DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wry and Notch2

DIOPT Version :9

Sequence 1:	NP_995611.2	Gene:	wry / 33361	FlyBaseID:	FBgn0051665	Length:	1157	Species:	Drosophila melanogaster
Sequence 2:	NP_077334.2	Gene:	Notch2 / 29492	RGDID:	3188	Length:	2471	Species:	Rattus norvegicus

Alignment Length:	581	Identity:	153/581 - (26%)
Similarity:	220/581 - (37%)	Gaps:	171/581 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   561 WRGNETHELLLPIVTTEHCKPDEHCVPNVLTW-----RGEAEIQSGDILIVEINDAML-NPSHEP 619
            |.|::..|.:....... |.|...|:..|.::     .|:|.      |:..::||.: ||.|
  Rat   330 WSGDDCSENIDDCAFAS-CTPGSTCIDRVASFSCLCPEGKAG------LLCHLDDACISNPCH-- 385

  Fly   620 NNTSSAVHATQVYQVTRSGHEHCDVTEGVLLDITPLVVDGRKLVTLYDKDLTEGVNLLIVVSELW 684
                                      :|.|.|..||  :|:.:.|     ..:|..
  Rat   386 --------------------------KGALCDTNPL--NGQYICT-----CPQGYK--------- 408

  Fly   685 GAQCVRLKVTTKTDNC--GENADCSGKGVCYSNSGMEEYECQCCSGFAGPHCE------------ 735
            ||.|     |...|.|  ..:..|...|.|.:..|  .:.|:|..|:|||.||
  Rat   409 GADC-----TEDVDECAMANSNPCEHAGKCVNTDG--AFHCECLKGYAGPRCEMDINECHSDPCQ 466

  Fly   736 ---------------------------EIDACNPSPCTNNGICVDLSQGHEGNSYQCLCPYGYAG 773
                                       |::.|..:||.|||.|||     :.|.:|||||.|:.|
  Rat   467 NDATCLDKIGGFTCLCMPGFKGVHCELEVNECQSNPCVNNGQCVD-----KVNRFQCLCPPGFTG 526

  Fly   774 KNCQYESDPCNPAECMNGGSCVGNSTHFRCDCAPGFTGPLCQHSLNECESSPCVHGICVDQEDGF 838
            ..||.:.|.|:...|:||..|:.:...:.|.||.||||.||..:::.|:..||.||.|.|..|.:
  Rat   527 PVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGTLCDENIDNCDPDPCHHGQCQDGIDSY 591

  Fly   839 RCFCQPGFAGELCNFEYNECESNPCQNGGECIDHIGSYECR------------------------ 879
            .|.|.||:.|.:|:.:.:||.|:||.|.|.|||.:..|:|.
  Rat   592 TCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGLNCEINFDDCASNPCLH 656

  Fly   880 -------------CTKGFSGNRCQIKVDFCANKPCPEGHRCIDHGNDFSCECPGGRNGPDCNQMP 931
                         |:.||:|.||.|.:|.||:.||.:|..||:..|.|.|.||.|.:.|.|
  Rat   657 GACVDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINDVNGFRCMCPEGPHHPSC---- 717

  Fly   932 RTYFQ--QCNVNPCTHGGTCWSSGDSFYCACRPGYTGTMCEDEFVVETVVSSSEFIVDDA-NARN 993
              |.|  :|..:||.| |.|......:.|.|..|:.|..||        |..:|.:.:.. |...
  Rat   718 --YSQVNECLSSPCIH-GNCTGGLSGYKCLCDAGWVGINCE--------VDKNECLSNPCQNGGT 771

  Fly   994 FNDKTFGSSVVLKSPIELHNAYFAAGVLAA------AIFIVAVVVTICHCKVNQTYRKFST 1048
            .|:...|.....|...:.:|........|:      ...:..|....|||.:..|.:...|
  Rat   772 CNNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCLDDVSGYTCHCMLPYTGKNCQT 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wry	NP_995611.2	EGF_CA	737..777	CDD:238011	17/39 (44%)
		EGF	783..812	CDD:278437	11/28 (39%)
		EGF_CA	819..851	CDD:238011	13/31 (42%)
		EGF_CA	856..890	CDD:238011	17/70 (24%)
		EGF_CA	893..927	CDD:238011	15/33 (45%)
		EGF_CA	<941..970	CDD:238011	9/28 (32%)
Notch2	NP_077334.2	EGF_CA	109..143	CDD:238011
		EGF_CA	182..218	CDD:238011
		EGF_CA	260..296	CDD:238011
		EGF_CA	298..335	CDD:238011	2/4 (50%)
		EGF_CA	415..454	CDD:238011	12/40 (30%)
		EGF_CA	456..492	CDD:238011	0/35 (0%)
		EGF_CA	495..530	CDD:238011	17/39 (44%)
		EGF_CA	532..567	CDD:238011	13/34 (38%)
		EGF_CA	570..604	CDD:238011	13/33 (39%)
		EGF_CA	608..643	CDD:238011	12/34 (35%)
		EGF_CA	645..679	CDD:238011	4/33 (12%)
		EGF_CA	682..717	CDD:238011	15/34 (44%)
		EGF_CA	757..793	CDD:238011	6/35 (17%)
		EGF_CA	795..831	CDD:238011	6/35 (17%)
		EGF_CA	873..909	CDD:238011
		EGF_CA	911..947	CDD:238011
		EGF_CA	949..985	CDD:238011
		EGF_CA	987..1022	CDD:238011
		EGF_CA	1025..1061	CDD:238011
		EGF_CA	1117..1147	CDD:238011
		EGF_CA	1151..1185	CDD:238011
		EGF_CA	1188..1223	CDD:238011
		EGF_CA	1225..1262	CDD:238011
		EGF_CA	1264..1302	CDD:238011
		EGF_CA	<1312..1343	CDD:238011
		Notch	1423..1456	CDD:278494
		Negative regulatory region (NRR). /evidence=ECO:0000250	1425..1677
		Notch	1463..1497	CDD:278494
		Notch	1501..1534	CDD:278494
		NOD	1540..1591	CDD:284282
		NODP	1619..1673	CDD:284987
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1751..1788
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1794..1813
		Ank_2	<1820..1907	CDD:289560
		ANK repeat	1827..1874	CDD:293786
		ANK 1	1827..1871
		ANK	1872..1997	CDD:238125
		ANK 2	1876..1905
		ANK repeat	1877..1907	CDD:293786
		Ank_2	1881..1974	CDD:289560
		ANK 3	1909..1939
		ANK	1938..2062	CDD:238125
		ANK repeat	1943..1974	CDD:293786
		ANK 4	1943..1972
		Ank_2	1948..2040	CDD:289560
		ANK repeat	1976..2007	CDD:293786
		ANK 5	1976..2005
		ANK repeat	2009..2040	CDD:293786
		ANK 6	2009..2038
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2097..2116
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2380..2471
		DUF3454	2381..2439	CDD:288764
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D7525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920