DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Wdr62 and wdr-5.1

DIOPT Version :9

Sequence 1:NP_001259886.1 Gene:Wdr62 / 33367 FlyBaseID:FBgn0031374 Length:2397 Species:Drosophila melanogaster
Sequence 2:NP_497749.1 Gene:wdr-5.1 / 175474 WormBaseID:WBGene00006474 Length:376 Species:Caenorhabditis elegans


Alignment Length:352 Identity:75/352 - (21%)
Similarity:133/352 - (37%) Gaps:107/352 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   438 TCSSDDTIRVWGLDGCTNNDIYRRNIYSKEL--LKIVYSDDELQFIKDQGSSLFDKAGNSSYDGR 500
            |.|:|.|:::|.:|    :.|..|.:...:|  ..|.:|.|.                       
 Worm   104 TSSADKTVKIWNMD----HMICERTLTGHKLGVNDIAWSSDS----------------------- 141

  Fly   501 NGVRCIKISPELQHLASGDRCGNIRVYSLVNLRLLTTIEAHESEVLCLEYSNEKIERKLLASASR 565
               ||: :|      ||.|:  .::::.:|..|:..|::.|.:.|.|..::.:.   .|:.|.|.
 Worm   142 ---RCV-VS------ASDDK--TLKIFEIVTSRMTKTLKGHNNYVFCCNFNPQS---SLVVSGSF 191

  Fly   566 DRLIHVFDVAQNYLLLQTLDDHSSSITSIKFVGAGLNFQMISCGADKSIMFRSFQGNIFMRGTNT 630
            |..:.::|| :..:.::||..||..::::.|                                |.
 Worm   192 DESVRIWDV-KTGMCIKTLPAHSDPVSAVSF--------------------------------NR 223

  Fly   631 SGKTTLYDMEVDSNAKHILTACQDRNVRVYGTQNAKQTKTFKGSHSDEGSLIKLSLDPSGIYVAT 695
            .|..             |.:...|..||::.|.|.:..||.....:...:.:|.|  |:|.|:..
 Worm   224 DGSL-------------IASGSYDGLVRIWDTANGQCIKTLVDDENPPVAFVKFS--PNGKYILA 273

  Fly   696 SCTDKTLAVYDYYSNECMARMYGHSE---------LVTGLKFTNDCRHLISASGDGCIFIWQVPH 751
            |..|.||.::|:...:.:.:..||..         .|||.|:      :||.|.|..|:||.:..
 Worm   274 SNLDSTLKLWDFSKGKTLKQYTGHENSKYCIFANFSVTGGKW------IISGSEDCKIYIWNLQT 332

  Fly   752 DMIVTMQARMSQQRLRSGHAPLPRPLA 778
            ..||......:|..|.|...|:...:|
 Worm   333 REIVQCLEGHTQPVLASDCHPVQNIIA 359

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Wdr62NP_001259886.1 WD40 73..448 CDD:295369 4/9 (44%)
WD40 repeat 73..107 CDD:293791
WD40 repeat 113..161 CDD:293791
WD40 158..574 CDD:225201 28/137 (20%)
WD40 repeat 167..207 CDD:293791
WD40 repeat 209..285 CDD:293791
WD40 repeat 254..294 CDD:293791
WD40 repeat 303..338 CDD:293791
WD40 repeat 353..407 CDD:293791
WD40 385..747 CDD:225201 66/319 (21%)
WD40 436..748 CDD:295369 67/320 (21%)
WD40 repeat 505..540 CDD:293791 8/34 (24%)
WD40 repeat 546..586 CDD:293791 9/39 (23%)
WD40 repeat 591..631 CDD:293791 2/39 (5%)
WD40 repeat 637..672 CDD:293791 8/34 (24%)
WD40 repeat 679..717 CDD:293791 10/37 (27%)
WD40 repeat 723..749 CDD:293791 11/25 (44%)
wdr-5.1NP_497749.1 WD40 <76..372 CDD:225201 75/352 (21%)
WD40 79..373 CDD:238121 75/352 (21%)
WD40 repeat 90..127 CDD:293791 8/26 (31%)
WD40 repeat 133..169 CDD:293791 12/70 (17%)
WD40 repeat 174..210 CDD:293791 9/39 (23%)
WD40 repeat 217..252 CDD:293791 11/79 (14%)
WD40 repeat 259..295 CDD:293791 10/37 (27%)
WD40 repeat 303..340 CDD:293791 13/42 (31%)
WD40 repeat 346..372 CDD:293791 4/14 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160157525
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.930

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