DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr62 and WDR62

DIOPT Version :9

Sequence 1:	NP_001259886.1	Gene:	Wdr62 / 33367	FlyBaseID:	FBgn0031374	Length:	2397	Species:	Drosophila melanogaster
Sequence 2:	NP_001077430.1	Gene:	WDR62 / 284403	HGNCID:	24502	Length:	1523	Species:	Homo sapiens

Alignment Length:	1524	Identity:	511/1524 - (33%)
Similarity:	750/1524 - (49%)	Gaps:	339/1524 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SLSASTPTLSTLHHQRMALQSQSQSPLASPL---------TPSPSSVFGSPKFPANYERSEKIKL 60
            |:.|..|          |.:.||..|.|.|:         |.|..:|            ..::.|
Human    20 SVMAGVP----------ARRGQSSPPPAPPICLRRRTRLSTASEETV------------QNRVSL 62

  Fly    61 KKVLGLTVCSNAALDVSPVSGLLAYPAGCTVVLFNAKRQTQAYLVNTSRKAFTSVAFSRCGRYVA 125
            :||||:|..:::.|...|.:|.:||.|||.||:.:.|...|.::.||:||:.:::|||..|:|:.
Human    63 EKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYIV 127

  Fly   126 TGECGINPAIKVWELETPNGSLEHCSGGSVVAEFVDHKYAVTCVAFSPTGKYLVSVGSQHDMIVN 190
            |||.|..||:::|::|..|          .|||.:.|||.|.||||||..|::||:|.||||::|
Human   128 TGENGHRPAVRIWDVEEKN----------QVAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLN 182

  Fly   191 VFDWRANLKMASNKISSKVAAVCFSEDGSYFVTVGNRHVKYWYLEGGRKYK--DPIPLMGRSAIL 253
            |:||:.::.:||||:|.:|.|:.||||.|||||||||||::|:||...:.|  ..:||:|||.||
Human   183 VWDWKKDIVVASNKVSCRVIALSFSEDSSYFVTVGNRHVRFWFLEVSTETKVTSTVPLVGRSGIL 247

  Fly   254 GDLRDNDFCAVACGKGICAESTYAITRQGHLVEFSSRRLLDKWVQCRTTNANCICVNERFILVGC 318
            |:|.:|.||.||||:|..|.||:.::..|.|.:|:.:|:|:||:..:.:.::|:||::..|..||
Human   248 GELHNNIFCGVACGRGRMAGSTFCVSYSGLLCQFNEKRVLEKWINLKVSLSSCLCVSQELIFCGC 312

  Fly   319 AESIIRIFNSATLEYVTTLPRTHYLGVDVAQGIQINHIMSVPQQAKFPDCIAMVFDEQRSKVSCV 383
            .:.|:|||.:.:|.|:..||:.||||||||||::.:.:.....:|.:||.:|:.||.....:|||
Human   313 TDGIVRIFQAHSLHYLANLPKPHYLGVDVAQGLEPSFLFHRKAEAVYPDTVALTFDPIHQWLSCV 377

  Fly   384 YNDHSLYIWDLRDISRVGKSHSFLYHSTCIWGVETVPYNVEREPSQT-LPEECFVTCSSDDTIRV 447
            |.|||:||||::||:||||..|.|:||:.:|.||..|   |.|..:. ||...|:|||||:|||.
Human   378 YKDHSIYIWDVKDINRVGKVWSELFHSSYVWNVEVYP---EFEDQRACLPSGSFLTCSSDNTIRF 439

  Fly   448 WGLDGCTNNDIYRRNIYSKELLKIVYSDDELQFIKDQGSSLFDKAGNSS---YDGRNGVRCIKIS 509
            |.||...::. :::||:|..|||:||.::::|.::|.  |.|...|:.:   .|.:.|||.:::|
Human   440 WNLDSSPDSH-WQKNIFSNTLLKVVYVENDIQHLQDM--SHFPDRGSENGTPMDVKAGVRVMQVS 501

  Fly   510 PELQHLASGDRCGNIRVYSLVNLRLLTTIEAHESEVLCLEYSNEKIERKLLASASRDRLIHVFDV 574
            |:.||||||||.||:|::.|..:..|..:|||::||||||||..:....|||||||||||||.:|
Human   502 PDGQHLASGDRSGNLRIHELHFMDELVKVEAHDAEVLCLEYSKPETGLTLLASASRDRLIHVLNV 566

