DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr62 and Wdr62

DIOPT Version :9

Sequence 1:	NP_001259886.1	Gene:	Wdr62 / 33367	FlyBaseID:	FBgn0031374	Length:	2397	Species:	Drosophila melanogaster
Sequence 2:	NP_001178552.2	Gene:	Wdr62 / 308492	RGDID:	1306714	Length:	1551	Species:	Rattus norvegicus

Alignment Length:	1641	Identity:	524/1641 - (31%)
Similarity:	767/1641 - (46%)	Gaps:	346/1641 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ASLSASTPTLSTLHHQRMALQSQSQSPLASP--------LTPSPSSVFGSPKFPANYERSEKIKL 60
            :|:.|..|          |.::||..|.|.|        |..:|....           ..::.|
  Rat    20 SSVMAGVP----------ARRNQSSPPPAPPLCLRRRTRLAAAPEDTV-----------QNRVTL 63

  Fly    61 KKVLGLTVCSNAALDVSPVSGLLAYPAGCTVVLFNAKRQTQAYLVNTSRKAFTSVAFSRCGRYVA 125
            :||||:|..:::.|...|.:|.:||.|||.||:.|.|...|.::.||:||:.:::|||..|:|:.
  Rat    64 EKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVVLNPKENKQQHIFNTTRKSLSALAFSPDGKYIV 128

  Fly   126 TGECGINPAIKVWELETPNGSLEHCSGGSVVAEFVDHKYAVTCVAFSPTGKYLVSVGSQHDMIVN 190
            |||.|..||:::|::|..          :.|||.:.|||.|.||||||..|::||:|.||||::|
  Rat   129 TGENGHRPAVRIWDVEEK----------TQVAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLN 183

  Fly   191 VFDWRANLKMASNKISSKVAAVCFSEDGSYFVTVGNRHVKYWYLEGGRKYK--DPIPLMGRSAIL 253
            |:||:.::.:||||:|.:|.|:.||||.|||||||||||::|:||...:.|  ..:||:|||.||
  Rat   184 VWDWKKDIVVASNKVSCRVIALSFSEDSSYFVTVGNRHVRFWFLEASTEAKVTSTMPLVGRSGIL 248

  Fly   254 GDLRDNDFCAVACGKGICAESTYAITRQGHLVEFSSRRLLDKWVQCRTTNANCICVNERFILVGC 318
            |:|.:|.||.||||:|..|.:|:.::..|.|.:|:.:|:||||:..:.:.::|:||::..|..||
  Rat   249 GELHNNIFCGVACGRGRMAGNTFCVSYSGLLCQFNEKRVLDKWINLKVSLSSCLCVSDELIFCGC 313

  Fly   319 AESIIRIFNSATLEYVTTLPRTHYLGVDVAQGIQINHIMSVPQQAKFPDCIAMVFDEQRSKVSCV 383
            .:.|:|||.:.:|.|:|.||:.||||:|||||:..:.:.....:|.:||.:|:.||.....:|||
  Rat   314 TDGIVRIFQAHSLLYLTNLPKPHYLGIDVAQGLDSSFLFHRKAEAVYPDTVALTFDPIHQWLSCV 378

  Fly   384 YNDHSLYIWDLRDISRVGKSHSFLYHSTCIWGVETVPYNVEREPSQT-LPEECFVTCSSDDTIRV 447
            |.|||:||||::||:.|.|..|.|:||:.:|.||..|   |.|..:. ||...|:|||||:|||.
  Rat   379 YKDHSVYIWDVKDINEVSKIWSELFHSSFVWNVEVYP---EFEDQRACLPSGTFLTCSSDNTIRF 440

  Fly   448 WGLDGCTNNDIYRRNIYSKELLKIVYSDDELQFIKDQGSSLFDKAGNSS---YDGRNGVRCIKIS 509
            |.:|..::.. :|:||:|..|||:||.::::|.::|.  |.|...|:.:   .|.:.|||.:::|
  Rat   441 WNMDSGSDTQ-WRKNIFSDSLLKVVYVENDIQHLQDM--SHFPDRGSENGTPMDMKAGVRVMQVS 502

  Fly   510 PELQHLASGDRCGNIRVYSLVNLRLLTTIEAHESEVLCLEYSNEKIERKLLASASRDRLIHVFDV 574
            |:.||||||||.||:|::.|..:..|..:|||::||||||||..:....|||||||||||||.:|
  Rat   503 PDGQHLASGDRSGNLRIHELHFMDELIKVEAHDAEVLCLEYSKPETGVTLLASASRDRLIHVLNV 567

