Protein Alignment Wdr62 and mapkbp1

DIOPT Version :10

• Sequence 1: NP_001259886.1
• Gene: Wdr62 / 33367
• FlyBaseID: FBgn0031374
• Length: 2397
• Species: Drosophila melanogaster
• Sequence 2: XP_002933767.2
• Gene: mapkbp1 / 100495737
• XenbaseID: XB-GENE-485536
• Length: 1583
• Species: Xenopus tropicalis
• Alignment Length: 1891
• Identity: 591/1891 - (31%)
• Similarity: 846/1891 - (44%)
• Gaps: 479/1891 - (25%)

  Fly    35 LTPSPSSVFGSPKFPANYER-SEKIKLKKVLGLTVCSNAALDVSPVSGLLAYPAGCTVVLFNAKR 98
            |..|||......|..|..|. ..|:.|:||||:||.:...|...|.:||:||||||.|||.|.::
 Frog    17 LLRSPSIKLRRHKAGAKKEDIGTKVTLEKVLGITVTAGRGLSCDPKTGLVAYPAGCVVVLLNPRK 81

  Fly    99 QTQAYLVNTSRKAFTSVAFSRCGRYVATGECGINPAIKVWELETPNGSLEHCSGGSVVAEFVDHK 163
            ..|.:::|:|||..|::|||..|:::.|||.|..||::||::          :..:.|||..:||
 Frog    82 NKQQHILNSSRKTITALAFSPDGKFLVTGESGHMPAVRVWDV----------AERTQVAELQEHK 136

  Fly   164 YAVTCVAFSPTGKYLVSVGSQHDMIVNVFDWRANLKMASNKISSKVAAVCFSEDGSYFVTVGNRH 228
            |.|.|||||||.||:||||.||||||||:.|:.|:.:|:||:||||.||.||||.|||||.||||
 Frog   137 YGVACVAFSPTSKYIVSVGYQHDMIVNVWSWKKNVVVAANKVSSKVTAVSFSEDSSYFVTAGNRH 201

  Fly   229 VKYWYLEGGR--KYKDPIPLMGRSAILGDLRDNDFCAVACGKGICAESTYAITRQGHLVEFSSRR 291
            ||:|||:..:  |....|||:|||.:||:||:|.|..||||||..:.||:.||..|.|.||:.:|
 Frog   202 VKFWYLDEAKSSKVNSTIPLLGRSGLLGELRNNFFTDVACGKGKKSNSTFCITSSGLLCEFNDQR 266

  Fly   292 LLDKWVQCRTTNANCICVNERFILVGCAESIIRIFNSATLEYVTTLPRTHYLGVDVAQGIQINHI 356
            ||||||:.|||.||||.||..:|..|||:..:||||...|.:::|:|:.|.||||:|...:.:.:
 Frog   267 LLDKWVELRTTVANCILVNHEYIFCGCADGTVRIFNPNNLHFLSTMPKPHCLGVDIATVTEASRL 331

  Fly   357 MSVPQQAKFPDCIAMVFDEQRSKVSCVYNDHSLYIWDLRDISRVGKSHSFLYHSTCIWGVETVPY 421
            .|....||:||.|||.||.....:||||||||||:||::|:.:|||.:|.||||:|:|.||..|
 Frog   332 FSSAADAKYPDTIAMTFDPTNQWLSCVYNDHSLYVWDVKDLKKVGKVYSALYHSSCVWSVEIYP- 395

  Fly   422 NVEREPSQTLPEECFVTCSSDDTIRVWGLDGCTNN---DIYRRNIYSKELLKIVYSDDELQFIKD 483
            .::......||...|:|||||.|||:|.::  |:|   ....|||.|.:|:|||..||..|.:.|
 Frog   396 EIKDSNQACLPPNSFITCSSDSTIRLWNME--TSNIHGTALHRNILSNDLMKIVLIDDNTQALLD 458

  Fly   484 ---QGSSLFDKAGNSSYDGRNGVRCIKISPELQHLASGDRCGNIRVYSLVNLRLLTTIEAHESEV 545
               ..:.|.||..:...|.:.|:|.:.:||..||||||||.|.:||:.|..:..|..:|||:||:
 Frog   459 TEYNSAGLGDKVDHQGLDTKVGIRSVCVSPNGQHLASGDRTGTLRVHELQTVTELLKVEAHDSEI 523

  Fly   546 LCLEYSNEKIERKLLASASRDRLIHVFDVAQNYLLLQTLDDHSSSITSIKFVGAGLNFQMISCGA 610
            ||||||.......|||||||||||||.|.|::|.|.|||||||||||::||.......:||||||
 Frog   524 LCLEYSKPDTGFNLLASASRDRLIHVLDAAKDYSLQQTLDDHSSSITAVKFAANDGKVRMISCGA 588

  Fly   611 DKSIMFRSFQ--GNIFMRGTNTS---GKTTLYDMEVDSNAKHILTACQDRNVRVYGTQNAKQTKT 670
            ||||.||:..  |:..:..|.|.   .|||||||:||.:.|:....|||||:|::...:.||.|.
 Frog   589 DKSIYFRTADKVGDAAVHFTRTHHIVRKTTLYDMDVDPSLKYAAIGCQDRNIRIFNISSGKQKKL 653