  Fly   575 AQNYLLLQTLDDHSSSITSIKFVGAGLNFQMISCGADKSIMFRSFQ----GNIFMRGTNTSGKTT 635
            .:||.|.|||||||||||:|||.| ..:.|||||||||||.|||.|    |..|:|..:.:.|||
Human   567 EKNYNLEQTLDDHSSSITAIKFAG-NRDIQMISCGADKSIYFRSAQQGSDGLHFVRTHHVAEKTT 630

  Fly   636 LYDMEVDSNAKHILTACQDRNVRVYGTQNAKQTKTFKGSHSDEGSLIKLSLDPSGIYVATSCTDK 700
            ||||::|...|::..||||||||||.|.|.||.|.:|||..|||||:|:.:||||.::||||:||
Human   631 LYDMDIDITQKYVAVACQDRNVRVYNTVNGKQKKCYKGSQGDEGSLLKVHVDPSGTFLATSCSDK 695

  Fly   701 TLAVYDYYSNECMARMYGHSELVTGLKFTNDCRHLISASGDGCIFIWQVPHDM-------IVTMQ 758
            :::|.|:||.||:|:|:||||::|.:|||.||.|||:.|||.|:|||.:..::       ::.:.
Human   696 SISVIDFYSGECIAKMFGHSEIITSMKFTYDCHHLITVSGDSCVFIWHLGPEITNCMKQHLLEID 760

  Fly   759 ARMSQQ----RLRSGHAPLPRPLAPISPPDGIVLESPTSEIE---QPQLQPKFGVAERFSDV--- 813
            .|..||    :.||||   ||....:|.|..|...||..:.|   :.:.:|:..:.....|.
Human   761 HRQQQQHTNDKKRSGH---PRQDTYVSTPSEIHSLSPGEQTEDDLEEECEPEEMLKTPSKDSLDP 822

  Fly   814 --------GQLPQWAMRKAAADSDSGALSIPTPSGGSATVPGMHAASSMGNLSSSPSQQMTGLAP 870
                    |:||.||.|....|..:..|:             .||..|.
Human   823 DPRCLLTNGKLPLWAKRLLGDDDVADGLA-------------FHAKRSY---------------- 858

  Fly   871 RARGRWAQRSTQ------LETAD---------------------------DLRSNSESPLGTVSS 902
            :..||||:|:.|      |:..|                           .|.|.||||    ..
Human   859 QPHGRWAERAGQEPLKTILDAQDLDCYFTPMKPESLENSILDSLEPQSLASLLSESESP----QE 919

  Fly   903 VG-GHSGVNVQTSDYNSASSKDITYN----QTYLSEDS-----SIDSGMETRRGELKFIGSSNNG 957
            .| ||.....|..: :|.:|:.|.|:    .|....||     .:::|...::|:
Human   920 AGRGHPSFLPQQKE-SSEASELILYSLEAEVTVTGTDSQYCRKEVEAGPGDQQGD---------- 973

  Fly   958 TVVTVSSVSSIAVSASNGAMSTGSGAAQQRLQL-----------PDKRLKPGLRFDT---HTHDH 1008
            :.:.|||     .|..:.:....||.::..|:.           ||    |..||.|   |....
Human   974 SYLRVSS-----DSPKDQSPPEDSGESEADLECSFAAIHSPAPPPD----PAPRFATSLPHFPGC 1029

  Fly  1009 DGDVED---ISDGERTSSDHGMFYNNLAPSTPTDFKVTAMNEDELRKSVRRQKFEKSGLQLTPSA 1070
            .|..||   :.:|....|       :..|.||...|....:.:.|.:|..|:.|        |:|
Human  1030 AGPTEDELSLPEGPSVPS-------SSLPQTPEQEKFLRHHFETLTESPCRELF--------PAA 1079

  Fly  1071 LSGNGSSHTASTGTGTSDTEDEGSTPSAENAERSLASTLGGS--SENLPQSSTNSFLHAALPEGP 1133
            |.          ....|:.||....|....:.:.|:|....|  :...|..:|...:.:  ||
Human  1080 LG----------DVEASEAEDHFFNPRLSISTQFLSSLQKASRFTHTFPPRATQCLVKS--PE-- 1130

  Fly  1134 GLTTPMERGGSSRRSISAKHNTENGKSVAA-------------PPTITKSYTSTKKEELLQVINK 1185
              ...|:||||..|:.:...:.:....:||             ||.:|...:......:|.
Human  1131 --VKLMDRGGSQPRAGTGYASPDRTHVLAAGKAEETLEAWRPPPPCLTSLASCVPASSVLP---- 1189

