DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr62 and Mapkbp1

DIOPT Version :9

Sequence 1:	NP_001259886.1	Gene:	Wdr62 / 33367	FlyBaseID:	FBgn0031374	Length:	2397	Species:	Drosophila melanogaster
Sequence 2:	NP_001342222.1	Gene:	Mapkbp1 / 26390	MGIID:	1347004	Length:	1509	Species:	Mus musculus

Alignment Length:	1609	Identity:	538/1609 - (33%)
Similarity:	773/1609 - (48%)	Gaps:	287/1609 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LQSQSQSPLASPLTPSPSSVFGSPKFPANYERSEKIKLKKVLGLTVCSNAALDVSPVSGLLAYPA 87
            :.|:.::.|.||......|..|:.:    .:.|.|:.|:||||:||.....|...|.|||:||||
Mouse     9 ITSRIKNLLRSPSIKLRRSKAGNRR----EDLSSKVTLEKVLGVTVSGGRGLACDPRSGLVAYPA 69

  Fly    88 GCTVVLFNAKRQTQAYLVNTSRKAFTSVAFSRCGRYVATGECGINPAIKVWELETPNGSLEHCSG 152
            ||.|||||.::..|.:::|:|||..|::|||..|:|:.|||.|..||::||::          :.
Mouse    70 GCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWDV----------AE 124

  Fly   153 GSVVAEFVDHKYAVTCVAFSPTGKYLVSVGSQHDMIVNVFDWRANLKMASNKISSKVAAVCFSED 217
            .|.|||..:|||.|.||||||:.||:||||.||||||||:.|:.|:.:||||:||:|.||.||||
Mouse   125 RSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRVTAVSFSED 189

  Fly   218 GSYFVTVGNRHVKYWYLEGGR--KYKDPIPLMGRSAILGDLRDNDFCAVACGKGICAESTYAITR 280
            .|||||.||||:|:|||:..:  |....:||:|||.:||:||:|.|..||||:|..|:||:.||.
Mouse   190 CSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACGRGEKADSTFCITS 254

  Fly   281 QGHLVEFSSRRLLDKWVQCR------TTNANCICVNERFILVGCAESIIRIFNSATLEYVTTLPR 339
            .|.|.|||.||||||||:.|      ||.|:||.|.:.:|..|||:..:|:||.:.|.:::||||
Mouse   255 SGLLCEFSDRRLLDKWVELRNTDSFTTTVAHCISVTQEYIFCGCADGTVRLFNPSNLHFLSTLPR 319

  Fly   340 THYLGVDVAQGIQINHIMSVPQQAKFPDCIAMVFDEQRSKVSCVYNDHSLYIWDLRDISRVGKSH 404
            .|.||.|:|...:.:.:.|....|::||.||:.||.....:||||||||:|:||:||..:|||.:
Mouse   320 PHALGTDIASITEASRLFSGGVNARYPDTIALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVY 384

  Fly   405 SFLYHSTCIWGVETVPYNVEREPSQTLPEECFVTCSSDDTIRVW-----GLDGCTNNDIYRRNIY 464
            |.||||:|:|.||..| .::......||...|:|||||:|||:|     |:.|.|    ..|||.
Mouse   385 SALYHSSCVWSVEVYP-EIKDSHQACLPPSSFITCSSDNTIRLWNTESSGVHGST----LHRNIL 444

  Fly   465 SKELLKIVYSDDELQFIKDQGSSLFDKAGNSSYDGRNGVRCIKISPELQHLASGDRCGNIRVYSL 529
            |.:|:||:|.|...|.:.|......|||..|..|.|.|:|.:.|||..||||||||.|.:|::.|
Mouse   445 SNDLIKIIYVDGNTQALLDTELPGGDKADGSLMDPRVGIRSVCISPNGQHLASGDRMGTLRIHEL 509

  Fly   530 VNLRLLTTIEAHESEVLCLEYSNEKIERKLLASASRDRLIHVFDVAQNYLLLQTLDDHSSSITSI 594
            .:|..:..:|||:||:||||||......||||||||||||||.|..:.|.|.||||:||||||::
Mouse   510 QSLSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLDEHSSSITAV 574

  Fly   595 KFVGAGLNFQMISCGADKSIMFRSFQ----GNIFMRGTNTSGKTTLYDMEVDSNAKHILTACQDR 655
            ||..:....:||||||||||.||:.|    |..|.|..:...|||||||:|:.:.|:....||||
Mouse   575 KFAASDGQVRMISCGADKSIYFRTAQKSGEGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDR 639

