DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wry and ACAN

DIOPT Version :9

Sequence 1:	NP_995611.2	Gene:	wry / 33361	FlyBaseID:	FBgn0051665	Length:	1157	Species:	Drosophila melanogaster
Sequence 2:	NP_001356197.1	Gene:	ACAN / 176	HGNCID:	319	Length:	2568	Species:	Homo sapiens

Alignment Length:	1107	Identity:	216/1107 - (19%)
Similarity:	333/1107 - (30%)	Gaps:	388/1107 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TLVIAVVAATTSE-----TI------------TNDLTAKSNRTLLKTSTE----------ESREI 45
            |||..|.|:|.||     ||            :::|......:.|.:.||          .|.||
Human  1665 TLVEVVTASTASELEGRGTIGISGAGEISGLPSSELDISGRASGLPSGTELSGQASGSPDVSGEI 1729

  Fly    46 SALGGSTS--TATPTTTATTSTTTTRATTVAEDEMEETSTPTP-----TTVRLMTTTQKMVQANL 103
            ..|.|.:.  :..|.|:..||..|         |:...|:..|     .:..|..|:|.....:|
Human  1730 PGLFGVSGQPSGFPDTSGETSGVT---------ELSGLSSGQPGISGEASGVLYGTSQPFGITDL 1785

  Fly   104 -GEIGSIKDALHRIKLSEKP----------------VDGATTTTEQPEAMDQDEQDEQDVTPTIS 151
             ||...:.|      ||.:|                |.|.|:.:.:...:...:....:|.||
Human  1786 SGETSGVPD------LSGQPSGLPGFSGATSGVPDLVSGTTSGSGESSGITFVDTSLVEVAPT-- 1842

  Fly   152 PLQIQMQAAASYQVAETLADLNEEERARYDAMLAQQPTASKLNIVDLYPLKIEDIQPIIRNDNDE 216
                      :::..|.|..:........:|.|     :.|..:||:.......:      |:..
Human  1843 ----------TFKEEEGLGSVELSGLPSGEADL-----SGKSGMVDVSGQFSGTV------DSSG 1886

  Fly   217 LIKQRTVFTQHENAEEYKQNLMPNEVEMMVDKEVIEMKDKIQINQEKFGSSTTVKPTTSRPHQGT 281
            ...|...|:.           :|:.:     .||.....:.:|     |||.   |:.:....||
Human  1887 FTSQTPEFSG-----------LPSGI-----AEVSGESSRAEI-----GSSL---PSGAYYGSGT 1927

  Fly   282 TADFTGKLLADQDDLITEIESKFQLHETTTLRPRVTTVQHPGNTFIDRRVKKSFEFPMQHRASDV 346
            .:.|....|.|:           .|.|:.|..|   |.|..|     .......|....|..:..
Human  1928 PSSFPTVSLVDR-----------TLVESVTQAP---TAQEAG-----EGPSGILELSGAHSGAPD 1973

  Fly   347 MAMPHIDFANTK------FQTDADAPNPPASHPEFSTTKFYNSKELYNEMLLHNKRKLMKAAKAE 405
            |:..|..|.:..      .:...:.|..|....:|::|...:.:         :...:..:.:|.
Human  1974 MSGEHSGFLDLSGLQSGLIEPSGEPPGTPYFSGDFASTTNVSGE---------SSVAMGTSGEAS 2029

  Fly   406 GSPIKSAEDTTRATSSNVTPEGKTFGPTTTTAAGSTATTT-----AESTTTAATTTRLPATTTGK 465
            |.|     :.|..||..|  ||.| .||.:...|.....|     .||:...:|...:...|
Human  2030 GLP-----EVTLITSEFV--EGVT-EPTISQELGQRPPVTHTPQLFESSGKVSTAGDISGAT--- 2083

  Fly   466 YQKELKRAKLLLKALTPPKSVDKSTASPSSTTSTSTSTTTTMATLLATARTRPSAANP--TKTAS 528
                         .:.|...|:.|:. |.|::.||...........|...:|..:.:|  ::|.|
Human  2084 -------------PVLPGSGVEVSSV-PESSSETSAYPEAGFGASAAPEASREDSGSPDLSETTS 2134

  Fly   529 ----KPIARPRILSRLQEKINSLECEIPNVPQDSHLWRGNETHELLLPIVTTEHCKPDEHCVPNV 589
                ..:.|...|......:...|.|....|:.|    |..|        ||.....:...:|:.
Human  2135 AFHEANLERSSGLGVSGSTLTFQEGEASAAPEVS----GEST--------TTSDVGTEAPGLPSA 2187

