DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr62 and KATNB1

DIOPT Version :9

Sequence 1:	NP_001259886.1	Gene:	Wdr62 / 33367	FlyBaseID:	FBgn0031374	Length:	2397	Species:	Drosophila melanogaster
Sequence 2:	NP_005877.2	Gene:	KATNB1 / 10300	HGNCID:	6217	Length:	655	Species:	Homo sapiens

Alignment Length:	615	Identity:	127/615 - (20%)
Similarity:	208/615 - (33%)	Gaps:	207/615 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   416 VETVPYNVEREPSQTLPEECFVTCSSDDTIRVWGLD---------GCTNNDIYRRNIYSKELLKI 471
            ||:|..|.        |||..|..|...:||||.|:         |      ::.||.|.:...
Human    66 VESVRLNT--------PEELIVAGSQSGSIRVWDLEAAKILRTLMG------HKANICSLDFHP- 115

  Fly   472 VYSDDELQFIKDQGSSLFD---KAGNSSYDGRN-GVRCIKISPELQHLASGDRCGNIRVYSLVNL 532
             |.:......:|....|:|   |.....|.|.: .|||::.||:.:.|||......::::.|...
Human   116 -YGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAG 179

  Fly   533 RLLTTIEAHESEVLCLEY-SNEKIERKLLASASRDRLIHVFDVAQNYLLLQTLDDHSSSITSIKF 596
            ::::....|...|..:|: .||    .||||.|.||.|..:|:.:
Human   180 KMMSEFPGHTGPVNVVEFHPNE----YLLASGSSDRTIRFWDLEK-------------------- 220

  Fly   597 VGAGLNFQMISC-----GADKSIMFRSFQGNIFMRGTNTSGKTTLYDMEVDSNAKHILTACQDRN 656
                  ||::||     |..:|::|            |..| ..||            :.||| :
Human   221 ------FQVVSCIEGEPGPVRSVLF------------NPDG-CCLY------------SGCQD-S 253

  Fly   657 VRVYGTQNAKQTKTFKGSHSDEGSLIKLSLDPSGIYVATSCTDKTLAVYDYYSNECMARMYGHSE 721
            :||||.:   ..:.|.....:.|.:..|::          |.|:.:.|....||.        |.
Human   254 LRVYGWE---PERCFDVVLVNWGKVADLAI----------CNDQLIGVAFSQSNV--------SS 297

  Fly   722 LVTGLKFTNDCRHLISASGDGCIFIWQVPHDMIVTMQARMSQQRLRSGHAPLPRPLAPI------ 780
            .|..|.       .::.:|                ..||...|..|....|||.|.||:
Human   298 YVVDLT-------RVTRTG----------------TVARDPVQDHRPLAQPLPNPSAPLRRIYER 339

  Fly   781 -----SPPDGI------VLESPTSEIEQPQLQPKFGV--AERFSDVGQLPQWAMRKAAADSDSGA 832
                 |.|..:      ...||:||.::.:.:.:..:  ||.::::.|......|.....|:
Human   340 PSTTCSKPQRVKQNSESERRSPSSEDDRDERESRAEIQNAEDYNEIFQPKNSISRTPPRRSE--- 401

  Fly   833 LSIPTPSGGSATV--------PGMHAASSMGNLSSSPSQQMTGLAPRARGRWAQRSTQLETADDL 889
             ..|.|....|..        |.|.....:.||...|...:....|..:...|          .:
Human   402 -PFPAPPEDDAATAKEAAKPSPAMDVQFPVPNLEVLPRPPVVASTPAPKAEPA----------II 455

  Fly   890 RSNSESPLGTVSSVGGHSGVNVQTSDYNSASSKDITYNQTYLSED--SSIDSGMETRRGELKFIG 952
            .:....|:|            ::.||:..|..  |......:.||  |.|..|.:|    :..:.
Human   456 PATRNEPIG------------LKASDFLPAVK--IPQQAELVDEDAMSQIRKGHDT----MCVVL 502

  Fly   953 SSNNGTVVTVSSV-----------SSIAVS 971
            :|.:..:.||.:|           |::|::
Human   503 TSRHKNLDTVRAVWTMGDIKTSVDSAVAIN 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr62	NP_001259886.1	WD40	73..448	CDD:295369	11/31 (35%)
		WD40 repeat	73..107	CDD:293791
		WD40 repeat	113..161	CDD:293791
		WD40	158..574	CDD:225201	47/171 (27%)
		WD40 repeat	167..207	CDD:293791
		WD40 repeat	209..285	CDD:293791
		WD40 repeat	254..294	CDD:293791
		WD40 repeat	303..338	CDD:293791
		WD40 repeat	353..407	CDD:293791
		WD40	385..747	CDD:225201	78/349 (22%)
		WD40	436..748	CDD:295369	71/330 (22%)
		WD40 repeat	505..540	CDD:293791	7/34 (21%)
		WD40 repeat	546..586	CDD:293791	12/40 (30%)
		WD40 repeat	591..631	CDD:293791	8/44 (18%)
		WD40 repeat	637..672	CDD:293791	8/34 (24%)
		WD40 repeat	679..717	CDD:293791	7/37 (19%)
		WD40 repeat	723..749	CDD:293791	3/25 (12%)
KATNB1	NP_005877.2	Interaction with centrosomes	1..300		75/326 (23%)
		Interaction with dynein. /evidence=ECO:0000250	1..284		70/302 (23%)
		WD40	7..257	CDD:238121	63/262 (24%)
		WD40 repeat	67..103	CDD:293791	13/43 (30%)
		WD40 repeat	108..144	CDD:293791	7/37 (19%)
		WD40 repeat	151..186	CDD:293791	8/34 (24%)
		WD40 repeat	192..228	CDD:293791	17/65 (26%)
		WD40 repeat	234..261	CDD:293791	13/55 (24%)
		Interaction with PAFAH1B1. /evidence=ECO:0000250	285..434		34/183 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..422		24/114 (21%)
		DNA_pol3_gamma3	<386..>494	CDD:331207	23/135 (17%)
		Interaction with KATNA1 and NDEL1. /evidence=ECO:0000250	433..655		22/128 (17%)
		Katanin_con80	497..648	CDD:316447	7/40 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000