Protein Alignment wry and crb

DIOPT Version :10

• Sequence 1: NP_995611.2
• Gene: wry / 33361
• FlyBaseID: FBgn0051665
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: NP_001247284.1
• Gene: crb / 42896
• FlyBaseID: FBgn0259685
• Length: 2253
• Species: Drosophila melanogaster
• Alignment Length: 843
• Identity: 196/843 - (23%)
• Similarity: 302/843 - (35%)
• Gaps: 249/843 - (29%)

  Fly   432 PTTTTAAGSTATTTAESTT---------TAATTTRLPATTTGKYQKELKRAKLLLKALT----PP 483
            |||||.......||...||         |..|||::|..||         ::.|:...|    ||
  Fly   533 PTTTTPTPEQEPTTTPRTTPNPNPAIPNTLTTTTKIPPITT---------SRTLVGTTTGSRRPP 588

  Fly   484 KSVDKSTASPSSTTS-----------TSTSTTTTMATLLATARTRPSAANPTKTASKPIARPRIL 537
            :...:|....|::.:           |....:...:.:.|:..|..:....|...:..:|
  Fly   589 QQPLQSPTQRSASLNACPQENCLNGGTCLGYSGNYSCICASGYTGYNCQTSTGDGASALA----- 648

  Fly   538 SRLQEKINSLECEIPNVPQDSHLWRG----NETHELLLPIVTTEHCKPDEHCVPNVLTWRGEAEI 598
                  :..:.|   |......|..|    |.||.......:.:.|:..|:|.|          :
  Fly   649 ------LTPINC---NATNGKCLNGGTCSMNGTHCYCAVGYSGDRCEKAENCSP----------L 694

  Fly   599 QSGDILIVEINDAMLNPSHEPNNTSSAVHATQVYQVTRSGHEHCDVTEGVLLDITPLVVDGRKLV 663
            ...:.::...|..:.     |.|......|||..|   :|.|..|:..|.
  Fly   695 NCQEPMVCVQNQCLC-----PENKVCNQCATQPCQ---NGGECVDLPNGD--------------- 736

  Fly   664 TLYDKDLTEGVNLLIVVSELW-GAQCVRLKVTTKTDNCGENADCSGKGVCYSNSGMEEYECQCCS 727
              |:...|.|          | |..|     ....|.|..:....|.|:|.:..|  .|:|.|..
  Fly   737 --YECKCTRG----------WTGRTC-----GNDVDECTLHPKICGNGICKNEKG--SYKCYCTP 782

  Fly   728 GFAGPHCE-EIDACNPSPCTNNGICVDLSQGHEGNSYQCLCPYGYAGKNCQYESDPCNPAECMNG 791
            ||.|.||: ::|.|...||.|...|     .::.|:|:|:|..||.|:||:.:.|.|....|.||
  Fly   783 GFTGVHCDSDVDECLSFPCLNGATC-----HNKINAYECVCQPGYEGENCEVDIDECGSNPCSNG 842

  Fly   792 GSCVGNSTHFRCDCAPGFTGPLCQHSLNECESSPCVH-GICVDQEDGFRCFCQ-PGFAGELCNFE 854
            .:|:....:|.|:|.||.||.:|...:::|...||:: |.|:||..||||.|. .|:.||.|...
  Fly   843 STCIDRINNFTCNCIPGMTGRICDIDIDDCVGDPCLNGGQCIDQLGGFRCDCSGTGYEGENCELN 907

  Fly   855 YNECESNPCQNGGECIDHIGSYECRCTKGFSGNRCQIKVDFCANKPCPEGHRCIDHGN------- 912
            .:||.||||.||.:|:|.:..|.|.|..|:.|..|:..::.|.:.||.....|::..|
  Fly   908 IDECLSNPCTNGAKCLDRVKDYFCDCHNGYKGKNCEQDINECESNPCQYNGNCLERSNITLYQMS 972

