DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdr62 and wdr-5.3

DIOPT Version :9

Sequence 1:	NP_001259886.1	Gene:	Wdr62 / 33367	FlyBaseID:	FBgn0031374	Length:	2397	Species:	Drosophila melanogaster
Sequence 2:	NP_001024299.1	Gene:	wdr-5.3 / 179489	WormBaseID:	WBGene00013862	Length:	501	Species:	Caenorhabditis elegans

Alignment Length:	176	Identity:	43/176 - (24%)
Similarity:	89/176 - (50%)	Gaps:	18/176 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   578 YLLLQTLDDHSSSITSIKF------VGAGLNFQMISCGADKSIMFRSFQGNIFMRGTNTSGKTTL 636
            :.|::|:..|:.|::.|||      :|.|        .|||.|...:.....::: |..|.:..:
Worm   203 FSLVKTISGHTKSVSVIKFSYCGKYLGTG--------SADKQIKVWNTVDMTYLQ-TLASHQLGI 258

  Fly   637 YDMEVDSNAKHILTACQDRNVRVYGTQNAKQTKTFKGSHSDEGSLIKLSLDPSGIYVATSCTDKT 701
            .|....||::.|.:|..|..|:::...:....:|.:| |::  .:...|.:|....:|::..|:|
Worm   259 NDFSWSSNSQFIASASDDTTVKIFDVISGACLRTMRG-HTN--YVFCCSFNPQSSLIASAGFDET 320

  Fly   702 LAVYDYYSNECMARMYGHSELVTGLKFTNDCRHLISASGDGCIFIW 747
            :.|:|:.:..|:..:..||:.:|.:.:.:|...:.::|.||||.:|
Worm   321 VRVWDFKTGLCVKCIPAHSDPITSISYNHDGNTMATSSYDGCIRVW 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr62	NP_001259886.1	WD40	73..448	CDD:295369
		WD40 repeat	73..107	CDD:293791
		WD40 repeat	113..161	CDD:293791
		WD40	158..574	CDD:225201
		WD40 repeat	167..207	CDD:293791
		WD40 repeat	209..285	CDD:293791
		WD40 repeat	254..294	CDD:293791
		WD40 repeat	303..338	CDD:293791
		WD40 repeat	353..407	CDD:293791
		WD40	385..747	CDD:225201	42/174 (24%)
		WD40	436..748	CDD:295369	43/176 (24%)
		WD40 repeat	505..540	CDD:293791
		WD40 repeat	546..586	CDD:293791	2/7 (29%)
		WD40 repeat	591..631	CDD:293791	10/45 (22%)
		WD40 repeat	637..672	CDD:293791	8/34 (24%)
		WD40 repeat	679..717	CDD:293791	8/37 (22%)
		WD40 repeat	723..749	CDD:293791	8/25 (32%)
wdr-5.3	NP_001024299.1	WD40	<200..501	CDD:225201	43/176 (24%)
		WD40	205..499	CDD:238121	43/174 (25%)
		WD40 repeat	216..253	CDD:293791	10/45 (22%)
		WD40 repeat	259..295	CDD:293791	8/35 (23%)
		WD40 repeat	300..336	CDD:293791	8/35 (23%)
		WD40 repeat	343..378	CDD:293791	8/24 (33%)
		WD40 repeat	385..421	CDD:293791
		WD40 repeat	429..466	CDD:293791
		WD40 repeat	472..498	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157526
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930