DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Wdr62 and wdr62

DIOPT Version :9

Sequence 1:	NP_001259886.1	Gene:	Wdr62 / 33367	FlyBaseID:	FBgn0031374	Length:	2397	Species:	Drosophila melanogaster
Sequence 2:	XP_017952347.1	Gene:	wdr62 / 100493893	XenbaseID:	XB-GENE-6052321	Length:	1481	Species:	Xenopus tropicalis

Alignment Length:	1583	Identity:	504/1583 - (31%)
Similarity:	739/1583 - (46%)	Gaps:	326/1583 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 PLTPSP----SSVFGSPKFPANYERSEKIKLKKVLGLTVCSNAALDVSPVSGLLAYPAGCTVVLF 94
            |..|||    ||...|.. ..|.....:::|:||||:||.||:::...|:|||:||||||.:|:.
Frog    16 PQPPSPGRRKSSRVQSGN-AGNGRGHRQVELEKVLGITVSSNSSITCDPISGLIAYPAGCVIVVL 79

  Fly    95 NAKRQTQAYLVNTSRKAFTSVAFSRCGRYVATGECGINPAIKVWELETPNGSLEHCSGGSVVAEF 159
            ..::..|.::.||.||..::::||..|:::.|||.|.|||:::|::          :...:|:|.
Frog    80 CPRKNKQTHIFNTCRKPLSALSFSPNGKFIVTGESGHNPAVRIWDV----------AEKVLVSEM 134

  Fly   160 VDHKYAVTCVAFSPTGKYLVSVGSQHDMIVNVFDWRANLKMASNKISSKVAAVCFSEDGSYFVTV 224
            :.|||.|:||.|||..||:||||.||||::||:||:.|:.:|.||:||||:||.||||.||||||
Frog   135 LGHKYGVSCVCFSPDMKYVVSVGYQHDMVINVWDWKVNMIVAKNKVSSKVSAVSFSEDSSYFVTV 199

  Fly   225 GNRHVKYWYLEGGRKYK--DPIPLMGRSAILGDLRDNDFCAVACGKGICAESTYAITRQGHLVEF 287
            |:||||:||||..:|.:  ..:||:|||.:||||.||.||.||||||..:.||:.|...|.|.:|
Frog   200 GSRHVKFWYLETSKKIQVNGTVPLVGRSGLLGDLHDNIFCGVACGKGSNSRSTFCIAYSGVLCQF 264

  Fly   288 SSRRLLDKWVQCRTTNANCICVNERFILVGCAESIIRIFNSATLEYVTTLPRTHYLGVDVAQGIQ 352
            :.:|:|:||::.:.:.:.|:.|.|.|:..||.:.|:||||:..|:|:|.||:.|||||||:.|..
Frog   265 TDKRVLEKWIKLKVSASYCLAVTELFVFCGCEDGIVRIFNAQNLQYITDLPKPHYLGVDVSLGTD 329

  Fly   353 INHIMSVPQQAKFPDCIAMVFDEQRSKVSCVYNDHSLYIWDLRDISRVGKSHSFLYHSTCIWGVE 417
            .:.:.:....:.:||..|:|:||:...:.|||||||||:||:.|..:|||.:|.||||:.:|.:|
Frog   330 PSTLFTKQTDSSYPDTSALVYDERNQWLCCVYNDHSLYVWDVNDTRKVGKVYSGLYHSSFVWNIE 394

  Fly   418 TVPYNVEREPSQTLPEECFVTCSSDDTIRVWGLDGCTNNDIY-RRNIYSKELLKIVYSDDELQFI 481
            ..|...||   ..||..||.:||||:|||:|.::  .|.::| .:||||.:|.|::|.|:.::.:
Frog   395 VFPELGER---PCLPSGCFFSCSSDNTIRLWNIE--RNANLYLGKNIYSNDLHKVIYVDNNIEHL 454

  Fly   482 KDQGSSLFDKAGNSSYDGRNGVRCIKISPELQHLASGDRCGNIRVYSLVNLRLLTTIEAHESEVL 546
            ||. ||:.:|  :...|.::|:|.:||.|:.||||||||.||||:|.|.....|.|||||:.|||
Frog   455 KDT-SSMAEK--SDVRDTKSGIRVLKIRPDGQHLASGDRTGNIRIYDLGIFDELLTIEAHDGEVL 516

  Fly   547 CLEYSNEKIERKLLASASRDRLIHVFDVAQNYLLLQTLDDHSSSITSIKFVGAGLNFQMISCGAD 611
            |||||.......|||||||||||||.:..::|:|.|||||||||||::||.|......|||||||
Frog   517 CLEYSKPSTGVTLLASASRDRLIHVLNAEKDYILEQTLDDHSSSITAVKFAGDQEEILMISCGAD 581

