DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wry and DLL4

DIOPT Version :10

Sequence 1:NP_995611.2 Gene:wry / 33361 FlyBaseID:FBgn0051665 Length:1157 Species:Drosophila melanogaster
Sequence 2:NP_061947.1 Gene:DLL4 / 54567 HGNCID:2910 Length:685 Species:Homo sapiens


Alignment Length:292 Identity:103/292 - (35%)
Similarity:143/292 - (48%) Gaps:27/292 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   700 CGENADC------SGK--GVCYSNSGMEE------YECQCCSGFAGPHC-EEIDAC-NPSPCTNN 748
            |.:.|:|      .|:  ..|..::|...      ::|.|..|:.|..| ::::.| :.|||.|.
Human   233 CSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNG 297

  Fly   749 GICVDLSQGHEGNSYQCLCPYGYAGKNCQYESDPCNPAECMNGGSCVGNSTHFRCDCAPGFTGPL 813
            ..|.:..|    .||.|.|..||.|.:|:.|...|:...|.|||||......:.|.|.||:.|..
Human   298 ATCSNSGQ----RSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLH 358

  Fly   814 CQHSLNECESSPCVH-GICVDQEDG--FRCFCQPGFAGELCNFEYNECESNPCQNGGECIDHIGS 875
            |:||...|..|||.: |.|.::..|  :.|.|.|.|.|..|..:.:.|.||||.|||:|::...|
Human   359 CEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPS 423

  Fly   876 YECRCTKGFSGNRCQIKVDFCANKPCPEGHRCIDHGNDFSCECPGGRNGPDCNQMPRTYFQQCNV 940
            ..|||..||:|..|::.|..||..||..|..|.|..|...|.||.|.:|..|.  .||....|..
Human   424 RMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCE--VRTSIDACAS 486

  Fly   941 NPCTHGGTCWS--SGDSFYCACRPGYTGTMCE 970
            :||.:..||::  |.|:|.|.|..|:.|:.||
Human   487 SPCFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wryNP_995611.2 EGF_CA 737..777 CDD:238011 14/40 (35%)
EGF 783..812 CDD:394967 11/28 (39%)
EGF_CA 819..851 CDD:238011 12/34 (35%)
EGF_CA 856..890 CDD:238011 16/33 (48%)
EGF_CA 893..927 CDD:238011 14/33 (42%)
EGF 938..966 CDD:394967 11/29 (38%)
DLL4NP_061947.1 MNNL 27..173 CDD:462222
DSL 175..220 CDD:460202
Interaction with Notch1. /evidence=ECO:0000250|UniProtKB:D3ZHH1 185..187
Interaction with Notch1. /evidence=ECO:0000250|UniProtKB:D3ZHH1 191..195
EGF_CA 284..322 CDD:238011 14/41 (34%)
EGF_CA 327..360 CDD:238011 12/32 (38%)
EGF_CA 403..438 CDD:238011 16/34 (47%)
EGF_CA <447..476 CDD:238011 11/28 (39%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.