DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wry and NOTCH4

DIOPT Version :9

Sequence 1:	NP_995611.2	Gene:	wry / 33361	FlyBaseID:	FBgn0051665	Length:	1157	Species:	Drosophila melanogaster
Sequence 2:	NP_004548.3	Gene:	NOTCH4 / 4855	HGNCID:	7884	Length:	2003	Species:	Homo sapiens

Alignment Length:	618	Identity:	149/618 - (24%)
Similarity:	214/618 - (34%)	Gaps:	204/618 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   549 CEIPNVPQDSHLWRGNETHELLLPI----------------------VTTEHC--KPDEHCVPNV 589
            |:.|:..|::.|.:...:.:.|||.                      .|.|.|  |.::.|.|:.
Human    62 CQFPDPCQNAQLCQNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSF 126

  Fly   590 LTWRGEAEIQ------------------------------SGDILIV------------------ 606
            .:.||...||                              :|.:.:.
Human   127 CSKRGRCHIQASGRPQCSCMPGWTGEQCQLRDFCSANPCVNGGVCLATYPQIQCHCPPGFEGHAC 191

  Fly   607 --EINDAMLNPSHEPNNTSSAVHATQVYQVTRSGHEHCDVTEGVLLDITPLVVDGRK-------- 661
              ::|:...:|...|..||                  |..|.|....:.|:..:|.:
Human   192 ERDVNECFQDPGPCPKGTS------------------CHNTLGSFQCLCPVGQEGPRCELRAGPC 238

  Fly   662 ----------LVTLYDKDLTEGVNLLIVVSELWGAQCVRLKVTTKTDN----------------- 699
                      ...:.:||.|  .:|.:......|..|     ....||
Human   239 PPRGCSNGGTCQLMPEKDST--FHLCLCPPGFIGPDC-----EVNPDNCVSHQCQNGGTCQDGLD 296

  Fly   700 --------------CGENAD---------CSGKGVCYSNSGMEEYECQCCSGFAGPHCEE-IDAC 740
                          |.|:.|         |...|.|.:::|  .:.|.|.||:.|..||| :|.|
Human   297 TYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAG--SFHCVCVSGWGGTSCEENLDDC 359

  Fly   741 NPSPCTNNGICVD------------------------LSQGHEGN----------SYQCLCPYGY 771
            ..:.|.....|:|                        |||...|:          |..|||..||
Human   360 IAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGY 424

  Fly   772 AGKNCQYESDPC-----NPAECMNGGSCVGNSTHFRCDCAPGFTGPLCQHSLNECESSPCVHG-I 830
            :|..|..:.|.|     .|:.|.:||||:.....|.|.|.||:||..|:...|||.|.||..| .
Human   425 SGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNECLSQPCHPGST 489

  Fly   831 CVDQEDGFRCFCQPGFAGELCNFEYNECESNPCQNGGECIDHIGSYECRCTKGFSGNRCQIKVDF 895
            |:|....|.|.|.||..|:||..|.|||.|.||.|..:|.|.:..::|.|..||||.||:..:|.
Human   490 CLDLLATFHCLCPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDE 554

  Fly   896 CANKPCPEGHRCIDHGNDFSCECPGGRNGPDCNQMPRTYFQQCNVNPCTHGGTCWSSGDSFYCAC 960
            |.:.||..|.:|.|....|.|:|..|..||.|    :|...:|..:||..|.:|.....:|:|.|
Human   555 CRSSPCANGGQCQDQPGAFHCKCLPGFEGPRC----QTEVDECLSDPCPVGASCLDLPGAFFCLC 615

  Fly   961 RPGYTGTMCEDEFVVETVVSSSEFIVDDANARN 993
            ..|:||.:||.......:....:...|..:..|
Human   616 PSGFTGQLCEVPLCAPNLCQPKQICKDQKDKAN 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wry	NP_995611.2	EGF_CA	737..777	CDD:238011	16/73 (22%)
		EGF	783..812	CDD:278437	13/33 (39%)
		EGF_CA	819..851	CDD:238011	15/32 (47%)
		EGF_CA	856..890	CDD:238011	16/33 (48%)
		EGF_CA	893..927	CDD:238011	13/33 (39%)
		EGF_CA	<941..970	CDD:238011	10/28 (36%)
NOTCH4	NP_004548.3	EGF_CA	194..232	CDD:238011	10/55 (18%)
		EGF_CA	314..353	CDD:238011	10/40 (25%)
		EGF_CA	432..473	CDD:238011	15/40 (38%)
		EGF_CA	475..511	CDD:238011	16/35 (46%)
		EGF_CA	515..549	CDD:238011	16/33 (48%)
		EGF_CA	551..587	CDD:238011	14/39 (36%)
		EGF_CA	590..625	CDD:238011	11/34 (32%)
		EGF_CA	<699..726	CDD:238011
		EGF_CA	<736..765	CDD:238011
		EGF_CA	769..803	CDD:238011
		EGF_CA	<899..928	CDD:238011
		EGF_CA	931..965	CDD:238011
		EGF_CA	970..1004	CDD:238011
		Notch	1165..1203	CDD:321927
		LNR 1	1170..1213
		NL	1207..1245	CDD:197463
		LNR 2	1214..1250
		Notch	1249..1285	CDD:306554
		LNR 3	1251..1294
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1347..1371
		NODP	1380..>1420	CDD:311559
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1485..1508
		ANK	1586..1721	CDD:238125
		ANK repeat	1586..1630	CDD:293786
		ANK 1	1633..1665
		ANK repeat	1634..1664	CDD:293786
		ANK	1661..1787	CDD:238125
		ANK repeat	1666..1698	CDD:293786
		ANK 2	1666..1698
		ANK 3	1700..1732
		ANK repeat	1700..1731	CDD:293786
		ANK 4	1733..1765
		ANK repeat	1733..1764	CDD:293786
		Ank_5	1753..>1851	CDD:330893
		ANK 5	1766..1798
		ANK repeat	1766..1797	CDD:293786
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1900..1927
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1968..2003
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D7525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010