DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr62 and WDR17

DIOPT Version :9

Sequence 1:	NP_001259886.1	Gene:	Wdr62 / 33367	FlyBaseID:	FBgn0031374	Length:	2397	Species:	Drosophila melanogaster
Sequence 2:	XP_024309653.1	Gene:	WDR17 / 116966	HGNCID:	16661	Length:	1338	Species:	Homo sapiens

Alignment Length:	1016	Identity:	190/1016 - (18%)
Similarity:	334/1016 - (32%)	Gaps:	316/1016 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 YERSEKIKLKKV--LGLTV--CSNAALDVSPVSG-LLAYPAGCTVVLFNAKRQTQAY----LVNT 107
            ||..::..:.:|  :||..  |.....||...|| ..||.|...:.::....:...:    :::.
Human    17 YEGLQRANMSQVRQVGLLAAGCQPWNKDVCAASGDRFAYCATLAIYIYQLDHRYNEFKLHAIMSE 81

  Fly   108 SRKAFTSVAFSRCGRYVATGECGINP----------AIKVW---------ELETPNG---SLEHC 150
            .:|..|::::           |..||          .:.:|         :|::..|   ||..|
Human    82 HKKTITAISW-----------CPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDSTKGIPASLSWC 135

  Fly   151 SGGSVVAEFVDHKYAVTCVAFSPTGKYLVSVGSQHDMIVNV--FDWRANLKMASNKISSKVAAVC 213
            .....|..||.|:..:.....|.....::.....|..:.::  |.|..:.|          ..|.
Human   136 WNAEDVVAFVSHRGPLFIWTISGPDSGVIVHKDAHSFLSDICMFRWHTHQK----------GKVV 190

  Fly   214 FSE-DGSYFV-TVGNRHVKYWY----LEGGRKYKDPIPLMGRSAILGDLRDNDF----------- 261
            |.. |||..: ..||::.|:..    |||..: :||:     :|:..|....|:
Human   191 FGHIDGSLSIFHPGNKNQKHVLRPESLEGTDE-EDPV-----TALEWDPLSTDYLLVVNLHYGIR 249

  Fly   262 -------------------CAVACGKGICAESTYAITRQGHLVEFSSRRLLDKWVQCRTTNANCI 307
                               .:|.|...:.:.....||.:|....|:...      .|:...|:..
Human   250 LVDSESLSCITTFNLPSAAASVQCLAWVPSAPGMFITGEGACFYFAFHH------DCKFPEASSA 308

  Fly   308 CVNERFILVGCAESIIRIFN-SAT---------------LEYVTTLPRTHYLGVDVAQGIQINHI 356
            ..|  :..||    ::||:| |.|               |..:.:.||..:    ..|....||.
Human   309 MQN--YSQVG----VLRIWNVSRTTPIDNLKLKKTGFHCLHVLNSPPRKKF----SVQSPTKNHY 363

  Fly   357 MSVPQQAKFPDCIA--MVFDEQRSKVSCVYNDHSLYIWD--------LRDISRVGKSHSFLYHST 411
            .|...:|..|..:.  ..|........|.:.|..:.::|        |||:..
Human   364 TSSTSEAVPPPTLTQNQAFSLPPGHAVCCFLDGGVGLYDMGAKKWDFLRDLGH------------ 416

  Fly   412 CIWGVETVPYNVEREPSQTLPEECFVTCSSDDTIRVWGLDGCTNNDIYRRNIYSKELLKIVYSDD 476
                |||: ::.:.:|..   .....|.|.|.||:||.::..|
Human   417 ----VETI-FDCKFKPDD---PNLLATASFDGTIKVWDINTLT---------------------- 451

  Fly   477 ELQFIKDQGSSLFDKAGNSS--YD---GRNGVRCIKISPELQHLASGDRCGNIRVYSLVNLRLLT 536
                      :::...||..  |.   ...|:.||         |.|.......::::...:::.
Human   452 ----------AVYTSPGNEGVIYSLSWAPGGLNCI---------AGGTSRNGAFIWNVQKGKIIQ 497

  Fly   537 TIEAHESE-VLCLEYSNEKIERKLLASASRDRLIHVFDVAQNYLLLQTLD-------DHSSSITS 593
            ....|.:. :.|:.:|::  :.|.:|:.|.|          .:.:::|:|       .|.:::
Human   498 RFNEHGTNGIFCIAWSHK--DSKRIATCSSD----------GFCIIRTIDGKVLHKYKHPAAV-- 548

