DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wry and crb

DIOPT Version :9

Sequence 1:	NP_995611.2	Gene:	wry / 33361	FlyBaseID:	FBgn0051665	Length:	1157	Species:	Drosophila melanogaster
Sequence 2:	NP_001247284.1	Gene:	crb / 42896	FlyBaseID:	FBgn0259685	Length:	2253	Species:	Drosophila melanogaster

Alignment Length:	843	Identity:	196/843 - (23%)
Similarity:	302/843 - (35%)	Gaps:	249/843 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   432 PTTTTAAGSTATTTAESTT---------TAATTTRLPATTTGKYQKELKRAKLLLKALT----PP 483
            |||||.......||...||         |..|||::|..||         ::.|:...|    ||
  Fly   533 PTTTTPTPEQEPTTTPRTTPNPNPAIPNTLTTTTKIPPITT---------SRTLVGTTTGSRRPP 588

  Fly   484 KSVDKSTASPSSTTS-----------TSTSTTTTMATLLATARTRPSAANPTKTASKPIARPRIL 537
            :...:|....|::.:           |....:...:.:.|:..|..:....|...:..:|
  Fly   589 QQPLQSPTQRSASLNACPQENCLNGGTCLGYSGNYSCICASGYTGYNCQTSTGDGASALA----- 648

  Fly   538 SRLQEKINSLECEIPNVPQDSHLWRG----NETHELLLPIVTTEHCKPDEHCVPNVLTWRGEAEI 598
                  :..:.|   |......|..|    |.||.......:.:.|:..|:|.|          :
  Fly   649 ------LTPINC---NATNGKCLNGGTCSMNGTHCYCAVGYSGDRCEKAENCSP----------L 694

  Fly   599 QSGDILIVEINDAMLNPSHEPNNTSSAVHATQVYQVTRSGHEHCDVTEGVLLDITPLVVDGRKLV 663
            ...:.::...|..:.     |.|......|||..|   :|.|..|:..|.
  Fly   695 NCQEPMVCVQNQCLC-----PENKVCNQCATQPCQ---NGGECVDLPNGD--------------- 736

  Fly   664 TLYDKDLTEGVNLLIVVSELW-GAQCVRLKVTTKTDNCGENADCSGKGVCYSNSGMEEYECQCCS 727
              |:...|.|          | |..|     ....|.|..:....|.|:|.:..|  .|:|.|..
  Fly   737 --YECKCTRG----------WTGRTC-----GNDVDECTLHPKICGNGICKNEKG--SYKCYCTP 782

  Fly   728 GFAGPHCE-EIDACNPSPCTNNGICVDLSQGHEGNSYQCLCPYGYAGKNCQYESDPCNPAECMNG 791
            ||.|.||: ::|.|...||.|...|     .::.|:|:|:|..||.|:||:.:.|.|....|.||
  Fly   783 GFTGVHCDSDVDECLSFPCLNGATC-----HNKINAYECVCQPGYEGENCEVDIDECGSNPCSNG 842

  Fly   792 GSCVGNSTHFRCDCAPGFTGPLCQHSLNECESSPCVH-GICVDQEDGFRCFCQ-PGFAGELCNFE 854
            .:|:....:|.|:|.||.||.:|...:::|...||:: |.|:||..||||.|. .|:.||.|...
  Fly   843 STCIDRINNFTCNCIPGMTGRICDIDIDDCVGDPCLNGGQCIDQLGGFRCDCSGTGYEGENCELN 907

  Fly   855 YNECESNPCQNGGECIDHIGSYECRCTKGFSGNRCQIKVDFCANKPCPEGHRCIDHGN------- 912
            .:||.||||.||.:|:|.:..|.|.|..|:.|..|:..::.|.:.||.....|::..|
  Fly   908 IDECLSNPCTNGAKCLDRVKDYFCDCHNGYKGKNCEQDINECESNPCQYNGNCLERSNITLYQMS 972