  Fly  1186 VKQQLENGTRKNGNTRLNA----IAEVGHRPLRGSHSISDLSLAANLDGSRNAGGGPGRYQKPVD 1246
                    |.:|..|..:|    :|:..|.|...|:..:..|..|.:..|.:.|...|    |:.
Human  1190 --------TDRNLPTPTSAPTPGLAQGVHAPSTCSYMEATASSRARISRSISLGDSEG----PIV 1242

  Fly  1247 SHDTSQYTSPQN--------------TTATAAPTNTQQQ-------------------------- 1271
            :........|.:              ||||....:::.|
Human  1243 ATLAQPLRRPSSVGELASLGQELQAITTATTPSLDSEGQEPALRSWGNHEARANLRLTLSSACDG 1307

  Fly  1272 -IQPPVQQQ---------YQIPKEPHQQAQQQHQQYAPPASQQFFNCAAPKSKLQQNFQTMRQVQ 1326
             :||||..|         :..|....:.|.:.|.....|      :..||:|
Human  1308 LLQPPVDTQPGVTVPAVSFPAPSPVEESALRLHGSAFRP------SLPAPES------------- 1353

  Fly  1327 QHYPPYPHHVGVHQI-HPPPGVPFGGSAA 1354
               |..|.|....|: ...||:| ||:|:
Human  1354 ---PGLPAHPSNPQLPEARPGIP-GGTAS 1378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr62	NP_001259886.1	WD40	73..448	CDD:295369	176/377 (47%)
		WD40 repeat	73..107	CDD:293791	12/33 (36%)
		WD40 repeat	113..161	CDD:293791	17/47 (36%)
		WD40	158..574	CDD:225201	203/421 (48%)
		WD40 repeat	167..207	CDD:293791	22/39 (56%)
		WD40 repeat	209..285	CDD:293791	42/77 (55%)
		WD40 repeat	254..294	CDD:293791	17/39 (44%)
		WD40 repeat	303..338	CDD:293791	12/34 (35%)
		WD40 repeat	353..407	CDD:293791	24/53 (45%)
		WD40	385..747	CDD:225201	199/369 (54%)
		WD40	436..748	CDD:295369	175/318 (55%)
		WD40 repeat	505..540	CDD:293791	15/34 (44%)
		WD40 repeat	546..586	CDD:293791	26/39 (67%)
		WD40 repeat	591..631	CDD:293791	24/43 (56%)
		WD40 repeat	637..672	CDD:293791	20/34 (59%)
		WD40 repeat	679..717	CDD:293791	21/37 (57%)
		WD40 repeat	723..749	CDD:293791	16/25 (64%)
WDR62	NP_001077430.1	WD40	95..518	CDD:225201	198/438 (45%)
		WD 1	109..150		18/50 (36%)
		WD40	111..441	CDD:295369	162/342 (47%)
		WD40 repeat	114..153	CDD:293791	17/48 (35%)
		WD 2	153..194		22/40 (55%)
		WD40 repeat	159..197	CDD:293791	21/37 (57%)
		WD 3	196..234		22/37 (59%)
		WD40 repeat	201..239	CDD:293791	21/37 (57%)
		WD40 repeat	270..332	CDD:293791	19/61 (31%)
		WD 4	291..330		12/38 (32%)
		WD40 repeat	350..399	CDD:293791	23/48 (48%)
		WD 5	357..396		21/38 (55%)
		WD 6	402..450		22/51 (43%)
		WD40 repeat	407..442	CDD:293791	18/37 (49%)
		WD40	436..>744	CDD:225201	170/311 (55%)
		WD 7	490..529		19/38 (50%)
		WD40	492..744	CDD:295369	150/252 (60%)
		WD40 repeat	498..532	CDD:293791	15/33 (45%)
		WD 8	532..574		27/41 (66%)
		WD40 repeat	538..578	CDD:293791	26/39 (67%)
		WD 9	578..618		27/40 (68%)
		WD40 repeat	583..620	CDD:293791	22/37 (59%)
		WD 10	626..665		23/38 (61%)
		WD40 repeat	632..667	CDD:293791	20/34 (59%)
		WD 11	671..713		24/41 (59%)
		WD40 repeat	676..712	CDD:293791	19/35 (54%)
		WD 12	714..752		19/37 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..824		17/64 (27%)
		WD 13	803..846		9/42 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	908..935		10/31 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	962..1055		23/118 (19%)
		WD 14	1137..1178		9/40 (23%)
		WD 15	1260..1298		5/37 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1344..1382		14/58 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143296
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1017450at2759
OrthoFinder	1	1.000	-	-		FOG0003218
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103235
Panther	1	1.100	-	-	O	PTHR45589
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4088
SonicParanoid	1	1.000	-	-		X2177
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.740