DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Wdr62 and wdr-62

DIOPT Version :9

Sequence 1:NP_001259886.1 Gene:Wdr62 / 33367 FlyBaseID:FBgn0031374 Length:2397 Species:Drosophila melanogaster
Sequence 2:NP_001343681.1 Gene:wdr-62 / 179326 WormBaseID:WBGene00019237 Length:1657 Species:Caenorhabditis elegans


Alignment Length:1891 Identity:426/1891 - (22%)
Similarity:741/1891 - (39%) Gaps:420/1891 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    59 KLKKVLGLTVCSNAALDVSPVSGLLAYPAGCTVVLFN--AKRQTQAYLVNTSRKAFTSVAFSRCG 121
            :||.|:|.:..:...:.:...|..|...||.::::.:  :..:.:.:|::.:::.||.||.:.||
 Worm    10 RLKNVVGRSGVTVNGIALHHASDTLLQVAGSSIIVSSTASHDRFEGHLISQTKQQFTCVAVTSCG 74

  Fly   122 RYVATGECGINPAIKVWELETPNGSLEHCSGGSVVAEFVDHKYAVTCVAFSPTGKYLVSVGSQHD 186
            :|.||||.|..||:::|:|....|:..    |.:|.....|..::|.|.|:|....|:|:|.|||
 Worm    75 KYAATGETGHQPAVRLWQLRDAQGNFV----GRLVRSMQSHTVSITIVRFTPDDSTLISIGCQHD 135

  Fly   187 MIVNVFDWRANLKMASNKISSKVAAVCFSEDGSYFVTVGNRHVKYWYL----EGGRKYKDPIPLM 247
            ..:..:|||....:...|:.|.|.|:..|.|.|..||||::.||||:|    :|..|...   |.
 Worm   136 AQIFTWDWRTGHDLGVGKLMSPVNALTISFDSSMCVTVGSKSVKYWFLPLASDGMNKRTG---LT 197

  Fly   248 GRSAILGDLRDNDFCAVACGKGICAEST---YAITRQGHLVEFSSRRLLDKWVQCRT------TN 303
            .|||||.|.|:.:|...|    .| :||   ..:|..|.::||:..:   |:|:|.|      ..
 Worm   198 SRSAILADKRNVNFVDAA----FC-DSTNRMVTVTSSGEILEFNGNK---KYVKCYTWKESGDFK 254

  Fly   304 ANCICVNERFILVGCAESIIRIF--NSATLEYVTTL-PRTHYLGVDVAQGIQINHIMSVPQQAKF 365
            |.||......:||||::.::|:|  ....|:::..| |.|| |..|.:.......:.:.|:.|.|
 Worm   255 AICIARVPEGLLVGCSDGLVRLFCLIGDDLDFLADLAPPTH-LFQDPSNVYDPQQLQNHPEDAIF 318

  Fly   366 PDCIAMVFDEQRSKVSCVYNDHSLYIWDLRDISRVGKSHSF----LYHSTCIWGVETVPYNVERE 426
            |:...:|...........|.|.||.     :.:|..||.||    |.|:..:..:|..|     .
 Worm   319 PEPRCLVASSSSPTFVVGYADRSLI-----EFARENKSWSFRRASLGHTGSVNCIEPFP-----S 373

  Fly   427 PSQTLPEECFVTCSSDDTIRVWGLDGCTNNDIYRRNIYSKELLKIVYSDDELQFIKDQGSSLFDK 491
            .|..||....:|..||.|||.|..:|.:.:.....||....|||:::.|:....:.|:.:  .:.
 Worm   374 SSPCLPIGTLITGGSDGTIRFWNFNGDSEDKKEIANILCPSLLKVIFLDENPDLLVDKRN--LES 436

  Fly   492 AGNSSYDGR----NGVRCIKISPELQHLASGDRCGNIRV--YSLVNLRLLTTIEAHESEVLCLEY 550
            .|.|:.:.:    :||.|.::|.:.:.|.:|...|.:.:  .|..:..::..|.||:.:|..:::
 Worm   437 VGPSNDENQSASSSGVLCTRVSHDGRMLIAGTATGMLYIVDLSFSDTPIIDVINAHDHDVTSIDF 501