  Fly   656 NVRVYGTQNAKQTKTFKGSHSDEGSLIKLSLDPSGIYVATSCTDKTLAVYDYYSNECMARMYGHS 720
            |:|::...:.||.|.||||..::|:|||:..||||||:||||:||.|:::|:.|.||:|.|:|||
Mouse   640 NIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHS 704

  Fly   721 ELVTGLKFTNDCRHLISASGDGCIFIWQVPHDMIVTMQARMSQQRLRSGHAPLPRPL-------- 777
            |:|||:||:|||:||||.|||.|||:|::..:|.::|:.|:::.|.|........|.
Mouse   705 EIVTGMKFSNDCKHLISVSGDSCIFVWRLSSEMTISMRQRLAELRQRQRGIKQQGPTSPQRASGA 769

  Fly   778 ----APISPPDGIVLESP---------TSEIEQPQL-----QPKFGVAERFSD--VGQLPQWAMR 822
                ||:.||.|..|.|.         |.|.|.|.|     ..|..:|...|.  :..|..|.|.
Mouse   770 KQHHAPVVPPSGPALSSDSDKEGEDEGTEEEELPALPILSKSTKKELASGSSPALLRSLSHWEMS 834

  Fly   823 KAAADSDSGALSIPTPSGGSATVPGMHAASSMGNLSSSPSQQMTGLAPRARGRWAQRSTQLETAD 887
            :                          |..:|..|..:|   :....|:.||||||...:|....
Mouse   835 R--------------------------AQETMEYLDPAP---VANTGPKRRGRWAQPGVELSVRS 870

  Fly   888 --DLR---SNSESPLG------TVSSVG----GHSG------------VNVQTSDYNSA------ 919
              |||   :.:.||.|      .||..|    |..|            ..:|||...|.
Mouse   871 MLDLRQIETLAPSPRGPSQDSLAVSPAGPGKHGPQGPELSCVSQNERAPRLQTSQPCSCPHIIQL 935

  Fly   920 -SSKDITYNQTYLSEDSSIDSGMETRRGELKFIGSSNNGTVVTVSSVSSIAVSASNGAMSTGSGA 983
             |.::..:.|..  |.:.|:.|       :.:...|::.|:.|.:.........|.|.|..||..
Mouse   936 LSQEEGVFAQDL--EPAPIEDG-------IVYPEPSDSPTMDTSAFQVQAPTGGSLGRMYPGSRG 991

  Fly   984 AQQRLQLPDKRLK---PGLRFDTHTHDH-----------DG---DVEDISDGERTSSDHG----- 1026
            :::  ..||....   ...|..:..|.:           ||   |:|:.::|:....:.|
Mouse   992 SEK--HSPDSACSVDYSSSRLSSPEHPNEDSESTEPLSVDGISSDLEEPAEGDEDEEEEGGTGLC 1054

  Fly  1027 ---------------------MFYNNLAPSTPTDFKVTAMNEDELRKSVRRQKFEKSGLQLTPSA 1070
                                 ...|..||..|.  :|....|.:...|       :..||:..|.
Mouse  1055 GLQEGGPHTPDQEQFLKQHFETLANGTAPGGPA--RVLERTESQSISS-------RFLLQVQTSP 1110

  Fly  1071 LSGNGSSHTASTGTGTSDTEDEGSTPSAENAERSLASTLGGSSENLPQSSTNSFLHAALPEGPGL 1135
            |.   ....:|:|...:...|:.|..|.|..:.|.|:..|...|..| ||.||        ||..
Mouse  1111 LR---EPSLSSSGLALTSRPDQVSQVSGEQLKGSGATPPGAPPEMEP-SSGNS--------GPKQ 1163

  Fly  1136 TTPMERGGSSRRSISAKHNTENGKSVAAPPTITKSYTSTKKEELLQVINKVKQQLENGTRKNGNT 1200
            ..|:        .::.:||..:....:.....|:.....:|.:  .|.:.|.|.....:|.....
Mouse  1164 VAPV--------LLTRRHNNLDNSWASKKMAATRPLAGLQKAQ--SVHSLVPQDEVPSSRPLLFQ 1218

  Fly  1201 RLNAIAEVGHRPLRGS-----HSISD--LSLAANLDGSRNAGGGPG------------------- 1239
            .......:|..|..|.     ||..:  .|..|.|..|.:.|..||
Mouse  1219 EAETQGSLGSLPQAGGCSSQPHSYQNHTTSSMAKLARSISVGENPGLATEPQAPVPIRISPFNKL 1283

  Fly  1240 ----------RYQKPVDSHDTSQYTSP------QNTTATAAPTNTQQQIQPPVQQQYQIPKEPHQ 1288
                      ...||:....|....||      .|.|..:.|..:..:....|::...:.:....
Mouse  1284 ALPSRAHLVLDIPKPLPDRPTLTTFSPVSKGLAHNETEQSGPLVSLGKAHTTVEKHSCLGEGTTH 1348

