DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr62 and Gm35339

DIOPT Version :9

Sequence 1:	NP_001259886.1	Gene:	Wdr62 / 33367	FlyBaseID:	FBgn0031374	Length:	2397	Species:	Drosophila melanogaster
Sequence 2:	XP_006521682.1	Gene:	Gm35339 / 102638882	MGIID:	5594498	Length:	1689	Species:	Mus musculus

Alignment Length:	1822	Identity:	320/1822 - (17%)
Similarity:	540/1822 - (29%)	Gaps:	651/1822 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   758 QARMSQQRLRSGHAPLPRPLAPIS-----PPDGIVLESPTSE---IEQPQLQ------------- 801
            ||::....:.:|...:|.||..|.     .|.|:.:..|...   :.:|::.
Mouse   147 QAKLKPPVILNGLVTVPGPLGEIGRFVGWGPAGLSILGPDFHLLWLSKPRVNKSLDQEPFCCLPV 211

  Fly   802 PKFGVAERFSDVGQLPQWAMRKAAADSDSGALSIPTPSGGSATVPGMHAASSMGNLSSSPSQQMT 866
            |...:.......|.|..|..|                |||...||..........||.|......
Mouse   212 PSLSLLIVAQMGGSLELWKFR----------------SGGRCLVPCGSPLRPPPGLSGSFKCLAL 260

  Fly   867 GLAP--------RARGR---------WAQRSTQLETADDLRSNSESPLGTVSSVGGHSGVNVQTS 914
            ||.|        .|.|.         ||    .:..:.||.....|.|
Mouse   261 GLEPDHCSWHCFAAYGSAVLTFDLDDWA----LINVSQDLHKTIISDL----------------- 304

  Fly   915 DYNSASSKDITYNQTYLSEDSSIDSGMETRRGELKFIGSSNNGTVVTVSSVSSIAVSAS-NGAMS 978
            ||.......:|     .|.||::.......:..:.|:|.:...|.:||...|::||||| :|.:.
Mouse   305 DYCEEMDAMVT-----ASRDSTVKVWEADWQIRMVFVGHTGPVTAMTVLPNSTLAVSASQDGTIR 364

  Fly   979 TGSGAAQQRLQLPDKRLKPGLRFDTHTHDHDGDV------EDISDGERTSSDHGMFYNNLAPSTP 1037
            |                     :|.......|:|      |||. .|:.|       :.|||::|
Mouse   365 T---------------------WDLRAAAQVGEVTLGCWTEDII-SEKVS-------HLLAPASP 400

  Fly  1038 TDFKVTAMNEDELRKSVR--RQKFEKSGL-QLTPSAL-----------------------SGNGS 1076
             .:.|.::    ..||:.  |.:...|.| ||:...|                       ..:||
Mouse   401 -GWPVLSL----CSKSIELWRVRTLYSPLAQLSAPVLHIQVAPVLPAPTDPSLPARLVCACADGS 460

  Fly  1077 SHTASTGTGTSDTEDEGSTPSAENAERSLASTLGGSSENLPQSSTNSFLHAALPEGPGLTT---P 1138
            .|..|..||                 |:::|.|     ..|:.......:....|...:.|   .
Mouse   461 VHLVSATTG-----------------RTVSSLL-----LEPEDCAAGVAYCLSREALWVLTRSGH 503

  Fly  1139 MERGGSSRRSISAKHNTENGKSVAAPPTITKSYTS-TKKEELLQVINKVKQQLENGTR------- 1195
            :.|..::|..:...|........|..|.....|:. |...........|:|...:..|
Mouse   504 LVRANAARCPMVVVHRLRPPPPPAPQPCCLHLYSHLTDSRSAFACWEIVRQNQGDMLRSAIAWAW 568

  Fly  1196 KNGNTRLNAIAEVGHRPLRGSHSISDLSLAANLDGSRNAGGGPGRYQKPVDSHDTSQYTSPQNTT 1260
            ||.|..|..   :||..  |:.|:.|...:..:..:.....||   ...:.|..:|..||..:.|
Mouse   569 KNKNRFLPV---MGHSD--GTLSVLDWRTSVTVFHTEAHSPGP---VTAIGSTWSSIVTSGGDLT 625

  Fly  1261 ATAAPTNTQQQIQPPVQQQYQIPKEPHQQAQQQHQQYAPPASQQFFNCAAP-------KSKLQQN 1318
            .      ...::.|..::...:                    .|.|:|..|       ..::...
Mouse   626 V------KMWRVFPYAEECLSL--------------------LQTFSCCHPVVMLCVLGKRITAG 664

