DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdr62 and WDR88

DIOPT Version :9

Sequence 1:	NP_001259886.1	Gene:	Wdr62 / 33367	FlyBaseID:	FBgn0031374	Length:	2397	Species:	Drosophila melanogaster
Sequence 2:	NP_775750.3	Gene:	WDR88 / 126248	HGNCID:	26999	Length:	472	Species:	Homo sapiens

Alignment Length:	464	Identity:	86/464 - (18%)
Similarity:	164/464 - (35%)	Gaps:	169/464 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   336 TLPRTHYLGVDVAQGIQIN-----HIMSVPQQAKFPDCIAMVFDEQRSKVSCVYNDHSLYIWDLR 395
            ::|.||.|.  ....:.::     |::  |::.:.|:.:                     ||..:
Human    48 SIPHTHLLA--TLDPLALDREPPPHLL--PEKHQVPEKL---------------------IWGDQ 87

  Fly   396 D-ISRV------GKSHSFLYHSTCIWGVE---------------------TVPYNVEREPSQTLP 432
            | :|::      |..|:.   |||.:.|:                     :|..:.|..|...:
Human    88 DPLSKIPFKILSGHEHAV---STCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPV- 148

  Fly   433 EECFVT--------CSSDDTIRVWGLDGCTNNDIYRRNIYSKELLKIVYSDDELQFIKDQGSSLF 489
            .||.:|        .|.|.|:|.|.|:            ..|.|.|:.|.    .||
Human   149 VECSITGDSSRVIAASYDKTVRAWDLE------------TGKLLWKVRYD----TFI-------- 189

  Fly   490 DKAGNSSYDGRNGVRCIKISPELQHLASG-DRCGNIRVYSLVNLRLLTTIEAHESEVL---CLEY 550
                         |.| |.||:.:::.|| |....|.:....|:..::.|:.|.:..:   |.:.
Human   190 -------------VSC-KFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDP 240

  Fly   551 SNEKIERKLLASASRDRLIHVFDVAQNYLLLQTLDDHSSSITSIKFVGAGLNFQMISCGADKSIM 615
            .::::     ||.|.||.|.::||.....||.....||::|::..|
Human   241 DSQRV-----ASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCF------------------- 281

  Fly   616 FRSFQGNIFMRGTNTSGKTTLYDMEVDSNAKHILTACQDRNVRVYGT-----QNAKQTKTFKGSH 675
              :|.|:.                        :.|:..|:|::::..     :|.....|....|
Human   282 --TFSGHF------------------------LCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGH 320

  Fly   676 SDEGSLIKLSLDPSGIYVATSCTDKTLAVYDYYSNECMARMYGHSELVTGLKFTNDCRHLISASG 740
              |||:..........::.:...|:|:|::|.........:.||::.|..:..:|:.:.::|||.
Human   321 --EGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASK 383

  Fly   741 DGCIFIWQV 749
            |..:.:|.:
Human   384 DRTMRLWNI 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr62	NP_001259886.1	WD40	73..448	CDD:295369	27/152 (18%)
		WD40 repeat	73..107	CDD:293791
		WD40 repeat	113..161	CDD:293791
		WD40	158..574	CDD:225201	54/282 (19%)
		WD40 repeat	167..207	CDD:293791
		WD40 repeat	209..285	CDD:293791
		WD40 repeat	254..294	CDD:293791
		WD40 repeat	303..338	CDD:293791	0/1 (0%)
		WD40 repeat	353..407	CDD:293791	9/65 (14%)
		WD40	385..747	CDD:225201	78/406 (19%)
		WD40	436..748	CDD:295369	63/328 (19%)
		WD40 repeat	505..540	CDD:293791	10/35 (29%)
		WD40 repeat	546..586	CDD:293791	11/42 (26%)
		WD40 repeat	591..631	CDD:293791	4/39 (10%)
		WD40 repeat	637..672	CDD:293791	5/39 (13%)
		WD40 repeat	679..717	CDD:293791	6/37 (16%)
		WD40 repeat	723..749	CDD:293791	7/25 (28%)
WDR88	NP_775750.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		WD40	96..391	CDD:238121	74/388 (19%)
		WD40	97..>398	CDD:225201	75/390 (19%)
		WD 1	100..139		7/41 (17%)
		WD40 repeat	106..142	CDD:293791	5/35 (14%)
		WD 2	143..182		12/51 (24%)
		WD40 repeat	148..181	CDD:293791	10/45 (22%)
		WD 3	184..224		13/65 (20%)
		WD40 repeat	190..226	CDD:293791	10/36 (28%)
		WD 4	228..267		11/43 (26%)
		WD40 repeat	233..270	CDD:293791	11/41 (27%)
		WD 5	271..310		9/83 (11%)
		WD40 repeat	276..317	CDD:293791	9/85 (11%)
		WD 6	319..358		8/40 (20%)
		WD40 repeat	324..348	CDD:293791	3/23 (13%)
		WD 7	361..400		9/32 (28%)
		WD40 repeat	366..390	CDD:293791	6/23 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..472
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143285
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930