  Fly   590 L-TWRGEAEIQSGDI------LIVEINDAMLNPSHEPNNTSSAVHATQVYQVTRSGHEHCDVTEG 647
            . |..|:....|||:      |.|.|:.::  |..|         .||  |..|....|.::...
Human  2188 TPTASGDRTEISGDLSGHTSQLGVVISTSI--PESE---------WTQ--QTQRPAETHLEIESS 2239

  Fly   648 VLLDITPLVVDGRKLVTLYDKDLTEGVNLLIVVSELWGAQCVRLKVTTKTDNCGENADCSGKGVC 712
            .|               ||..:.|..|.                ..|:.||
Human  2240 SL---------------LYSGEETHTVE----------------TATSPTD-------------- 2259

  Fly   713 YSNSGMEEYECQCCSGFAGPHCEEIDACNPSPCTNNGICVDLSQGHEGNSYQCLCPYGYAGKNCQ 777
            .|.....|::.:..|..|.|                                        .::|.
Human  2260 ASIPASPEWKRESESTAAAP----------------------------------------ARSCA 2284

  Fly   778 YESDPCNPAECMNGGSCVGNSTHFRCDCAPGFTGPLCQHSLNECESSPCVHG-ICVDQEDGFRCF 841
            .|  ||      ..|:|.....|..|.|.||:||..|...::||.||||::| .|||..|.|.|.
Human  2285 EE--PC------GAGTCKETEGHVICLCPPGYTGEHCNIDIDECLSSPCLNGATCVDAIDSFTCL 2341

  Fly   842 CQPGFAGELCNFEYNECESNPCQNGGECIDHIGSYECRCTKGFSGNRCQIKVDFCANKPCPEGHR 906
            |.|.:.|:||..:...||....:..|.|..|....|   |...:..||:.:....::...||...
Human  2342 CLPSYEGDLCEIDQEVCEEGWNKYQGHCYRHFPDRE---TWVDAERRCREQQSHLSSIVTPEEQE 2403

  Fly   907 CIDHGNDFSCECPGGRNGPDCNQMPRTYFQQCNVNPCT-HGGTCWSSG-------------DSFY 957
            .:::            |..|        :|...:|..| .|...||.|             |:|:
Human  2404 FVNN------------NAQD--------YQWIGLNDRTIEGDFRWSDGHPMQFENWRPNQPDNFF 2448

  Fly   958 CA---------------------------CRPGYTGTMCEDEFVVETVVSSSEFIVDDANARNFN 995
            .|                           |:.|...  |.:..|||             :||.|.
Human  2449 AAGEDCVVMIWHEKGEWNDVPCNYHLPFTCKKGTVA--CGEPPVVE-------------HARTFG 2498

  Fly   996 DK 997
            .|
Human  2499 QK 2500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wry	NP_995611.2	EGF_CA	737..777	CDD:238011	0/39 (0%)
		EGF	783..812	CDD:278437	9/28 (32%)
		EGF_CA	819..851	CDD:238011	16/32 (50%)
		EGF_CA	856..890	CDD:238011	8/33 (24%)
		EGF_CA	893..927	CDD:238011	3/33 (9%)
		EGF_CA	<941..970	CDD:238011	11/69 (16%)
ACAN	NP_001356197.1	Ig_Aggrecan	43..154	CDD:143308
		G1-A	48..141
		G1-B	152..247
		Link_domain_CSPGs_modules_1_3	153..247	CDD:239594
		G1-B'	253..349
		Link_domain_CSPGs_modules_2_4	254..349	CDD:239597
		G2-B	477..571
		Link_domain_CSPGs_modules_1_3	478..572	CDD:239594
		G2-B'	578..673
		Link_domain_CSPGs_modules_2_4	579..674	CDD:239597
		KS	677..849
		PHA03307	716..>975	CDD:223039
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	734..979
		12 X 6 AA approximate tandem repeats of E-[GVE]-P-[SFY]-[APT]-[TSP]	773..844
		CS-1	852..1612
		35 X 19 AA approximate tandem repeats of E-[IVDG]-[LV]-[EV]-[GTI]-[STA]-[ATV]-[SP]-[GA]-[VIFAD]- [GEDL]-[DE]-[LVI]-[SG]-[GERK]-[LV]-P-S-G	942..1612
		PRK15387	<1433..>1614	CDD:185285
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1499..1526
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1543..1649
		CS-2	1613..2277		149/796 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1687..1772		17/93 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1784..1827		10/48 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1883..1902		4/34 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1948..1977		7/36 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2048..2204		36/184 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2249..2281		9/101 (9%)
		EGF_CA	2283..2313	CDD:238011	13/37 (35%)
		EGF_CA	2316..2352	CDD:238011	17/35 (49%)
		CLECT_CSPGs	2358..2481	CDD:153058	24/145 (17%)
		CCP	2485..2541	CDD:153056	8/29 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2548..2568
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910