  Fly   913 -------------------DFSCECPGGRNGPDCNQMPRTYFQQCNVNPCTHGGTCWSSGDSFYC 958
                               .:.|.|..|..|.:|    .....:|:.|||:..|.|.....::.|
  Fly   973 RITDLPKVFSQPFSFENASGYECVCVPGIIGKNC----EININECDSNPCSKHGNCNDGIGTYTC 1033

  Fly   959 ACRPGYTGTMCE------------------DEFVVETVVSSSEFIVDDANA---RNFNDKTFGSS 1002
            .|.||:.||.||                  |:             :||.:.   .|:..|  ..|
  Fly  1034 ECEPGFEGTHCEINIDECDRYNPCQRGTCYDQ-------------IDDYDCDCDANYGGK--NCS 1083

  Fly  1003 VVLKSPIELHNAYFAAGVLAAAIFIVAVVVTICHCKVNQTYR-----KFSTRS---TSFIPI--- 1056
            |:||...:  |.....|  |...:::..|..:.:|.....::     |.:|.|   ||.|.:
  Fly  1084 VLLKGCDQ--NPCLNGG--ACLPYLINEVTHLYNCTCENGFQGDKCEKTTTLSMVATSLISVTTE 1144

  Fly  1057 ------------------------LGFSRRP------KVQGKLNKH------------------- 1072
                                    .|....|      .:.|:||.|
  Fly  1145 REEGYDINLQFRTTLPNGVLAFGTTGEKNEPVSYILELINGRLNLHSSLLNKWEGVFIGSKLNDS 1209

  Fly  1073 -WLSGKGATATSSTNIVAPPGGPRAGGAAGPQQVTRHLPGQPQ-TQTTLGGQLQE-RPFLRHL 1132
             |  .|...|.:::::|......:|....|..:...:  .||. .:|.|||.:.. :.:||||
  Fly  1210 NW--HKVFVAINTSHLVLSANDEQAIFPVGSYETANN--SQPSFPRTYLGGTIPNLKSYLRHL 1268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wry	NP_995611.2	EGF_CA	737..777	CDD:238011	14/39 (36%)
		EGF	783..812	CDD:278437	11/28 (39%)
		EGF_CA	819..851	CDD:238011	15/33 (45%)
		EGF_CA	856..890	CDD:238011	15/33 (45%)
		EGF_CA	893..927	CDD:238011	9/59 (15%)
		EGF_CA	<941..970	CDD:238011	11/28 (39%)
crb	NP_001247284.1	LamG	91..228	CDD:238058
		EGF_CA	386..423	CDD:238011
		EGF_CA	425..460	CDD:238011
		EGF	466..495	CDD:278437
		EGF	605..633	CDD:278437	2/27 (7%)
		EGF_CA	716..750	CDD:238011	13/63 (21%)
		EGF_CA	753..789	CDD:238011	12/37 (32%)
		EGF_CA	792..828	CDD:238011	14/40 (35%)
		EGF_CA	830..865	CDD:238011	13/34 (38%)
		EGF_CA	868..905	CDD:238011	15/36 (42%)
		EGF_CA	907..943	CDD:238011	15/35 (43%)
		EGF_CA	1009..1045	CDD:238011	12/35 (34%)
		EGF_CA	1047..1082	CDD:238011	5/49 (10%)
		Laminin_G_1	1155..1290	CDD:278483	22/118 (19%)
		EGF	1316..1346	CDD:278437
		Laminin_G_1	1388..1550	CDD:278483
		EGF_CA	<1593..1622	CDD:238011
		Laminin_G_2	1692..1828	CDD:280389
		EGF_CA	1901..1937	CDD:238011
		EGF_CA	1939..1974	CDD:238011
		EGF_CA	2057..2094	CDD:238011
		EGF_CA	2096..2133	CDD:238011
		EGF_CA	2137..2175	CDD:238011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24044
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010