLANGAAPGGP--ARALER--TESRSISSRFLLQVQTSPLREPSLSSSG 1120

  Fly  1172 TSTKKEELLQVINKVKQQLENGTRKNGNTRLNAIAEVGHRPLRGSHSISDLSLAANLDGSRNAGG 1236
            .:..                        :|.:.:::|....|:||.:..
  Rat  1121 LALM------------------------SRPDQVSQVSGEQLKGSGATP---------------- 1145

  Fly  1237 GPGRYQKPVDSHDTSQYTSPQNTTATAAP---TNTQQQIQPPVQQQYQIPKEPHQQAQQQHQQYA 1298
             ||   .|.:...:|..:.|:.......|   ||...
  Rat  1146 -PG---APPEMEPSSGNSGPKQVAPVLLPRRRTNLDN---------------------------- 1178

  Fly  1299 PPASQQFFNCAAPKSKLQQNFQTMRQVQQHYPPYPHHVGVHQIHPPPGVP-----FGGSAAGSTS 1358
                    :.|:.|:...:....:::.|          .||.:.|...||     |.....||..
  Rat  1179 --------SWASKKTAATRPLAGLQKAQ----------SVHSLVPQDEVPSRPLLFQAEVQGSLG 1225

  Fly  1359 AMRSHSQPQNRQQQQQQQQQRAKRNPAGNNRRTPSILKHYKSCPVSPVHEEVEWSAEGNERGALL 1423
            ::        .|......|..:..||.     |.|:.|..:|..|.   |....:||......:.
  Rat  1226 SL--------PQADGCPSQSHSYWNPT-----TSSVAKLARSISVG---ENPGLAAEPQAPAPIR 1274

  Fly  1424 GEPKRHSVYADDARTILD--------------------MIHADTEKMIDEITRKYGDLDEPGIPA 1468
            ..|.........|..:||                    :.|::||:            ..|.:..
  Rat  1275 TSPFNKLALPSRAHLVLDIPKPLPDRPTLTTFSPVSKGLAHSETEQ------------SGPSVSL 1327

  Fly  1469 SYSMPANLRNLGGLGSTGDSTPTGRTTQYYVYREFYQCERKVSLSDILQ-PEQFAASQRRLDEAR 1532
            ..:..| :.....||.  .:||..||.........:.|.:::.:|::|| ||    |.:.|...:
  Rat  1328 GKTHTA-IEKHSCLGE--GTTPKSRTECQAHPGPNHPCAQQLPVSNLLQGPE----SMQPLSPEK 1385

  Fly  1533 F---LETQRHSSASFFLTGQQSQESLSLLSDGDGPGSYCNSLESVL-----------SDESDCQS 1583
            .   :|:.|..:|    ..|.|:.:|||        ..|..|.:.|           ...:.|::
  Rat  1386 TRNPVESSRPGAA----LSQDSELALSL--------QQCEQLVAELRRNVRQAVQLYHSVTSCKT 1438

  Fly  1584 APLEYPQTQVA-VLQQRHAGIRNFI--IHGPVSKSYGNSPNAYGS 1625
            ...|  |:.:. :|:...:.:|..:  :.|.|..|.|.||.|.|:
  Rat  1439 PSAE--QSHITRLLRDTFSSVRQELEALDGAVLSSPGGSPGAVGA 1481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr62	NP_001259886.1	WD40	73..448	CDD:295369	195/382 (51%)
		WD40 repeat	73..107	CDD:293791	17/33 (52%)
		WD40 repeat	113..161	CDD:293791	18/47 (38%)
		WD40	158..574	CDD:225201	219/424 (52%)
		WD40 repeat	167..207	CDD:293791	26/39 (67%)
		WD40 repeat	209..285	CDD:293791	43/77 (56%)
		WD40 repeat	254..294	CDD:293791	23/39 (59%)
		WD40 repeat	303..338	CDD:293791	13/34 (38%)
		WD40 repeat	353..407	CDD:293791	25/53 (47%)
		WD40	385..747	CDD:225201	193/366 (53%)
		WD40	436..748	CDD:295369	169/316 (53%)
		WD40 repeat	505..540	CDD:293791	17/34 (50%)
		WD40 repeat	546..586	CDD:293791	26/39 (67%)
		WD40 repeat	591..631	CDD:293791	20/43 (47%)
		WD40 repeat	637..672	CDD:293791	14/34 (41%)
		WD40 repeat	679..717	CDD:293791	22/37 (59%)
		WD40 repeat	723..749	CDD:293791	19/25 (76%)
Mapkbp1	NP_001102059.1	WD40	<45..121	CDD:295369	39/75 (52%)
		WD40	84..428	CDD:295369	178/354 (50%)
		WD40 repeat	94..133	CDD:293791	18/48 (38%)
		WD40 repeat	139..173	CDD:293791	22/33 (67%)
		WD40 repeat	181..219	CDD:293791	21/37 (57%)
		WD40	244..736	CDD:225201	248/492 (50%)
		WD40 repeat	281..318	CDD:293791	15/36 (42%)
		WD40 repeat	336..385	CDD:293791	24/48 (50%)
		WD40	350..732	CDD:295369	200/382 (52%)
		WD40 repeat	485..520	CDD:293791	17/34 (50%)
		WD40 repeat	526..566	CDD:293791	26/39 (67%)
		WD40 repeat	571..611	CDD:293791	19/39 (49%)
		WD40 repeat	621..656	CDD:293791	14/34 (41%)
		WD40 repeat	663..701	CDD:293791	22/37 (59%)
		WD40 repeat	707..733	CDD:293791	19/25 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337024
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1017450at2759
OrthoFinder	1	1.000	-	-		FOG0003218
OrthoInspector	1	1.000	-	-		otm44858
orthoMCL	1	0.900	-	-		OOG6_103235
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2177
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.650