DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wry and NOTCH2

DIOPT Version :9

Sequence 1:NP_995611.2 Gene:wry / 33361 FlyBaseID:FBgn0051665 Length:1157 Species:Drosophila melanogaster
Sequence 2:NP_077719.2 Gene:NOTCH2 / 4853 HGNCID:7882 Length:2471 Species:Homo sapiens


Alignment Length:496 Identity:141/496 - (28%)
Similarity:197/496 - (39%) Gaps:156/496 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   561 WRGNETHELLLPIVTTEHCKPDEHCVPNVLTW-----RGEAEIQSGDILIVEINDAML-NPSHEP 619
            |.|::..|.:....... |.|...|:..|.::     .|:|.      |:..::||.: ||.|  
Human   330 WSGDDCSENIDDCAFAS-CTPGSTCIDRVASFSCMCPEGKAG------LLCHLDDACISNPCH-- 385

  Fly   620 NNTSSAVHATQVYQVTRSGHEHCDVTEGVLLDITPLVVDGRKLVTLYDKDLTEGVNLLIVVSELW 684
                                      :|.|.|..||  :|:.:.|     ..:|..         
Human   386 --------------------------KGALCDTNPL--NGQYICT-----CPQGYK--------- 408

  Fly   685 GAQCVRLKVTTKTDNC--GENADCSGKGVCYSNSGMEEYECQCCSGFAGPHCE------------ 735
            ||.|     |...|.|  ..:..|...|.|.:..|  .:.|:|..|:|||.||            
Human   409 GADC-----TEDVDECAMANSNPCEHAGKCVNTDG--AFHCECLKGYAGPRCEMDINECHSDPCQ 466

  Fly   736 ---------------------------EIDACNPSPCTNNGICVDLSQGHEGNSYQCLCPYGYAG 773
                                       ||:.|..:||.|||.|||     :.|.:|||||.|:.|
Human   467 NDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVD-----KVNRFQCLCPPGFTG 526

  Fly   774 KNCQYESDPCNPAECMNGGSCVGNSTHFRCDCAPGFTGPLCQHSLNECESSPCVHGICVDQEDGF 838
            ..||.:.|.|:...|:||..|:.:...:.|.||.||||.||:.:::.|:..||.||.|.|..|.:
Human   527 PVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSY 591

  Fly   839 RCFCQPGFAGELCNFEYNECESNPCQNGGECIDHIGSYECR------------------------ 879
            .|.|.||:.|.:|:.:.:||.|:||.|.|.|||.:..|:|.                        
Human   592 TCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIH 656

  Fly   880 -------------CTKGFSGNRCQIKVDFCANKPCPEGHRCIDHGNDFSCECPGGRNGPDCNQMP 931
                         |:.||:|.||.|.:|.||:.||.:|..||:..|.|.|.||.|.:.|.|    
Human   657 GICMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSC---- 717

  Fly   932 RTYFQ--QCNVNPCTHGGTCWSSGDSFYCACRPGYTGTMCE 970
              |.|  :|..|||.| |.|......:.|.|..|:.|..||
Human   718 --YSQVNECLSNPCIH-GNCTGGLSGYKCLCDAGWVGINCE 755

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wryNP_995611.2 EGF_CA 737..777 CDD:238011 18/39 (46%)
EGF 783..812 CDD:278437 11/28 (39%)
EGF_CA 819..851 CDD:238011 13/31 (42%)
EGF_CA 856..890 CDD:238011 17/70 (24%)
EGF_CA 893..927 CDD:238011 15/33 (45%)
EGF_CA <941..970 CDD:238011 10/28 (36%)
NOTCH2NP_077719.2 EGF_CA 182..218 CDD:238011
EGF_CA 260..296 CDD:238011
EGF_CA 298..335 CDD:238011 2/4 (50%)
EGF_CA 415..454 CDD:238011 12/40 (30%)
EGF_CA 456..492 CDD:238011 0/35 (0%)
EGF_CA 495..530 CDD:238011 18/39 (46%)
EGF_CA 532..568 CDD:238011 14/35 (40%)
EGF_CA 570..604 CDD:238011 13/33 (39%)
EGF_CA 608..643 CDD:238011 12/34 (35%)
EGF_CA 645..679 CDD:238011 4/33 (12%)
EGF_CA 682..717 CDD:238011 15/34 (44%)
EGF_CA 757..793 CDD:238011
EGF_CA 795..831 CDD:238011
EGF_CA 873..909 CDD:238011
EGF_CA 911..947 CDD:238011
EGF_CA 949..985 CDD:238011
EGF_CA 987..1022 CDD:238011
EGF_CA 1026..1061 CDD:238011
EGF_CA 1117..1147 CDD:238011
EGF_CA 1151..1185 CDD:238011
EGF_CA 1188..1223 CDD:238011
EGF_CA 1225..1262 CDD:238011
EGF_CA 1264..1302 CDD:238011
EGF_CA <1312..1343 CDD:238011
Notch 1423..1456 CDD:278494
Notch 1463..1497 CDD:278494
Notch 1501..1534 CDD:278494
NOD 1540..1591 CDD:284282
NODP 1620..1673 CDD:284987
Ank_2 <1820..1907 CDD:289560
ANK repeat 1827..1874 CDD:293786
ANK 1872..1997 CDD:238125
ANK repeat 1877..1907 CDD:293786
Ank_2 1881..1974 CDD:289560
ANK 1938..2062 CDD:238125
ANK repeat 1943..1974 CDD:293786
Ank_2 1948..2040 CDD:289560
ANK repeat 1976..2007 CDD:293786
ANK repeat 2009..2040 CDD:293786
Chorion_3 <2292..2421 CDD:253174
DUF3454 2381..2444 CDD:288764
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D7525at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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