DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wry and dll4

DIOPT Version :9

Sequence 1:	NP_995611.2	Gene:	wry / 33361	FlyBaseID:	FBgn0051665	Length:	1157	Species:	Drosophila melanogaster
Sequence 2:	NP_001073304.1	Gene:	dll4 / 563920	ZFINID:	ZDB-GENE-041014-73	Length:	683	Species:	Danio rerio

Alignment Length:	366	Identity:	113/366 - (30%)
Similarity:	168/366 - (45%)	Gaps:	59/366 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   698 DNCGE-NADCSGKGVCYSNSGME--------EY------------ECQCCSGFAGPHC-EEIDAC 740
            :.|.| |.:||..|.|....|.:        .|            :|.|..|:.|..| ::::.|
Zfish   217 EGCSEANGNCSKPGECVCREGWQGKFCTECKTYPACKHGTCHLPGQCNCKEGWGGLFCDQDLNFC 281

  Fly   741 -NPSPCTNNGICVDLSQGHEGNSYQCLCPYGYAGKNCQYESDPCNPAECMNGGSCVGNSTHFRCD 804
             :..||.|...|::..||    ||.|:|..||.|.||:.:...|:.:...|||.|..:...:.|.
Zfish   282 THHKPCVNGATCMNTGQG----SYTCICRPGYTGVNCELQVRECDSSPRKNGGLCTDHDKSYTCT 342

  Fly   805 CAPGFTGPLCQHSLNECESSPCVH-GICVDQEDG--FRCFCQPGFAGELCNFEYNECESNPCQNG 866
            |.|.|.|..|:|||..|..|||.| |.|.::::|  :.|.|..|:.|..|....::|.|..|.|.
Zfish   343 CLPDFEGTHCEHSLLTCADSPCFHKGRCHEKDNGRSYACECPLGYTGLNCERRMDKCTSMLCAND 407

  Fly   867 GECIDHIGSYECRCTKGFSGNRCQIKVDFCANKPCPEGHRCIDHGNDFSCECPGGRNGPDCNQMP 931
            |.|:...|...|.|..||:|.||:|.::.|||.||..|..|.|..|::.|.||.|..|.:|::
Zfish   408 GLCLILGGKRICSCRAGFTGQRCEININDCANNPCANGGTCYDRINEYVCSCPPGYKGRNCDR-- 470

  Fly   932 RTYFQQCNVNPCTHGGTCWS-SGDSFYCACRPGYTGTMCEDEFVVETVVSSSEFIVDDANARNFN 995
                ..|...||.:||:|.. :|:...|.|..|:||.:|| .:.|...|:..|          ..
Zfish   471 ----PSCLSTPCLNGGSCVGITGNPPACFCPSGFTGPLCE-YYAVTAPVTRGE----------TQ 520

  Fly   996 DKTFGSSVVLKSPIELHNAYFAAGVLAAAIFIVAVVVTICH 1036
            |:...::|.|           |.|::|..:.:..||:.:.|
Zfish   521 DRFQWAAVSL-----------AVGLVALVVLLCMVVIALRH 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wry	NP_995611.2	EGF_CA	737..777	CDD:238011	15/40 (38%)
		EGF	783..812	CDD:278437	9/28 (32%)
		EGF_CA	819..851	CDD:238011	12/34 (35%)
		EGF_CA	856..890	CDD:238011	13/33 (39%)
		EGF_CA	893..927	CDD:238011	14/33 (42%)
		EGF_CA	<941..970	CDD:238011	11/29 (38%)
dll4	NP_001073304.1	MNNL	22..83	CDD:284966
		DSL	148..210	CDD:279722
		EGF_CA	277..315	CDD:238011	15/41 (37%)
		EGF_CA	433..468	CDD:238011	14/34 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000