  Fly   575 AQNYLLLQTLDDHSSSITSIKFVGAGLNFQMISCGADKSIMFRSFQ----GNIFMRGTNTSGKTT 635
            .:||.|.|||||||||||:|||.|. .:.|||||||||||.|||.|    |..|:|..:.:.|||
  Rat   568 EKNYNLEQTLDDHSSSITAIKFAGT-RDVQMISCGADKSIYFRSAQQTSDGLHFVRTHHVAEKTT 631

  Fly   636 LYDMEVDSNAKHILTACQDRNVRVYGTQNAKQTKTFKGSHSDEGSLIKLSLDPSGIYVATSCTDK 700
            ||||::|...|::..||||||||||.|.:.||.|.:|||..|||||:|:.:||||.::||||:||
  Rat   632 LYDMDIDITQKYVAVACQDRNVRVYNTVSGKQKKCYKGSQGDEGSLLKVHVDPSGTFLATSCSDK 696

  Fly   701 TLAVYDYYSNECMARMYGHSELVTGLKFTNDCRHLISASGDGCIFIWQVPHDMIVTMQARM---- 761
            :::|.|:||.||:|:|:||||:|||:|||.||||||:.|||.|:|||.:..::...|:..:
  Rat   697 SISVIDFYSGECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIWHLGPEITTCMKQHLMEIN 761

  Fly   762 --SQQRL-----------RSGHAPLPRPLAPISPPDGI------------VLESPTSEIEQPQLQ 801
              .||.|           :...|..|..:..:||.:..            .|::|:.|...|  .
  Rat   762 HQEQQHLPKDQKWSGPPSQETSASTPSEIRSLSPGEQTEDEMEEECEPEETLKTPSKESLDP--D 824

  Fly   802 PKFGVAERFSDVGQLPQWAMRKAAAD--SDSGALSIP---TPSGGSA---------TVPGMHAAS 852
            |:..:..     |:||.||.|....|  :||.|....   .|.|..|         |:....|..
  Rat   825 PRCLLTN-----GKLPLWAKRLLGDDDVTDSSAFHAKRSYQPHGRWAERAEQEPLKTILDAWALD 884

  Fly   853 SM------GNLSSS-----PSQQMTGL---------------------------APR--ARGRWA 877
            |.      |||..|     ..|.:.||                           :|:  :||..:
  Rat   885 SYFTPMKPGNLEDSVLDSVEPQNLAGLLSECSPENGHTAPGEGLVSYLCHSESGSPKEDSRGHPS 949

  Fly   878 QRSTQLETADDLRSNSESPLGTVSSVGGH--------SGVNVQTSD----YNSASSKDITYNQTY 930
            ....|.|..:.......||...|:..|.|        :|...|..|    .:|.||||
  Rat   950 YLPLQREGTETRELILCSPEVEVTVTGMHREYYEEAEAGPEDQQGDSYLRVSSVSSKD------- 1007

  Fly   931 LSEDSSIDSGMETRRGELKFIGS------SNNGTVVTVSSV---SSIAVSASNGAMSTGSGAAQQ 986
              :....|||......|..|..:      ::.|..:|::..   ||....|..|....|:|:..
  Rat  1008 --QSPPEDSGESEAELECSFAAAHVSAPRTDPGPHLTMTGKPEHSSTDELAQPGVPGLGNGSLP- 1069

  Fly   987 RLQLPDKRLKPGLRFDTHTHDHDGDVEDI---SDGERTSSDHGMFYNNLAPSTPTDFKVTAMNED 1048
              |.|::.......|:|.|   |...|::   |.|:...|:...::.|...|..|.|........
  Rat  1070 --QTPEQEKFLRHHFETLT---DAPAEELFPGSLGDIKISETDDYFFNPRLSISTQFLSRLQKTS 1129

  Fly  1049 --------ELRKSVRRQKFEKSGLQLTPSALSGNGSSHTASTGTGTSDTEDEGSTPSAENAE--- 1102
                    .|.||...|...:.|.|.....|.. |:.:.:|.||.....:....||.|....
  Rat  1130 RFPPRLPLHLMKSPEVQPVGQGGNQPKAGPLRA-GTGYMSSDGTNVLSGQMAEETPEASCLPTPP 1193

  Fly  1103 -RSLAS-----------------TLG---GSSENLPQSSTNSFL------HAAL--------PEG 1132
             ..|||                 |.|   |..:::|..|..|:|      ||.:        .||
  Rat  1194 ITGLASCVPPSSVIPTDRKPPTPTSGLTTGREQSIPAPSPCSYLESTTSSHAKMTRSTSLGDSEG 1258

