DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr62 and MAPKBP1

DIOPT Version :9

Sequence 1:	NP_001259886.1	Gene:	Wdr62 / 33367	FlyBaseID:	FBgn0031374	Length:	2397	Species:	Drosophila melanogaster
Sequence 2:	NP_001122080.1	Gene:	MAPKBP1 / 23005	HGNCID:	29536	Length:	1514	Species:	Homo sapiens

Alignment Length:	1755	Identity:	580/1755 - (33%)
Similarity:	816/1755 - (46%)	Gaps:	417/1755 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 MALQSQSQSPLASPLTPSPSSVFGSPKFPANYER---SEKIKLKKVLGLTVCSNAALDVSPVSGL 82
            ||::..:.:.....|..|||......|  |...|   |.|:.|:||||:||.....|...|.|||
Human     1 MAVEGSTITSRIKNLLRSPSIKLRRSK--AGNRREDLSSKVTLEKVLGITVSGGRGLACDPRSGL 63

  Fly    83 LAYPAGCTVVLFNAKRQTQAYLVNTSRKAFTSVAFSRCGRYVATGECGINPAIKVWELETPNGSL 147
            :||||||.|||||.::..|.:::|:|||..|::|||..|:|:.|||.|..||::||::      .
Human    64 VAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWDV------A 122

  Fly   148 EHCSGGSVVAEFVDHKYAVTCVAFSPTGKYLVSVGSQHDMIVNVFDWRANLKMASNKISSKVAAV 212
            ||    |.|||..:|||.|.||||||:.||:||||.||||||||:.|:.|:.:||||:||:|.||
Human   123 EH----SQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRVTAV 183

  Fly   213 CFSEDGSYFVTVGNRHVKYWYLEGGR--KYKDPIPLMGRSAILGDLRDNDFCAVACGKGICAEST 275
            .||||.|||||.||||:|:|||:..:  |....:||:|||.:||:||:|.|..||||:|..|:||
Human   184 SFSEDCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACGRGKKADST 248

  Fly   276 YAITRQGHLVEFSSRRLLDKWVQCR------TTNANCICVNERFILVGCAESIIRIFNSATLEYV 334
            :.||..|.|.|||.||||||||:.|      ||.|:||.|::.:|..|||:..:|:||.:.|.::
Human   249 FCITSSGLLCEFSDRRLLDKWVELRNIDSFTTTVAHCISVSQDYIFCGCADGTVRLFNPSNLHFL 313

  Fly   335 TTLPRTHYLGVDVAQGIQINHIMSVPQQAKFPDCIAMVFDEQRSKVSCVYNDHSLYIWDLRDISR 399
            :||||.|.||.|:|...:.:.:.|....|::||.||:.||.....:||||||||:|:||:||..:
Human   314 STLPRPHALGTDIASVTEASRLFSGVANARYPDTIALTFDPTNQWLSCVYNDHSIYVWDVRDPKK 378

  Fly   400 VGKSHSFLYHSTCIWGVETVPYNVEREPSQTLPEECFVTCSSDDTIRVW-----GLDGCTNNDIY 459
            |||.:|.||||:|:|.||..| .|:......||...|:|||||:|||:|     |:.|.|    .
Human   379 VGKVYSALYHSSCVWSVEVYP-EVKDSNQACLPPSSFITCSSDNTIRLWNTESSGVHGST----L 438

  Fly   460 RRNIYSKELLKIVYSDDELQFIKDQGSSLFDKAGNSSYDGRNGVRCIKISPELQHLASGDRCGNI 524
            .|||.|.:|:||:|.|...|.:.|......|||..|..|.|.|:|.:.:||..||||||||.|.:
Human   439 HRNILSSDLIKIIYVDGNTQALLDTELPGGDKADASLLDPRVGIRSVCVSPNGQHLASGDRMGTL 503

  Fly   525 RVYSLVNLRLLTTIEAHESEVLCLEYSNEKIERKLLASASRDRLIHVFDVAQNYLLLQTLDDHSS 589
            ||:.|.:|..:..:|||:||:||||||......||||||||||||||.|..:.|.|.||||:|||
Human   504 RVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLDEHSS 568

  Fly   590 SITSIKFVGAGLNFQMISCGADKSIMFRSFQ----GNIFMRGTNTSGKTTLYDMEVDSNAKHILT 650
            |||::||..:....:||||||||||.||:.|    |..|.|..:...|||||||:|:.:.|:...
Human   569 SITAVKFAASDGQVRMISCGADKSIYFRTAQKSGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAI 633

  Fly   651 ACQDRNVRVYGTQNAKQTKTFKGSHSDEGSLIKLSLDPSGIYVATSCTDKTLAVYDYYSNECMAR 715
            .|||||:|::...:.||.|.||||..::|:|||:..||||||:||||:||.|:::|:.|.||:|.
Human   634 GCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVAT 698

