DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wry and Notch1

DIOPT Version :9

Sequence 1:	NP_995611.2	Gene:	wry / 33361	FlyBaseID:	FBgn0051665	Length:	1157	Species:	Drosophila melanogaster
Sequence 2:	NP_001099191.1	Gene:	Notch1 / 25496	RGDID:	3187	Length:	2531	Species:	Rattus norvegicus

Alignment Length:	633	Identity:	167/633 - (26%)
Similarity:	220/633 - (34%)	Gaps:	223/633 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   607 EINDAMLNPSHEPNNTSSAVHATQVYQVTRSGHE--HCDVT---EGVLLDI-------TPLVVDG 659
            |:|:...||.              ::...|.|..  .||..   .|...||       .|.|..|
  Rat   716 EVNECNSNPC--------------IHGACRDGLNGYKCDCAPGWSGTNCDINNNECESNPCVNGG 766

  Fly   660 RKLVTLYDKDLTEG--------------------------VNLLIVVSELWGAQCVRLKVTTKTD 698
            .      .||:|.|                          :|....:.::.|.:|
  Rat   767 T------CKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKC---------- 815

  Fly   699 NC-----GENAD----------CSGKGVCYSNSGMEEYECQCCSGFAGPHCE-EIDACNPSPCTN 747
            ||     |...:          |...|||..:...|.:.|.|.:|:.|..|| :|:.|..|||.:
  Rat   816 NCPLPYTGATCEVVLAPCATSPCKNSGVCKESEDYESFSCVCPTGWQGQTCEIDINECVKSPCRH 880

  Fly   748 NGICVDLSQGHEGNSYQCLCPYGYAGKNCQYESDPCNPAECMNGGSCVGNSTHFRCDCAPGFTGP 812
            ...|    |...| ||:|||..||.|:||:.:.|.|.|..|.|||||........|||.|||.|.
  Rat   881 GASC----QNTNG-SYRCLCQAGYTGRNCESDIDDCRPNPCHNGGSCTDGVNAAFCDCLPGFQGA 940

  Fly   813 LCQHSLNECESSPC-----------------------VH----------------GICVDQEDGF 838
            .|:..:|||.|:||                       :|                |.|||..:.|
  Rat   941 FCEEDINECASNPCQNGANCTDCVDSYTCTCPTGFNGIHCENNTPDCTESSCFNGGTCVDGINSF 1005

  Fly   839 RCFCQPGFAGELCNFEYNECESNPCQNGGECIDHIGSYECRCTKGFSGNRCQIKVDFCANKPCPE 903
            .|.|.|||.|..|.::.|||:|.||.:||.|.|..|:|:|.|.:|::|..||..|.:|.:.||..
  Rat  1006 TCLCPPGFTGSYCQYDVNECDSRPCLHGGTCQDSYGTYKCTCPQGYTGLNCQNLVRWCDSAPCKN 1070

  Fly   904 GHRCIDHGNDFSCECPGGRNGPDCNQMPRTYFQQCNVNP----------CTHGGTCWSSGDSFYC 958
            |.:|......:.|||..|..|.:|:.:.    ..|.|..          |.|||.|....|..||
  Rat  1071 GGKCWQTNTQYHCECRSGWTGFNCDVLS----VSCEVAAQKRGIDVTLLCQHGGLCVDEEDKHYC 1131

  Fly   959 ACRPGYTGTMCEDEFVVETVVSSSEFIVDDA------NARNFNDKTFGSSV-------------- 1003
            .|:.||||:.||||             ||:.      |.....|...|.|.
  Rat  1132 HCQAGYTGSYCEDE-------------VDECSPNPCQNGATCTDYLGGFSCKCVAGYHGSNCSEE 1183

  Fly  1004 ---VLKSP-------IELHNAYFAA------GVLAAAIFIVAVVVTICHCKVNQTYRKFSTRSTS 1052
               .|..|       |:|.|.|..:      ||               ||::|.        ...
  Rat  1184 INECLSQPCQNGGTCIDLTNTYKCSCPRGTQGV---------------HCEINV--------DDC 1225

