DRSC/TRiP Functional Genomics Resources

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Protein Alignment Wdr62 and Mapkbp1

DIOPT Version :10

Sequence 1:NP_001259886.1 Gene:Wdr62 / 33367 FlyBaseID:FBgn0031374 Length:2397 Species:Drosophila melanogaster
Sequence 2:NP_001342222.1 Gene:Mapkbp1 / 26390 MGIID:1347004 Length:1509 Species:Mus musculus


Alignment Length:1609 Identity:538/1609 - (33%)
Similarity:773/1609 - (48%) Gaps:287/1609 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 LQSQSQSPLASPLTPSPSSVFGSPKFPANYERSEKIKLKKVLGLTVCSNAALDVSPVSGLLAYPA 87
            :.|:.::.|.||......|..|:.:    .:.|.|:.|:||||:||.....|...|.|||:||||
Mouse     9 ITSRIKNLLRSPSIKLRRSKAGNRR----EDLSSKVTLEKVLGVTVSGGRGLACDPRSGLVAYPA 69

  Fly    88 GCTVVLFNAKRQTQAYLVNTSRKAFTSVAFSRCGRYVATGECGINPAIKVWELETPNGSLEHCSG 152
            ||.|||||.::..|.:::|:|||..|::|||..|:|:.|||.|..||::||::          :.
Mouse    70 GCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWDV----------AE 124

  Fly   153 GSVVAEFVDHKYAVTCVAFSPTGKYLVSVGSQHDMIVNVFDWRANLKMASNKISSKVAAVCFSED 217
            .|.|||..:|||.|.||||||:.||:||||.||||||||:.|:.|:.:||||:||:|.||.||||
Mouse   125 RSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRVTAVSFSED 189

  Fly   218 GSYFVTVGNRHVKYWYLEGGR--KYKDPIPLMGRSAILGDLRDNDFCAVACGKGICAESTYAITR 280
            .|||||.||||:|:|||:..:  |....:||:|||.:||:||:|.|..||||:|..|:||:.||.
Mouse   190 CSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACGRGEKADSTFCITS 254

  Fly   281 QGHLVEFSSRRLLDKWVQCR------TTNANCICVNERFILVGCAESIIRIFNSATLEYVTTLPR 339
            .|.|.|||.||||||||:.|      ||.|:||.|.:.:|..|||:..:|:||.:.|.:::||||
Mouse   255 SGLLCEFSDRRLLDKWVELRNTDSFTTTVAHCISVTQEYIFCGCADGTVRLFNPSNLHFLSTLPR 319

  Fly   340 THYLGVDVAQGIQINHIMSVPQQAKFPDCIAMVFDEQRSKVSCVYNDHSLYIWDLRDISRVGKSH 404
            .|.||.|:|...:.:.:.|....|::||.||:.||.....:||||||||:|:||:||..:|||.:
Mouse   320 PHALGTDIASITEASRLFSGGVNARYPDTIALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVY 384

  Fly   405 SFLYHSTCIWGVETVPYNVEREPSQTLPEECFVTCSSDDTIRVW-----GLDGCTNNDIYRRNIY 464
            |.||||:|:|.||..| .::......||...|:|||||:|||:|     |:.|.|    ..|||.
Mouse   385 SALYHSSCVWSVEVYP-EIKDSHQACLPPSSFITCSSDNTIRLWNTESSGVHGST----LHRNIL 444

  Fly   465 SKELLKIVYSDDELQFIKDQGSSLFDKAGNSSYDGRNGVRCIKISPELQHLASGDRCGNIRVYSL 529
            |.:|:||:|.|...|.:.|......|||..|..|.|.|:|.:.|||..||||||||.|.:|::.|
Mouse   445 SNDLIKIIYVDGNTQALLDTELPGGDKADGSLMDPRVGIRSVCISPNGQHLASGDRMGTLRIHEL 509

  Fly   530 VNLRLLTTIEAHESEVLCLEYSNEKIERKLLASASRDRLIHVFDVAQNYLLLQTLDDHSSSITSI 594
            .:|..:..:|||:||:||||||......||||||||||||||.|..:.|.|.||||:||||||::
Mouse   510 QSLSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLDEHSSSITAV 574

  Fly   595 KFVGAGLNFQMISCGADKSIMFRSFQ----GNIFMRGTNTSGKTTLYDMEVDSNAKHILTACQDR 655
            ||..:....:||||||||||.||:.|    |..|.|..:...|||||||:|:.:.|:....||||
Mouse   575 KFAASDGQVRMISCGADKSIYFRTAQKSGEGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDR 639

