DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wry and notch2

DIOPT Version :9

Sequence 1:	NP_995611.2	Gene:	wry / 33361	FlyBaseID:	FBgn0051665	Length:	1157	Species:	Drosophila melanogaster
Sequence 2:	XP_002939126.3	Gene:	notch2 / 100486344	XenbaseID:	XB-GENE-6046917	Length:	2455	Species:	Xenopus tropicalis

Alignment Length:	505	Identity:	148/505 - (29%)
Similarity:	204/505 - (40%)	Gaps:	128/505 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   548 ECEI-PNVPQDS---------------HLWRGNETHELLLPIVTTEHCKPDEHCVPNVLTWRGEA 596
            ||:: ||..|:.               :.|.|::..:.:....|.. |.....|:..|.::  ..
Frog   297 ECQLQPNACQNGGTCTNSNGGYNCVCVNGWSGDDCSQNIDDCATAA-CANGSTCIDRVASF--IC 358

  Fly   597 EIQSGDI-LIVEINDAML-NPSHEPNNTSSAVHATQVYQVTRSGHEHCDVTEGVLLDITPLVVDG 659
            ....|.| |:...|||.. ||.|                            .|.|.|..||.  |
Frog   359 VCPEGKIGLLCHKNDACFSNPCH----------------------------MGSLCDTNPLT--G 393

  Fly   660 RKLVTLYDKDLTEGVNLLIVVSELWGAQCVRLKVTTKTDNCG--ENADCSGKGVCYSNSGMEEYE 722
            :.:.|              ..|...|..|     |...|.|.  .:..|...|.|.:..|  .:.
Frog   394 QAICT--------------CPSGYKGTAC-----TEDIDECSLVNSNPCEHAGKCVNTEG--SFY 437

  Fly   723 CQCCSGFAGPHCE---------------------------------------EIDACNPSPCTNN 748
            |:|..||.||.||                                       ||:.|..:||.||
Frog   438 CECSKGFTGPRCEMDINECLSEPCQNDATCLDKIGGFTCLCMPGYKGIHCEIEINECLSNPCVNN 502

  Fly   749 GICVDLSQGHEGNSYQCLCPYGYAGKNCQYESDPCNPAECMNGGSCVGNSTHFRCDCAPGFTGPL 813
            |.|||     :.|.:.|:||.|:.|..||.:.|.|:...|.||..||.:.:.:.|.||.||||.|
Frog   503 GECVD-----KVNRFVCICPPGFTGSVCQIDIDDCSSTPCQNGAKCVDHPSGYDCICATGFTGVL 562

  Fly   814 CQHSLNECESSPCVHGICVDQEDGFRCFCQPGFAGELCNFEYNECESNPCQNGGECIDHIGSYEC 878
            |:.::|.||..||.:|.|.|..|.:.|.|:||:.|.:|:.:.:||.||||.|.|.|:|.:..|:|
Frog   563 CEENINNCEPPPCHYGTCQDGIDSYTCICEPGYMGAICSDQIDECLSNPCLNEGRCVDLVNGYQC 627

  Fly   879 RCTKGFSGNRCQIKVDFCANKPCPEGHRCIDHGNDFSCECPGGRNGPDCNQMPRTYFQQCNVNPC 943
            .|..|.||.||:..||.||:.||..|: |:|..|.:.|.|..|..||.|    :....:|..|||
Frog   628 NCLPGTSGPRCEKNVDDCASNPCTYGN-CVDGINRYDCVCSPGFTGPQC----KDDIDECASNPC 687

  Fly   944 THGGTCWSSGDSFYCACRPGYTGTMC---EDEFVVETVVSSSEFIVDDAN 990
            .:||||.:..:.|.|.|..|:....|   .||.|....:..:  ..||.|
Frog   688 HNGGTCVNEQNRFRCICPEGFRQPSCFSQVDECVNNPCIHGN--CTDDVN 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wry	NP_995611.2	EGF_CA	737..777	CDD:238011	16/39 (41%)
		EGF	783..812	CDD:278437	12/28 (43%)
		EGF_CA	819..851	CDD:238011	14/31 (45%)
		EGF_CA	856..890	CDD:238011	17/33 (52%)
		EGF_CA	893..927	CDD:238011	15/33 (45%)
		EGF_CA	<941..970	CDD:238011	12/31 (39%)
notch2	XP_002939126.3	EGF_CA	141..176	CDD:238011
		EGF_CA	178..215	CDD:238011
		EGF_CA	256..292	CDD:238011
		EGF_CA	294..331	CDD:238011	7/33 (21%)
		EGF_CA	334..369	CDD:238011	7/37 (19%)
		EGF_CA	411..450	CDD:238011	12/40 (30%)
		EGF_CA	452..488	CDD:238011	0/35 (0%)
		EGF_CA	491..526	CDD:238011	16/39 (41%)
		EGF_CA	528..564	CDD:238011	15/35 (43%)
		EGF_CA	566..600	CDD:238011	14/33 (42%)
		EGF_CA	604..639	CDD:238011	17/34 (50%)
		EGF_CA	641..676	CDD:238011	16/39 (41%)
		EGF_CA	678..713	CDD:238011	12/34 (35%)
		EGF_CA	717..751	CDD:238011	6/21 (29%)
		EGF_CA	753..789	CDD:238011
		EGF_CA	791..827	CDD:238011
		EGF_CA	869..905	CDD:238011
		EGF_CA	907..943	CDD:238011
		EGF_CA	945..980	CDD:238011
		EGF_CA	983..1018	CDD:238011
		EGF_CA	1022..1057	CDD:238011
		EGF_CA	1147..1181	CDD:238011
		EGF_CA	1184..1219	CDD:238011
		EGF_CA	1221..1261	CDD:238011
		EGF_CA	1263..1301	CDD:238011
		EGF_CA	<1311..1342	CDD:238011
		Notch	1430..1456	CDD:395019
		Notch	1469..1497	CDD:395019
		Notch	1506..1535	CDD:395019
		NOD	1541..1595	CDD:399654
		NODP	1621..1676	CDD:400155
		JMTM_Notch_APP	1661..1742	CDD:425406
		PHA03095	<1822..>2032	CDD:222980
		ANK repeat	1829..1876	CDD:293786
		ANK repeat	1879..1909	CDD:293786
		ANK repeat	1911..1976	CDD:293786
		ANK repeat	1978..2009	CDD:293786
		PTZ00322	1984..>2086	CDD:140343
		ANK repeat	2011..2042	CDD:293786
		DUF3454	2371..2431	CDD:403221
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D7525at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920