  Fly  1133 P---GLTTPMERGGSSRRSISAKHNTENGKSVAAPPTITKSYTSTKKEE--------------LL 1180
            |   .|..|:.:..|.            |:...|.||.....:|.|..|              |.
  Rat  1259 PVTGELPRPLHKPVSP------------GQEPQAVPTTVALTSSVKGHEPALPAWGNHEARASLR 1311

  Fly  1181 QVINKVKQQLENGTRKNGNTR-----------LNAIAEVGHRPLRGSHSISDLSLAANLDGSRNA 1234
            ..::.|.:||.:..:....|.           .:....|..........:|.|.|.:::...:.:
  Rat  1312 LTLSSVCEQLLSPPQLEPPTTPVWSQEAVDVPPSMAVTVASFSAPSPEDMSTLGLHSSVFLPKTS 1376

  Fly  1235 GGGPGRYQKPVDSHDTSQYTSPQN-------TTATAAPTNTQQQIQPPVQQQYQIPKEP-HQQAQ 1291
            ..||              .|.|.:       .|.:..|.:|...::|........|..| |....
  Rat  1377 ASGP--------------LTPPAHPNSLQLLETRSRMPGSTPALLEPTPDASSGSPDSPGHCGEP 1427

  Fly  1292 QQHQQYAPPASQQFFNCAAPKSKLQQNFQ-----------------TMRQVQQHYPP---YPHH- 1335
            .:..:..||...:..:..:...:||..||                 ..:|.|.....   :.||
  Rat  1428 GRRAEVPPPGPLELDSVESVLYRLQTAFQEALDLYRMLASSNQLGAEQQQAQTELASAFHWIHHQ 1492

  Fly  1336 ------VGVHQIHPPPGVPFGGSAAGSTSAMRSHSQPQNRQQQQQQQQQRAKRNPAGNNRRTPSI 1394
                  ||...:.||..:|..|..:..|....:....|                         ::
  Rat  1493 LEASNCVGAASVAPPLTLPSPGPPSPPTLCPLASPNLQ-------------------------AL 1532

  Fly  1395 LKHYKSCPVSPVHEEV 1410
            |:||....|..|..:|
  Rat  1533 LEHYSELLVQAVRRKV 1548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr62	NP_001259886.1	WD40	73..448	CDD:295369	174/377 (46%)
		WD40 repeat	73..107	CDD:293791	13/33 (39%)
		WD40 repeat	113..161	CDD:293791	16/47 (34%)
		WD40	158..574	CDD:225201	201/421 (48%)
		WD40 repeat	167..207	CDD:293791	22/39 (56%)
		WD40 repeat	209..285	CDD:293791	41/77 (53%)
		WD40 repeat	254..294	CDD:293791	16/39 (41%)
		WD40 repeat	303..338	CDD:293791	13/34 (38%)
		WD40 repeat	353..407	CDD:293791	22/53 (42%)
		WD40	385..747	CDD:225201	199/369 (54%)
		WD40	436..748	CDD:295369	177/318 (56%)
		WD40 repeat	505..540	CDD:293791	15/34 (44%)
		WD40 repeat	546..586	CDD:293791	26/39 (67%)
		WD40 repeat	591..631	CDD:293791	24/43 (56%)
		WD40 repeat	637..672	CDD:293791	19/34 (56%)
		WD40 repeat	679..717	CDD:293791	21/37 (57%)
		WD40 repeat	723..749	CDD:293791	19/25 (76%)
Wdr62	NP_001178552.2	WD40	96..519	CDD:225201	189/428 (44%)
		WD40	112..442	CDD:295369	151/331 (46%)
		WD40 repeat	118..154	CDD:293791	15/35 (43%)
		WD40 repeat	159..195	CDD:293791	14/35 (40%)
		WD40 repeat	203..237	CDD:293791	17/33 (52%)
		WD40 repeat	255..286	CDD:293791	17/32 (53%)
		WD40 repeat	292..342	CDD:293791	16/49 (33%)
		WD40 repeat	409..468	CDD:293791	27/59 (46%)
		WD40	437..>745	CDD:225201	167/315 (53%)
		WD40	493..745	CDD:295369	143/258 (55%)
		WD40 repeat	499..533	CDD:293791	13/36 (36%)
		WD40 repeat	538..579	CDD:293791	19/40 (48%)
		WD40 repeat	585..627	CDD:293791	28/41 (68%)
		WD40 repeat	632..668	CDD:293791	16/39 (41%)
		WD40 repeat	676..713	CDD:293791	20/36 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337027
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1017450at2759
OrthoFinder	1	1.000	-	-		FOG0003218
OrthoInspector	1	1.000	-	-		otm44858
orthoMCL	1	0.900	-	-		OOG6_103235
Panther	1	1.100	-	-	O	PTHR45589
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2177
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.750