DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wry and Sned1

DIOPT Version :9

Sequence 1:	NP_995611.2	Gene:	wry / 33361	FlyBaseID:	FBgn0051665	Length:	1157	Species:	Drosophila melanogaster
Sequence 2:	NP_766051.4	Gene:	Sned1 / 208777	MGIID:	3045960	Length:	1403	Species:	Mus musculus

Alignment Length:	941	Identity:	212/941 - (22%)
Similarity:	314/941 - (33%)	Gaps:	333/941 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   439 GSTATTTAESTTTAATTTRLPATTTGKYQKELKRAK--------------LLLKALTPPKSVDKS 489
            ||.....||..||  |...:|    |::...:..|:              :|...|...|.:|..
Mouse   230 GSRTADMAEVETT--TNVGVP----GRWAFRIDDAQVRVGGCGHTTSVCLVLRPCLNGGKCIDDC 288

  Fly   490 -TASPSSTTSTSTSTTTTMATLLATARTRPSAANPTKTASKPIARPRILSRLQEKINSLECEIP- 552
             |.:||.|.|           .||....|....:..:.||.|....   ......:||..|:.|
Mouse   289 VTGNPSYTCS-----------CLAGFTGRRCHLDVNECASHPCQNG---GTCTHGVNSFSCQCPA 339

  Fly   553 ----------NVPQDSHLWRG--------------------NETHELLLPIVTTEHCKPDEHCVP 587
                      ..|.|:.:.:.                    ..|.|..:...:::.|:....||.
Mouse   340 GFKGPTCESAQSPCDNKVCQNGGQCQAESSSAVCVCQAGYTGATCETDVDECSSDPCQNGGSCVD 404

  Fly   588 NVLTW--------RGEAEIQSGDILIVEINDAMLNPSHEPNNTSSAVHATQVYQVTRSGHEHCDV 644
            .|..:        .| .:.::|..|:.  :..:.||.   .|..:.|.|.:.|.        |:.
Mouse   405 LVGNYSCICVEPFEG-PQCETGSYLVP--SPCLSNPC---QNGGTCVDADEGYV--------CEC 455

  Fly   645 TEGVLLDITPLVVDGRKLVTLYDKDLTEGVNLLIVVSEL-------WGAQCVRLKVTTKTDNCGE 702
            .||.      :.:|.|:.: |.|.|...|...|...:.|       :|..| ..:||...  |..
Mouse   456 PEGF------MGLDCRERI-LNDCDCRNGGRCLGANTTLCQCPPGFFGLLC-EFEVTATP--CNM 510

  Fly   703 NADCSGKGVCYSNSGM----------------------------------EEYECQCCSGFAGPH 733
            |..|...|.|....|.                                  :.|.|:|..||.|.|
Mouse   511 NTQCPDGGYCMEYGGSYLCVCHTDHNISHSLPSPCDSDPCFNGGSCDAHEDSYTCECPRGFHGRH 575

  Fly   734 CEEI--DACNPSPCTNNGICVDLSQGHEGNSYQCLCPY--------------------------- 769
            ||:.  ..|:..||.|.|.|.::     |:.|:|.|||
Mouse   576 CEKARPHLCSSGPCRNGGTCKEM-----GDEYRCTCPYRFTGRHCEIGKPDSCASGPCHNGGTCF 635

  Fly   770 ------------GYAGKNCQYESDPCNPAECMNGGSCVGNSTHFRCDCAPGFTGPLCQ------- 815
                        |::|::|:....||..:.|||||:|....|.|.|.|.||:||..||
Mouse   636 HYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCMNGGTCEDLGTDFSCYCQPGYTGHRCQAEVDCGH 700

  Fly   816 -----HS----------------------------------------------LNECESSPCVH- 828
                 |:                                              ::||.|.||:|
Mouse   701 PEEVEHATMRFNGTHVGSVALYTCEPGFSLSALSHIRVCQPQGVWSQPPQCIEVDECRSQPCLHG 765

