DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr62 and mapkbp1

DIOPT Version :9

Sequence 1:	NP_001259886.1	Gene:	Wdr62 / 33367	FlyBaseID:	FBgn0031374	Length:	2397	Species:	Drosophila melanogaster
Sequence 2:	XP_002933767.2	Gene:	mapkbp1 / 100495737	XenbaseID:	XB-GENE-485536	Length:	1583	Species:	Xenopus tropicalis

Alignment Length:	1891	Identity:	591/1891 - (31%)
Similarity:	846/1891 - (44%)	Gaps:	479/1891 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 LTPSPSSVFGSPKFPANYER-SEKIKLKKVLGLTVCSNAALDVSPVSGLLAYPAGCTVVLFNAKR 98
            |..|||......|..|..|. ..|:.|:||||:||.:...|...|.:||:||||||.|||.|.::
Frog    17 LLRSPSIKLRRHKAGAKKEDIGTKVTLEKVLGITVTAGRGLSCDPKTGLVAYPAGCVVVLLNPRK 81

  Fly    99 QTQAYLVNTSRKAFTSVAFSRCGRYVATGECGINPAIKVWELETPNGSLEHCSGGSVVAEFVDHK 163
            ..|.:::|:|||..|::|||..|:::.|||.|..||::||::          :..:.|||..:||
Frog    82 NKQQHILNSSRKTITALAFSPDGKFLVTGESGHMPAVRVWDV----------AERTQVAELQEHK 136

  Fly   164 YAVTCVAFSPTGKYLVSVGSQHDMIVNVFDWRANLKMASNKISSKVAAVCFSEDGSYFVTVGNRH 228
            |.|.|||||||.||:||||.||||||||:.|:.|:.:|:||:||||.||.||||.|||||.||||
Frog   137 YGVACVAFSPTSKYIVSVGYQHDMIVNVWSWKKNVVVAANKVSSKVTAVSFSEDSSYFVTAGNRH 201

  Fly   229 VKYWYLEGGR--KYKDPIPLMGRSAILGDLRDNDFCAVACGKGICAESTYAITRQGHLVEFSSRR 291
            ||:|||:..:  |....|||:|||.:||:||:|.|..||||||..:.||:.||..|.|.||:.:|
Frog   202 VKFWYLDEAKSSKVNSTIPLLGRSGLLGELRNNFFTDVACGKGKKSNSTFCITSSGLLCEFNDQR 266

  Fly   292 LLDKWVQCRTTNANCICVNERFILVGCAESIIRIFNSATLEYVTTLPRTHYLGVDVAQGIQINHI 356
            ||||||:.|||.||||.||..:|..|||:..:||||...|.:::|:|:.|.||||:|...:.:.:
Frog   267 LLDKWVELRTTVANCILVNHEYIFCGCADGTVRIFNPNNLHFLSTMPKPHCLGVDIATVTEASRL 331

  Fly   357 MSVPQQAKFPDCIAMVFDEQRSKVSCVYNDHSLYIWDLRDISRVGKSHSFLYHSTCIWGVETVPY 421
            .|....||:||.|||.||.....:||||||||||:||::|:.:|||.:|.||||:|:|.||..|
Frog   332 FSSAADAKYPDTIAMTFDPTNQWLSCVYNDHSLYVWDVKDLKKVGKVYSALYHSSCVWSVEIYP- 395

  Fly   422 NVEREPSQTLPEECFVTCSSDDTIRVWGLDGCTNN---DIYRRNIYSKELLKIVYSDDELQFIKD 483
            .::......||...|:|||||.|||:|.::  |:|   ....|||.|.:|:|||..||..|.:.|
Frog   396 EIKDSNQACLPPNSFITCSSDSTIRLWNME--TSNIHGTALHRNILSNDLMKIVLIDDNTQALLD 458

