DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wry and SNED1

DIOPT Version :9

Sequence 1:	NP_995611.2	Gene:	wry / 33361	FlyBaseID:	FBgn0051665	Length:	1157	Species:	Drosophila melanogaster
Sequence 2:	XP_011509233.1	Gene:	SNED1 / 25992	HGNCID:	24696	Length:	1437	Species:	Homo sapiens

Alignment Length:	940	Identity:	212/940 - (22%)
Similarity:	304/940 - (32%)	Gaps:	331/940 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   439 GSTATTTAESTTTAATTTRLPATTTGKYQKELKRAKL--------------LLKALTPPKSVDKS 489
            ||.....||..||  |...:|    |::...:..|::              |...|...|.:|..
Human   254 GSRTADMAEVETT--TNVGVP----GRWAFRIDDAQVRVGGCGHTTSVCLALRPCLNGGKCIDDC 312

  Fly   490 -TASPSSTTSTSTSTTTTMATLLATARTRPSAANPTKTASKPIARPRILSRLQEKINSLECEIPN 553
             |.:||.|.|..:..|.....|           :..:.||:|....   ......|||..|:.|
Human   313 VTGNPSYTCSCLSGFTGRRCHL-----------DVNECASQPCQNG---GTCTHGINSFRCQCP- 362

  Fly   554 VPQDSHLWRGNETHELLLPIVTTEHCKPDEHCVPNVLTWRGEAEIQSGDILIV------------ 606
                  ...|..|.|.......|:.|   :|        .|:.::::|..:.|
Human   363 ------AGFGGPTCETAQSPCDTKEC---QH--------GGQCQVENGSAVCVCQAGYTGAACEM 410

  Fly   607 EINDAMLNP-----------------SHEP----------------------NNTSSAVHATQVY 632
            :::|...:|                 ..||                      :|..:.|.|.|.|
Human   411 DVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGY 475

  Fly   633 QVTRSGHEHCDVTEGVL-LDITPLVVD-------GRKLVTLYDKDLTEGVNLLIVVSEL--WGAQ 687
            .        |:..||.: ||....|.|       ||.|          |.|..:....|  :|..
Human   476 V--------CECPEGFMGLDCRERVPDDCECRNGGRCL----------GANTTLCQCPLGFFGLL 522

  Fly   688 CVRLKVTTKTDNCGENADCSGKGVCYSNSGM---------------------------------- 718
            | ..::|...  |..|..|...|.|..:.|.
Human   523 C-EFEITAMP--CNMNTQCPDGGYCMEHGGSYLCVCHTDHNASHSLPSPCDSDPCFNGGSCDAHD 584

  Fly   719 EEYECQCCSGFAGPHCEEI--DACNPSPCTNNGICVD-------------------------LSQ 756
            :.|.|:|..||.|.|||:.  ..|:..||.|.|.|.:                         .:.
Human   585 DSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPDSCAS 649

  Fly   757 G--HEGNS-------YQCLCPYGYAGKNCQYESDPCNPAECMNGGSCVGNSTHFRCDCAPGFTGP 812
            |  |.|.:       |:|.||.|::|::|:....||..:.|:|||:|....|.|.|.|..|:.|.
Human   650 GPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTDFFCHCQAGYMGR 714

  Fly   813 LCQ------------HS----------------------------------------------LN 819
            .||            |:                                              ::
Human   715 RCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEPPQCLEID 779

  Fly   820 ECESSPCVH-GICVDQEDGFRCFCQPGFAGELCNFEYNECESNPCQNGGECIDHIGSYECRCTKG 883
            ||.|.||:| |.|.|:..|:.|.|..|:.|..|..|.:||.::||:|||.|.:..|:|.|||..|
Human   780 ECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECRAHPCRNGGSCRNLPGAYVCRCPAG 844

  Fly   884 FSGNRCQIKVDFCANKPCPEGHRCIDHGNDFSCECPGGRNGPDCNQMPRTYFQQCNVNPCTHGGT 948
            |.|..|:.:||.|.:.||..|.||...|..:.|.||....|..|    .|....|..:||...|.
Human   845 FVGVHCETEVDACDSSPCQHGGRCESGGGAYLCVCPESFFGYHC----ETVSDPCFSSPCGGRGY 905

  Fly   949 CWSSGDSFYCACRPGYTGTMCEDEF----------VVETVVSSS------------------EFI 985
            |.:|..|..|.|:.||||..|..|.          |.|:.||.|                  .::
Human   906 CLASNGSHSCTCKVGYTGEDCAKELFPPTALKMERVEESGVSISWNPPNGPAARQMLDGYAVTYV 970

  Fly   986 VDDANAR--NFNDKTFGSSVVLKSPIELHNAYFAAGVLAAAIFIVAVVVTICHCKVNQTYRKFST 1048
            ..|.:.|  :|.|:|..|          |.....|...|..|.:.:|       |.|...:...:
Human   971 SSDGSYRRTDFVDRTRSS----------HQLQALAAGRAYNISVFSV-------KRNSNNKNDIS 1018

  Fly  1049 RSTSFI------PILGFSRRPKVQGKLNKHWLSG--KGATATSSTNIVAPPGGPRAGGAAGPQQV 1105
            |....:      |:.||.........::..|...  :.||.:.....:..|...|.......:.|
Human  1019 RPAVLLARTRPRPVEGFEVTNVTASTISVQWALHRIRHATVSGVRVSIRHPEALRDQATDVDRSV 1083

  Fly  1106 TRH-----LPGQPQT--QTTLGG-QLQERP 1127
            .|.     |||:..|  .|||.| :.:|.|
Human  1084 DRFTFRALLPGKRYTIQLTTLSGLRGEEHP 1113

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wry	NP_995611.2	EGF_CA	737..777	CDD:238011	15/75 (20%)
		EGF	783..812	CDD:278437	11/28 (39%)
		EGF_CA	819..851	CDD:238011	14/32 (44%)
		EGF_CA	856..890	CDD:238011	16/33 (48%)
		EGF_CA	893..927	CDD:238011	13/33 (39%)
		EGF_CA	<941..970	CDD:238011	12/28 (43%)
SNED1	XP_011509233.1	NIDO	128..284	CDD:214712	10/35 (29%)
		EGF_CA	296..332	CDD:238011	10/35 (29%)
		EGF_CA	335..371	CDD:238011	10/45 (22%)
		EGF_CA	411..447	CDD:238011	4/35 (11%)
		EGF_CA	455..488	CDD:238011	9/40 (23%)
		EGF_CA	569..601	CDD:238011	7/31 (23%)
		EGF_CA	609..640	CDD:238011	5/30 (17%)
		EGF_CA	645..679	CDD:238011	9/33 (27%)
		EGF_CA	<688..717	CDD:238011	11/28 (39%)
		Sushi	722..775	CDD:278512	1/52 (2%)
		EGF_CA	778..813	CDD:238011	14/34 (41%)
		EGF_CA	817..851	CDD:238011	16/33 (48%)
		EGF_CA	854..889	CDD:238011	14/38 (37%)
		fn3	932..1012	CDD:278470	18/96 (19%)
		fn3	1031..1106	CDD:278470	17/74 (23%)
		fn3	1130..1208	CDD:278470
		EGF_CA	1336..1367	CDD:238011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D7525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010