  Fly  1319 FQTMRQVQQHYPPYPHHVGVHQIHPPPGVPFGGSAAGSTSAMRSHSQPQNRQQQQ--QQQQQRAK 1381
            |:                      .|....:|....|....||...:||:.....  .:.....:
Mouse   665 FE----------------------DPERATYGLVQFGLGDKMRCDHRPQDDPMDHITGEHGTEPR 707

  Fly  1382 RNPAGNNRRTPSILKHYKS------CPVSPVH--EEVE-----WSAEGNERGALL---GEPKR-- 1428
            |:|..:    |.:|.:..|      ||...:.  ..::     |:.| |....||   |.|:.
Mouse   708 RSPCPH----PQLLPNLSSALGLCCCPTLKIFACSSLDCTIRIWTRE-NHLLRLLQLDGPPQALA 767

  Fly  1429 -HSVYADDARTILDMIH-------ADTEKMIDEITRKYGD-LDEPGIPASYSMP------ANLRN 1478
             .|.|.|...::...:|       ..|..::.::..|..| :.:|.:|.:...|      ..|.|
Mouse   768 FASNYGDLVFSLGSRLHLVSYSTYLPTSYLVKKLCLKASDVISDPPLPLTSKKPLTSSQLQRLAN 832

  Fly  1479 LGGLGSTGDSTPTGRTTQYYVYREFYQCERKVSLSDILQPEQFAASQRRLDEARFLE-------- 1535
            |.|..|...:.|.|    ||...|..|...|..|..|:..:|        |....::
Mouse   833 LRGAASLSVALPFG----YYKRSEPQQPVLKKDLETIIARDQ--------DLQELIQGLVAPATR 885

  Fly  1536 -----TQRHSSASFFLTGQQSQESLSLLSDGDGP--GSYCNSLESVLSDE--------------- 1578
                 .|||.:...:|......:.:.:..:.:..  |:...|.|...||:
Mouse   886 PPLTLKQRHKAFDNYLRLVYGSDLMDINPERESQQWGTSALSTEKESSDQESQPGPVMIVGQAAF 950

  Fly  1579 -SDCQSA-PLEYPQTQVAVLQQRHAGIRNFIIHGPVSKSYGNSPNAYGSFDYYMRQQHSTTTDSF 1641
             :|.|.. ||.:||..                .|...|.:...|..
Mouse   951 SNDVQPVFPLSFPQPP----------------GGAPGKRFARPPRV------------------- 980

  Fly  1642 DVTGYNLEPLKPLPSSKTYPRI----AQVQASENIP-------TLRSKNKQY-TSGVNKSLSTDF 1694
                       .||...||.|:    :|:.|..::.       .|:.:..|: ...::...|.|:
Mouse   981 -----------SLPIPPTYRRVHSRASQLLARSSLSCELGLGLDLQVQWDQFAVKAIDLDASIDY 1034

  Fly  1695 AQQRQQRNSNPMQSGDNLFVRKPLKPKP------PVPAKPHNL---------------------- 1731
                 .:|..|:     |..|||.:|..      |...||:.|
Mouse  1035 -----MKNRVPL-----LLQRKPAEPLSKLMGFFPATIKPYRLRSRPIKFPGCVPNSVVLRQMWL 1089

  Fly  1732 ------VSTLSHMEKQQKQKSQSRTASVVQQFEHN----------LQKFEKEKQREREQQRRPAM 1780
                  :.:|:.:..|.:.|::|......::.:|:          |.:..:.|..|.|::.| ..
Mouse  1090 QAEVSGLGSLAELSSQSRTKAESEDEQWSRRRKHSSLRWRNKLFGLLRLTRRKGGEEEEEER-RK 1153

  Fly  1781 RSSVSSGALAGGSTTQSCLKKVSRFDTSESSRRATSVRQKNRPKISVRFNTVSQIK-YTPSAKRE 1844
            ...|....|...|.|.:...:..:.||..    ||.:       ||...|..|:.| |:...:..
Mouse  1154 EEEVFERDLIPSSQTSATEPEHWKPDTDS----ATDL-------ISKLCNEASKTKGYSQPLQFG 1207

  Fly  1845 RQAREEEPPEMEVGSLPSDYGERSFEMYFAENGNAPENLENMQTLKLYTKPQLQAVVDEIQQERE 1909
            |...||     ..|.||      .|..||... |..:.|..:.||:.|  |::
Mouse  1208 RSFLEE-----RYGHLP------KFLHYFVVQ-NWFKKLFPIFTLEAY--PEM------------ 1246