  Fly   551 SNEKIERK-----LLASASRDRLIHVF---DVAQNYLLLQTLDDHSSSITSIKFVGAGLNFQMIS 607
            |:......     .|||..|||.:|||   ..:..::....||.|.|:|.||||........:.:
 Worm   502 SDHASTSSHDHPIFLASGGRDRFVHVFRRIPYSSQFVHCAVLDGHQSAIKSIKFASNNGQLHLYT 566

  Fly   608 CGADKSIM---FRSF--QGNIFMRGTNTSGKTTLYDMEVDSNAKHILTACQDRNVRVYGTQNAKQ 667
            ..:|:|::   ..||  |...|.|....|..:::.||....:....:.|..||.:|.:.. |.|.
 Worm   567 AASDRSLIIWKLSSFSDQHCEFTRVQMISVASSIGDMNFIKHVDLFVVAGHDRMLRQFDI-NGKT 630

  Fly   668 TKTFKGSHSD---EGSLIKLSLDPSGIYVATSCTDKTLAVYDYYSNECMARMYGHSELVTGLKFT 729
            .:..||:..|   .|.::|:::|.||.|..:.|:||.:.|.|..|..|:|.:.|.....|...|:
 Worm   631 VREVKGTDDDVAHSGKILKVAIDHSGSYAISVCSDKFVYVTDLRSGVCLAVLCGFGAPATDATFS 695

  Fly   730 NDCRHLISASGDGCIFIWQVPHDM---IVTMQAR-MSQQRLRSGHAPLPRPLAPISPPDGIV--- 787
            :|.:::|..:.:|.|||||:..::   :::.|.| |.:..:|:            :.||.::   
 Worm   696 DDFKNVIVTTSNGSIFIWQLAKNLTERMISAQVRLMEEVTMRT------------ATPDSLLGSG 748

  Fly   788 ---LESPTSEIEQPQLQPKF--GVAERFSDVGQLPQWAMRKAAADSDSGALSIPT---------P 838
               :...::...:|...|:|  ..|..:||              |.||...|...         |
 Worm   749 SETISGDSNSFGRPLGAPEFSGSSASLYSD--------------DDDSTRFSSSVRSSRTKRILP 799

  Fly   839 SGGSATVPGMHAASSMGNLSSSPSQQMTGLAPRARGRWAQRSTQLETADDLRSN-SESPLGTVSS 902
            :||.  :.|..:.:.:|:.|.||:.|.   ||....|   ..|.|.:.|...:: ||:....|||
 Worm   800 NGGH--LIGDSSYARVGDSSFSPAVQS---APAVERR---THTNLFSHDQYETDVSETQSDFVSS 856

  Fly   903 VGGHSGVNVQTSDYNSASSKDITYNQTYLSED-SSIDSGMETRRGELKFIGSSNN--------GT 958
            .......:.:..|.|..|::   |....::|| .|....:...:.:|:...||.:        |.
 Worm   857 RRKTRLFSDEDQDSNLGSAQ---YLAAPINEDRRSASPSLYPPQDQLRGYQSSKSMMNLRDVTGG 918

  Fly   959 VVTVSSVSSIAVSASNGAMSTGSGAAQQRLQL-PDKRLKPG-LRFDTHTHD-HDG---DVEDISD 1017
            .|.|.:...:.:|......::.||::...... ...|:|.| :...::.:| |..   |:..:|.
 Worm   919 GVRVQTAKELMMSQIASQRNSQSGSSSHLSSTNTSGRMKWGDMPQQSNNNDWHPSSTVDIHHVSP 983

