DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wry and Notch4

DIOPT Version :9

Sequence 1:	NP_995611.2	Gene:	wry / 33361	FlyBaseID:	FBgn0051665	Length:	1157	Species:	Drosophila melanogaster
Sequence 2:	XP_006523861.1	Gene:	Notch4 / 18132	MGIID:	107471	Length:	1968	Species:	Mus musculus

Alignment Length:	579	Identity:	165/579 - (28%)
Similarity:	219/579 - (37%)	Gaps:	163/579 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   516 TRPSAANPTKTASKPIARPRILSRLQEKINSLECEIPNVPQDSHLWRGNETHELLLPIVTTE--H 578
            |.||:.:||    .|:. |..............|:       :||      .||..|...:.  |
Mouse    87 TPPSSRSPT----SPLT-PHFSCTCPSGFTGDRCQ-------THL------EELCPPSFCSNGGH 133

  Fly   579 C------KPDEHCVPNVLTWRGE-----------------------AEIQ-------SGDILIVE 607
            |      :|...|.|.   |.||                       .:||       .|.....:
Mouse   134 CYVQASGRPQCSCEPG---WTGEQCQLRDFCSANPCANGGVCLATYPQIQCRCPPGFEGHTCERD 195

  Fly   608 INDAMLNPSHEPNNTSSAVHAT-QVYQ----VTRSGHEHCDVTEGVLLDITP----------LVV 657
            ||:..|.|...|..||  .|.| ..||    |.:.|.: |.:.:|.   ..|          ||.
Mouse   196 INECFLEPGPCPQGTS--CHNTLGSYQCLCPVGQEGPQ-CKLRKGA---CPPGSCLNGGTCQLVP 254

  Fly   658 DGRKL--VTLYDKDLTEGVNLLIVVSELWGAQCVRLKV-------------------TTKTDNCG 701
            :|...  :.|.....| |::     .|:....|||.:.                   |.|..:|.
Mouse   255 EGHSTFHLCLCPPGFT-GLD-----CEMNPDDCVRHQCQNGATCLDGLDTYTCLCPKTWKGWDCS 313

  Fly   702 ENAD---------CSGKGVCYSNSGMEEYECQCCSGFAGPHCEE-IDACNPSPCTNNGICVD--- 753
            |:.|         |...|.|.:.:|  .:.|.|.||:.|..||| :|.|..:.|.....|:|
Mouse   314 EDIDECEARGPPRCRNGGTCQNTAG--SFHCVCVSGWGGAGCEENLDDCAAATCAPGSTCIDRVG 376

  Fly   754 ---------------------LSQGHEGN----------SYQCLCPYGYAGKNCQYESDPC---- 783
                                 |||....|          |..|:|..||:|..|..:.|.|
Mouse   377 SFSCLCPPGRTGLLCHLEDMCLSQPCHVNAQCSTNPLTGSTLCICQPGYSGSTCHQDLDECQMAQ 441

  Fly   784 -NPAECMNGGSCVGNSTHFRCDCAPGFTGPLCQHSLNECESSPCVHG-ICVDQEDGFRCFCQPGF 846
             .|:.|.:||||:.....|.|.|.||:||..|:...|||.|.||..| .|:|....|.|.|.||.
Mouse   442 QGPSPCEHGGSCINTPGSFNCLCLPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGL 506

  Fly   847 AGELCNFEYNECESNPCQNGGECIDHIGSYECRCTKGFSGNRCQIKVDFCANKPCPEGHRCIDHG 911
            .|.||..|.|||.||||.|...|.|.:..::|.|..||:|.||:..:|.|::.||..|.||.|..
Mouse   507 EGRLCEVEVNECTSNPCLNQAACHDLLNGFQCLCLPGFTGARCEKDMDECSSTPCANGGRCRDQP 571

  Fly   912 NDFSCECPGGRNGPDCNQMPRTYFQQCNVNPCTHGGTCWSSGDSFYCACRPGYTGTMCE 970
            ..|.|||..|..||.|.:    ...:|..:||..|.:|.....:|:|.||||:||.:||
Mouse   572 GAFYCECLPGFEGPHCEK----EVDECLSDPCPVGASCLDLPGAFFCLCRPGFTGQLCE 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wry	NP_995611.2	EGF_CA	737..777	CDD:238011	15/73 (21%)
		EGF	783..812	CDD:278437	13/33 (39%)
		EGF_CA	819..851	CDD:238011	15/32 (47%)
		EGF_CA	856..890	CDD:238011	16/33 (48%)
		EGF_CA	893..927	CDD:238011	15/33 (45%)
		EGF_CA	<941..970	CDD:238011	12/28 (43%)
Notch4	XP_006523861.1	EGF_CA	162..193	CDD:238011	3/30 (10%)
		EGF_CA	195..233	CDD:214542	13/40 (33%)
		EGF_CA	315..354	CDD:238011	10/40 (25%)
		EGF_CA	356..391	CDD:238011	5/34 (15%)
		EGF_CA	433..474	CDD:238011	15/40 (38%)
		EGF_CA	476..512	CDD:238011	16/35 (46%)
		EGF_CA	515..550	CDD:238011	16/34 (47%)
		EGF_CA	552..588	CDD:238011	15/35 (43%)
		EGF_CA	591..626	CDD:238011	13/34 (38%)
		EGF_CA	<700..727	CDD:238011
		EGF_CA	769..804	CDD:238011
		EGF_CA	<814..843	CDD:238011
		EGF_CA	896..928	CDD:238011
		EGF_CA	930..965	CDD:238011
		EGF_CA	970..1004	CDD:238011
		EGF_CA	1006..1044	CDD:238011
		NL	1207..1245	CDD:197463
		Notch	1257..1285	CDD:365847
		Ank_2	<1575..1663	CDD:372319
		ANK repeat	1582..1629	CDD:293786
		ANK repeat	1633..1663	CDD:293786
		Ank_2	1637..1730	CDD:372319
		ANKYR	1644..1819	CDD:223738
		ANK repeat	1665..1697	CDD:293786
		ANK repeat	1699..1730	CDD:293786
		ANK repeat	1732..1763	CDD:293786
		ANK repeat	1765..1796	CDD:293786
		ANK repeat	1798..1826	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D7525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010