DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr62 and Wdr62

DIOPT Version :9

Sequence 1:	NP_001259886.1	Gene:	Wdr62 / 33367	FlyBaseID:	FBgn0031374	Length:	2397	Species:	Drosophila melanogaster
Sequence 2:	XP_011248842.1	Gene:	Wdr62 / 233064	MGIID:	1923696	Length:	1550	Species:	Mus musculus

Alignment Length:	1489	Identity:	495/1489 - (33%)
Similarity:	733/1489 - (49%)	Gaps:	345/1489 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ASLSASTPTLSTLHHQRMALQSQSQSPLASP--------LTPSPSSVFGSPKFPANYERSEKIKL 60
            :|:.|..|          |.::||..|.|.|        |..:|....           ..::.|
Mouse    20 SSVMAGVP----------ARRNQSSPPPAPPLCLRRRTRLAAAPEDTV-----------QNRVTL 63

  Fly    61 KKVLGLTVCSNAALDVSPVSGLLAYPAGCTVVLFNAKRQTQAYLVNTSRKAFTSVAFSRCGRYVA 125
            :||||:|..:::.|...|.:|.:||.|||.||:.|.|...|.::.||:||:.:::|||..|:|:.
Mouse    64 EKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVVLNPKENKQQHIFNTTRKSLSALAFSPDGKYIV 128

  Fly   126 TGECGINPAIKVWELETPNGSLEHCSGGSVVAEFVDHKYAVTCVAFSPTGKYLVSVGSQHDMIVN 190
            |||.|..||:::|::|..          :.|||.:.|||.|.||||||..|::||:|.||||::|
Mouse   129 TGENGHRPAVRIWDVEEK----------TQVAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLN 183

  Fly   191 VFDWRANLKMASNKISSKVAAVCFSEDGSYFVTVGNRHVKYWYLEGGRKYK--DPIPLMGRSAIL 253
            |:||:.::.:||||:|.:|.|:.||||.|||||||||||::|:||...:.|  ..:||:|||.||
Mouse   184 VWDWKKDIVVASNKVSCRVIALSFSEDSSYFVTVGNRHVRFWFLEASTEAKVTSTVPLVGRSGIL 248

  Fly   254 GDLRDNDFCAVACGKGICAESTYAITRQGHLVEFSSRRLLDKWVQCRTTNANCICVNERFILVGC 318
            |:|.:|.||.||||:|..|.:|:.::..|.|.:|:.:|:||||:..:.:.::|:||::..|..||
Mouse   249 GELHNNIFCGVACGRGRMAGNTFCVSYSGLLCQFNEKRVLDKWINLKVSLSSCLCVSDELIFCGC 313

  Fly   319 AESIIRIFNSATLEYVTTLPRTHYLGVDVAQGIQINHIMSVPQQAKFPDCIAMVFDEQRSKVSCV 383
            .:.|:|||.:.:|.|:|.||:.||||||||.|:..:.:.....:|.:||.:|:.||.....:|||
Mouse   314 TDGIVRIFQAHSLLYLTNLPKPHYLGVDVAHGLDSSFLFHRKAEAVYPDTVALTFDPVHQWLSCV 378

  Fly   384 YNDHSLYIWDLRDISRVGKSHSFLYHSTCIWGVETVPYNVEREPSQT-LPEECFVTCSSDDTIRV 447
            |.|||:||||::||..|.|..|.|:||:.:|.||..|   |.|..:. ||...|:|||||:|||.
Mouse   379 YKDHSIYIWDVKDIDEVSKIWSELFHSSFVWNVEVYP---EFEDQRACLPSGTFLTCSSDNTIRF 440

  Fly   448 WGLDGCTNNDIYRRNIYSKELLKIVYSDDELQFIKDQGSSLFDKAGNSS---YDGRNGVRCIKIS 509
            |.||..::.. :::||:|..|||:||.::::|.::|  .|.|...|:.:   .|.:.|||.:::|
Mouse   441 WNLDSASDTR-WQKNIFSDSLLKVVYVENDIQHLQD--LSHFPDRGSENGTPMDMKAGVRVMQVS 502