  Fly  1018 GERTS------------SDHGMFY--------NNLAPSTPTDFKVTAMNEDEL------------ 1050
            ...||            .|||..|        ..|||.|.:....||.::..|            
 Worm   984 VMATSMIPPQTQHQYGYRDHGTSYPMPDSTHPPPLAPRTTSRVLSTAPSQQALQQIQASSPFRRK 1048

  Fly  1051 ---RKSVRRQKFEKSGLQ----LTPSALSGNGSSHTASTGTGTSDTEDEGSTPSAENAERSLAST 1108
               |.|:.|:..|..|.|    .:||||:..|:                   |...|:....|:.
 Worm  1049 SMDRNSLSRRFLENGGAQPKTVWSPSALANQGA-------------------PRRSNSNLFAATN 1094

  Fly  1109 LGGSSENLPQSSTN-SFLHA-ALPEGPGLTTPMERGGSSRRSISAKHNTENGKSVAAPPTITKSY 1171
            |     .:|.:||| |..|. ..|:....||.::     .|.||...........|        .
 Worm  1095 L-----EVPPTSTNLSRRHTDKQPQKLRFTTTVQ-----TREISLDDEVVESDDDA--------I 1141

  Fly  1172 TSTKKEELLQVINKVKQQLENGTRKNGNTRLNA-IAEVGHRPLRG-----SHSISDLSLAANLDG 1230
            |||..|.      |.|.::  |.|:.....::. .|:|..|.:.|     |....||:.|::|  
 Worm  1142 TSTTFEP------KYKNRI--GYRRPSTVTVDTRDADVARRRVAGTSFKKSDRADDLNFASSL-- 1196

  Fly  1231 SRNAGGGPGRY--QKPVDSHDTSQYTSPQNTTATAAPTNTQQQIQPPVQQQYQIPKEPHQQAQQQ 1293
             |:....|.::  .:.::|.||.  :||.:||.::.       :...:||:.:.....:.::..:
 Worm  1197 -RSRSQSPNKFALSQMINSRDTP--SSPSSTTGSSI-------VGRNLQQRRRGSDVSYVRSATR 1251

  Fly  1294 HQQYAPPASQQFFNCAAPKSKLQQNFQTMRQVQQHYPPYPHHVGVHQIHPPPGVPFGGSAAGSTS 1358
            .:.....::.......|.:|||.|:.:.:|:..::.                      :...:..
 Worm  1252 GRDEMRKSTDALNKLMAVRSKLHQSSENLRKSTENL----------------------ALLKNLE 1294

  Fly  1359 AMRSHSQPQNRQQQQQQQQQRAKRNPAGNNRRTPSILKHYKSCPVSPVHEEVEWSAEGNERGALL 1423
            ...:||.|            :|:...:.|.|...:                             |
 Worm  1295 EASNHSTP------------KARTRSSSNLRNADN-----------------------------L 1318

  Fly  1424 GEPKRHSVYADDARTILDMIHADTEKMIDE--ITRKYGDLDEPGIPASYSMPANLRNLGGLGSTG 1486
            |..:....:..|:|    |....|..:...  :.|..|:|::              :|...||..
 Worm  1319 GNMESFGTFDADSR----MKSGSTSSLAHSRMMARSIGNLND--------------SLAMEGSNN 1365

  Fly  1487 DSTPTGRTTQYYVYREFYQCERKVSLSDILQPEQF-------------AASQRRLDEARFLETQR 1538
            ..:|:.|..      ...|..||.|..|:..||||             .|.|::::..|    .:
 Worm  1366 YDSPSQRLA------NTIQMMRKASNPDLTAPEQFEDTGSPFAQRMARGAVQKKMERYR----AK 1420

  Fly  1539 HSSASFFLTGQQSQESLSLLSDGDGPGSYCNSLESVLSDESDCQSAPLEYPQTQVAVLQQRHAGI 1603
            :.|.:.....|.|:|                      ||.::....||...:..:....:...| 
 Worm  1421 NKSGNVVGRNQTSEE----------------------SDSNNSDMMPLSINKRALTAGNRSTTG- 1462