  Fly   716 MYGHSELVTGLKFTNDCRHLISASGDGCIFIWQVPHDMIVTMQARMSQ--QRLRSGHAPLP---- 774
            |:||||:|||:||:|||:||||.|||.|||:|::..:|.::|:.|:::  ||.|.|....|
Human   699 MFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSEMTISMRQRLAELRQRQRGGKQQGPSSPQ 763

  Fly   775 ------RPLAPISPPDGIVLESPTSEIEQPQLQPKFGVAERFSDVGQLPQWAMRKAAADSDSGAL 833
                  |..||.....|..|.|.:.:..:.:     |..|      :||  |:...|..:.....
Human   764 RASGPNRHQAPSMLSPGPALSSDSDKEGEDE-----GTEE------ELP--ALPVLAKSTKKALA 815

  Fly   834 SIPTPSGGSATVPG-------MHAASSMGNLSSSPSQQMTGLAPRARGRWAQ-------RS---- 880
            |:|:|:     :|.       ..|..|:|.|..:|:   ....||.||||.|       ||
Human   816 SVPSPA-----LPRSLSHWEMSRAQESVGFLDPAPA---ANPGPRRRGRWVQPGVELSVRSMLDL 872

  Fly   881 TQLET-ADDLRSNSESPLGTVSSVGGHSGVNVQTSDYNSASSKD-----------------ITYN 927
            .|||| |..|:..|:..|..:.|.....|.....:...|.:.|.                 ::..
Human   873 RQLETLAPSLQDPSQDSLAIIPSGPRKHGQEALETSLTSQNEKPPRPQASQPCSYPHIIRLLSQE 937

  Fly   928 QTYLSED---SSIDSGMETRRGELKFIGSSNNGTVVTVSSVSSIAVSA-SNGAMSTGSGAAQQRL 988
            :...::|   :.|:.|       :.:...|:|.|:.|    |...|.| :.|.:.
Human   938 EGVFAQDLEPAPIEDG-------IVYPEPSDNPTMDT----SEFQVQAPARGTLG---------- 981

  Fly   989 QLPDKRLKPGLR-FDTHTHDHDGDVEDISDGERTSSDHGMFYNNLAPSTPTDFKVTAMNEDELRK 1052
                 |:.||.| .:.|:.|....| |.|....:|.:|           ||:       :.|
Human   982 -----RVYPGSRSSEKHSPDSACSV-DYSSSCLSSPEH-----------PTE-------DSE--- 1019

  Fly  1053 SVRRQKFEKSGLQLTPSALSGNGSSHTASTGTGTSDTEDEGSTPSAENAERSLASTLG--GSSEN 1115
                          :...||.:|.|         ||.|:.......|..|.   ..:|  |..|.
Human  1020 --------------STEPLSVDGIS---------SDLEEPAEGDEEEEEEE---GGMGPYGLQEG 1058

  Fly  1116 LPQS-STNSFL--------HAALPEGPGLTTPMERGGSSRRSISAKHNTENGKSVAAPPTITKSY 1171
            .||: ....||        ..|.|..| :..| ||  |..||||::.
Human  1059 SPQTPDQEQFLKQHFETLASGAAPGAP-VQVP-ER--SESRSISSRF------------------ 1101

  Fly  1172 TSTKKEELLQVINKVKQQLENGTRKNGNTRLNAIAEVGHRPLR-GSHSISDLSLAA------NLD 1229
                   ||||..                          |||| .|.|.|.|:|.:      ...
Human  1102 -------LLQVQT--------------------------RPLREPSPSSSSLALMSRPAQVPQAS 1133

  Fly  1230 GSRNAGGGPGRYQKPVDSHDTSQYTSPQNT--------------------TATAAPTNTQQQIQP 1274
            |.:..|.|......|.:...:|...|||..                    .|||:|.:..|:.|
Human  1134 GEQPRGNGANPPGAPPEVEPSSGNPSPQQAASVLLPRCRLNPDSSWAPKRVATASPFSGLQKAQ- 1197

  Fly  1275 PVQQQYQIPKEPHQQAQQQHQQYAPPASQQFFNCAAPKSKLQQNFQTMRQVQQHYPPYPHHVGVH 1339
              .....:|:|.|:.:.|     ||          :|.:.|.:..:...             |:.
Human  1198 --SVHSLVPQERHEASLQ-----AP----------SPGALLSREIEAQD-------------GLG 1232

  Fly  1340 QIHPPPGVPFGGSAAGSTSAMRSHSQPQNRQQQQQQQQQRAKRNPAGNNRRTPSILKHYKSCPVS 1404
            .:.|..|.|               |:|.:.|            ||.     |.|:.|..:|..|
Human  1233 SLPPADGRP---------------SRPHSYQ------------NPT-----TSSMAKISRSISV- 1264

