DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31663 and mfsd-6

DIOPT Version :9

Sequence 1:	NP_001259884.1	Gene:	CG31663 / 33363	FlyBaseID:	FBgn0051663	Length:	966	Species:	Drosophila melanogaster
Sequence 2:	NP_498662.1	Gene:	mfsd-6 / 176073	WormBaseID:	WBGene00020051	Length:	630	Species:	Caenorhabditis elegans

Alignment Length:	792	Identity:	136/792 - (17%)
Similarity:	245/792 - (30%)	Gaps:	279/792 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 FGEFCQRRGINPNLIMLKITLFVMYGATSSLLPYLTIHMQSIGLTVEEIAIIYLALPFTTFLSPP 88
            ||:...|......|..|  :.|..:|   ||.|.|.::.:.:|:|..:...:..:.|...|||.|
Worm    13 FGKVFPRDAFICRLFYL--SFFASFG---SLFPLLAVYFKQLGMTAAQAGFLIGSRPIVEFLSGP 72

  Fly    89 ITGFLVDKFGKYKPVVVMSL-----------LLNAIFHHSLLFIPQ-----QEIPGVVPSAFVLR 137
            .......:|.|.|.:::.||           |:..:..:.::::|:     |.:  :.|:..::|
Worm    73 FWSQFASRFRKQKLLLLFSLGSLVLFTLGIGLVQPVTPYCIVYVPEGNKTCQTM--LAPAGKIIR 135

  Fly   138 HPDSGDIEVWWSPCPSRECPEEPELELAVHQCVDYCLMQEQVNPQLYTNTPAYDVRPAATTSTTQ 202
            ....|.::
Worm   136 GGALGMLK--------------------------------------------------------- 143

  Fly   203 RSQLTATTARTTTMEPSSESSSSPAPTTSTTTSPASSLPALFATQTRSRYQEVLNMSSTMFPPMS 267
                          |.....|:.||.....|.||.              .::::::||
Worm   144 --------------ETLVGGSTRPARQRRQTQSPL--------------VEKIIDLSS------- 173

  Fly   268 QLKDALEEGVEPGQSSSAELSAMSMQGLNLTNSSQKKLLWSSWVHSDNDDATYFMLQMHPDLADP 332

Worm   174 ----------------------------------------------------------------- 173

  Fly   333 TEQLGMEIEQDANETVTDILQRFGHDYLVRGNINLTDMDDLDLRCGGLVRRTNMTNIASGAVECM 397
                 .:.|:|   ||..|    ..:|:.|..:...:.|:.    |.||...:.|.:
Worm   174 -----FDSEED---TVAGI----APEYITRDRVCNYNEDNY----GILVSPPHSTRV-------- 214

  Fly   398 MQRCTFTLNAPEICPPDYKE-TDEIIFWVYFLLRFLATTMLSAGVTIMDPIALTMIEKYGGDFGR 461
                             |:: ..|..|.:..:|..|.....:..:.:.|...|..:.....:||:
Worm   215 -----------------YRQPAVEQAFMLLLILICLCEFFSAPALPLADAATLHSVRDNPAEFGK 262

  Fly   462 ERLFSSIGMAIFSPITGIMIDYS---------SRGLGYTDYSAAFYTYDVLLVISTMSV------ 511
            .||.:|:|......|.||.:|||         :......:|:..| ...|:.:::.|.:
Worm   263 IRLMASVGWGFAMFIMGIALDYSDTFRNHPCPAENTTEKNYTLCF-VMCVIFMLAAMGLASKFKF 326

  Fly   512 ------------LMMP---------LGEKLPA-----------DNVFRDLWNLLKMPHVIAFICF 544
                        |:|.         :.||..|           :|........|...|::.|...
Worm   327 DDDVPAPGEVHGLVMDTREAEVSHVVAEKARARITQSEGGGGSENSLLLAMKALASMHILLFFVS 391

  Fly   545 LFVLGNFWGFIESFLFLYLKELGAPNYLLGITITVGTVSSIPFLYGAEKITRIFGHVNLIIIAFF 609
            :.|:|...|.:.|||:.:|:::|....|.||...|...|.|...:...|:...:|||.::.:...
Worm   392 VVVMGGGAGLVFSFLYWHLQDIGGSPVLFGILSVVNHASEIITYFYVFKLINKYGHVRVMYLCLA 456

  Fly   610 SHAGRLVGYSFIETAWWCFPFEAMESLSCHLMWVAAATYCSILAPKSLLATLIGVLGMAHFSLGR 674
            .:..|.:..|.::..|...|.:.::......:|..|::|.|::||..........|.:.:..:|:
Worm   457 VNFFRFMALSILDNPWMVLPLQILQGACLATVWSCASSYISLVAPPHAKQHAQYALQVGYHGIGK 521

  Fly   675 GSGSFTGGLLIGQFGTRDAFRYMGL--LAVVGGIAYGLLHLIWLRKFDHTTEESEEE------VE 731
            |.||..||.:|...|||..|...||  ||...| ::||..|.......:.....|||      .:
Worm   522 GLGSIIGGSVISIIGTRTTFVIYGLICLATCAG-SFGLNKLFKYEGIKYGAGNFEEEDMDIMAPQ 585

  Fly   732 AVEAGETEKLTE 743
            .|......|:|:
Worm   586 GVPMARDGKITD 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31663	NP_001259884.1	MFS_1_like	36..111	CDD:289593	21/85 (25%)
		MFS	<423..711	CDD:119392	76/336 (23%)
		MFS_1	<423..678	CDD:284993	61/301 (20%)
mfsd-6	NP_498662.1	MFS_MFSD6	23..560	CDD:340893	126/743 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3762
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810