DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdr62 and NEDD1

DIOPT Version :9

Sequence 1:	NP_001259886.1	Gene:	Wdr62 / 33367	FlyBaseID:	FBgn0031374	Length:	2397	Species:	Drosophila melanogaster
Sequence 2:	NP_001128647.1	Gene:	NEDD1 / 121441	HGNCID:	7723	Length:	667	Species:	Homo sapiens

Alignment Length:	805	Identity:	157/805 - (19%)
Similarity:	282/805 - (35%)	Gaps:	226/805 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   548 LEYSNEKIERKLLASASRDRLIHVFDVAQNYLLLQTLDDHSS--SITSIKFVGAGLNFQMISCGA 610
            :.::...::..|..::|.|. |.::| |.:..|:...:.|:|  .|:||             |.:
Human     1 MHFTGAVMQENLRFASSGDD-IKIWD-ASSMTLVDKFNPHTSPHGISSI-------------CWS 50

  Fly   611 DKSIMFRSFQGNIFMRGTNTSGKTTLYDMEVDSNAKHILTACQDRNVRVYG-TQNAKQTKTFKGS 674
                     ..|.|:...::||.            |.::::|:.:.|.:.. .:..|||
Human    51 ---------SNNNFLVTASSSGD------------KIVVSSCKCKPVPLLELAEGQKQT------ 88

  Fly   675 HSDEGSLIKLSLDPSGIYVATSCTDKTLAVYDYYSNECMARMYGHSELVTGLKFT-NDCRHLISA 738
                    .::|:.:.:|:.:...:.|:.::|..|......:..|.:.||.:.:. ||| ::.|.
Human    89 --------CVNLNSTSMYLVSGGLNNTVNIWDLKSKRVHRSLKDHKDQVTCVTYNWNDC-YIASG 144

  Fly   739 SGDGCIFIWQVPHDMIVTMQARMSQQRLRS-GHAPLPRPLAPISPPDGIVL------ESPTSEIE 796
            |..|.|.:..|..::..|.....|.|.:|. .::...:.|......:|||.      :||....:
Human   145 SLSGEIILHSVTTNLSSTPFGHGSNQSVRHLKYSLFKKSLLGSVSDNGIVTLWDVNSQSPYHNFD 209

  Fly   797 QPQLQPKFGVAERFSDVGQL-----------------PQWAMRKAAADSDSGALSIPTPSGGSAT 844
            .....|..|:.  ||.|.:|                 .:..::...||:...|:.. .|.|.:..
Human   210 SVHKAPASGIC--FSPVNELLFVTIGLDKRIILYDTSSKKLVKTLVADTPLTAVDF-MPDGATLA 271

  Fly   845 VPGMHAASSMGNLSSSPSQQMTGLAPRARGRWAQRSTQLETADDLRSNSESPLGTVSS------- 902
            :     .||.|.:...                           |||. .:||:.|:|:
Human   272 I-----GSSRGKIYQY---------------------------DLRM-LKSPVKTISAHKTSVQC 303

  Fly   903 -VGGHSGVNVQTSDYNSASSKDITYNQTYLSEDSSIDSGMETRRGELKFIGSSNNGTV--VTVSS 964
             ...:|.|..::|.....|:|..|.|:..::.:::  ||           |..|:|.|  ...:|
Human   304 IAFQYSTVLTKSSLNKGCSNKPTTVNKRSVNVNAA--SG-----------GVQNSGIVREAPATS 355

  Fly   965 VSSIAVSASNGAMSTGSGAAQQRLQLPDKRLKPGLRFDTHTHDHD-GDVEDISDGERT--SSDHG 1026
            ::::.......||..|:.|.|::..||     ..:..||.:.:.| |..:|.|..:.|  ||...
Human   356 IATVLPQPMTSAMGKGTVAVQEKAGLP-----RSINTDTLSKETDSGKNQDFSSFDDTGKSSLGD 415

  Fly  1027 MFYNNLAPSTPTDFKVTAMNEDELRKSVRRQKFEKSGLQLTP---SALSGNGSSHTASTGTGTSD 1088
            ||      |...|..|.....||   |:.:    ..|....|   |......:..|:||....|.
Human   416 MF------SPIRDDAVVNKGSDE---SIGK----GDGFDFLPQLNSVFPPRKNPVTSSTSVLHSS 467

  Fly  1089 TED--EGSTPSAENAERSLASTLGGSSENL---PQSSTNSFLHAALPEGPGLTTPMERGGSSRRS 1148
            ..:  .||....||..|.|.:    .|:.:   .|.|.:||...|     .|.|.....|:...|
Human   468 PLNVFMGSPGKEENENRDLTA----ESKKIYMGKQESKDSFKQLA-----KLVTSGAESGNLNTS 523

  Fly  1149 ISAKHNTENGKSVAAPPTITKSYTSTKKEELLQVINKVKQQLENGTRKNGNTRLNAIAEVGHRPL 1213
            .|: :.|.|.:....|.                  |:::.||                 :...|:
Human   524 PSS-NQTRNSEKFEKPE------------------NEIEAQL-----------------ICEPPI 552

  Fly  1214 RGSHSISDLSLAANLDGSRNAGGGPGRYQKPVDSHDTSQYTSPQNTTATAAPTNTQQQI------ 1272
            .|| |..:..:|:::    .||......:|..||...::..:|..:.......|..|:.
Human   553 NGS-STPNPKIASSV----TAGVASSLSEKIADSIGNNRQNAPLTSIQIRFIQNMIQETLDDFRE 612

  Fly  1273 ---QPPVQQQYQIPKEPHQQAQQQH 1294
               :..|..|.::.|:.|.|..:.|
Human   613 ACHRDIVNLQVEMIKQFHMQLNEMH 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr62	NP_001259886.1	WD40	73..448	CDD:295369
		WD40 repeat	73..107	CDD:293791
		WD40 repeat	113..161	CDD:293791
		WD40	158..574	CDD:225201	4/25 (16%)
		WD40 repeat	167..207	CDD:293791
		WD40 repeat	209..285	CDD:293791
		WD40 repeat	254..294	CDD:293791
		WD40 repeat	303..338	CDD:293791
		WD40 repeat	353..407	CDD:293791
		WD40	385..747	CDD:225201	38/202 (19%)
		WD40	436..748	CDD:295369	38/203 (19%)
		WD40 repeat	505..540	CDD:293791
		WD40 repeat	546..586	CDD:293791	7/37 (19%)
		WD40 repeat	591..631	CDD:293791	6/39 (15%)
		WD40 repeat	637..672	CDD:293791	6/35 (17%)
		WD40 repeat	679..717	CDD:293791	5/37 (14%)
		WD40 repeat	723..749	CDD:293791	9/26 (35%)
NEDD1	NP_001128647.1	WD40	<10..285	CDD:225201	64/360 (18%)
		WD40	31..306	CDD:238121	64/359 (18%)
		WD40 repeat	44..81	CDD:293791	11/70 (16%)
		WD40 repeat	88..124	CDD:293791	6/49 (12%)
		WD40 repeat	130..167	CDD:293791	10/37 (27%)
		WD40 repeat	172..209	CDD:293791	7/36 (19%)
		WD40 repeat	217..253	CDD:293791	5/37 (14%)
		WD40 repeat	258..295	CDD:293791	12/70 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143289
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930