  Fly   656 NVRVYGTQNAKQTKTFKGSHSDEGSLIKLSLDPSGIYVATSCTDKTLAVYDYYSNECMARMYGHS 720
            |:|::...:.||.|.||||..::|:|||:..||||||:||||:||.|:::|:.|.||:|.|:|||
Mouse   640 NIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHS 704

  Fly   721 ELVTGLKFTNDCRHLISASGDGCIFIWQVPHDMIVTMQARMSQQRLRSGHAPLPRPL-------- 777
            |:|||:||:|||:||||.|||.|||:|::..:|.::|:.|:::.|.|........|.        
Mouse   705 EIVTGMKFSNDCKHLISVSGDSCIFVWRLSSEMTISMRQRLAELRQRQRGIKQQGPTSPQRASGA 769

  Fly   778 ----APISPPDGIVLESP---------TSEIEQPQL-----QPKFGVAERFSD--VGQLPQWAMR 822
                ||:.||.|..|.|.         |.|.|.|.|     ..|..:|...|.  :..|..|.|.
Mouse   770 KQHHAPVVPPSGPALSSDSDKEGEDEGTEEEELPALPILSKSTKKELASGSSPALLRSLSHWEMS 834

  Fly   823 KAAADSDSGALSIPTPSGGSATVPGMHAASSMGNLSSSPSQQMTGLAPRARGRWAQRSTQLETAD 887
            :                          |..:|..|..:|   :....|:.||||||...:|....
Mouse   835 R--------------------------AQETMEYLDPAP---VANTGPKRRGRWAQPGVELSVRS 870

  Fly   888 --DLR---SNSESPLG------TVSSVG----GHSG------------VNVQTSDYNSA------ 919
              |||   :.:.||.|      .||..|    |..|            ..:|||...|.      
Mouse   871 MLDLRQIETLAPSPRGPSQDSLAVSPAGPGKHGPQGPELSCVSQNERAPRLQTSQPCSCPHIIQL 935

  Fly   920 -SSKDITYNQTYLSEDSSIDSGMETRRGELKFIGSSNNGTVVTVSSVSSIAVSASNGAMSTGSGA 983
             |.::..:.|..  |.:.|:.|       :.:...|::.|:.|.:.........|.|.|..||..
Mouse   936 LSQEEGVFAQDL--EPAPIEDG-------IVYPEPSDSPTMDTSAFQVQAPTGGSLGRMYPGSRG 991

  Fly   984 AQQRLQLPDKRLK---PGLRFDTHTHDH-----------DG---DVEDISDGERTSSDHG----- 1026
            :::  ..||....   ...|..:..|.:           ||   |:|:.::|:....:.|     
Mouse   992 SEK--HSPDSACSVDYSSSRLSSPEHPNEDSESTEPLSVDGISSDLEEPAEGDEDEEEEGGTGLC 1054

  Fly  1027 ---------------------MFYNNLAPSTPTDFKVTAMNEDELRKSVRRQKFEKSGLQLTPSA 1070
                                 ...|..||..|.  :|....|.:...|       :..||:..|.
Mouse  1055 GLQEGGPHTPDQEQFLKQHFETLANGTAPGGPA--RVLERTESQSISS-------RFLLQVQTSP 1110

  Fly  1071 LSGNGSSHTASTGTGTSDTEDEGSTPSAENAERSLASTLGGSSENLPQSSTNSFLHAALPEGPGL 1135
            |.   ....:|:|...:...|:.|..|.|..:.|.|:..|...|..| ||.||        ||..
Mouse  1111 LR---EPSLSSSGLALTSRPDQVSQVSGEQLKGSGATPPGAPPEMEP-SSGNS--------GPKQ 1163

  Fly  1136 TTPMERGGSSRRSISAKHNTENGKSVAAPPTITKSYTSTKKEELLQVINKVKQQLENGTRKNGNT 1200
            ..|:        .::.:||..:....:.....|:.....:|.:  .|.:.|.|.....:|.....
Mouse  1164 VAPV--------LLTRRHNNLDNSWASKKMAATRPLAGLQKAQ--SVHSLVPQDEVPSSRPLLFQ 1218

  Fly  1201 RLNAIAEVGHRPLRGS-----HSISD--LSLAANLDGSRNAGGGPG------------------- 1239
            .......:|..|..|.     ||..:  .|..|.|..|.:.|..||                   
Mouse  1219 EAETQGSLGSLPQAGGCSSQPHSYQNHTTSSMAKLARSISVGENPGLATEPQAPVPIRISPFNKL 1283

