DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wry and notch1a

DIOPT Version :9

Sequence 1:	NP_995611.2	Gene:	wry / 33361	FlyBaseID:	FBgn0051665	Length:	1157	Species:	Drosophila melanogaster
Sequence 2:	NP_571516.1	Gene:	notch1a / 30718	ZFINID:	ZDB-GENE-990415-173	Length:	2437	Species:	Danio rerio

Alignment Length:	474	Identity:	141/474 - (29%)
Similarity:	198/474 - (41%)	Gaps:	111/474 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   548 ECEI-PNVPQDS----------HL-----WRGNETHELLLPIVTTEHCKPDEHCVPNVLTWRGEA 596
            |||: ||..|:.          |.     |.|::..|.:....:.. |.....|...|.::..|.
Zfish   297 ECELSPNACQNGGTCHNTIGGFHCVCVNGWTGDDCSENIDDCASAA-CSHGATCHDRVASFFCEC 360

  Fly   597 -EIQSGDILIVEINDAML-NPSHEPNNTSSAVHATQVYQVTRSGHEHCDVTEGVLLDITPLVVDG 659
             ..::|  |:..::||.: ||..:.:|                    ||...          |.|
Zfish   361 PHGRTG--LLCHLDDACISNPCQKGSN--------------------CDTNP----------VSG 393

  Fly   660 RKLVTLYDKDLTEGVNLLIVVSELWGAQCVRLKVTTKTDNCGENAD-CSGKGVCYSNSGMEEYEC 723
            :.:.|     ...|..         |:.|     ....|.|...|: |...|.|.:..|  .::|
Zfish   394 KAICT-----CPPGYT---------GSAC-----NQDIDECSLGANPCEHGGRCLNTKG--SFQC 437

  Fly   724 QCCSGFAGPHCE-EIDACNPSPCTNNGICVD--------LSQGHEG------------------- 760
            :|..|:.||.|| :::.|..:||.|:..|:|        ...|:||
Zfish   438 KCLQGYEGPRCEMDVNECKSNPCQNDATCLDQIGGFHCICMPGYEGVFCQINSDDCASQPCLNGK 502

  Fly   761 -----NSYQCLCPYGYAGKNCQYESDPCNPAECMNGGSCVGNSTHFRCDCAPGFTGPLCQHSLNE 820
                 ||:.|.||.|::|..||.:.|.|....|.||..|......:.|:|.|||:|..|:..:||
Zfish   503 CIDKINSFHCECPKGFSGSLCQVDVDECASTPCKNGAKCTDGPNKYTCECTPGFSGIHCELDINE 567

  Fly   821 CESSPCVHGICVDQEDGFRCFCQPGFAGELCNFEYNECESNPCQNGGECIDHIGSYECRCTKGFS 885
            |.||||.:|:|.|....|.|.|:||:.|.||....|||.|.||:|||.|.|...:|.|.|.||.:
Zfish   568 CASSPCHYGVCRDGVASFTCDCRPGYTGRLCETNINECLSQPCRNGGTCQDRENAYICTCPKGTT 632

  Fly   886 GNRCQIKVDFCANKPCPEGHRCIDHGNDFSCECPGGRNGPDCNQMPRTYFQQCNVNPCTHGGTCW 950
            |..|:|.:|.|..|||..| :|||..|.:.|.|..|.:|..||    .....|.:|||.:||||.
Zfish   633 GVNCEINIDDCKRKPCDYG-KCIDKINGYECVCEPGYSGSMCN----INIDDCALNPCHNGGTCI 692

  Fly   951 SSGDSFYCACRPGYTGTMC 969
            ...:||.|.|..|:....|
Zfish   693 DGVNSFTCLCPDGFRDATC 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wry	NP_995611.2	EGF_CA	737..777	CDD:238011	16/71 (23%)
		EGF	783..812	CDD:278437	10/28 (36%)
		EGF_CA	819..851	CDD:238011	16/31 (52%)
		EGF_CA	856..890	CDD:238011	17/33 (52%)
		EGF_CA	893..927	CDD:238011	14/33 (42%)
		EGF_CA	<941..970	CDD:238011	13/29 (45%)
notch1a	NP_571516.1	EGF_CA	141..174	CDD:238011
		EGF_CA	177..215	CDD:238011
		EGF_CA	294..331	CDD:238011	9/33 (27%)
		EGF_CA	334..369	CDD:238011	6/37 (16%)
		EGF_CA	411..449	CDD:238011	12/39 (31%)
		EGF_CA	451..487	CDD:238011	9/35 (26%)
		EGF_CA	491..524	CDD:238011	7/32 (22%)
		EGF_CA	526..562	CDD:238011	12/35 (34%)
		EGF_CA	564..599	CDD:238011	17/34 (50%)
		EGF_CA	601..637	CDD:238011	17/35 (49%)
		EGF_CA	676..711	CDD:238011	13/34 (38%)
		EGF_CA	716..748	CDD:238011
		EGF_CA	751..787	CDD:238011
		EGF_CA	789..825	CDD:238011
		EGF_CA	867..903	CDD:238011
		EGF_CA	905..940	CDD:238011
		EGF_CA	943..979	CDD:238011
		EGF_CA	986..1017	CDD:238011
		EGF_CA	1019..1055	CDD:238011
		EGF_CA	1144..1178	CDD:238011
		EGF_CA	1182..1217	CDD:238011
		EGF_CA	1219..1263	CDD:238011
		EGF_CA	1265..1303	CDD:238011
		NL	1440..1477	CDD:197463
		LNR 1	1447..1487
		Notch	1485..1520	CDD:278494
		LNR 2	1488..1525
		Notch	1523..1559	CDD:278494
		LNR 3	1526..1566
		NOD	1565..1616	CDD:284282
		NODP	1664..1721	CDD:284987
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1770..1790
		Ank_2	<1860..1946	CDD:289560
		ANK	1862..2003	CDD:238125
		ANK repeat	1867..1913	CDD:293786
		ANK 1	1867..1910
		ANK repeat	1915..1946	CDD:293786
		ANK 2	1915..1944
		Ank_2	1920..2013	CDD:289560
		ANK repeat	1948..1979	CDD:293786
		ANK 3	1948..1978
		ANK	1977..2101	CDD:238125
		ANK 4	1982..2011
		Ank_2	1987..2079	CDD:289560
		ANK repeat	2015..2079	CDD:293786
		ANK 5	2015..2044
		ANK 6	2048..2077
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2127..2174
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2356..2437
		DUF3454	2364..2424	CDD:288764
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12101
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D7525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010