  Fly   594 IKFVGAGLNFQMISCGADKSIMFRSFQGNIFMRGTNTSGKTTLYDMEVDSNAKHILTACQDRNVR 658
                          .|.|.|                            .:|...|.|.|:|.|||
Human   549 --------------FGCDWS----------------------------QNNKDMIATGCEDTNVR 571

  Fly   659 VY--GTQNAKQTKTFKGSHSDEGSLIKLSLDPSGIYVATSCTDKTLAVYDYYSNECMARMYGHSE 721
            ||  .|.:.:..|.|.| |:.:...:|.|....|| :.:...|.|:.::||..:.|:..:.||:.
Human   572 VYYVATSSDQPLKVFSG-HTAKVFHVKWSPLREGI-LCSGSDDGTVRIWDYTQDACINILNGHTA 634

  Fly   722 LVTGLKFTNDCRH-LISASGDGCIFIWQVPHDMIV-TMQARMSQQRLRSGHAPLPRPLAPISPPD 784
            .|.||.:..:..: |||.|.|..|.:|.......| |:....:.....:.|...|..:|..|...
Human   635 PVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDTVYDHGADVYGLTCHPSRPFTMASCSRDS 699

  Fly   785 GIVLESPTSEIEQPQL--------QPKFGVAERFSDVGQLP----------QWAMRKAAADSD-- 829
            .:.|.|.|:.:...|:        :...|..:...:.|..|          :..:.|..|:|.
Human   700 TVRLWSLTALVTPVQINILADRSWEEIIGNTDYAIEPGTPPLLCGKVSRDIRQEIEKLTANSQVK 764

  Fly   830 -----SGALSIPTPSGGSATVPGMHAASSMGNLSSSPSQQMTGLAPRARGRWAQRSTQLETADDL 889
                 |..||   |.|||         .::.||.:....|...|.|:   .:.:....|:.....
Human   765 KLRWFSECLS---PPGGS---------DNLWNLVAVIKGQDDSLLPQ---NYCKGIMHLKHLIKF 814

  Fly   890 RSNSESPLGTV--SSVGGHSGVNVQTSDYNSASSKDITYNQ 928
            |::....|.||  |..||..||..:......|:...:...|
Human   815 RTSEAQELTTVKMSKFGGGIGVPAKEERLKEAAEIHLRLGQ 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr62	NP_001259886.1	WD40	73..448	CDD:295369	84/465 (18%)
		WD40 repeat	73..107	CDD:293791	7/38 (18%)
		WD40 repeat	113..161	CDD:293791	12/69 (17%)
		WD40	158..574	CDD:225201	83/485 (17%)
		WD40 repeat	167..207	CDD:293791	5/41 (12%)
		WD40 repeat	209..285	CDD:293791	21/111 (19%)
		WD40 repeat	254..294	CDD:293791	8/69 (12%)
		WD40 repeat	303..338	CDD:293791	10/50 (20%)
		WD40 repeat	353..407	CDD:293791	12/63 (19%)
		WD40	385..747	CDD:225201	73/385 (19%)
		WD40	436..748	CDD:295369	64/327 (20%)
		WD40 repeat	505..540	CDD:293791	4/34 (12%)
		WD40 repeat	546..586	CDD:293791	8/46 (17%)
		WD40 repeat	591..631	CDD:293791	3/39 (8%)
		WD40 repeat	637..672	CDD:293791	12/36 (33%)
		WD40 repeat	679..717	CDD:293791	9/37 (24%)
		WD40 repeat	723..749	CDD:293791	10/26 (38%)
WDR17	XP_024309653.1	WD40	<44..468	CDD:225201	90/518 (17%)
		WD40 repeat	87..124	CDD:293791	6/47 (13%)
		WD40 repeat	129..166	CDD:293791	8/36 (22%)
		WD40 repeat	174..218	CDD:293791	11/53 (21%)
		WD40 repeat	226..263	CDD:293791	3/41 (7%)
		WD40 repeat	381..415	CDD:293791	7/33 (21%)
		WD40	415..705	CDD:238121	76/408 (19%)
		WD40 repeat	421..458	CDD:293791	9/71 (13%)
		WD40 repeat	463..500	CDD:293791	6/45 (13%)
		WD40 repeat	508..541	CDD:293791	8/44 (18%)
		WD40 repeat	548..587	CDD:293791	15/82 (18%)
		WD40 repeat	593..630	CDD:293791	9/37 (24%)
		WD40 repeat	636..661	CDD:293791	9/24 (38%)
		WD40 repeat	679..704	CDD:293791	4/24 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143284
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930