  Fly   484 ---QGSSLFDKAGNSSYDGRNGVRCIKISPELQHLASGDRCGNIRVYSLVNLRLLTTIEAHESEV 545
               ..:.|.||..:...|.:.|:|.:.:||..||||||||.|.:||:.|..:..|..:|||:||:
Frog   459 TEYNSAGLGDKVDHQGLDTKVGIRSVCVSPNGQHLASGDRTGTLRVHELQTVTELLKVEAHDSEI 523

  Fly   546 LCLEYSNEKIERKLLASASRDRLIHVFDVAQNYLLLQTLDDHSSSITSIKFVGAGLNFQMISCGA 610
            ||||||.......|||||||||||||.|.|::|.|.|||||||||||::||.......:||||||
Frog   524 LCLEYSKPDTGFNLLASASRDRLIHVLDAAKDYSLQQTLDDHSSSITAVKFAANDGKVRMISCGA 588

  Fly   611 DKSIMFRSFQ--GNIFMRGTNTS---GKTTLYDMEVDSNAKHILTACQDRNVRVYGTQNAKQTKT 670
            ||||.||:..  |:..:..|.|.   .|||||||:||.:.|:....|||||:|::...:.||.|.
Frog   589 DKSIYFRTADKVGDAAVHFTRTHHIVRKTTLYDMDVDPSLKYAAIGCQDRNIRIFNISSGKQKKL 653

  Fly   671 FKGSHSDEGSLIKLSLDPSGIYVATSCTDKTLAVYDYYSNECMARMYGHSELVTGLKFTNDCRHL 735
            :|||.|::|:|||:..||||:|:||||:||.|:::|:||.||:|.|:||||:|||:||||||:||
Frog   654 YKGSQSEDGTLIKVQTDPSGLYIATSCSDKNLSIFDFYSGECVATMFGHSEIVTGMKFTNDCKHL 718

  Fly   736 ISASGDGCIFIWQVPHDMIVTMQARMSQQRLRSGHAPLPRP----------LAPISPPDGIVLES 790
            ||.|||.|||||::..:|.:.|:.|:::.|.|.....:..|          :|.:|....:..:|
Frog   719 ISVSGDSCIFIWRLSSEMTINMRQRLAEVRQRGKQVEMSAPHKTPNARRETIAVMSTAPAMSSDS 783

  Fly   791 PTSEIEQPQLQPKFG---VAERFSDVGQ-LPQWAMRKAAADSDSGALSIPTPSGGSATVPGMHAA 851
            ....:|....:...|   .:...|..|: |..|.|::                       |.:|:
Frog   784 DKEGVEDGSDEDMAGSDKTSSASSSFGRSLSYWEMKR-----------------------GTNAS 825

  Fly   852 SSMGNLSSSPSQQMTGLAPRARGRWAQRSTQLETADDLRSNSESPLGTVSSVGGHSGVNVQTSDY 916
            |...:..|.        .||.|.||:|.:..:|.             ||.|:     ::::..|
Frog   826 SERSDCLSK--------MPRQRVRWSQPAGNIEM-------------TVKSM-----LDLRQLD- 863

  Fly   917 NSASSKDITYNQTYLSEDSSIDSGMETRRGELKFIGSSNNGTVVTVSSVSSIAVSASNGAMSTGS 981
            :.|.|.|:      :....|...|||       |:.:.|..:            .|..|.:...|
Frog   864 SFAPSDDV------IGFQPSEGLGME-------FVDTDNPRS------------QAPFGPIGNRS 903

  Fly   982 GAAQQRLQLPDKRLKPGLRFDTHTHDHDGDVEDISDGERTSSDHGMFYNNLAPSTPTDFKVTAMN 1046
            .....||.                                |.:..||..::  .||...:.|...
Frog   904 RPRVIRLM--------------------------------SCEETMFKQDV--DTPEGKECTIFP 934

