DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr62 and WDR43

DIOPT Version :9

Sequence 1:	NP_001259886.1	Gene:	Wdr62 / 33367	FlyBaseID:	FBgn0031374	Length:	2397	Species:	Drosophila melanogaster
Sequence 2:	NP_055946.1	Gene:	WDR43 / 23160	HGNCID:	28945	Length:	677	Species:	Homo sapiens

Alignment Length:	802	Identity:	153/802 - (19%)
Similarity:	271/802 - (33%)	Gaps:	272/802 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   436 FVTCSSDDTIRVWGLDGCTNNDIYRRNIYSKEL----LKIVYSDDELQFIKDQGSSLFDKAGNSS 496
            |...|:|..:|||   ...||.:::..:.|..|    ..:.::...||            |..|.
Human    29 FALASTDGHLRVW---ETANNRLHQEYVPSAHLSGTCTCLAWAPARLQ------------AKESP 78

  Fly   497 YDGRNGVRCIKISPELQHLASGDRCGNIRVYSLVNLRLLTTI--EAHESEVLCLEYSNEKIERKL 559
            ...:.....:.:|.:...||.|...|:|.:||.|...|.:.:  ..|::.|.|:::..:.   ..
Human    79 QRKKRKSEAVGMSNQTDLLALGTAVGSILLYSTVKGELHSKLISGGHDNRVNCIQWHQDS---GC 140

  Fly   560 LASASRDRLIHVFDVAQNYLLLQTLDDHSSSITSIKFVGAGLNFQMISCG-------ADKSIMFR 617
            |.|.|.|:.|..::|....:..:...| :||::|:.....|.  .::|.|       .:...::|
Human   141 LYSCSDDKHIVEWNVQTCKVKCKWKGD-NSSVSSLCISPDGK--MLLSAGRTIKLWVLETKEVYR 202

  Fly   618 SFQGN-------IF--MRGTNTS----GKTTLYDMEVDSNAKHILTACQDR--NVRVYGTQNAKQ 667
            .|.|:       :|  :|..|.|    |.|.||.:   |.|.|      ||  ||....::|.::
Human   203 HFTGHATPVSSLMFTTIRPPNESQPFDGITGLYFL---SGAVH------DRLLNVWQVRSENKEK 258

  Fly   668 TKTFKGSHSDEGSLIKLSLDPS---GIYVATSCTDKTLAVYDYYSNECMARMYGHSELVTGLKFT 729
            :.....:.:||...|.|:|..:   .:.:|..|.|..:.::::..|       |:.:    ...|
Human   259 SAVMSFTVTDEPVYIDLTLSENKEEPVKLAVVCRDGQVHLFEHILN-------GYCK----KPLT 312

  Fly   730 NDCRHLISASGDGCIFIWQVPHDMIVTMQARMSQQRLRSGHAPLPRPLAPI------SPPDGIVL 788
            ::|...|:..|                           .|....|:|: ||      |....::|
Human   313 SNCTIQIATPG---------------------------KGKKSTPKPI-PILAAGFCSDKMSLLL 349

  Fly   789 E-----SPTSEIEQPQL---QPKFGVAERFSDVGQLPQWAMRKAAADSDSGALSIPTPSGGSAT- 844
            .     .||  ||:..|   :|...:....|:.     ||.:     .::....:.||...|..
Human   350 VYGSWFQPT--IERVALNSREPHMCLVRDISNC-----WAPK-----VETAITKVRTPVMNSEAK 402

  Fly   845 -----VPGMHAASSMGNLSSSPSQQMTGLAPRARG----RWAQR------STQLETADDLRSNS- 893
                 :||.|||     :..:|.|.....:.|..|    ...:|      .|..:..:||::||
Human   403 VLVPGIPGHHAA-----IKPAPPQTEQVESKRKSGGNEVSIEERLGAMDIDTHKKGKEDLQTNSF 462

  Fly   894 --------ES-------------------------PLGTV--------SSVGGHSGVNVQTSDYN 917
                    ||                         ||.|:        ..:.||....|....:.
Human   463 PVLLTQGLESNDFEMLNKVLQTRNVNLIKKTVLRMPLHTIIPLLQELTKRLQGHPNSAVLMVQWL 527

  Fly   918 SASSKDITYNQTYLS-------EDSSIDSGMETRRGELKFIGSSNNGTVVTVSSVSSIAVSASNG 975
            ...   :|.:.:|||       :..::...||:|....:.:...:...::.::.|:  |...:.|
Human   528 KCV---LTVHASYLSTLPDLVPQLGTLYQLMESRVKTFQKLSHLHGKLILLITQVT--ASEKTKG 587

  Fly   976 AMSTGSGAAQQRLQLPDKRLKPGLRFDTHTHDHDGDVEDISDGERTSSDHGMFYNNLAPSTPTDF 1040
            |.|.|.              |..|.::..:.:.:.| ::|:|  :.|.|
Human   588 ATSPGQ--------------KAKLVYEEESSEEESD-DEIAD--KDSED---------------- 619

  Fly  1041 KVTAMNEDELRKSVRRQKFEKSGLQLTPSALSGNGSSHTASTGTGTSDTEDEGSTPSA---ENAE 1102
                 |.||..:....:|.|                           |.|:|......   ||.|
Human   620 -----NWDEDEEESESEKDE---------------------------DVEEEDEDAEGKDEENGE 652

  Fly  1103 -RSLAS--TLGGSSENLPQSST 1121
             |..||  .|.|.|:..|::.:
Human   653 DRDTASEKELNGDSDLDPENES 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr62	NP_001259886.1	WD40	73..448	CDD:295369	4/11 (36%)
		WD40 repeat	73..107	CDD:293791
		WD40 repeat	113..161	CDD:293791
		WD40	158..574	CDD:225201	32/143 (22%)
		WD40 repeat	167..207	CDD:293791
		WD40 repeat	209..285	CDD:293791
		WD40 repeat	254..294	CDD:293791
		WD40 repeat	303..338	CDD:293791
		WD40 repeat	353..407	CDD:293791
		WD40	385..747	CDD:225201	73/341 (21%)
		WD40	436..748	CDD:295369	73/342 (21%)
		WD40 repeat	505..540	CDD:293791	10/36 (28%)
		WD40 repeat	546..586	CDD:293791	7/39 (18%)
		WD40 repeat	591..631	CDD:293791	10/55 (18%)
		WD40 repeat	637..672	CDD:293791	9/36 (25%)
		WD40 repeat	679..717	CDD:293791	7/40 (18%)
		WD40 repeat	723..749	CDD:293791	4/25 (16%)
WDR43	NP_055946.1	WD 1	11..51		8/24 (33%)
		WD40	19..272	CDD:295369	61/272 (22%)
		WD40	<19..217	CDD:225201	43/208 (21%)
		WD40 repeat	19..57	CDD:293791	9/30 (30%)
		WD 2	57..119		15/73 (21%)
		WD40 repeat	63..124	CDD:293791	14/72 (19%)
		WD 3	124..163		9/41 (22%)
		WD40 repeat	129..165	CDD:293791	8/38 (21%)
		WD 4	166..205		8/41 (20%)
		WD40 repeat	172..205	CDD:293791	5/34 (15%)
		WD 5	207..259		16/60 (27%)
		WD40 repeat	211..262	CDD:293791	16/59 (27%)
		WD 6	267..309		10/52 (19%)
		WD40 repeat	271..320	CDD:293791	10/59 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	414..445		6/35 (17%)
		Utp12	474..570	CDD:281932	13/98 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	582..677		29/158 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143291
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930