  Fly   510 PELQHLASGDRCGNIRVYSLVNLRLLTTIEAHESEVLCLEYSNEKIERKLLASASRDRLIHVFDV 574
            |:.||||||||.||:|::.|..:..|..:|||::||||||||..:....|||||||||||||.:|
Mouse   503 PDGQHLASGDRSGNLRIHELHFMDELIKVEAHDAEVLCLEYSKPETGVTLLASASRDRLIHVLNV 567

  Fly   575 AQNYLLLQTLDDHSSSITSIKFVGAGLNFQMISCGADKSIMFRSFQ----GNIFMRGTNTSGKTT 635
            .:||.|.|||||||||||:|||.|. .:.|||||||||||.|||.|    |..|:|..:.:.|||
Mouse   568 EKNYNLEQTLDDHSSSITAIKFAGT-RDVQMISCGADKSIYFRSAQQASDGLHFVRTHHVAEKTT 631

  Fly   636 LYDMEVDSNAKHILTACQDRNVRVYGTQNAKQTKTFKGSHSDEGSLIKLSLDPSGIYVATSCTDK 700
            ||||::|...|::..||||||||||.|.:.||.|.:|||..|||||:|:.:||||.::||||:||
Mouse   632 LYDMDIDITQKYVAVACQDRNVRVYNTVSGKQKKCYKGSQGDEGSLLKVHVDPSGTFLATSCSDK 696

  Fly   701 TLAVYDYYSNECMARMYGHSELVTGLKFTNDCRHLISASGDGCIFIWQVPHDMIVTMQARM---- 761
            ::::.|:||.||:|:|:||||:|||:|||.||||||:.|||.|:|||.:..::...|:..:
Mouse   697 SISLIDFYSGECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIWHLGPEITTCMKQHLLEIN 761

  Fly   762 ---SQQRLR----SG------HAPLPRPLAPISP-------------PDGIVLESPTSEIEQPQL 800
               .||:.:    ||      :|..|..:..:||             |:.: |::|:.:...|
Mouse   762 HQEQQQQPKDQKWSGPPSQETYASTPSEIRSLSPGEQTEDEMEEECEPEEL-LKTPSKDSLDP-- 823

  Fly   801 QPKFGVAERFSDVGQLPQWAMRKAAAD--SDSGAL------------------------------ 833
            .|:..:..     |:||.||.|....|  :||.|.
Mouse   824 DPRCLLTN-----GKLPLWAKRLLGDDDVADSSAFHAKRSYQPHGRWAERAEQEPLKTILDAWSL 883

  Fly   834 -SIPTP------------SGGSATVPGMHAASSMGNLSSSPSQQMTGL-------APRA--RGRW 876
             |..||            |.....:.|:.:..|:||..:||.:.:...       :|:.  ||..
Mouse   884 DSYFTPMKPENLQDSVLDSVEPQNLAGLLSECSLGNGHTSPGEGLVSYLLHPELGSPKEDNRGHP 948

  Fly   877 AQRSTQLETADDLRSNSESPLGTVSSVGGHSGVNVQTSDYNSASSKDITYNQTYLSEDSSIDSGM 941
            :....|.|..:.......||...||..|.|                     :.|..|::  ::|.
Mouse   949 SYLPLQREATEASELILCSPEAEVSLTGMH---------------------REYYEEET--EAGP 990

  Fly   942 ETRRGELKFIGSSNNGTVVTVSSVSS------------------IAVSASNGAMSTGSG------ 982
            |.::|:          |.:.||||||                  ...:|.:.|..|..|
Mouse   991 EDQQGD----------TYLRVSSVSSKDQSPPEDSGESEAELECSFAAAHSSAPQTDPGPHLTMT 1045

  Fly   983 ------AAQQRLQLPDKRLKPGL-----------------RFDTHT---------------HDHD 1009
                  .:.:.|..|:   .|||                 .|:|.|               |...
Mouse  1046 AGKPEYPSTEELSQPE---LPGLGNGSLPQTPEQEKFLRHHFETLTDAPTEGPMGIFLELFHGSL 1107

  Fly  1010 GDVEDISDGERTSSDHGMFYNNLAPSTPTDFKVTAMNEDELRKSVRRQKFEKSGLQLTPSALS-G 1073
            ||:: ||:.|.       ::.|...|..|.|.      ..|:|:.|........|..:|.|.. |
Mouse  1108 GDIK-ISETED-------YFFNPRLSISTQFL------SRLQKTSRCPPRLPLHLMKSPEAQPVG 1158