  Fly   671 FKGSHSDEGSLIKLSLDPSGIYVATSCTDKTLAVYDYYSNECMARMYGHSELVTGLKFTNDCRHL 735
            :|||.|::|:|||:..||||:|:||||:||.|:::|:||.||:|.|:||||:|||:||||||:||
 Frog   654 YKGSQSEDGTLIKVQTDPSGLYIATSCSDKNLSIFDFYSGECVATMFGHSEIVTGMKFTNDCKHL 718

  Fly   736 ISASGDGCIFIWQVPHDMIVTMQARMSQQRLRSGHAPLPRP----------LAPISPPDGIVLES 790
            ||.|||.|||||::..:|.:.|:.|:::.|.|.....:..|          :|.:|....:..:|
 Frog   719 ISVSGDSCIFIWRLSSEMTINMRQRLAEVRQRGKQVEMSAPHKTPNARRETIAVMSTAPAMSSDS 783

  Fly   791 PTSEIEQPQLQPKFG---VAERFSDVGQ-LPQWAMRKAAADSDSGALSIPTPSGGSATVPGMHAA 851
            ....:|....:...|   .:...|..|: |..|.|::                       |.:|:
 Frog   784 DKEGVEDGSDEDMAGSDKTSSASSSFGRSLSYWEMKR-----------------------GTNAS 825

  Fly   852 SSMGNLSSSPSQQMTGLAPRARGRWAQRSTQLETADDLRSNSESPLGTVSSVGGHSGVNVQTSDY 916
            |...:..|.        .||.|.||:|.:..:|.             ||.|:     ::::..|
 Frog   826 SERSDCLSK--------MPRQRVRWSQPAGNIEM-------------TVKSM-----LDLRQLD- 863

  Fly   917 NSASSKDITYNQTYLSEDSSIDSGMETRRGELKFIGSSNNGTVVTVSSVSSIAVSASNGAMSTGS 981
            :.|.|.|:      :....|...|||       |:.:.|..:            .|..|.:...|
 Frog   864 SFAPSDDV------IGFQPSEGLGME-------FVDTDNPRS------------QAPFGPIGNRS 903

  Fly   982 GAAQQRLQLPDKRLKPGLRFDTHTHDHDGDVEDISDGERTSSDHGMFYNNLAPSTPTDFKVTAMN 1046
            .....||.                                |.:..||..::  .||...:.|...
 Frog   904 RPRVIRLM--------------------------------SCEETMFKQDV--DTPEGKECTIFP 934

  Fly  1047 EDELRKSVRR-QKFEKSGLQL------------TP-SALSGNGSSHTA---------------ST 1082
            |.|..:|:.| ..||..||.|            :| ||.|.:.||..:               |.
 Frog   935 ETEEDESLDRCSIFEVKGLPLRSYHDNVCQEKHSPDSACSVDYSSRLSSPEHPNEDSESTEPLSV 999

  Fly  1083 GTGTSDTED--------------EGSTPSAENAERSLASTLGGSSENLPQSSTNSFLHAALPEGP 1133
            ...:||.|:              :|..|...:.|:.|....|    ||   ||.:|     |:||
 Frog  1000 DANSSDLEEQVEAEDLEPNSPLMDGEIPQTPDQEKFLKRHFG----NL---STGNF-----PDGP 1052

  Fly  1134 GLTTPMERGGSSRRSISAKHNTENGKSVAAPPTITKSYT---STKKEELLQVINKVKQQLE---N 1192
            .||:  ||...|  |||::...:     |.||.:.:..:   |....|....:.:..|:|.   |
 Frog  1053 LLTS--ERNDFS--SISSRFLAK-----AQPPALGRHQSIEPSVPDSEFSPALFQPSQELPTLIN 1108

  Fly  1193 GTRKNGNTRLNAIAEVGHRPLRGSHSISDLSLAANLDGSRNAGGGPGRYQKPVDSHDTSQYTSPQ 1257
            ||              .|:|          ..|..||                  ||   :.|||
 Frog  1109 GT--------------DHQP----------KSAIMLD------------------HD---FASPQ 1128

  Fly  1258 NTTATAAPTNTQQQIQPPVQQQYQIPKEPHQQAQQQH-QQYAPPASQQFFNCAAPKSKLQQNFQT 1321
                                      |..:.|.:::| |:|.      ......|.|.|.|
 Frog  1129 --------------------------KFNYFQRKRKHLQEYG------HIGKGGPFSSLMQ---- 1157

  Fly  1322 MRQVQQHYPPYPHHVGVHQIHPPPGVPFGGSAAGSTSAMRSHSQPQNRQQQQQQQQQRAKRNPAG 1386
            :|:.|          .||.:     |..|...|.:...::..||.|...:::::..:|
 Frog  1158 IRKTQ----------SVHDL-----VHEGDKTAANGGVVKMRSQVQTAAEREEKAIRR------- 1200