  Fly  1047 EDELRKSVRR-QKFEKSGLQL------------TP-SALSGNGSSHTA---------------ST 1082
            |.|..:|:.| ..||..||.|            :| ||.|.:.||..:               |.
Frog   935 ETEEDESLDRCSIFEVKGLPLRSYHDNVCQEKHSPDSACSVDYSSRLSSPEHPNEDSESTEPLSV 999

  Fly  1083 GTGTSDTED--------------EGSTPSAENAERSLASTLGGSSENLPQSSTNSFLHAALPEGP 1133
            ...:||.|:              :|..|...:.|:.|....|    ||   ||.:|     |:||
Frog  1000 DANSSDLEEQVEAEDLEPNSPLMDGEIPQTPDQEKFLKRHFG----NL---STGNF-----PDGP 1052

  Fly  1134 GLTTPMERGGSSRRSISAKHNTENGKSVAAPPTITKSYT---STKKEELLQVINKVKQQLE---N 1192
            .||:  ||...|  |||::...:     |.||.:.:..:   |....|....:.:..|:|.   |
Frog  1053 LLTS--ERNDFS--SISSRFLAK-----AQPPALGRHQSIEPSVPDSEFSPALFQPSQELPTLIN 1108

  Fly  1193 GTRKNGNTRLNAIAEVGHRPLRGSHSISDLSLAANLDGSRNAGGGPGRYQKPVDSHDTSQYTSPQ 1257
            ||              .|:|          ..|..||                  ||   :.|||
Frog  1109 GT--------------DHQP----------KSAIMLD------------------HD---FASPQ 1128

  Fly  1258 NTTATAAPTNTQQQIQPPVQQQYQIPKEPHQQAQQQH-QQYAPPASQQFFNCAAPKSKLQQNFQT 1321
                                      |..:.|.:::| |:|.      ......|.|.|.|
Frog  1129 --------------------------KFNYFQRKRKHLQEYG------HIGKGGPFSSLMQ---- 1157

  Fly  1322 MRQVQQHYPPYPHHVGVHQIHPPPGVPFGGSAAGSTSAMRSHSQPQNRQQQQQQQQQRAKRNPAG 1386
            :|:.|          .||.:     |..|...|.:...::..||.|...:::::..:|
Frog  1158 IRKTQ----------SVHDL-----VHEGDKTAANGGVVKMRSQVQTAAEREEKAIRR------- 1200

  Fly  1387 NNRRTPSILKHYKSCPVSPVHEEVEWSAEGNERGALLGEPKRHSVYADDARTILDMIHADTEKMI 1451
              |..||.|...::......|.:...||:|                    |:.::    .|...:
Frog  1201 --RTLPSNLIKVENITSGTPHAKDGKSAKG--------------------RSYMN----PTTSSM 1239

  Fly  1452 DEITRKYGDLDEPGIPASYSMPANL-------RNLGGLGSTGDSTPTGRTTQYYVYREFYQCERK 1509
            .:|:|            |.|:..||       .:|...|.....:.||..|......:..|..::
Frog  1240 AKISR------------SMSVGENLDIGDNQDTSLSSDGKGNCESETGAVTSLIETEKNRQTAKE 1292

  Fly  1510 -VSLSDILQPEQFAASQRRLDEARFLETQRHSSASFFLTGQQSQESLSLLSDGDGPGSYCNSLES 1573
             |.:...|||....:|.:..        |..:.|...|...:......|||...|.|..  .:||
Frog  1293 TVIIKPHLQPVTNCSSTKTF--------QAKNRAHLTLDIAKPLPDRPLLSFNKGKGQL--EMES 1347

  Fly  1574 VLSDESDCQSAPLEYPQTQVAVLQQRHAGIRNFIIHGPV-----SKSYG------------NSPN 1621
            ..|..:.|:   ::...|::....:.|:.       |.|     |:.||            :.||
Frog  1348 PRSPANSCK---VKNSFTELTCRNENHSS-------GAVEKISPSEDYGCGKSKDDDVKANSKPN 1402

