DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wry and F25D7.5

DIOPT Version :9

Sequence 1:	NP_995611.2	Gene:	wry / 33361	FlyBaseID:	FBgn0051665	Length:	1157	Species:	Drosophila melanogaster
Sequence 2:	NP_492725.2	Gene:	F25D7.5 / 184923	WormBaseID:	WBGene00009114	Length:	1216	Species:	Caenorhabditis elegans

Alignment Length:	925	Identity:	166/925 - (17%)
Similarity:	306/925 - (33%)	Gaps:	287/925 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VAATTSETITNDLTAKSNRTL------LKTSTEESREISALGGSTSTATPTTTATT--------- 63
            :..:|..|..:|:....|.|:      .|:...|:.|....|.||.:.:...|:||
Worm    34 IEPSTPTTTPSDIVLPENTTMSDILKNTKSGQCETLEEVLCGCSTCSTSCLGTSTTVGSSKRSSI 98

  Fly    64 STTTTRATTVAEDEMEETSTPTPTTVRLMTTTQKMVQANLGEIGSIKDALHRIKLSEKPVDGATT 128
            ||.|...|:.........|.||..::...||:.|.::..   ..:|..:...|..|.|.:...||
Worm    99 STVTKNETSTRSSSSTSQSLPTSKSLVSSTTSNKDLETT---SATITVSSSSITSSTKEISSRTT 160

  Fly   129 TTEQPEAMDQDEQDEQDVTPTISPLQIQMQAAASYQVAETLADLNEEERARYDAMLAQQPTASKL 193
                     .:.....:||.|.|.:.:..|::.|..:..|                   |:.|
Worm   161 ---------GNSSGTSEVTSTFSKVPLATQSSHSTSLPST-------------------PSTS-- 195

  Fly   194 NIVDLYPLKIEDIQPIIRNDNDELIKQRTVFTQHENAEEYKQNLMPNEVEMMVDKEVIEMKDKIQ 258
                        .||
Worm   196 ------------TQP-------------------------------------------------- 198

  Fly   259 INQEKFGSSTTVKPTTSRPHQGTTADFTGKLLADQDDLITEIESKFQLHETTTLRPRVTTVQHPG 323
                   |||:.|        |:|....|.|...:...|:..|      :::::.|.:.: ..|.
Worm   199 -------SSTSAK--------GSTTSTIGDLNTTRTSTISSTE------KSSSMSPTIKS-SSPS 241

  Fly   324 NTFIDRRVKKSFEFPMQHRASDVMAMPH--IDFANTKF---QTDADAPNPPAS------HPEFST 377
            :..:...:|.|.:   :..:|..::.|.  :.:..:.:   :|::...:|.:|      :..|||
Worm   242 SPPMTPTIKISTQ---KGLSSSTVSFPRCFVFYQKSTYISTRTESTTVSPTSSSTAIQDNTTFST 303

  Fly   378 TKFYNSKELYNEMLLHNKRKLMKAAKAEGSPIKSAEDTTRATSSNVTPEGKTFGPTTTTAAGSTA 442
            .|   |....::..:|:     .:|....|.:||:.    ..||..|....|..|:|::.  :|.
Worm   304 AK---STATSSQTPIHS-----TSATLASSTVKSSS----PASSGSTSSSSTSQPSTSSK--NTD 354

  Fly   443 TTTAESTTTAATTTRLPATTTGKYQKELKRAKLLLKALTPPKSVDKSTASPSSTTSTSTSTTTTM 507
            ::||..|..|.....:.:|||.|          :..:|:..:|...::::|.||:|:.|..::|.
Worm   355 SSTAPWTEHAKAEDIISSTTTSK----------ISSSLSSTQSTASTSSTPYSTSSSETPDSSTT 409

  Fly   508 ATLLATARTRPSAANPTKTASKPIARPRILSRLQEKINSLECEIPNVPQDSHLWRGNETHELLLP 572
            .|:::|.|. ||.                         |::|....|..::..:...|..::...
Worm   410 TTVISTTRD-PSC-------------------------SVQCPDGYVAGETMCYYFAELSDIKSY 448

  Fly   573 IVTTEHCKPDEHCVPNVLTWRGEAEIQSGDILIVEINDAMLNPSHEPNNTSSAVHATQVYQVTRS 637
            .....:|:                .:...:::.:| |...||......:.||::.:|..|.....
Worm   449 QSALSYCQ----------------TVNLRNLIFLE-NLRDLNDLQTLRSKSSSIQSTSFYFANGG 496

  Fly   638 GHEHCDVTEGV-----LLDITPLVVDGRKL-VTLYDKDLTEGVNLLIVVSELWGAQCVRLKVTTK 696
            |    .|.|.:     :||||.|......: :|:...|.|..|:.:.|:.:.
Worm   497 G----SVQERLNKKAQVLDITQLTAMTSPIAMTVGISDTTTNVSAICVLPQY------------- 544

  Fly   697 TDNCGENADCSGKGVCYSNSGMEEYECQCCSGFAGPHCEEIDACNPS--PCTNNGICVDLSQGHE 759
               |..:.       ||..:.:...|   .:.......|.||..:.:  .|:.......:|.|..
Worm   545 ---CNISK-------CYVETALNILE---LNSILSSSKETIDTTSTASLTCSYTKSITTVSCGTR 596

  Fly   760 GN------SYQCLCPYGYAGKNCQYESDPCNPAECMNGGSCVGNSTHFRCDCAPGFTGPLCQHSL 818
            ||      :..|... |.|.|.....||                   |...||..||     ...
Worm   597 GNIMPSPTTISCAAE-GVAQKLANTTSD-------------------FVSSCAMCFT-----RGT 636

  Fly   819 NECESSPCVHGICVDQEDGFRCFCQPGFAGELCNFEYNECESNPCQNGGECIDHIGSYECRCTKG 883
            :.||::     :..|....::|.|:|.::...|.:..:.|....|...|:|.|::...:|.|..|
Worm   637 DFCETT-----VDADGNYAYQCHCKPKYSMSTCWYTPDACTPTTCNGHGKCYDYVEDVKCDCYWG 696

  Fly   884 FSGNRCQIKVDFCAN 898
            :.|..|::..|...|
Worm   697 YEGEHCEVNKDRVTN 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wry	NP_995611.2	EGF_CA	737..777	CDD:238011	11/47 (23%)
		EGF	783..812	CDD:278437	5/28 (18%)
		EGF_CA	819..851	CDD:238011	6/31 (19%)
		EGF_CA	856..890	CDD:238011	9/33 (27%)
		EGF_CA	893..927	CDD:238011	2/6 (33%)
		EGF_CA	<941..970	CDD:238011
F25D7.5	NP_492725.2	EGF_CA	669..703	CDD:238011	9/33 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000