DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wry and Notch4

DIOPT Version :9

Sequence 1:	NP_995611.2	Gene:	wry / 33361	FlyBaseID:	FBgn0051665	Length:	1157	Species:	Drosophila melanogaster
Sequence 2:	NP_001002827.1	Gene:	Notch4 / 406162	RGDID:	1303282	Length:	1961	Species:	Rattus norvegicus

Alignment Length:	588	Identity:	163/588 - (27%)
Similarity:	218/588 - (37%)	Gaps:	172/588 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   510 LLATARTRPSAANPTKTASKPIARPRILSRLQEKINSLECEIPNVPQDSHLWRGNETHELLLPIV 574
            ||.||   ||:.:||    .|:. |..............|:.|             ..||..|..
  Rat    80 LLPTA---PSSHSPT----SPLT-PHFSCTCPSGFTGDRCQSP-------------LEELCPPSF 123

  Fly   575 TTE--HC------KPDEHCVPNVLTWRGE-----------------------AEIQ-------SG 601
            .:.  ||      :|...|.|.   |.||                       .:||       .|
  Rat   124 CSNGGHCSVQVSGRPQCSCEPG---WTGEQCQLRDFCSANPCANGGVCLATYPQIQCRCPTGFEG 185

  Fly   602 DILIVEINDAMLNPSHEPNNTSSAVHATQ-----VYQVTRSGHEHCDVTEGVLLDITPLVVDGRK 661
            .|...::|:..|.|...|..||  .|.|.     :..|.:.|.: |.:.:|..|..|.|  :|..
  Rat   186 HICERDVNECFLEPGPCPRGTS--CHNTLGSFQCLCPVGQEGPQ-CKLRKGACLPGTCL--NGGT 245

  Fly   662 LVTLYDKDLT----------EGVNLLIVVSELWGAQCVRLKV-------------------TTKT 697
            ...:.:.|.|          .|:|     .|:....|||.:.                   |.|.
  Rat   246 CQLVPEGDTTFHLCLCPPGFTGLN-----CEMNPDDCVRNQCQNGATCQDGLGTYTCLCPKTWKG 305

  Fly   698 DNCGENAD---------CSGKGVCYSNSGMEEYECQCCSGFAGPHCEE-IDACNPSPCTNNGICV 752
            .:|.|:.|         |...|.|.:::|  .:.|.|.||:.|..|:| :|.|..:.|.....|:
  Rat   306 WDCSEDIDECEAQGPPRCRNGGTCQNSAG--GFHCVCVSGWGGEGCDENLDDCAAATCALGSTCI 368

  Fly   753 DLSQGHEGNSYQCLCP---------------------------------------YGYAGKNCQY 778
            |     ...|:.||||                                       .||:|..|..
  Rat   369 D-----RVGSFSCLCPPGRTGLLCHLEDMCLRQPCHVNAQCSTNPLTGSTLCICQPGYSGPTCHQ 428

  Fly   779 ESDPC-----NPAECMNGGSCVGNSTHFRCDCAPGFTGPLCQHSLNECESSPCVHG-ICVDQEDG 837
            :.|.|     .|:.|.:||||:.....|.|.|.||:||..|:...|||.|.||..| .|:|....
  Rat   429 DLDECQMAQQGPSPCEHGGSCINTPGSFNCLCLPGYTGSRCEADHNECLSQPCHPGSTCLDLLAT 493

  Fly   838 FRCFCQPGFAGELCNFEYNECESNPCQNGGECIDHIGSYECRCTKGFSGNRCQIKVDFCANKPCP 902
            |:|.|.||..|.||..|.|||.||||.|...|.|.:..:.|.|..||:|.||:..:|.|::.||.
  Rat   494 FQCLCPPGLEGRLCEVEINECASNPCLNQAACHDQLNGFLCLCLPGFTGARCEKDMDECSSAPCA 558

  Fly   903 EGHRCIDHGNDFSCECPGGRNGPDCNQMPRTYFQQCNVNPCTHGGTCWSSGDSFYCACRPGYTGT 967
            .|..|.|....|.|||..|..||.|    .|...:|..:||..|.:|.....:|.|.||||:||.
  Rat   559 NGGHCQDQPGAFHCECLPGFEGPRC----ETEADECRSDPCPVGASCLDLPGAFLCLCRPGFTGQ 619

  Fly   968 MCE 970
            :||
  Rat   620 LCE 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wry	NP_995611.2	EGF_CA	737..777	CDD:238011	13/78 (17%)
		EGF	783..812	CDD:278437	13/33 (39%)
		EGF_CA	819..851	CDD:238011	15/32 (47%)
		EGF_CA	856..890	CDD:238011	16/33 (48%)
		EGF_CA	893..927	CDD:238011	14/33 (42%)
		EGF_CA	<941..970	CDD:238011	12/28 (43%)
Notch4	NP_001002827.1	EGF_CA	191..>224	CDD:284955	9/34 (26%)
		EGF_CA	311..349	CDD:238011	10/39 (26%)
		EGF_CA	352..387	CDD:238011	10/39 (26%)
		EGF_CA	429..470	CDD:238011	15/40 (38%)
		EGF_CA	472..508	CDD:238011	16/35 (46%)
		EGF_CA	511..546	CDD:238011	16/34 (47%)
		EGF_CA	548..584	CDD:238011	15/39 (38%)
		EGF_CA	588..622	CDD:238011	13/33 (39%)
		EGF_CA	<696..723	CDD:238011
		EGF_CA	765..800	CDD:238011
		EGF_CA	<810..839	CDD:238011
		EGF_CA	892..924	CDD:238011
		EGF_CA	927..961	CDD:238011
		EGF_CA	966..1000	CDD:238011
		EGF_CA	1002..1040	CDD:238011
		Notch	1207..1242	CDD:278494
		Notch	1245..1281	CDD:278494
		NOD	1291..1337	CDD:284282
		NODP	1376..>1415	CDD:284987
		Ank_2	<1571..1656	CDD:289560
		ANK	1625..1732	CDD:238125
		ANK repeat	1626..1656	CDD:293786
		Ank_2	1630..1723	CDD:289560
		ANK repeat	1658..1690	CDD:293786
		ANK	1687..1811	CDD:238125
		ANK repeat	1692..1723	CDD:293786
		Ank_2	1697..1789	CDD:289560
		ANK repeat	1725..1756	CDD:293786
		ANK repeat	1758..1789	CDD:293786
		ANK repeat	1791..1827	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D7525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920