Protein Alignment wry and Dner

DIOPT Version :10

• Sequence 1: NP_995611.2
• Gene: wry / 33361
• FlyBaseID: FBgn0051665
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: NP_001386260.1
• Gene: Dner / 316573
• RGDID: 1359385
• Length: 746
• Species: Rattus norvegicus
• Alignment Length: 668
• Identity: 171/668 - (25%)
• Similarity: 269/668 - (40%)
• Gaps: 143/668 - (21%)

  Fly   481 TPPKSVDKS----TASPSSTTSTSTSTTTTMATLLATARTRPSAANP-------------TKTAS 528
            ||....|:.    .|.|..:.:.....:.|....:|.    |.|:||             :.::|
  Rat    60 TPRSVTDQEHPAVDAEPGYSCTCPAGVSGTDCQFVAD----PCASNPCHHGNCSSSSSSSSSSSS 120

  Fly   529 KPIARPRILSRLQEKINSLECE--IPNVPQDSHLWRGNETHELLLPIVTTEHCKPDEHCVPNVLT 591
            ...:....|....:....|.||  :|::|...  |..:.....|.|:..|:.        |:::.
  Rat   121 SSSSSDSYLCICNDGYEGLNCEQPLPSIPTSG--WTESMAPRQLQPVPATQE--------PDIIL 175

  Fly   592 WRGEAEI-------QSGDILI------VEI------NDAMLNPS--------HEPNNTSSAVH-- 627
            .|.:|.:       ::|..::      ||:      .:|..|.|        ..|.|||..:.
  Rat   176 PRSQATVTLPTWQPKTGQKVVEMKWDQVEVVPDVACGNASSNNSAGGRLVSFEVPQNTSVKIRQD 240

  Fly   628 ATQ----VYQVTRSGHEHCDVTEGVLLDITPLVVDGRKLVTLYDKDLTEGVNLLI-VVSELWGAQ 687
            ||.    :::||.:|.:.|.:.:|  ..:|||...|.  :.|.::.||.|.|..| .|::.....
  Rat   241 ATALLILLWKVTATGFQQCSLIDG--RSVTPLQAPGG--LVLLEEMLTLGPNHFIGFVNDSVAKS 301

  Fly   688 CVRLKVT--TKTDNC------GENADCSGKGVCYSNSGMEEYECQCCSGFAGPHCEEIDACNPSP 744
            .|.|::|  .|...|      ..:.:|||||.|.:......:.|.|...:.|..|||.|||...|
  Rat   302 IVALRLTLVVKASTCVPGDGHSNDIECSGKGKCATKPSEATFSCTCEDQYIGTFCEEFDACQRKP 366

  Fly   745 CTNNGICVDLSQGHEGNSYQCLCPYGYAGKNCQ-------------------------------- 777
            |.|...|:|.::..:|:::.|||..||.|:.||
  Rat   367 CQNEASCIDANEKQDGSNFTCLCLPGYTGELCQSKIDYCVLDPCRNGATCVSSLSGFTCQCLEGY 431

  Fly   778 ------YESDPCNPAECMNGGSCVGNSTHFRCDCAPGFTGPLCQHSLNECESSPCVHGICVDQED 836
                  .:.|||..:.|.|.|:|..:..||.|.|:||||||.|...::.|..|||.||:|.....
  Rat   432 FGSACEEKVDPCMSSPCQNNGTCYVDGVHFTCSCSPGFTGPTCAQLVDFCALSPCAHGMCRSVGT 496

  Fly   837 GFRCFCQPGFAGELCNFEYNECESNPCQNGGECIDHIGSYECRCTKGFSGNRCQIKVDFCANKPC 901
            .::|.|.||:.|..|..|||||.|.||.|...|.|.:..|||.|...:.|..|::..|.|||..|
  Rat   497 SYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANISC 561

  Fly   902 PEGHRCIDHGNDFSCECPGGRNGPDCNQMPRTYFQQCNVNPCTHGGTCWSSGDSFYCACRPGYTG 966
            ..|..|...|.:.:|.|..|..|.:|:    ....:|:.|||.|.|||....:.:.|.|..|:.|
  Rat   562 LNGGTCDSEGLNGTCICAPGFTGEECD----IDINECDSNPCHHAGTCLDQPNGYTCHCPHGWVG 622

  Fly   967 TMCEDEFVVETVVSSSEFIVDDANARNFNDKTFGSSVVLKSPIELHNAYFAAGVLAAAIFIVAVV 1031
            ..||.....::                      |......:.:..|:.|...|.|..|..::.::
  Rat   623 ANCEIHLQWKS----------------------GHMAESLTNMPRHSLYIIIGALCVAFILMLII 665

  Fly  1032 VTICHCKVNQTYRKFSTR 1049
            :.:..|::::...:.|:|
  Rat   666 LIVGICRISRIEYQGSSR 683

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wry	NP_995611.2	EGF_CA	737..777	CDD:238011	15/39 (38%)
		EGF	783..812	CDD:394967	13/28 (46%)
		EGF_CA	819..851	CDD:238011	12/31 (39%)
		EGF_CA	856..890	CDD:238011	14/33 (42%)
		EGF_CA	893..927	CDD:238011	12/33 (36%)
		EGF	938..966	CDD:394967	11/27 (41%)
Dner	NP_001386260.1	EGF_CA	402..437	CDD:238011	0/34 (0%)
		EGF_CA	440..474	CDD:238011	17/33 (52%)
		EGF_CA	516..550	CDD:238011	14/33 (42%)
		EGF_CA	590..626	CDD:238011	12/35 (34%)
		DNER_C	644..746	CDD:437162	8/40 (20%)