  Fly  1074 NGSSH------TASTGTGTSDTEDEGSTPSAENAERSLA---STLGGSSENLPQSSTNSFLHAAL 1129
            .|.:.      .|.||..:||..:..|...||..:.:|:   ..|.|.:..:|.||
Mouse  1159 QGGNQPKAGPLRAGTGYMSSDGTNVLSGQKAEETQEALSLLVPPLSGLTSCVPPSS--------- 1214

  Fly  1130 PEGPGLTTPMERGGSSRRSISAKHNTENGKSVAAP------PTITKSYTSTKKEELLQVINKVKQ 1188
                  ..|.:|...:..|:.   .|...:|::||      .:.|.|:..|.:...|
Mouse  1215 ------VPPTDRKPPTPTSVL---TTGREQSISAPSSCSYLESTTSSHAKTTRSISL-------- 1262

  Fly  1189 QLENGTRKNGNTRLNAIAEVG---HRPLRGSHSISDLSLAANLDGSRNAGGGPGRYQKPVDSHDT 1250
                     |::.....||:.   |:||.....:..:.....|..|             :..|:.
Mouse  1263 ---------GDSEGPVTAELPQSLHKPLSPGQELQAIPTTVALTSS-------------IKDHEP 1305

  Fly  1251 SQYTSPQNTTATAAPTNT-----QQQIQPPVQQQYQIPKEP---HQQAQQQHQQYAPPA 1301
            :. .|..|..|.|:...|     :|.:.||       |:||   |..:|:...  .||:
Mouse  1306 AP-LSWGNHEARASLKLTLSSVCEQLLSPP-------PQEPPITHVWSQEPVD--VPPS 1354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr62	NP_001259886.1	WD40	73..448	CDD:295369	174/377 (46%)
		WD40 repeat	73..107	CDD:293791	13/33 (39%)
		WD40 repeat	113..161	CDD:293791	16/47 (34%)
		WD40	158..574	CDD:225201	201/421 (48%)
		WD40 repeat	167..207	CDD:293791	22/39 (56%)
		WD40 repeat	209..285	CDD:293791	41/77 (53%)
		WD40 repeat	254..294	CDD:293791	16/39 (41%)
		WD40 repeat	303..338	CDD:293791	13/34 (38%)
		WD40 repeat	353..407	CDD:293791	22/53 (42%)
		WD40	385..747	CDD:225201	198/369 (54%)
		WD40	436..748	CDD:295369	176/318 (55%)
		WD40 repeat	505..540	CDD:293791	15/34 (44%)
		WD40 repeat	546..586	CDD:293791	26/39 (67%)
		WD40 repeat	591..631	CDD:293791	24/43 (56%)
		WD40 repeat	637..672	CDD:293791	19/34 (56%)
		WD40 repeat	679..717	CDD:293791	20/37 (54%)
		WD40 repeat	723..749	CDD:293791	19/25 (76%)
Wdr62	XP_011248842.1	WD40	112..442	CDD:392136	151/331 (46%)
		WD40 repeat	118..154	CDD:293791	15/35 (43%)
		WD40 repeat	159..195	CDD:293791	14/35 (40%)
		WD40 repeat	203..237	CDD:293791	17/33 (52%)
		WD40 repeat	255..286	CDD:293791	17/32 (53%)
		WD40 repeat	292..342	CDD:293791	16/49 (33%)
		WD40	365..743	CDD:392136	195/385 (51%)
		WD40 repeat	365..403	CDD:293791	11/37 (30%)
		WD40 repeat	446..480	CDD:293791	15/34 (44%)
		WD40 repeat	497..532	CDD:293791	12/37 (32%)
		WD40 repeat	538..579	CDD:293791	19/40 (48%)
		WD40 repeat	585..627	CDD:293791	28/41 (68%)
		WD40 repeat	632..668	CDD:293791	16/39 (41%)
		WD40 repeat	676..713	CDD:293791	20/36 (56%)
		PHA03247	<1027..1533	CDD:223021	65/318 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833469
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1017450at2759
OrthoFinder	1	1.000	-	-		FOG0003218
OrthoInspector	1	1.000	-	-		otm42794
orthoMCL	1	0.900	-	-		OOG6_103235
Panther	1	1.100	-	-	O	PTHR45589
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4088
SonicParanoid	1	1.000	-	-		X2177
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.740