DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wry and Ncan

DIOPT Version :9

Sequence 1:	NP_995611.2	Gene:	wry / 33361	FlyBaseID:	FBgn0051665	Length:	1157	Species:	Drosophila melanogaster
Sequence 2:	NP_113841.2	Gene:	Ncan / 58982	RGDID:	619941	Length:	1263	Species:	Rattus norvegicus

Alignment Length:	954	Identity:	191/954 - (20%)
Similarity:	297/954 - (31%)	Gaps:	318/954 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 ETITND-----LTAKSNRTLLKTSTEESRE--ISALGGSTSTATPT-----TTATTSTTTTRATT 72
            |.||.|     :::..:..|..|.|:.|:|  .|..||.|..:.|:     .|..||:|...:.:
  Rat   397 EVITPDFQEPLVSSGEDEPLDLTRTQASQETLASTPGGPTLASWPSREKWLLTGVTSSTGVPSPS 461

  Fly    73 VAEDEMEETSTPTPTTVRLMTTTQKMVQANLGEIGSIKDALHRIKLSEKPVDGATTTTEQPEAMD 137
            ....:|||| ||:.|.|....|.::         |..|....|....:.|.|   ...|..||..
  Rat   462 SLGVDMEET-TPSGTQVAPTPTMRR---------GRFKGLNGRHFQQQGPED---QLLEAAEASA 513

  Fly   138 QDEQDEQDVTPTISPLQIQMQAAASYQVAETLADLNEEERARYDAMLAQQ---PTASKLNIVDLY 199
            |        .||:......|..:|:.:..|     :::..:.: |:|..:   |.|..|....|
  Rat   514 Q--------PPTLEVTADHMGPSAATEALE-----SDQSHSPW-AILTNEVDVPGAGSLGSRSL- 563

  Fly   200 PLKIEDIQPIIRNDNDELIKQRTVFTQHENAEEYKQNLMPNEVEMMVDKEVI--------EMKDK 256
                    |..|..:..||...||     .:.:....|.|...|....|..|        |....
  Rat   564 --------PESRKWSPSLISPSTV-----PSTDSTPGLKPGADEAPGVKSAIHHPPWLPSEPAVP 615

  Fly   257 IQINQEKFGS-STTVKPTTSRPHQGTTADFTGKLLADQDDLITEIES-KFQLHETTTLRPRVTTV 319
            ..|..|...: |....|....|      ||         .::..:.: |..|...:||.|.|:.:
  Rat   616 SSIPSEALSAVSLQASPGDGSP------DF---------PIVAMLRAPKLWLLPHSTLVPNVSPI 665

  Fly   320 Q-HPGNTFIDRRVKKSFEFPMQHRASDVMAMPHIDFA----NTKFQTDADAPNPPASH--PEFST 377
            . .|.:             |:.....:..|:..:.|.    .|.|||...||. .|||  ||..:
  Rat   666 PLSPAS-------------PLPSSVPEEQAVRPVSFGAEDPETPFQTTMAAPG-EASHGSPEADS 716

  Fly   378 TKFYNSKELYNEMLLHNKRKLMKAAKAEGSPIKSAEDTTRATSSNVTPEGKTFGPTTTTAAGSTA 442
            .:......             |:|.|...|...::.|::..|.:.|..:....|
  Rat   717 IEIEGISS-------------MQATKHPISGPWASLDSSNVTVNPVPSDAGILG----------- 757

  Fly   443 TTTAESTTTAATTTRLPATTTGKYQKELKRAKLLLKALTPPKSVDKSTASPSSTTSTSTSTTTTM 507
                    |.:....||.:.|...|                .:|||
  Rat   758 --------TESGVLDLPGSPTSDGQ----------------ATVDK------------------- 779

  Fly   508 ATLLATARTRPSAANPTKTASKPIARPRILSRLQEKINSLECEIPNVPQDSHLWRGNETHELLLP 572
              :|||....|.....|.:.|.|:....:...::..: :||              |..|.:   |
  Rat   780 --VLATWLPLPGHGLDTGSQSTPMEAHGVTMSVEPTV-ALE--------------GGATKD---P 824

  Fly   573 IVTTEHCKPDEHCVPNVLTWRGEAEIQSGDILIVEINDAMLNPSHEPNNTSSAVHATQVYQVTRS 637
            :..|....|            ...:..||.               ||.::.|:.|..    ||.:
  Rat   825 MEATMDVVP------------STVDATSGS---------------EPKSSISSTHVV----VTAA 858

  Fly   638 GHEHCDVTEGVLLDITPLVVDGR-----KLVTLYD------KDLTEGVNLLIVVSE-----LWGA 686
            |.:....       :||...:|:     .|.||..      ..|...::.:..||.     ||..
  Rat   859 GDQGTPT-------LTPTSSEGQVVAQESLGTLTSLPSHPWSSLASSMDEVASVSSGEPTGLWDI 916

  Fly   687 QCVRLKVTTKTDNCGENADCSGKGVCYSNSGMEEYECQCCSGFAGPHCEEIDACNPSPCTNNGIC 751
            ....:.|:...|.       |...|...:.|:|.:..:..||...|    .|.|..:||.:.|.|
  Rat   917 PSTLIPVSLGLDE-------SDLKVVAESPGLEGFWEEVASGQEDP----TDPCENNPCLHGGTC 970

  Fly   752 VDLSQGHEGNSYQCLCPYGYAGKNCQYESDPCNPAECMNGGSCVGNSTHFRCDCAPGFTGPLCQH 816
                 ...|..|.|.|..||||:||:.:.|.|..:.|.|||:
  Rat   971 -----RTNGTMYGCSCDQGYAGENCEIDIDDCLCSPCENGGT----------------------- 1007

  Fly   817 SLNECESSPCVHGICVDQEDGFRCFCQPGFAGELCNFEYNECESNPCQNGGECIDHIGSYECRCT 881
                          |:|:.:||.|.|.|.:.|.||     |.::..|..|..      .::..|.
  Rat  1008 --------------CIDEVNGFICLCLPSYGGNLC-----EKDTEGCDRGWH------KFQGHCY 1047

  Fly   882 KGFSGNR--------CQIKVDFCANKPCPEGHRCID---HGNDF 914
            :.|:..|        |:.:.....:...||.|:.|:   |.|.:
  Rat  1048 RYFAHRRAWEDAERDCRRRAGHLTSVHSPEEHKFINSFGHENSW 1091

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wry	NP_995611.2	EGF_CA	737..777	CDD:238011	15/39 (38%)
		EGF	783..812	CDD:278437	5/28 (18%)
		EGF_CA	819..851	CDD:238011	8/31 (26%)
		EGF_CA	856..890	CDD:238011	6/41 (15%)
		EGF_CA	893..927	CDD:238011	6/25 (24%)
		EGF_CA	<941..970	CDD:238011
Ncan	NP_113841.2	Ig	50..160	CDD:299845
		Link_domain_CSPGs_modules_1_3	159..253	CDD:239594
		Link_domain_CSPGs_modules_2_4	260..355	CDD:239597
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	361..391
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	453..499		14/55 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	556..616		14/73 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	689..713		9/24 (38%)
		EGF	959..989	CDD:278437	13/34 (38%)
		EGF_CA	993..1029	CDD:238011	16/77 (21%)
		CLECT	1035..1158	CDD:295302	12/63 (19%)
		CCP	1162..1218	CDD:153056
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1221..1263
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910