  Fly  1604 RNFIIHGPVSKSYGNSPNAYGSFDYYMRQQHSTTTDSFDVTGYNLEPL-KPLPSS-KTYPRIAQV 1666
            .:|   .|.| |.|:|..|.||                       .|: ..|||| :.|.:...|
 Worm  1463 SDF---SPAS-SRGSSSLAMGS-----------------------GPIGSGLPSSRRLYDQQRSV 1500

  Fly  1667 QASENIPTLRSKN---KQYTSGVNKSL-STDFAQQRQQRNSNPMQSGDNLFVRKPLKPKPPVPAK 1727
            .:|...|.....|   .:.:..:|||: ..|.......|:|.......||........|.|:...
 Worm  1501 LSSSGTPRRTGNNYLVTKMSEQMNKSMEGPDLGSDESPRSSVNSHEWQNLMENSQDGTKNPLICH 1565

  Fly  1728 PHNLVSTLS-HMEK--QQKQKSQSRTASVVQQFEHNLQKFEKEKQR--EREQQRRPAMRSSVSSG 1787
            ..:.:..|. |::|  |.|:..:..|:..::|.:..:.:.::..:|  |:....:.:..:..|:|
 Worm  1566 VQDCMEQLRIHVDKSLQAKKLVEDDTSLAMEQKKIVMCEIDRSIERLIEKLAPNQLSRSNDRSNG 1630

  Fly  1788 ALAGGS 1793
            .::.|:
 Worm  1631 NVSVGN 1636

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Wdr62NP_001259886.1 WD40 73..448 CDD:295369 120/396 (30%)
WD40 repeat 73..107 CDD:293791 5/35 (14%)
WD40 repeat 113..161 CDD:293791 18/47 (38%)
WD40 158..574 CDD:225201 129/449 (29%)
WD40 repeat 167..207 CDD:293791 14/39 (36%)
WD40 repeat 209..285 CDD:293791 31/82 (38%)
WD40 repeat 254..294 CDD:293791 11/42 (26%)
WD40 repeat 303..338 CDD:293791 11/37 (30%)
WD40 repeat 353..407 CDD:293791 14/57 (25%)
WD40 385..747 CDD:225201 104/387 (27%)
WD40 436..748 CDD:295369 90/333 (27%)
WD40 repeat 505..540 CDD:293791 7/36 (19%)
WD40 repeat 546..586 CDD:293791 11/47 (23%)
WD40 repeat 591..631 CDD:293791 12/44 (27%)
WD40 repeat 637..672 CDD:293791 8/34 (24%)
WD40 repeat 679..717 CDD:293791 14/37 (38%)
WD40 repeat 723..749 CDD:293791 9/25 (36%)
wdr-62NP_001343681.1 WD40 <17..257 CDD:225201 78/254 (31%)
WD40 repeat 66..110 CDD:293791 18/47 (38%)
WD40 104..529 CDD:330360 129/448 (29%)
WD40 repeat 115..151 CDD:293791 13/35 (37%)
WD40 repeat 159..202 CDD:293791 18/45 (40%)
WD40 repeat 209..248 CDD:293791 13/46 (28%)
WD40 repeat 256..310 CDD:293791 15/54 (28%)
WD40 repeat 317..342 CDD:293791 5/24 (21%)
WD40 355..714 CDD:330360 97/366 (27%)
WD40 repeat 366..409 CDD:293791 13/47 (28%)
WD40 repeat 453..491 CDD:293791 7/37 (19%)
WD40 repeat 496..545 CDD:293791 12/48 (25%)
WD40 repeat 551..595 CDD:293791 11/43 (26%)
WD40 repeat 600..636 CDD:293791 8/36 (22%)
WD40 repeat 648..682 CDD:293791 13/33 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160157514
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003218
OrthoInspector 1 1.000 - - oto18869
orthoMCL 1 0.900 - - OOG6_103235
Panther 1 1.100 - - LDO PTHR45589
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4088
SonicParanoid 1 1.000 - - X2177
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
109.870

Return to query results.
Submit another query.