DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wry and notch3

DIOPT Version :9

Sequence 1:NP_995611.2 Gene:wry / 33361 FlyBaseID:FBgn0051665 Length:1157 Species:Drosophila melanogaster
Sequence 2:NP_571624.2 Gene:notch3 / 58066 ZFINID:ZDB-GENE-000329-5 Length:2468 Species:Danio rerio


Alignment Length:546 Identity:156/546 - (28%)
Similarity:203/546 - (37%) Gaps:192/546 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   520 AANPTKTASKPIARPRILSRLQEKINSLECEIPNVPQDSHLWRGNETHELLLPIVTTEHCKPDE- 583
            |:.|.:..:|.|.||          |..||            |..|..|..|.....::||||. 
Zfish   488 ASTPCQNGAKCIDRP----------NGYEC------------RCAEGFEGRLCESNIDNCKPDPC 530

  Fly   584 --------------HCVPNVLTWRGEAEIQSGDILIVEINDAMLNPSHEPNNTSSAVHATQVYQV 634
                          :|.|....:|.|.          ::|:...||                   
Zfish   531 HHGTCVDGIASYTCNCEPGYTGYRCEN----------QLNECHSNP------------------- 566

  Fly   635 TRSGHEHCDVTEGVLLDITPLVVDGRKLVTLYDKDL------TEGVNLLIVVSELWGAQCVRLKV 693
                   |.              :|.|.|.|.:|.:      |.|.|..|               
Zfish   567 -------CQ--------------NGGKCVDLVNKYICQCQHGTSGTNCEI--------------- 595

  Fly   694 TTKTDNCGENADCSGKGVCYSNSGMEEYECQCCSGFAGPHC-EEIDACNPSPCTNNGICVDLSQG 757
              ..|:|..| .|. .|:|  ..|:..|||.|..||.||.| :|||.|..:||.|.|.|||...|
Zfish   596 --NFDDCASN-PCD-YGIC--KDGINRYECVCKPGFTGPQCKDEIDECQSNPCRNGGTCVDDENG 654

  Fly   758 H-----EG---------------------------NSYQCLCPYGYAGKNCQYESDPCNPAECMN 790
            .     ||                           |.|:|.|..|:.||||..:.:.|.|:.|.|
Zfish   655 FHCQCPEGFHDPYCYSQVDECASNPCLHGTCRDDPNGYRCDCEPGWVGKNCDLDRNDCLPSPCQN 719

  Fly   791 GGSCVGNSTHFRCDCAPGFTGPLCQHSLNECESSPCV---------------------------- 827
            .|:|......|.|.|..||.|.|||.::|||.||||:                            
Zfish   720 AGTCFDQLNGFTCKCRQGFRGNLCQVNINECASSPCLNQGTCVDGVASFTCLCEPPYSGPTCAEL 784

  Fly   828 -----------HGICVDQED--GFRCFCQPGFAGELCNFEYNECESNPCQNGGECIDHIGSYECR 879
                       |..||...|  |::|.||||:.|.|||.:.|||.||||:|.|.|.:.:|.|.|.
Zfish   785 LTPCSPNPCANHASCVHTPDYLGYQCNCQPGWQGHLCNNDINECTSNPCKNRGTCTNTLGGYVCS 849

  Fly   880 CTKGFSGNRCQIKVDFCANKPCPEGHRCIDHGNDFSCECPGGRNGPDCNQMPRTYFQQCNVNPCT 944
            |..|::|..|:..::.|:..||..|..|.|..|.|.|.|..|..|..|    .|...:|...||.
Zfish   850 CRAGYTGPNCETDINDCSPNPCLNGGSCTDGVNSFRCSCLPGFTGARC----ATELNECQSVPCK 910

  Fly   945 HGGTCWSSGDSFYCACRPGYTGTMCE 970
            :||||....:|:.|.|:||:||.:||
Zfish   911 NGGTCTDYVNSYTCTCKPGFTGLLCE 936

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wryNP_995611.2 EGF_CA 737..777 CDD:238011 21/71 (30%)
EGF 783..812 CDD:278437 11/28 (39%)
EGF_CA 819..851 CDD:238011 18/72 (25%)
EGF_CA 856..890 CDD:238011 16/33 (48%)
EGF_CA 893..927 CDD:238011 12/33 (36%)
EGF_CA <941..970 CDD:238011 13/28 (46%)
notch3NP_571624.2 EGF_CA 97..131 CDD:238011
EGF_CA 134..171 CDD:238011
EGF_CA 212..247 CDD:238011
EGF_CA 250..287 CDD:238011
EGF_CA 290..325 CDD:238011
EGF_CA 367..405 CDD:238011
EGF_CA 407..443 CDD:238011
EGF_CA 445..481 CDD:238011
EGF_CA 483..519 CDD:238011 13/52 (25%)
EGF_CA 521..556 CDD:238011 7/34 (21%)
EGF_CA 560..594 CDD:238011 12/73 (16%)
EGF_CA 596..631 CDD:238011 15/38 (39%)
EGF_CA 634..668 CDD:238011 13/33 (39%)
EGF_CA 672..705 CDD:238011 7/32 (22%)
EGF_CA 708..744 CDD:238011 13/35 (37%)
EGF_CA 746..781 CDD:238011 7/34 (21%)
EGF_CA 824..860 CDD:238011 16/35 (46%)
EGF_CA 862..897 CDD:238011 12/34 (35%)
EGF_CA 902..936 CDD:238011 14/33 (42%)
EGF_CA 938..974 CDD:238011
EGF_CA 977..1012 CDD:238011
EGF_CA 1015..1050 CDD:238011
EGF_CA 1103..1137 CDD:238011
EGF_CA 1140..1175 CDD:238011
EGF_CA <1193..1220 CDD:238011
EGF_CA 1222..1260 CDD:238011
Notch 1392..1423 CDD:278494
Notch 1429..1462 CDD:278494
Notch 1475..1502 CDD:278494
NOD 1508..1559 CDD:284282
NODP 1577..1634 CDD:284987
ANKYR <1784..1896 CDD:223738
ANK <1784..1895 CDD:238125
ANK repeat 1791..1839 CDD:293786
ANK repeat 1841..1872 CDD:293786
Ank_5 1861..1916 CDD:290568
ANK 1869..1995 CDD:238125
ANK repeat 1875..1906 CDD:293786
ANK repeat 1908..1939 CDD:293786
Ank_2 1913..2005 CDD:289560
ANK 1936..2057 CDD:238125
ANK repeat 1941..1972 CDD:293786
ANK repeat 1974..2005 CDD:293786
Ank_2 1979..>2039 CDD:289560
Amelogenin 2232..2325 CDD:197891
DUF3454 2384..2445 CDD:288764
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 46 1.000 Domainoid score I12101
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D7525at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.920

Return to query results.
Submit another query.