  Fly   913 -------------------DFSCECPGGRNGPDCNQMPRTYFQQCNVNPCTHGGTCWSSGDSFYC 958
                               .:.|.|..|..|.:|    .....:|:.|||:..|.|.....::.|
  Fly   973 RITDLPKVFSQPFSFENASGYECVCVPGIIGKNC----EININECDSNPCSKHGNCNDGIGTYTC 1033

  Fly   959 ACRPGYTGTMCE------------------DEFVVETVVSSSEFIVDDANA---RNFNDKTFGSS 1002
            .|.||:.||.||                  |:             :||.:.   .|:..|  ..|
  Fly  1034 ECEPGFEGTHCEINIDECDRYNPCQRGTCYDQ-------------IDDYDCDCDANYGGK--NCS 1083

  Fly  1003 VVLKSPIELHNAYFAAGVLAAAIFIVAVVVTICHCKVNQTYR-----KFSTRS---TSFIPI--- 1056
            |:||...:  |.....|  |...:::..|..:.:|.....::     |.:|.|   ||.|.:
  Fly  1084 VLLKGCDQ--NPCLNGG--ACLPYLINEVTHLYNCTCENGFQGDKCEKTTTLSMVATSLISVTTE 1144

  Fly  1057 ------------------------LGFSRRP------KVQGKLNKH------------------- 1072
                                    .|....|      .:.|:||.|
  Fly  1145 REEGYDINLQFRTTLPNGVLAFGTTGEKNEPVSYILELINGRLNLHSSLLNKWEGVFIGSKLNDS 1209

  Fly  1073 -WLSGKGATATSSTNIVAPPGGPRAGGAAGPQQVTRHLPGQPQ-TQTTLGGQLQE-RPFLRHL 1132
             |  .|...|.:::::|......:|....|..:...:  .||. .:|.|||.:.. :.:||||
  Fly  1210 NW--HKVFVAINTSHLVLSANDEQAIFPVGSYETANN--SQPSFPRTYLGGTIPNLKSYLRHL 1268

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wry	NP_995611.2	EGF_CA	737..777	CDD:238011	14/39 (36%)
		EGF	783..812	CDD:394967	11/28 (39%)
		EGF_CA	819..851	CDD:238011	15/33 (45%)
		EGF_CA	856..890	CDD:238011	15/33 (45%)
		EGF_CA	893..927	CDD:238011	9/59 (15%)
		EGF	938..966	CDD:394967	10/27 (37%)
crb	NP_001247284.1	LamG	91..228	CDD:238058
		EGF	269..299	CDD:394967
		EGF_CA	<311..341	CDD:238011
		EGF_CA	386..423	CDD:238011
		EGF_CA	425..460	CDD:238011
		EGF	466..495	CDD:394967
		EGF	605..633	CDD:394967	2/27 (7%)
		EGF_CA	716..750	CDD:238011	13/63 (21%)
		EGF_CA	753..789	CDD:238011	12/37 (32%)
		EGF_CA	792..828	CDD:238011	14/40 (35%)
		EGF_CA	830..865	CDD:238011	13/34 (38%)
		EGF_CA	868..905	CDD:238011	15/36 (42%)
		EGF_CA	907..943	CDD:238011	15/35 (43%)
		EGF_CA	1009..1045	CDD:238011	12/35 (34%)
		EGF_CA	1047..1082	CDD:238011	5/49 (10%)
		Laminin_G_1	1155..1290	CDD:395008	22/118 (19%)
		EGF	1316..1346	CDD:394967
		Laminin_G_1	1388..1550	CDD:395008
		EGF_CA	<1593..1622	CDD:238011
		Laminin_G_2	1692..1828	CDD:460494
		EGF_CA	1901..1937	CDD:238011
		EGF_CA	1939..1974	CDD:238011
		EGF_CA	2057..2094	CDD:238011
		EGF_CA	2096..2133	CDD:238011
		EGF_CA	2137..2175	CDD:238011