  Fly  1053 FIPILGFSRRPKVQGKLNKHWLSGKGATATSSTNIVAPPG--GPRAGG 1098
            ..|:...||.||.       :.:|.............|||  |.|..|
  Rat  1226 HPPLDPASRSPKC-------FNNGTCVDQVGGYTCTCPPGFVGERCEG 1266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wry	NP_995611.2	EGF_CA	737..777	CDD:238011	17/39 (44%)
		EGF	783..812	CDD:278437	14/28 (50%)
		EGF_CA	819..851	CDD:238011	18/70 (26%)
		EGF_CA	856..890	CDD:238011	16/33 (48%)
		EGF_CA	893..927	CDD:238011	11/33 (33%)
		EGF_CA	<941..970	CDD:238011	13/38 (34%)
Notch1	NP_001099191.1	EGF_CA	142..175	CDD:238011
		EGF_CA	178..216	CDD:238011
		EGF_CA	257..293	CDD:238011
		EGF_CA	295..332	CDD:238011
		EGF_CA	335..370	CDD:238011
		EGF_CA	412..450	CDD:238011
		Interaction with DLL4. /evidence=ECO:0000269\|PubMed:25700513, ECO:0007744\|PDB:4XL1	420..421
		Interaction with DLL4. /evidence=ECO:0000269\|PubMed:25700513, ECO:0007744\|PDB:4XL1	448..452
		EGF_CA	452..488	CDD:238011
		EGF_CA	490..526	CDD:238011
		EGF_CA	528..564	CDD:238011
		EGF_CA	566..601	CDD:238011
		EGF_CA	603..639	CDD:238011
		EGF_CA	641..675	CDD:238011
		EGF_CA	678..713	CDD:238011
		EGF_CA	717..750	CDD:238011	8/46 (17%)
		EGF_CA	755..789	CDD:238011	7/39 (18%)
		EGF_CA	791..827	CDD:238011	6/45 (13%)
		EGF_CA	869..905	CDD:238011	17/40 (43%)
		EGF_CA	907..943	CDD:238011	16/35 (46%)
		EGF_CA	945..981	CDD:238011	7/35 (20%)
		EGF_CA	988..1019	CDD:238011	11/30 (37%)
		EGF_CA	1021..1057	CDD:238011	16/35 (46%)
		EGF_CA	1146..1180	CDD:238011	6/33 (18%)
		EGF_CA	1184..1219	CDD:238011	9/49 (18%)
		EGF_CA	1221..1265	CDD:238011	12/58 (21%)
		EGF_CA	1267..1305	CDD:238011	167/633 (26%)
		NL	1442..1479	CDD:197463
		LNR 1	1449..1489
		Notch	1487..1522	CDD:278494
		LNR 2	1490..1531
		Notch	1525..1561	CDD:278494
		LNR 3	1532..1571
		NOD	1567..1618	CDD:284282
		NODP	1662..1719	CDD:284987
		Interaction with PSEN1. /evidence=ECO:0000250\|UniProtKB:P46531	1718..1750
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1770..1798
		Ank_2	<1863..1948	CDD:289560
		ANK repeat	1870..1915	CDD:293786
		ANK	1912..2024	CDD:238125
		ANK repeat	1917..1948	CDD:293786
		ANK 1	1917..1946
		Ank_2	1922..2015	CDD:289560
		HIF1AN-binding. /evidence=ECO:0000250	1937..1945
		ANK repeat	1950..1981	CDD:293786
		ANK 2	1950..1980
		ANK	1979..2103	CDD:238125
		ANK repeat	1984..2015	CDD:293786
		ANK 3	1984..2013
		Ank_2	1989..2081	CDD:289560
		HIF1AN-binding. /evidence=ECO:0000250	2004..2012
		ANK repeat	2017..2081	CDD:293786
		ANK 4	2017..2046
		ANK 5	2050..2079
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2141..2185
		TFIIA	2201..>2417	CDD:281188
		Med25_SD1	2339..2490	CDD:288132
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2382..2428
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2440..2531
		DUF3454	2454..2516	CDD:288764
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D7525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920