  Fly  1240 ----------RYQKPVDSHDTSQYTSP------QNTTATAAPTNTQQQIQPPVQQQYQIPKEPHQ 1288
                      ...||:....|....||      .|.|..:.|..:..:....|::...:.:....
Mouse  1284 ALPSRAHLVLDIPKPLPDRPTLTTFSPVSKGLAHNETEQSGPLVSLGKAHTTVEKHSCLGEGTTH 1348

  Fly  1289 QAQQQHQQY-AP--PASQQFFNCAAPKSKLQQNFQTMRQVQQHYPPYPHHVGVHQIHPPPGVPFG 1350
            :::.:.|.| .|  |.:||.     |.:.|.|..::::      |..|...........|||...
Mouse  1349 KSRTECQAYPGPNHPCAQQL-----PVNNLLQGPESLQ------PLSPEKTRNPVESSRPGVALS 1402

  Fly  1351 GSAAGSTSAMR-----SHSQPQNRQQQQQQQQQRAKRNPAGNNRRTPSILKHYKSCPVSPVHEEV 1410
            ..:..:.|..:     :..|...||..:..:...:.:.|:........:|:.    ..|.|.:|:
Mouse  1403 QDSELALSLQQCEQLVAELQGNVRQAVELYRAVTSYKTPSAEQSHITRLLRD----TFSSVRQEL 1463

  Fly  1411 EWSAEGNERGALLGEP--KRHSVYADDARTILDMIHADTEKMIDEITRK 1457
            |..|     ||:|..|  ...:|.|:..:.:|:..   :|.::..:.|:
Mouse  1464 EVLA-----GAVLSSPGGSPGAVGAEQTQALLEQY---SELLLRAVERR 1504

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Wdr62NP_001259886.1 WD40 <73..236 CDD:441893 91/162 (56%)
WD40 repeat 73..107 CDD:293791 17/33 (52%)
WD40 repeat 113..161 CDD:293791 18/47 (38%)
WD40 156..573 CDD:475233 222/429 (52%)
WD40 repeat 167..207 CDD:293791 26/39 (67%)
WD40 repeat 209..285 CDD:293791 43/77 (56%)
WD40 repeat 303..338 CDD:293791 13/34 (38%)
WD40 repeat 353..407 CDD:293791 25/53 (47%)
WD40 <437..750 CDD:441893 170/321 (53%)
WD40 repeat 505..540 CDD:293791 15/34 (44%)
WD40 repeat 546..586 CDD:293791 26/39 (67%)
WD40 repeat 591..631 CDD:293791 20/43 (47%)
WD40 repeat 637..672 CDD:293791 14/34 (41%)
WD40 repeat 679..717 CDD:293791 22/37 (59%)
WD40 repeat 723..749 CDD:293791 19/25 (76%)
Mapkbp1NP_001342222.1 WD40 <45..121 CDD:475233 39/75 (52%)
WD40 84..428 CDD:475233 178/354 (50%)
WD 1 89..130 19/50 (38%)
WD40 repeat 94..133 CDD:293791 18/48 (38%)
WD 2 133..174 26/40 (65%)
WD40 repeat 139..173 CDD:293791 22/33 (67%)
WD 3 176..214 23/37 (62%)
WD40 repeat 181..219 CDD:293791 21/37 (57%)
WD40 repeat 281..318 CDD:293791 15/36 (42%)
WD40 <297..735 CDD:441893 223/442 (50%)
WD40 repeat 336..385 CDD:293791 24/48 (50%)
WD 5 343..382 21/38 (55%)
WD 6 388..437 21/49 (43%)
WD40 repeat 405..469 CDD:293791 26/67 (39%)
WD 7 478..517 19/38 (50%)
WD40 repeat 485..520 CDD:293791 15/34 (44%)
WD 8 520..562 27/41 (66%)
WD40 repeat 526..566 CDD:293791 26/39 (67%)
WD 9 566..607 22/40 (55%)
WD40 repeat 571..611 CDD:293791 19/39 (49%)
WD 10 615..654 17/38 (45%)
WD40 repeat 621..656 CDD:293791 14/34 (41%)
WD 11 660..699 21/38 (55%)
WD40 repeat 663..701 CDD:293791 22/37 (59%)
WD 12 702..741 24/38 (63%)
WD40 repeat 707..733 CDD:293791 19/25 (76%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 751..823 17/71 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 880..923 8/42 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 957..1182 49/255 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1223..1244 5/20 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1375..1397 3/27 (11%)

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