  Fly  1289 QAQQQHQQY-AP--PASQQFFNCAAPKSKLQQNFQTMRQVQQHYPPYPHHVGVHQIHPPPGVPFG 1350
            :::.:.|.| .|  |.:||.     |.:.|.|..::::      |..|...........|||...
Mouse  1349 KSRTECQAYPGPNHPCAQQL-----PVNNLLQGPESLQ------PLSPEKTRNPVESSRPGVALS 1402

  Fly  1351 GSAAGSTSAMR-----SHSQPQNRQQQQQQQQQRAKRNPAGNNRRTPSILKHYKSCPVSPVHEEV 1410
            ..:..:.|..:     :..|...||..:..:...:.:.|:........:|:.    ..|.|.:|:
Mouse  1403 QDSELALSLQQCEQLVAELQGNVRQAVELYRAVTSYKTPSAEQSHITRLLRD----TFSSVRQEL 1463

  Fly  1411 EWSAEGNERGALLGEP--KRHSVYADDARTILDMIHADTEKMIDEITRK 1457
            |..|     ||:|..|  ...:|.|:..:.:|:..   :|.::..:.|:
Mouse  1464 EVLA-----GAVLSSPGGSPGAVGAEQTQALLEQY---SELLLRAVERR 1504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr62	NP_001259886.1	WD40	73..448	CDD:295369	195/382 (51%)
		WD40 repeat	73..107	CDD:293791	17/33 (52%)
		WD40 repeat	113..161	CDD:293791	18/47 (38%)
		WD40	158..574	CDD:225201	220/428 (51%)
		WD40 repeat	167..207	CDD:293791	26/39 (67%)
		WD40 repeat	209..285	CDD:293791	43/77 (56%)
		WD40 repeat	254..294	CDD:293791	23/39 (59%)
		WD40 repeat	303..338	CDD:293791	13/34 (38%)
		WD40 repeat	353..407	CDD:293791	25/53 (47%)
		WD40	385..747	CDD:225201	194/370 (52%)
		WD40	436..748	CDD:295369	170/320 (53%)
		WD40 repeat	505..540	CDD:293791	15/34 (44%)
		WD40 repeat	546..586	CDD:293791	26/39 (67%)
		WD40 repeat	591..631	CDD:293791	20/43 (47%)
		WD40 repeat	637..672	CDD:293791	14/34 (41%)
		WD40 repeat	679..717	CDD:293791	22/37 (59%)
		WD40 repeat	723..749	CDD:293791	19/25 (76%)
Mapkbp1	NP_001342222.1	WD40	<45..121	CDD:421866	39/75 (52%)
		WD40	84..428	CDD:421866	178/354 (50%)
		WD 1	89..130		19/50 (38%)
		WD40 repeat	94..133	CDD:293791	18/48 (38%)
		WD 2	133..174		26/40 (65%)
		WD40 repeat	139..173	CDD:293791	22/33 (67%)
		WD 3	176..214		23/37 (62%)
		WD40 repeat	181..219	CDD:293791	21/37 (57%)
		WD40 repeat	281..318	CDD:293791	15/36 (42%)
		WD40 repeat	336..385	CDD:293791	24/48 (50%)
		WD 5	343..382		21/38 (55%)
		WD40	350..732	CDD:421866	201/386 (52%)
		WD 6	388..437		21/49 (43%)
		WD40 repeat	405..469	CDD:293791	26/67 (39%)
		WD 7	478..517		19/38 (50%)
		WD40 repeat	485..520	CDD:293791	15/34 (44%)
		WD 8	520..562		27/41 (66%)
		WD40 repeat	526..566	CDD:293791	26/39 (67%)
		WD 9	566..607		22/40 (55%)
		WD40 repeat	571..611	CDD:293791	19/39 (49%)
		WD 10	615..654		17/38 (45%)
		WD40 repeat	621..656	CDD:293791	14/34 (41%)
		WD 11	660..699		21/38 (55%)
		WD40 repeat	663..701	CDD:293791	22/37 (59%)
		WD 12	702..741		24/38 (63%)
		WD40 repeat	707..733	CDD:293791	19/25 (76%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	751..823		17/71 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	880..923		8/42 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	957..1182		49/255 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1223..1244		5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1375..1397		3/27 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833466
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003218
OrthoInspector	1	1.000	-	-		otm42794
orthoMCL	1	0.900	-	-		OOG6_103235
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4088
SonicParanoid	1	1.000	-	-		X2177
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.630