  Fly   612 KSIMFRSFQ----GNIFMRGTNTSGKTTLYDMEVDSNAKHILTACQDRNVRVYGTQNAKQTKTFK 672
            |||.||..|    |..|.|..:|..||.:|||:||.:.|.:..||||:|:|:|...:.||.|..|
Frog   582 KSIYFRPAQMLPDGIHFSRLHHTVEKTAMYDMDVDVSQKTVAVACQDKNIRLYSISSGKQEKILK 646

  Fly   673 GSHSDEGSLIKLSLDPSGIYVATSCTDKTLAVYDYYSNECMARMYGHSELVTGLKFTNDCRHLIS 737
            .| .:.|:|:|:.:||||.:..|||:.|.::.:|..|.||:|.:||||:|||.:||||||:.||:
Frog   647 SS-PNGGALLKVQIDPSGTFFTTSCSSKNISFFDLLSGECIAEVYGHSDLVTDMKFTNDCKRLIT 710

  Fly   738 ASGDGCIFIWQVPHDMIVTMQARM------SQQR--------LRSGHAPLPRPLAPISPPDGIVL 788
            .|||.|:|||::...|...|:.|:      .:|:        |.:........|...|..:.|.:
Frog   711 VSGDSCVFIWKLDPAMTACMKQRLIELGIFGEQKTTCYDECLLNNRRETYITNLLGESVQNEIFM 775

  Fly   789 ----ESPTSEIEQP-----QLQPKFGVAERFSDVGQLPQWAMRKAAADSD----SGALSIPTPSG 840
                |:..|..:.|     :..|.|     ....|::|.| :||...|.|    ...:::..|
Frog   776 DSSYETDDSSTQTPSKKTNEADPAF-----LKTNGKMPLW-VRKLDKDQDPLLNQNTINVYQP-- 832

  Fly   841 GSATVPGMHAASSMGNLSSSPSQQMTGLAPRARGRWAQRST------QLETADDLRSNSESPLGT 899
                                            ||||||..:      .|:|.|  :|...||
Frog   833 --------------------------------RGRWAQSDSNIIIMKSLDTED--KSYCFSP--- 860

  Fly   900 VSSVGGHSGVNVQTSDYNSASSKDITY-------------NQTYLSEDSSIDSGMETRRGELKFI 951
            .....||..::.:| |:..|..::..:             |:|.:.:.|..||       ::|..
Frog   861 DQEETGHFFLHDKT-DFVFAEPQNFQHLLESEERNVHSLANETCVQDLSDEDS-------DVKSH 917

  Fly   952 GSSNNGTVVTVSSVSSIAVSASNGAMSTGSGAAQQRLQLPDKRLKPGLRFDTHTHD------HDG 1010
            ...:||.:...||:.......|:.|:.... .......:.|.|.         .||      .|.
Frog   918 SLDSNGGIFYPSSLQLSGQEESDYAIEEHQ-IFSDTFDMSDVRT---------MHDFLPSCHQDK 972

  Fly  1011 DVEDISDGERTSSDHGMFYNNL----APSTPTDFKVTAMNEDELRKSVRRQKF------------ 1059
            |.|.::  ..|.|:..:..|.|    .|.||.:.|....:.|.|......::|
Frog   973 DEESLT--SETCSEADLDENELPGTSQPHTPEEEKFLLKHFDTLIDDFSEERFDYSLKDLKPPDD 1035

  Fly  1060 ---------------------------EKSGLQL-----TPSALSGNGSSHTASTGTGTSDTEDE 1092
                                       |.|.|.|     |||.:.||....:.|.......|||:
Frog  1036 DDHDFIQNPRLSFSAKFLSRCQKTSRPENSDLPLEQQVKTPSPILGNDEQISHSKTFSEKPTEDK 1100

  Fly  1093 ----------------------------------GSTP---SAENAE-------RSLASTLGGSS 1113
                                              .|.|   |::|..       ||.......|.
Frog  1101 LLDTLEKNKNVNATDFSKLCHLQKVQMNEKVASRSSFPPCVSSKNGAFNKPKKGRSYMDATASSK 1165

  Fly  1114 ENLPQS-STNSFLHAALPEGPGLTTPMERGGSSRRSISAK----HNTENGKSVAAP-PTITKSYT 1172
            ..:.:| |....|:.:..||....:.:.|..||...:|.:    :|.|:.....|| .|..|..|
Frog  1166 AKIFRSVSMGDSLNTSHSEGQKKLSNLSRPASSNDLLSLEQNNCYNAEDNLCDPAPILTTNKPAT 1230

