Protein Alignment wry and lin-12

DIOPT Version :10

• Sequence 1: NP_995611.2
• Gene: wry / 33361
• FlyBaseID: FBgn0051665
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: NP_499007.1
• Gene: lin-12 / 176282
• WormBaseID: WBGene00003001
• Length: 1429
• Species: Caenorhabditis elegans
• Alignment Length: 355
• Identity: 111/355 - (31%)
• Similarity: 147/355 - (41%)
• Gaps: 100/355 - (28%)

  Fly   700 CGENADCSGKGVCYSNSGMEEYECQCCSGFAGPHCEEIDACNPSPCTNNGICV------------ 752
            ||.|..|....|   |.....|.|:|..||.|.:||:  .|:.|.|..:..||
 Worm    29 CGRNGHCHAGPV---NGTQTSYWCRCDEGFGGEYCEQ--QCDVSKCGADEKCVFDKDYRMETCVC 88

  Fly   753 ---DLSQGHEGNS-YQCLCPYGYAGKNCQYESDPCNPAECMNGGSCVGNSTHFRCDCAPGFTGPL 813
               |::    ||| .:..||.||.|.:|:.:. .|.|:.|||||.|:|.....:|.|..||.|..
 Worm    89 KDCDIN----GNSLLKPSCPSGYGGDDCKTQG-WCYPSVCMNGGQCIGAGNRAKCACPDGFKGER 148

  Fly   814 CQHSLNECES--------SPCVHG----ICV--------------------------------DQ 834
            |:..:||||.        |.|::.    |||                                |.
 Worm   149 CELDVNECEENKNACGNRSTCMNTLGTYICVCPQGFLPPDCLKPGNTSTVEFKQPVCFLEISADH 213

  Fly   835 EDG---------------FRCFCQPGFAGELCNF--EYNECESNPCQNGGECIDHIGSYECRCTK 882
            .||               .:|.|.||:.|..|..  :.:.|.||||.: |.||...|.::|.|..
 Worm   214 PDGRSMYCQNGGFCDKASSKCQCPPGYHGSTCELLEKEDSCASNPCSH-GVCISFSGGFQCICDD 277

  Fly   883 GFSGNRCQIKVDFCANKPCPEGHRCIDHGNDFSCECPGGRNGPDCNQMPRTYFQQCNVNP--CTH 945
            |:||:.||...|.|.|..|..|.:||:..|.:.|:||..|.||.|.:|      .|:..|  |.|
 Worm   278 GYSGSYCQEGKDNCVNNKCEAGSKCINGVNSYFCDCPPERTGPYCEKM------DCSAIPDICNH 336

  Fly   946 GGTCWS---SGDSFYCACRPGYTGTMCEDE 972
             |||..   |..:|.|.|.|||.|.:||.:
 Worm   337 -GTCIDSPLSEKAFECQCEPGYEGILCEQD 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wry	NP_995611.2	EGF_CA	737..777	CDD:238011	14/55 (25%)
		EGF	783..812	CDD:394967	13/28 (46%)
		EGF_CA	819..851	CDD:238011	17/90 (19%)
		EGF_CA	856..890	CDD:238011	14/33 (42%)
		EGF_CA	893..927	CDD:238011	14/33 (42%)
		EGF	938..966	CDD:394967	14/32 (44%)
lin-12	NP_499007.1	EGF_CA	152..189	CDD:238011	9/36 (25%)
		EGF_2	220..245	CDD:400365	5/24 (21%)
		EGF_CA	252..285	CDD:238011	14/33 (42%)
		EGF_CA	293..323	CDD:238011	12/29 (41%)
		EGF_CA	365..401	CDD:238011	0/1 (0%)
		EGF_CA	505..541	CDD:238011
		EGF_CA	545..579	CDD:238011
		NL	635..668	CDD:197463
		Notch	675..709	CDD:459658
		Notch	715..750	CDD:459658
		NOD	753..807	CDD:462014
		NODP	842..898	CDD:462229
		ANK repeat	1052..1091	CDD:293786
		ANKYR	1070..1295	CDD:440430
		ANK repeat	1093..1124	CDD:293786
		ANK repeat	1126..1160	CDD:293786
		ANK repeat	1162..1201	CDD:293786
		ANK repeat	1203..1238	CDD:293786
		ANK repeat	1240..1271	CDD:293786