  Fly   829 GICVDQEDGFRCFCQPGFAGELCNFEYNECESNPCQNGGECIDHIGSYECRCTKGFSGNRCQIKV 893
            |.|.|....::|.|.||:.|..|..|.:||::.||:|||.|.|...::.|:|.:||.|..|:.:|
Mouse   766 GSCQDLIADYQCLCSPGYEGVHCELETDECQAQPCRNGGSCRDLPRAFICQCPEGFVGIHCETEV 830

  Fly   894 DFCANKPCPEGHRCIDHGNDFSCECPGGRNGPDCNQMPRTYFQQCNVNPCTHGGTCWSSGDSFYC 958
            |.||:.||..|.||.|.|..:.|.||.|..|.:|    .|....|..:||...|.|.:|..|..|
Mouse   831 DACASSPCQHGGRCEDGGGAYLCVCPEGFFGYNC----ETVSDPCFSSPCGSRGYCLASNGSHSC 891

  Fly   959 ACRPGYTGTMCEDEFV------VETVVSSSEFI-------------------------------- 985
            .|:.||||..|..|.:      ||.|..|...|
Mouse   892 TCKVGYTGKDCTKELLPPTALRVERVEESGVSISWSPPEGTTARQVLDGYAVTYASSDGSSRRTD 956

  Fly   986 -VDDA------------------------NARNFNDKTFGSSVVLKS---PIELHNAYFAAGVLA 1022
             ||.:                        |..|.||.:..::::.::   |||   .:....:.|
Mouse   957 FVDRSRSSHQLRALAAGRAYNISVFSVKRNTNNKNDISRPAALLTRTRPRPIE---DFEVTNISA 1018

  Fly  1023 AAIFIVAVVVTICHCKVNQTYRKFSTRSTSFIPILGFSRRPKVQGKLNK----HWLSGKGATATS 1083
            .||.:...:..|.|..|::      .|.:...|.....:..:|...:::    ..|.|:..|...
Mouse  1019 NAISVQWALHRIQHATVSR------VRVSILYPEASAVQSTEVDRSVDRLTFGDLLPGRRYTVRL 1077

  Fly  1084 STNIVAPPGG---PRAGGAAGPQQV-TRHLP 1110
            :|  ::.|||   |....|:.|..| ||.||
Mouse  1078 TT--LSGPGGAEYPTESLASAPLNVWTRPLP 1106

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wry	NP_995611.2	EGF_CA	737..777	CDD:238011	14/80 (18%)
		EGF	783..812	CDD:278437	14/28 (50%)
		EGF_CA	819..851	CDD:238011	14/32 (44%)
		EGF_CA	856..890	CDD:238011	14/33 (42%)
		EGF_CA	893..927	CDD:238011	16/33 (48%)
		EGF_CA	<941..970	CDD:238011	12/28 (43%)
Sned1	NP_766051.4	NIDO	104..260	CDD:214712	10/35 (29%)
		EGF_CA	272..308	CDD:238011	12/46 (26%)
		EGF_CA	311..347	CDD:238011	7/38 (18%)
		EGF_CA	387..423	CDD:238011	5/36 (14%)
		EGF_CA	433..464	CDD:238011	9/47 (19%)
		EGF_CA	545..577	CDD:238011	7/31 (23%)
		EGF_CA	585..616	CDD:238011	11/35 (31%)
		EGF_CA	621..655	CDD:238011	2/33 (6%)
		EGF_CA	<664..693	CDD:238011	14/28 (50%)
		CCP	698..752	CDD:153056	1/53 (2%)
		EGF_CA	754..789	CDD:238011	14/34 (41%)
		EGF_CA	793..827	CDD:238011	14/33 (42%)
		EGF_CA	830..865	CDD:238011	17/38 (45%)
		fn3	908..988	CDD:278470	8/79 (10%)
		FN3	1005..1084	CDD:214495	16/89 (18%)
		fn3	1106..1184	CDD:278470	1/1 (100%)
		EGF_CA	1311..1342	CDD:238011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11579
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D7525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010