  Fly  1173 STKKEELLQ---------------VINKVKQQLENGT---------------RKNGNTRLNAIAE 1207
            |....|.:|               ||.::|::.::.:               |||.|........
Frog  1231 SGYMNEHVQDSPDKLLMPPPLSCVVIPRLKRKAQSASNLAKPPGKEDQHDIVRKNKNKESRRSGV 1295

  Fly  1208 VGHRPLRGSHSISDL--SLAANL-DGSRNAGGG-----PGRYQKPVD----SHDTSQYTSPQNTT 1260
            ......:.|...|.|  |..||: |.||.|...     ...:|:..|    ||..:..||.:..|
Frog  1296 ENSINTKNSFRRSSLTTSKTANMADSSRRASVAEIPTCKNEFQEVEDHKNESHMVAVVTSNEMAT 1360

  Fly  1261 ATAAPTNTQQQIQPPVQQQYQIPKEPHQQAQQQHQQYAPPASQQFFNCAAPKSKLQQNFQTMRQV 1325
            .:..|                        ....|..:.  |......|.|....|...||...::
Frog  1361 LSTMP------------------------FASNHDSHG--AKVLLGKCEAVIENLCSAFQKTLEL 1399

  Fly  1326 QQHYPPYPHHVGVHQIHPPPGVPFGGSAAGSTSAMRSHSQPQN---RQQQQQQQQQRAKRNPAGN 1387
               |.......|.|:........|..|.....|.|......||   ...:..::.:..:|||
Frog  1400 ---YSEIDICGGSHEEKQQMKSLFYASFNHIRSEMDLIETDQNTNTANNKNSRRNEHQERNP--- 1458

  Fly  1388 NRRTPSILKHYKSCPVSPVHEEV 1410
               |..:|:||....:..:.|::
Frog  1459 ---TLDLLEHYSEMMLKVMKEKI 1478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdr62	NP_001259886.1	WD40	73..448	CDD:295369	177/376 (47%)
		WD40 repeat	73..107	CDD:293791	12/33 (36%)
		WD40 repeat	113..161	CDD:293791	13/47 (28%)
		WD40	158..574	CDD:225201	212/418 (51%)
		WD40 repeat	167..207	CDD:293791	23/39 (59%)
		WD40 repeat	209..285	CDD:293791	46/77 (60%)
		WD40 repeat	254..294	CDD:293791	20/39 (51%)
		WD40 repeat	303..338	CDD:293791	14/34 (41%)
		WD40 repeat	353..407	CDD:293791	22/53 (42%)
		WD40	385..747	CDD:225201	185/366 (51%)
		WD40	436..748	CDD:295369	161/316 (51%)
		WD40 repeat	505..540	CDD:293791	20/34 (59%)
		WD40 repeat	546..586	CDD:293791	24/39 (62%)
		WD40 repeat	591..631	CDD:293791	21/43 (49%)
		WD40 repeat	637..672	CDD:293791	16/34 (47%)
		WD40 repeat	679..717	CDD:293791	16/37 (43%)
		WD40 repeat	723..749	CDD:293791	17/25 (68%)
wdr62	XP_017952347.1	WD40 repeat	56..91	CDD:293791	13/34 (38%)
		WD40	94..423	CDD:392136	163/341 (48%)
		WD40 repeat	98..136	CDD:293791	13/47 (28%)
		WD40 repeat	141..177	CDD:293791	21/35 (60%)
		WD40 repeat	185..218	CDD:293791	22/32 (69%)
		WD40 repeat	233..265	CDD:293791	16/31 (52%)
		WD40 repeat	274..335	CDD:293791	24/60 (40%)
		WD40	346..721	CDD:392136	193/383 (50%)
		WD40 repeat	391..468	CDD:293791	32/84 (38%)
		WD40 repeat	476..510	CDD:293791	20/33 (61%)
		WD40 repeat	515..556	CDD:293791	25/40 (63%)
		WD40 repeat	562..605	CDD:293791	20/42 (48%)
		WD40 repeat	610..646	CDD:293791	16/35 (46%)
		WD40 repeat	654..689	CDD:293791	15/34 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1017450at2759
OrthoFinder	1	1.000	-	-		FOG0003218
OrthoInspector	1	1.000	-	-		otm47905
Panther	1	1.100	-	-	O	PTHR45589
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2177
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.020