  Fly  1387 NNRRTPSILKHYKSCPVSPVHEEVEWSAEGNERGALLGEPKRHSVYADDARTILDMIHADTEKMI 1451
              |..||.|...::......|.:...||:|                    |:.::    .|...:
 Frog  1201 --RTLPSNLIKVENITSGTPHAKDGKSAKG--------------------RSYMN----PTTSSM 1239

  Fly  1452 DEITRKYGDLDEPGIPASYSMPANL-------RNLGGLGSTGDSTPTGRTTQYYVYREFYQCERK 1509
            .:|:|            |.|:..||       .:|...|.....:.||..|......:..|..::
 Frog  1240 AKISR------------SMSVGENLDIGDNQDTSLSSDGKGNCESETGAVTSLIETEKNRQTAKE 1292

  Fly  1510 -VSLSDILQPEQFAASQRRLDEARFLETQRHSSASFFLTGQQSQESLSLLSDGDGPGSYCNSLES 1573
             |.:...|||....:|.:..        |..:.|...|...:......|||...|.|..  .:||
 Frog  1293 TVIIKPHLQPVTNCSSTKTF--------QAKNRAHLTLDIAKPLPDRPLLSFNKGKGQL--EMES 1347

  Fly  1574 VLSDESDCQSAPLEYPQTQVAVLQQRHAGIRNFIIHGPV-----SKSYG------------NSPN 1621
            ..|..:.|:   ::...|::....:.|:.       |.|     |:.||            :.||
 Frog  1348 PRSPANSCK---VKNSFTELTCRNENHSS-------GAVEKISPSEDYGCGKSKDDDVKANSKPN 1402

  Fly  1622 ----AYGSFDYYMRQQH-------STTTDSFDVTGYNLEPLKP-LPSSKTYP----------RIA 1664
                |...|...::..|       ..|.|..  :|...||::| .||....|          ...
 Frog  1403 LSQEAAELFSDLLKPIHRGRAFTIGHTPDHH--SGLCSEPIRPRSPSLNAAPTQNSASSVSFEQC 1465

  Fly  1665 QVQASENIPTLRSKNKQYTSGVNKSLSTDFAQQR-------------------QQRNSNP----- 1705
            ::.|||...:||.....|.|......||:..:.:                   ::.|.:|
 Frog  1466 ELIASELQDSLRKALSLYRSVTTADPSTNLERCKIAGLLTETFGMVKRELDFLKEGNGSPGTGEA 1530

  Fly  1706 ----MQSGDNLFVRKPLKPKPPVPAKPHNLVSTLSHMEKQQKQKSQSRTASVVQQF-EHNLQKFE 1765
                ..:|.||     ..|..|.....|.|              ...:|.:::||: |..||..|
 Frog  1531 LTPLNDTGSNL-----TAPSLPEEHTTHRL--------------GDDKTLALLQQYSELLLQAVE 1576

  Fly  1766 KEKQRE 1771
            |...::
 Frog  1577 KRMDKK 1582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wdr62	NP_001259886.1	WD40	<73..236	CDD:441893	89/162 (55%)
		WD40 repeat	73..107	CDD:293791	15/33 (45%)
		WD40 repeat	113..161	CDD:293791	16/47 (34%)
		WD40	156..573	CDD:475233	224/424 (53%)
		WD40 repeat	167..207	CDD:293791	26/39 (67%)
		WD40 repeat	209..285	CDD:293791	45/77 (58%)
		WD40 repeat	303..338	CDD:293791	16/34 (47%)
		WD40 repeat	353..407	CDD:293791	27/53 (51%)
		WD40	<437..750	CDD:441893	171/323 (53%)
		WD40 repeat	505..540	CDD:293791	15/34 (44%)
		WD40 repeat	546..586	CDD:293791	26/39 (67%)
		WD40 repeat	591..631	CDD:293791	18/41 (44%)
		WD40 repeat	637..672	CDD:293791	15/34 (44%)
		WD40 repeat	679..717	CDD:293791	22/37 (59%)
		WD40 repeat	723..749	CDD:293791	21/25 (84%)
mapkbp1	XP_002933767.2	WD40	<65..553	CDD:441893	254/500 (51%)
		WD40 repeat	95..134	CDD:293791	16/48 (33%)
		WD40 repeat	140..178	CDD:293791	25/37 (68%)
		WD40 repeat	182..229	CDD:293791	28/46 (61%)
		WD40 repeat	237..313	CDD:293791	40/75 (53%)
		WD40	<345..734	CDD:441893	204/391 (52%)
		WD40 repeat	345..383	CDD:293791	21/37 (57%)
		WD40 repeat	433..474	CDD:293791	15/40 (38%)
		WD40 repeat	483..518	CDD:293791	15/34 (44%)
		WD40 repeat	524..564	CDD:293791	26/39 (67%)
		WD40 repeat	569..610	CDD:293791	18/40 (45%)
		WD40 repeat	620..655	CDD:293791	15/34 (44%)
		WD40 repeat	662..700	CDD:293791	22/37 (59%)
		WD40 repeat	706..732	CDD:293791	21/25 (84%)