DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wry and crb1

DIOPT Version :9

Sequence 1:	NP_995611.2	Gene:	wry / 33361	FlyBaseID:	FBgn0051665	Length:	1157	Species:	Drosophila melanogaster
Sequence 2:	NP_001038408.1	Gene:	crb1 / 560942	ZFINID:	ZDB-GENE-050208-382	Length:	1428	Species:	Danio rerio

Alignment Length:	314	Identity:	107/314 - (34%)
Similarity:	146/314 - (46%)	Gaps:	38/314 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   681 SELWGAQCVRLKVTTKTDNCGENADCSGKGVCYSNSGMEEYECQCCSGFAGPHCE-EIDACNPSP 744
            |.|.|..|:.........:||::|.|  ..|...:.|   |.|.|..|:.|..|| |:|.|:|:|
Zfish   107 SGLLGQDCLSSAQLCAQGHCGDSAHC--LAVRDQSPG---YACICQEGYTGRSCEKEVDHCSPNP 166

  Fly   745 CTNNGICVDLSQGHEGNSYQCLCPYGYAGKNCQYESDPCNPAECMNGGSCVGNSTHFRCDCAPGF 809
            |.|..||     ....|...|.|..|:.|:.|:.|.:.|....|.||.:||....|:.|.|.||:
Zfish   167 CRNRAIC-----RSRRNGPTCFCVPGFQGQLCEIEVNECVSRPCRNGATCVDKIGHYICLCRPGY 226

  Fly   810 TGPLCQHSLNECESSPCVHGI-CVDQEDGFRCFCQPGFAGELCNFEYNECESNPCQNGGECIDHI 873
            .|..|:..::||:|.||:||. |.|..:||.|.|..||.||.|....:||...|||||..|:|.|
Zfish   227 MGSSCELEIDECQSQPCLHGASCHDHINGFTCTCLAGFQGESCEINIDECRDQPCQNGALCVDEI 291

  Fly   874 GSYECRC--TKGFSGNRCQIKVDFCANKPCPEGHRCIDHGNDFSCECPGGRNGPDCNQMPRTYFQ 936
            .||.|.|  |..|:|..|:|....|.::||.....|.|...:::|.|..|..|.:|    .....
Zfish   292 NSYRCDCSQTANFTGVDCEIPPPPCWSQPCLNSALCEDQQENYTCNCWPGFEGRNC----EVDVS 352

  Fly   937 QCNVNPCTHGGTC----WSS----------------GDSFYCACRPGYTGTMCE 970
            :|..:||.:.|.|    |.:                ...|.|.|.||::|.:||
Zfish   353 ECESSPCVNEGICMELSWKTLYGTEPLFTARYNPRLASGFICKCPPGFSGALCE 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wry	NP_995611.2	EGF_CA	737..777	CDD:238011	13/39 (33%)
		EGF	783..812	CDD:278437	11/28 (39%)
		EGF_CA	819..851	CDD:238011	17/32 (53%)
		EGF_CA	856..890	CDD:238011	17/35 (49%)
		EGF_CA	893..927	CDD:238011	9/33 (27%)
		EGF_CA	<941..970	CDD:238011	11/48 (23%)
crb1	NP_001038408.1	EGF_CA	159..194	CDD:238011	13/39 (33%)
		EGF_CA	197..232	CDD:238011	12/34 (35%)
		EGF_CA	235..270	CDD:238011	17/34 (50%)
		EGF_CA	272..310	CDD:238011	17/37 (46%)
		EGF_CA	<320..348	CDD:238011	9/31 (29%)
		EGF_CA	413..441	CDD:214542
		EGF_CA	457..492	CDD:238011
		LamG	496..651	CDD:238058
		EGF_CA	676..709	CDD:238011
		Laminin_G_2	746..863	CDD:280389
		EGF_CA	896..927	CDD:238011
		Laminin_G_2	983..1113	CDD:280389
		EGF	1151..1181	CDD:278437
		EGF_CA	1320..1354	CDD:238011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11644
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910