  Fly  1910 KYRKNLDNAGKISGKGGSGKGKGAGSSTSHQCQNIAKKIDIIEKLIAMEENKMEQIRLATESRLR 1974
                     |.|.|...........:|.       |.:::|:..|:.:..:....:|:..:::|.
Mouse  1247 ---------GTIEGLASMFLDFLLKASW-------ADRVNILNSLLRLLPDITGNLRIRLQAKLL 1295

  Fly  1975 PFNCNAKEKGYVKSLTMNFDMLARGEDPTEDEDLASKDASDLCAYARNIRRNCSLPDVLEST--- 2036
                      |:    :|.|...:.:|||:.|         ....|..:...|:| ||||..
Mouse  1296 ----------YL----LNQDDPPKLQDPTQKE---------FVMIALQLLLACNL-DVLEVVLEI 1336

  Fly  2037 -------------------DFTGIYNSQGVELAKEVI--ADD---ESGDPV---------NPGIT 2068
                               :..|:::.:|| |.||::  .:|   ||...:         :..:.
Mouse  1337 ISYYLYSPISCRQELKKLLEGLGLHDPEGV-LFKEIMTWVEDLKVESKATIRIQCQQKLEDIYLQ 1400

  Fly  2069 ADSADHDGIGQTVVLRMEP--------------------------GNPKTLNPMPIE--ES--SI 2103
            ||:.:.    .||.:.:||                          .:..:|.|.|:|  ||  .:
Mouse  1401 ADTLEQ----STVSIFVEPSRQVSQTSLISGGSLPAMSTSWTFSRASEMSLVPSPVEPIESMEQV 1461

  Fly  2104 RRACSLSDLHMGN--------------------FGKPGKSQNGTPQKPQVQHRNGNVSRS----- 2143
            ....|:.:|.|.:                    |   |...:..|.|..|..|...::::
Mouse  1462 TSIVSIPELQMASSQAHMRIQKTKRVLADMLQTF---GLEDSEYPFKFDVPRRESPLAQTLWARS 1523

  Fly  2144 --------------ASKRNSLQGKTGLGASSNSMNVLNQGSDSEPEDSNRLRSASNGQGRSNGPI 2194
                          ..||...|.::.:|....     .:|.:.|.|:..........:...:.|:
Mouse  1524 QIVDLFHMDMLNLFCEKRRVQQQRSSMGEEKE-----EEGKEEEEEEEEEEEEEEEEEEEEHLPV 1583

  Fly  2195 AANRQYSNKINNVNNNRR-------------KTPNFSSATPMQDDSSSEETPNSTVNNKPIVPPR 2246
            :..|::..:.|.|...||             |.|:|..........|.|.|.:.::  :.:..|.
Mouse  1584 SLLRRHQLRPNAVLRPRRERWLYPILRLQEAKAPDFGVFLRSHKMQSRELTTDGSL--RVLKLPL 1646

  Fly  2247 PR 2248
            ||
Mouse  1647 PR 1648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr62	NP_001259886.1	WD40	73..448	CDD:295369
		WD40 repeat	73..107	CDD:293791
		WD40 repeat	113..161	CDD:293791
		WD40	158..574	CDD:225201
		WD40 repeat	167..207	CDD:293791
		WD40 repeat	209..285	CDD:293791
		WD40 repeat	254..294	CDD:293791
		WD40 repeat	303..338	CDD:293791
		WD40 repeat	353..407	CDD:293791
		WD40	385..747	CDD:225201
		WD40	436..748	CDD:295369
		WD40 repeat	505..540	CDD:293791
		WD40 repeat	546..586	CDD:293791
		WD40 repeat	591..631	CDD:293791
		WD40 repeat	637..672	CDD:293791
		WD40 repeat	679..717	CDD:293791
		WD40 repeat	723..749	CDD:293791
Gm35339	XP_006521682.1	WD40	<190..378	CDD:392136	46/250 (18%)
		WD40	297..630	CDD:392136	80/424 (19%)
		WD40 repeat	302..337	CDD:293791	9/56 (16%)
		WD40 repeat	342..368	CDD:293791	11/46 (24%)
		WD40 repeat	378..428	CDD:293791	16/62 (26%)
		WD40 repeat	486..537	CDD:293791	7/50 (14%)
		WD40 repeat	548..600	CDD:293791	12/56 (21%)
		WD40 repeat	607..629	CDD:293791	5/27 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833468
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930