  Fly  1622 ----AYGSFDYYMRQQH-------STTTDSFDVTGYNLEPLKP-LPSSKTYP----------RIA 1664
                |...|...::..|       ..|.|..  :|...||::| .||....|          ...
Frog  1403 LSQEAAELFSDLLKPIHRGRAFTIGHTPDHH--SGLCSEPIRPRSPSLNAAPTQNSASSVSFEQC 1465

  Fly  1665 QVQASENIPTLRSKNKQYTSGVNKSLSTDFAQQR-------------------QQRNSNP----- 1705
            ::.|||...:||.....|.|......||:..:.:                   ::.|.:|
Frog  1466 ELIASELQDSLRKALSLYRSVTTADPSTNLERCKIAGLLTETFGMVKRELDFLKEGNGSPGTGEA 1530

  Fly  1706 ----MQSGDNLFVRKPLKPKPPVPAKPHNLVSTLSHMEKQQKQKSQSRTASVVQQF-EHNLQKFE 1765
                ..:|.||     ..|..|.....|.|              ...:|.:::||: |..||..|
Frog  1531 LTPLNDTGSNL-----TAPSLPEEHTTHRL--------------GDDKTLALLQQYSELLLQAVE 1576

  Fly  1766 KEKQRE 1771
            |...::
Frog  1577 KRMDKK 1582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr62	NP_001259886.1	WD40	73..448	CDD:295369	196/376 (52%)
		WD40 repeat	73..107	CDD:293791	15/33 (45%)
		WD40 repeat	113..161	CDD:293791	16/47 (34%)
		WD40	158..574	CDD:225201	222/423 (52%)
		WD40 repeat	167..207	CDD:293791	26/39 (67%)
		WD40 repeat	209..285	CDD:293791	45/77 (58%)
		WD40 repeat	254..294	CDD:293791	21/39 (54%)
		WD40 repeat	303..338	CDD:293791	16/34 (47%)
		WD40 repeat	353..407	CDD:293791	27/53 (51%)
		WD40	385..747	CDD:225201	194/372 (52%)
		WD40	436..748	CDD:295369	171/322 (53%)
		WD40 repeat	505..540	CDD:293791	15/34 (44%)
		WD40 repeat	546..586	CDD:293791	26/39 (67%)
		WD40 repeat	591..631	CDD:293791	18/41 (44%)
		WD40 repeat	637..672	CDD:293791	15/34 (44%)
		WD40 repeat	679..717	CDD:293791	22/37 (59%)
		WD40 repeat	723..749	CDD:293791	21/25 (84%)
mapkbp1	XP_002933767.2	WD40	<65..122	CDD:421866	28/56 (50%)
		WD40	95..423	CDD:421866	177/338 (52%)
		WD40 repeat	95..134	CDD:293791	16/48 (33%)
		WD40 repeat	140..178	CDD:293791	25/37 (68%)
		WD40 repeat	182..229	CDD:293791	28/46 (61%)
		WD40 repeat	237..313	CDD:293791	40/75 (53%)
		WD40	345..731	CDD:421866	203/388 (52%)
		WD40 repeat	345..383	CDD:293791	21/37 (57%)
		WD40 repeat	433..474	CDD:293791	15/40 (38%)
		WD40 repeat	483..518	CDD:293791	15/34 (44%)
		WD40 repeat	524..564	CDD:293791	26/39 (67%)
		WD40 repeat	569..610	CDD:293791	18/40 (45%)
		WD40 repeat	620..655	CDD:293791	15/34 (44%)
		WD40 repeat	662..700	CDD:293791	22/37 (59%)
		WD40 repeat	706..732	CDD:293791	21/25 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2050
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1017450at2759
OrthoFinder	1	1.000	-	-		FOG0003218
OrthoInspector	1	1.000	-	-		otm47905
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2177
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010