  Fly  1405 PVHEEVEWSAEGNERGALLGEPKRHS----------VYADDARTILD----MIHADTEKMIDEIT 1455
                        .|...|:.||:.|:          .....|..:||    :....|......:|
Human  1265 ------------GENLGLVAEPQAHAPIRVSPLSKLALPSRAHLVLDIPKPLPDRPTLAAFSPVT 1317

  Fly  1456 --RKYGDLDEPGIPASYSMPANLRNLGGLGSTGD--------STPTGRTTQYYVYREFYQCERKV 1510
              |..|:.::||.|.         .||...||.:        :||..||...........|.:::
Human  1318 KGRAPGEAEKPGFPV---------GLGKAHSTTERWACLGEGTTPKPRTECQAHPGPSSPCAQQL 1373

  Fly  1511 SLSDILQ-PEQFAASQRRLDEARFLETQRHSSASFFLTGQQSQESLSLLSDGDGPGSYCNSLESV 1574
            .:|.:.| ||........ .....:|..:..:|    ..|.|:.::||        ..|..|.:.
Human  1374 PVSSLFQGPENLQPPPPE-KTPNPMECTKPGAA----LSQDSEPAVSL--------EQCEQLVAE 1425

  Fly  1575 LSDE-----------SDCQSAPLEYPQTQVA-VLQQRHAGIRNFI--IHGPVSKSYGNSPNAYGS 1625
            |...           :.|:....|  |:::| :|:...:.:|..:  :.|.|..|.|:||.|.|:
Human  1426 LRGSVRQAVRLYHSVAGCKMPSAE--QSRIAQLLRDTFSSVRQELEAVAGAVLSSPGSSPGAVGA 1488

Fly 1626 1625
Human 1489 1488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr62	NP_001259886.1	WD40	73..448	CDD:295369	198/382 (52%)
		WD40 repeat	73..107	CDD:293791	17/33 (52%)
		WD40 repeat	113..161	CDD:293791	20/47 (43%)
		WD40	158..574	CDD:225201	221/428 (52%)
		WD40 repeat	167..207	CDD:293791	26/39 (67%)
		WD40 repeat	209..285	CDD:293791	43/77 (56%)
		WD40 repeat	254..294	CDD:293791	23/39 (59%)
		WD40 repeat	303..338	CDD:293791	13/34 (38%)
		WD40 repeat	353..407	CDD:293791	25/53 (47%)
		WD40	385..747	CDD:225201	195/370 (53%)
		WD40	436..748	CDD:295369	170/320 (53%)
		WD40 repeat	505..540	CDD:293791	15/34 (44%)
		WD40 repeat	546..586	CDD:293791	26/39 (67%)
		WD40 repeat	591..631	CDD:293791	20/43 (47%)
		WD40 repeat	637..672	CDD:293791	14/34 (41%)
		WD40 repeat	679..717	CDD:293791	22/37 (59%)
		WD40 repeat	723..749	CDD:293791	19/25 (76%)
MAPKBP1	NP_001122080.1	WD40	83..427	CDD:295369	181/354 (51%)
		WD 1	88..129		21/50 (42%)
		WD40 repeat	93..132	CDD:293791	20/48 (42%)
		WD 2	132..173		26/40 (65%)
		WD40 repeat	138..172	CDD:293791	22/33 (67%)
		WD 3	175..213		23/37 (62%)
		WD40 repeat	180..218	CDD:293791	21/37 (57%)
		WD40	228..725	CDD:225201	254/501 (51%)
		WD 4	276..315		14/38 (37%)
		WD40 repeat	280..317	CDD:293791	15/36 (42%)
		WD40 repeat	335..384	CDD:293791	24/48 (50%)
		WD 5	342..381		21/38 (55%)
		WD40	349..731	CDD:295369	202/386 (52%)
		WD 6	387..436		22/49 (45%)
		WD 7	477..516		19/38 (50%)
		WD40 repeat	484..519	CDD:293791	15/34 (44%)
		WD 8	519..561		27/41 (66%)
		WD40 repeat	525..565	CDD:293791	26/39 (67%)
		WD 9	565..606		22/40 (55%)
		WD40 repeat	570..610	CDD:293791	19/39 (49%)
		WD 10	614..653		17/38 (45%)
		WD40 repeat	620..655	CDD:293791	14/34 (41%)
		WD 11	659..698		21/38 (55%)
		WD40 repeat	662..700	CDD:293791	22/37 (59%)
		WD 12	701..740		24/38 (63%)
		WD40 repeat	706..732	CDD:293791	19/25 (76%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	748..804		16/68 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	880..925		7/44 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	951..1256		96/496 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1299..1336		9/45 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143292
Domainoid	1	1.000	56	1.000	Domainoid score	I11099
eggNOG	1	0.900	-	-		E1_KOG1408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1017450at2759
OrthoFinder	1	1.000	-	-		FOG0003218
OrthoInspector	1	1.000	-	-		oto89027
orthoMCL	1	0.900	-	-		OOG6_103235
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4088
SonicParanoid	1	1.000	-	-		X2177
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.640